DE69705423T2 - Sandwichtest zum nachweis von kollagenfragmenten - Google Patents
Sandwichtest zum nachweis von kollagenfragmentenInfo
- Publication number
- DE69705423T2 DE69705423T2 DE69705423T DE69705423T DE69705423T2 DE 69705423 T2 DE69705423 T2 DE 69705423T2 DE 69705423 T DE69705423 T DE 69705423T DE 69705423 T DE69705423 T DE 69705423T DE 69705423 T2 DE69705423 T2 DE 69705423T2
- Authority
- DE
- Germany
- Prior art keywords
- collagen
- antibody
- sandwich
- epitope
- fragments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/108—Osteoporosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Paints Or Removers (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9625559.1A GB9625559D0 (en) | 1996-12-09 | 1996-12-09 | Sandwish assays for collagen type I fragments |
| GBGB9705687.3A GB9705687D0 (en) | 1997-03-19 | 1997-03-19 | Sandwich assays for collagen type i fragments |
| PCT/EP1997/006803 WO1998026286A2 (en) | 1996-12-09 | 1997-12-05 | Sandwich assays for collagen type i fragments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69705423D1 DE69705423D1 (de) | 2001-08-02 |
| DE69705423T2 true DE69705423T2 (de) | 2002-05-16 |
Family
ID=26310589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69705423T Expired - Lifetime DE69705423T2 (de) | 1996-12-09 | 1997-12-05 | Sandwichtest zum nachweis von kollagenfragmenten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6660481B2 (enExample) |
| EP (1) | EP0944833B1 (enExample) |
| JP (1) | JP3913787B2 (enExample) |
| AT (1) | ATE202632T1 (enExample) |
| AU (1) | AU5754298A (enExample) |
| DE (1) | DE69705423T2 (enExample) |
| ES (1) | ES2160985T3 (enExample) |
| WO (1) | WO1998026286A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962639A (en) * | 1987-11-06 | 1999-10-05 | Washington Research Foundation | Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites |
| DE69705423T2 (de) * | 1996-12-09 | 2002-05-16 | Osteometer Biotech As Herlev | Sandwichtest zum nachweis von kollagenfragmenten |
| GB9928052D0 (en) * | 1999-11-26 | 2000-01-26 | Osteometer Biotech As | Assay of isomerised and/or optically inverted proteins and protein fragments |
| US7354723B2 (en) | 1999-11-26 | 2008-04-08 | Nordic Bioscience Dagnostics A/S | Assay of isomerised and/or optically inverted proteins and protein fragments |
| AU2001276395A1 (en) * | 2000-07-12 | 2002-02-05 | Werner Naser | Direct assessment of relative concentrations of variants of an epitope on a dimeric molecule |
| EP2287330A1 (en) * | 2001-11-01 | 2011-02-23 | Rensselaer Polytechnic Institute | Biocatalytic Solgel Microarrays |
| US20050124071A1 (en) * | 2003-09-30 | 2005-06-09 | Kraus Virginia B. | Methods and compositions for diagnosing musculoskeletal, arthritic and joint disorders by biomarker dating |
| CA2628219C (en) * | 2005-11-01 | 2012-11-27 | Rensselaer Polytechnic Institute | Three-dimensional cellular array chip and platform for toxicology assays |
| WO2009038771A2 (en) * | 2007-09-19 | 2009-03-26 | Massachusetts Institute Of Technology | Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers |
| US20110281279A1 (en) * | 2007-12-21 | 2011-11-17 | Siemens Healthcare Diagnostics Inc. | CIRCULATING Epha2 RECEPTOR |
| US8796184B2 (en) | 2008-03-28 | 2014-08-05 | Sentilus, Inc. | Detection assay devices and methods of making and using the same |
| WO2013158217A1 (en) * | 2012-04-20 | 2013-10-24 | Thomas Jefferson University | Engineered antibody for inhibition of fibrosis |
| US9753030B2 (en) * | 2013-03-06 | 2017-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection |
| ES2687220B1 (es) * | 2017-03-23 | 2019-08-08 | Servicio Andaluz De Salud | Método de obtención de datos útiles para el cribado y diagnóstico de la osteoporosis |
| WO2022202876A1 (ja) * | 2021-03-24 | 2022-09-29 | 積水メディカル株式会社 | Ｉ型コラーゲンｃ末端テロペプチドの免疫学的分析方法 |
| WO2023068249A1 (ja) * | 2021-10-20 | 2023-04-27 | 積水メディカル株式会社 | Ｉ型コラーゲン架橋ｎ－テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6716836A (enExample) | 1967-12-11 | 1969-06-13 | ||
| DE2816841A1 (de) | 1978-04-18 | 1979-10-31 | Max Planck Gesellschaft | Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii) |
| US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| DE3209149A1 (de) | 1982-03-13 | 1983-10-06 | Hoechst Ag | Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum |
| US4628027A (en) | 1982-05-19 | 1986-12-09 | Molecular Engineering Associates, Ltd. | Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins |
| CA1251729A (en) | 1982-05-19 | 1989-03-28 | Steffen Gay | In vitro diagnostic methods using monoclonal antibodies against connective tissue proteins |
| SE8304836D0 (sv) | 1983-09-09 | 1983-09-09 | Pharmacia Ab | Sett att bestemma forendringar i ledbrosk |
| US5001225A (en) | 1986-12-08 | 1991-03-19 | Georgetown University | Monoclonal antibodies to a pan-malarial antigen |
| JPS63209318A (ja) | 1987-02-26 | 1988-08-30 | Sony Corp | 受信機 |
| US5679583A (en) | 1987-05-02 | 1997-10-21 | Hoechst Aktiengesellschaft | Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids |
| DE3714634A1 (de) | 1987-05-02 | 1988-11-17 | Hoechst Ag | Verfahren zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in koerperfluessigkeiten und mittel zu dessen durchfuehrung |
| GB2205643B (en) | 1987-05-08 | 1991-03-13 | Farmos Group Limited | Type iii collagen degradation assay |
| US5320970A (en) | 1987-11-06 | 1994-06-14 | Washington Research Foundation | Detection of collagen degradation in vivo |
| US4973666A (en) | 1987-11-06 | 1990-11-27 | Washington Research Foundation | Peptide fragments containing HP and LP cross-links |
| US5300434A (en) | 1987-11-06 | 1994-04-05 | Washington Research Foundation | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
| ATE115963T1 (de) | 1988-04-27 | 1995-01-15 | Hoechst Ag | Monoklonaler antikörper zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in körperflüssigkeiten. |
| GB8815174D0 (en) | 1988-06-25 | 1988-08-03 | Rowett Research Inst | Method of monitoring collagen degradation |
| WO1990004417A1 (en) | 1988-10-24 | 1990-05-03 | Bruce Caterson | Methods of and compositions for diagnosing, monitoring and treating the early stages of osteoarthritis |
| WO1990008195A1 (en) | 1989-01-13 | 1990-07-26 | President And Fellows Of Harvard College | Monoclonal antibody to human type ix collagen |
| ZA909755B (en) | 1989-12-07 | 1991-09-25 | Res Dev Foundation | Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product |
| GB9014220D0 (en) | 1990-06-26 | 1990-08-15 | Farmos Yhtymy Oy | Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen |
| GB9105893D0 (en) | 1991-03-20 | 1991-05-08 | Orion Yhtymae Oy | Bone resorption assay based on a peptide liberated during collagen degradation |
| DE4225038C2 (de) | 1992-07-29 | 1995-11-30 | Boehringer Mannheim Gmbh | Herstellung und Verwendung von Antikörpern gegen Kollagen |
| DE69333641T2 (de) | 1992-12-28 | 2005-11-03 | Baylink, David Jeston, Redlands | Methode zur messung der knochenresorption |
| DE59406512D1 (de) | 1993-07-28 | 1998-08-27 | Boehringer Mannheim Gmbh | Immunoassay zum nachweis von kollagen typ i oder kollagenfragmenten davon |
| DK104093D0 (da) | 1993-09-17 | 1993-09-17 | Osteometer A S | Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen |
| GB9506050D0 (en) * | 1995-03-24 | 1995-05-10 | Osteometer A S | Assaying collagen fragments in body fluids |
| JPH08100000A (ja) | 1994-09-30 | 1996-04-16 | Morinaga & Co Ltd | ヒトｉｖ型コラーゲンに対する抗体及びその利用 |
| ES2154739T3 (es) | 1994-10-17 | 2001-04-16 | Osteometer Biotech As | Estimacion del modelo de fragmentacion del colageno en fluidos corporales y el diagnostico de trastornos asociados con el metabolismo del colageno. |
| US5763272A (en) | 1994-12-23 | 1998-06-09 | Boehringer Mannheim Gmbh | Hybridoma for producing antibody for collagen I |
| DE59505585D1 (de) | 1994-12-23 | 1999-05-12 | Roche Diagnostics Gmbh | Antigene und Antikörper zum Nachweis von Kollagen I |
| US5750647A (en) | 1995-05-19 | 1998-05-12 | Washington Research Foundation | Synthetic peptide analogs of NTx |
| JPH0921803A (ja) * | 1995-07-07 | 1997-01-21 | Teijin Ltd | ２型コラーゲンテロペプチドの測定方法 |
| US6107047A (en) * | 1996-03-21 | 2000-08-22 | Osteometer Biotech A/S | Assaying protein fragments in body fluids |
| GB9617616D0 (en) * | 1996-08-22 | 1996-10-02 | Osteometer Biotech As | Assaying protein fragments in body fluids |
| JP3446493B2 (ja) | 1996-09-13 | 2003-09-16 | トヨタ自動車株式会社 | エキゾーストマニホルド |
| EP0829724A1 (en) * | 1996-09-17 | 1998-03-18 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Assay for detecting collagen degradation |
| DE69705423T2 (de) * | 1996-12-09 | 2002-05-16 | Osteometer Biotech As Herlev | Sandwichtest zum nachweis von kollagenfragmenten |
| GB9702252D0 (en) * | 1997-02-06 | 1997-03-26 | Univ Sheffield Medical The Sch | Collagen assay |
-
1997
- 1997-12-05 DE DE69705423T patent/DE69705423T2/de not_active Expired - Lifetime
- 1997-12-05 ES ES97953745T patent/ES2160985T3/es not_active Expired - Lifetime
- 1997-12-05 WO PCT/EP1997/006803 patent/WO1998026286A2/en not_active Ceased
- 1997-12-05 AT AT97953745T patent/ATE202632T1/de not_active IP Right Cessation
- 1997-12-05 JP JP52618698A patent/JP3913787B2/ja not_active Expired - Fee Related
- 1997-12-05 US US09/319,539 patent/US6660481B2/en not_active Expired - Lifetime
- 1997-12-05 EP EP97953745A patent/EP0944833B1/en not_active Expired - Lifetime
- 1997-12-05 AU AU57542/98A patent/AU5754298A/en not_active Abandoned
-
2003
- 2003-12-09 US US10/730,070 patent/US7195883B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0944833B1 (en) | 2001-06-27 |
| WO1998026286A2 (en) | 1998-06-18 |
| US7195883B2 (en) | 2007-03-27 |
| US6660481B2 (en) | 2003-12-09 |
| WO1998026286A3 (en) | 1998-08-13 |
| EP0944833A2 (en) | 1999-09-29 |
| ES2160985T3 (es) | 2001-11-16 |
| AU5754298A (en) | 1998-07-03 |
| JP3913787B2 (ja) | 2007-05-09 |
| ATE202632T1 (de) | 2001-07-15 |
| US20030148272A1 (en) | 2003-08-07 |
| US20040224375A1 (en) | 2004-11-11 |
| JP2001506000A (ja) | 2001-05-08 |
| DE69705423D1 (de) | 2001-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |