ES2160985T3 - Ensayos de tipo sandwich para fragmentos de colageno. - Google Patents

Ensayos de tipo sandwich para fragmentos de colageno.

Info

Publication number
ES2160985T3
ES2160985T3 ES97953745T ES97953745T ES2160985T3 ES 2160985 T3 ES2160985 T3 ES 2160985T3 ES 97953745 T ES97953745 T ES 97953745T ES 97953745 T ES97953745 T ES 97953745T ES 2160985 T3 ES2160985 T3 ES 2160985T3
Authority
ES
Spain
Prior art keywords
sandwich type
collagen fragments
type tests
collagen
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97953745T
Other languages
English (en)
Inventor
Christian Rosenquist
Per Qvist
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunodiagnostic Systems Nordic AS
Original Assignee
Osteometer Biotech AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625559.1A external-priority patent/GB9625559D0/en
Priority claimed from GBGB9705687.3A external-priority patent/GB9705687D0/en
Application filed by Osteometer Biotech AS filed Critical Osteometer Biotech AS
Application granted granted Critical
Publication of ES2160985T3 publication Critical patent/ES2160985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Paints Or Removers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE REALIZAN ENSAYOS EN EMPAREDADO DE PRODUCTOS DE DEGRADACION DEL COLAGENO, USANDO UN ANTICUERPO DE LA MISMA ESPECIFICIDAD EN AMBOS LADOS DEL EMPAREDADO, O USANDO UN PRIMER ANTICUERPO QUE REACCIONA CON UN EPITOPE CONTENIDO EN LA SECUENCIA EKAHDGGR Y UN SEGUNDO ANTICUERPO QUE PUEDE SER EL MISMO O DIFERENTE.
ES97953745T 1996-12-09 1997-12-05 Ensayos de tipo sandwich para fragmentos de colageno. Expired - Lifetime ES2160985T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9625559.1A GB9625559D0 (en) 1996-12-09 1996-12-09 Sandwish assays for collagen type I fragments
GBGB9705687.3A GB9705687D0 (en) 1997-03-19 1997-03-19 Sandwich assays for collagen type i fragments

Publications (1)

Publication Number Publication Date
ES2160985T3 true ES2160985T3 (es) 2001-11-16

Family

ID=26310589

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97953745T Expired - Lifetime ES2160985T3 (es) 1996-12-09 1997-12-05 Ensayos de tipo sandwich para fragmentos de colageno.

Country Status (8)

Country Link
US (2) US6660481B2 (es)
EP (1) EP0944833B1 (es)
JP (1) JP3913787B2 (es)
AT (1) ATE202632T1 (es)
AU (1) AU5754298A (es)
DE (1) DE69705423T2 (es)
ES (1) ES2160985T3 (es)
WO (1) WO1998026286A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
DE69705423T2 (de) * 1996-12-09 2002-05-16 Osteometer Biotech As Herlev Sandwichtest zum nachweis von kollagenfragmenten
US7354723B2 (en) 1999-11-26 2008-04-08 Nordic Bioscience Dagnostics A/S Assay of isomerised and/or optically inverted proteins and protein fragments
GB9928052D0 (en) * 1999-11-26 2000-01-26 Osteometer Biotech As Assay of isomerised and/or optically inverted proteins and protein fragments
WO2002008722A2 (en) * 2000-07-12 2002-01-31 Werner Naser Direct assessment of relative concentrations of variants of an epitope on a dimeric molecule
WO2003038131A1 (en) * 2001-11-01 2003-05-08 Rensselaer Polytechnic Institute Biocatalytic solgel microarrays
US20050124071A1 (en) * 2003-09-30 2005-06-09 Kraus Virginia B. Methods and compositions for diagnosing musculoskeletal, arthritic and joint disorders by biomarker dating
JP4959710B2 (ja) * 2005-11-01 2012-06-27 レンセレアー ポリテクニック インスティテュート 毒物学アッセイのための３次元細胞アレイチップおよびプラットフォーム
WO2009038771A2 (en) * 2007-09-19 2009-03-26 Massachusetts Institute Of Technology Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers
EP2223112A2 (en) * 2007-12-21 2010-09-01 Siemens Healthcare Diagnostics Inc. Circulating epha2 receptor
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
US9777055B2 (en) 2012-04-20 2017-10-03 Thomas Jefferson University Engineered antibody for inhibition of fibrosis
US9753030B2 (en) * 2013-03-06 2017-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection
ES2687220B1 (es) * 2017-03-23 2019-08-08 Servicio Andaluz De Salud Método de obtención de datos útiles para el cribado y diagnóstico de la osteoporosis
US20240125784A1 (en) * 2021-03-24 2024-04-18 Sekisui Medical Co., Ltd. Immunological analysis method for type-i collagen c-terminal telopeptide
WO2023068249A1 (ja) * 2021-10-20 2023-04-27 積水メディカル株式会社 Ｉ型コラーゲン架橋ｎ－テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6716836A (es) 1967-12-11 1969-06-13
DE2816841A1 (de) 1978-04-18 1979-10-31 Max Planck Gesellschaft Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii)
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
DE3209149A1 (de) 1982-03-13 1983-10-06 Hoechst Ag Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum
CA1251729A (en) 1982-05-19 1989-03-28 Steffen Gay In vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
US4628027A (en) 1982-05-19 1986-12-09 Molecular Engineering Associates, Ltd. Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
SE8304836D0 (sv) 1983-09-09 1983-09-09 Pharmacia Ab Sett att bestemma forendringar i ledbrosk
US5001225A (en) 1986-12-08 1991-03-19 Georgetown University Monoclonal antibodies to a pan-malarial antigen
JPS63209318A (ja) 1987-02-26 1988-08-30 Sony Corp 受信機
DE3714634A1 (de) 1987-05-02 1988-11-17 Hoechst Ag Verfahren zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in koerperfluessigkeiten und mittel zu dessen durchfuehrung
US5679583A (en) 1987-05-02 1997-10-21 Hoechst Aktiengesellschaft Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids
GB2205643B (en) 1987-05-08 1991-03-13 Farmos Group Limited Type iii collagen degradation assay
US5300434A (en) 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
US4973666A (en) 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5320970A (en) 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
ES2065350T3 (es) 1988-04-27 1995-02-16 Hoechst Ag Anticuerpo monoclonal para la determinacion immunologica selectiva de peptido (tipo iii) intacto y procolageno (tipo iii) en liquidos corporales.
GB8815174D0 (en) 1988-06-25 1988-08-03 Rowett Research Inst Method of monitoring collagen degradation
JPH04502854A (ja) 1988-10-24 1992-05-28 カターソン，ブルース 変形性関節症の初期段階の診断、モニタリングならびに治療の方法および組成物
WO1990008195A1 (en) 1989-01-13 1990-07-26 President And Fellows Of Harvard College Monoclonal antibody to human type ix collagen
ZA909755B (en) 1989-12-07 1991-09-25 Res Dev Foundation Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
GB9014220D0 (en) 1990-06-26 1990-08-15 Farmos Yhtymy Oy Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen
GB9105893D0 (en) 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation
DE4225038C2 (de) 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Herstellung und Verwendung von Antikörpern gegen Kollagen
CA2152667C (en) 1992-12-28 2003-02-11 David J. Baylink Bone resorption assay
CA2167496A1 (en) 1993-07-28 1995-02-09 Werner Naser Immunoassay for the detection of collagen or collagen fragments
DK104093D0 (da) * 1993-09-17 1993-09-17 Osteometer A S Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen
GB9506050D0 (en) * 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
JPH08100000A (ja) 1994-09-30 1996-04-16 Morinaga & Co Ltd ヒトｉｖ型コラーゲンに対する抗体及びその利用
AU3746295A (en) * 1994-10-17 1996-05-06 Osteometer Biotech As Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen
US5763272A (en) 1994-12-23 1998-06-09 Boehringer Mannheim Gmbh Hybridoma for producing antibody for collagen I
DE59505585D1 (de) 1994-12-23 1999-05-12 Roche Diagnostics Gmbh Antigene und Antikörper zum Nachweis von Kollagen I
US5750647A (en) 1995-05-19 1998-05-12 Washington Research Foundation Synthetic peptide analogs of NTx
JPH0921803A (ja) * 1995-07-07 1997-01-21 Teijin Ltd ２型コラーゲンテロペプチドの測定方法
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) * 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
JP3446493B2 (ja) 1996-09-13 2003-09-16 トヨタ自動車株式会社 エキゾーストマニホルド
EP0829724A1 (en) * 1996-09-17 1998-03-18 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Assay for detecting collagen degradation
DE69705423T2 (de) * 1996-12-09 2002-05-16 Osteometer Biotech As Herlev Sandwichtest zum nachweis von kollagenfragmenten
GB9702252D0 (en) * 1997-02-06 1997-03-26 Univ Sheffield Medical The Sch Collagen assay

Also Published As

Publication number Publication date
EP0944833A2 (en) 1999-09-29
US20030148272A1 (en) 2003-08-07
WO1998026286A2 (en) 1998-06-18
ATE202632T1 (de) 2001-07-15
EP0944833B1 (en) 2001-06-27
JP3913787B2 (ja) 2007-05-09
DE69705423T2 (de) 2002-05-16
AU5754298A (en) 1998-07-03
US7195883B2 (en) 2007-03-27
WO1998026286A3 (en) 1998-08-13
US6660481B2 (en) 2003-12-09
US20040224375A1 (en) 2004-11-11
DE69705423D1 (de) 2001-08-02
JP2001506000A (ja) 2001-05-08

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