JP2001506000A - I型コラーゲン断片のサンドウイッチ測定法 - Google Patents
I型コラーゲン断片のサンドウイッチ測定法Info
- Publication number
- JP2001506000A JP2001506000A JP52618698A JP52618698A JP2001506000A JP 2001506000 A JP2001506000 A JP 2001506000A JP 52618698 A JP52618698 A JP 52618698A JP 52618698 A JP52618698 A JP 52618698A JP 2001506000 A JP2001506000 A JP 2001506000A
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- antibody
- sandwich
- epitope
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/108—Osteoporosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Paints Or Removers (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. コラーゲンアミノ酸配列EKAHDGGRまたはその異性化および/ま たはラセミ化変異体に位置する第一のエピトープと反応性を有する第一の抗体お よびコラーゲン断片中に位置する第二のコラーゲンエピトープと反応性を有する 第二の抗体とを使用するサンドウイッチ測定法によって試料(例えば一種の体液 )中におけるコラーゲン断片集団の量を測定することからなるI型コラーゲン吸 収速度を測定する方法。 2. 前記第二のエピトープが、同一または異なるコラーゲン鎖の前記第一の エピトープを基準としてN−アミノ末端の方向に位置する、請求項1において記 載された方法。 3. 該第二のエピトープが、少なくともアミノ酸配列FDFSFの一部を含 むものである、請求項2において請求された方法。 4. 該測定法が、サンドウイッチ放射線免疫測定法であるかまたはサンドウ イッチELISA測定法である、前記請求項のうちの何れか一項において記載さ れた方法。 5. 該測定法において検出される断片の分子量が1500Da(ダルトン) を上回る、 前記請求項のうちの何れか一項において請求された方法。 6. 該測定法において検出される断片の分子量が25000Da(ダルトン )を上回る、 前記請求項のうちの何れか一項において請求された方法。 7. 前記コラーゲンエピトープが、アミノ酸配列EKAHDGGRまたはそ の異性化および/またはラセミ化変異体にも位置する、請求項1において請求さ れた方法。 8. 前記エピトープの各々が、架橋に結合したそれぞれのアミノ酸に存在す る、請求項7において請求された方法。 9. 前記エピトープの各々が、アミノ酸配列EKAH−βD−GGRに位置 する、請求項7において請求された方法。 10. 各抗体が、配列アミノ酸配列EKAH−βD−GGRを含むペプチド 類縁体に対して産生せしめたモノクローナル抗体である、請求項9において請求 された方法。 11. 以下の操作を行うことから成るサンドウイッチ測定法WP実施する方 法: −少なくとも二つの抗原性が類似したエピトープを前記エピトープの双方と反応 性を有し、捕捉部位と結合せしめられた第一の抗体および前記エピトープの双方 と反応性を有し、標識物と結合せしめられた第二の抗体とに混合し、その結果第 一の抗体/ターゲット抗原/第二の抗体なるサンドウイッチを生成させること; −前記第一の抗体の前記捕捉部位に対して親和性を有する捕捉基質に前記サンド ウイッチを捕捉させること;および 第二の抗体の標識を検出することによって前記サンドウイッチの捕捉を検出する こと。 12. 特異性が実質的に同一である抗体をサンドウイッチの両側におい手使用 するコラーゲン分解生成物のためのサンドウイッチ測定法。 13. 料中におけるコラーゲン分解産物の濃度を測定する方法において、生 体内でのコラーゲン分解に際して直ちに生成するN−末端テロペプチド断片内の エピトープと免疫学的反応性を有する第一および第二の免疫学的結合パートナー (これらは相互に同一かまたは異なる)を用いたサンドウイッチ測定法を実施す ることからなる前記測定方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9625559.1 | 1996-12-09 | ||
GBGB9625559.1A GB9625559D0 (en) | 1996-12-09 | 1996-12-09 | Sandwish assays for collagen type I fragments |
GB9705687.3 | 1997-03-19 | ||
GBGB9705687.3A GB9705687D0 (en) | 1997-03-19 | 1997-03-19 | Sandwich assays for collagen type i fragments |
PCT/EP1997/006803 WO1998026286A2 (en) | 1996-12-09 | 1997-12-05 | Sandwich assays for collagen type i fragments |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001506000A true JP2001506000A (ja) | 2001-05-08 |
JP2001506000A5 JP2001506000A5 (ja) | 2005-07-14 |
JP3913787B2 JP3913787B2 (ja) | 2007-05-09 |
Family
ID=26310589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52618698A Expired - Fee Related JP3913787B2 (ja) | 1996-12-09 | 1997-12-05 | I型コラーゲン断片のサンドウイッチ測定法 |
Country Status (8)
Country | Link |
---|---|
US (2) | US6660481B2 (ja) |
EP (1) | EP0944833B1 (ja) |
JP (1) | JP3913787B2 (ja) |
AT (1) | ATE202632T1 (ja) |
AU (1) | AU5754298A (ja) |
DE (1) | DE69705423T2 (ja) |
ES (1) | ES2160985T3 (ja) |
WO (1) | WO1998026286A2 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003515170A (ja) * | 1999-11-26 | 2003-04-22 | オステオミーター・ビオテク・エー/エス | 異性化及び/又は光学的反転したタンパク質及びタンパク質断片の測定法 |
WO2022202876A1 (ja) * | 2021-03-24 | 2022-09-29 | 積水メディカル株式会社 | I型コラーゲンc末端テロペプチドの免疫学的分析方法 |
WO2023068249A1 (ja) * | 2021-10-20 | 2023-04-27 | 積水メディカル株式会社 | I型コラーゲン架橋n-テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法 |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962639A (en) * | 1987-11-06 | 1999-10-05 | Washington Research Foundation | Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites |
JP3913787B2 (ja) * | 1996-12-09 | 2007-05-09 | オステオメーター・ビオテク・エー/エス | I型コラーゲン断片のサンドウイッチ測定法 |
US7354723B2 (en) | 1999-11-26 | 2008-04-08 | Nordic Bioscience Dagnostics A/S | Assay of isomerised and/or optically inverted proteins and protein fragments |
WO2002008722A2 (en) * | 2000-07-12 | 2002-01-31 | Werner Naser | Direct assessment of relative concentrations of variants of an epitope on a dimeric molecule |
AU2002353997A1 (en) * | 2001-11-01 | 2003-05-12 | Rensselaer Polytechnic Institute | In vitro metabolic engineering on microscale devices |
US20050124071A1 (en) * | 2003-09-30 | 2005-06-09 | Kraus Virginia B. | Methods and compositions for diagnosing musculoskeletal, arthritic and joint disorders by biomarker dating |
US20090221441A1 (en) * | 2005-11-01 | 2009-09-03 | Rensselaer Polytechnic Institute | Three-dimensional cellular array chip and platform for toxicology assays |
US20100298329A1 (en) * | 2007-09-19 | 2010-11-25 | Massachusette Institute Of Technology | Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers |
EP2223112A2 (en) * | 2007-12-21 | 2010-09-01 | Siemens Healthcare Diagnostics Inc. | Circulating epha2 receptor |
US8796184B2 (en) | 2008-03-28 | 2014-08-05 | Sentilus, Inc. | Detection assay devices and methods of making and using the same |
USRE49477E1 (en) | 2012-04-20 | 2023-03-28 | Thomas Jefferson University | Engineered antibody for inhibition of fibrosis |
US9753030B2 (en) * | 2013-03-06 | 2017-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection |
ES2687220B1 (es) * | 2017-03-23 | 2019-08-08 | Servicio Andaluz De Salud | Método de obtención de datos útiles para el cribado y diagnóstico de la osteoporosis |
Family Cites Families (39)
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NL6716836A (ja) | 1967-12-11 | 1969-06-13 | ||
DE2816841A1 (de) | 1978-04-18 | 1979-10-31 | Max Planck Gesellschaft | Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii) |
US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
DE3209149A1 (de) | 1982-03-13 | 1983-10-06 | Hoechst Ag | Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum |
US4628027A (en) | 1982-05-19 | 1986-12-09 | Molecular Engineering Associates, Ltd. | Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins |
CA1251729A (en) | 1982-05-19 | 1989-03-28 | Steffen Gay | In vitro diagnostic methods using monoclonal antibodies against connective tissue proteins |
SE8304836D0 (sv) | 1983-09-09 | 1983-09-09 | Pharmacia Ab | Sett att bestemma forendringar i ledbrosk |
US5001225A (en) | 1986-12-08 | 1991-03-19 | Georgetown University | Monoclonal antibodies to a pan-malarial antigen |
JPS63209318A (ja) | 1987-02-26 | 1988-08-30 | Sony Corp | 受信機 |
US5679583A (en) | 1987-05-02 | 1997-10-21 | Hoechst Aktiengesellschaft | Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids |
DE3714634A1 (de) | 1987-05-02 | 1988-11-17 | Hoechst Ag | Verfahren zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in koerperfluessigkeiten und mittel zu dessen durchfuehrung |
GB2205643B (en) | 1987-05-08 | 1991-03-13 | Farmos Group Limited | Type iii collagen degradation assay |
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US5300434A (en) | 1987-11-06 | 1994-04-05 | Washington Research Foundation | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
US4973666A (en) | 1987-11-06 | 1990-11-27 | Washington Research Foundation | Peptide fragments containing HP and LP cross-links |
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ZA909755B (en) | 1989-12-07 | 1991-09-25 | Res Dev Foundation | Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product |
GB9014220D0 (en) | 1990-06-26 | 1990-08-15 | Farmos Yhtymy Oy | Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen |
GB9105893D0 (en) | 1991-03-20 | 1991-05-08 | Orion Yhtymae Oy | Bone resorption assay based on a peptide liberated during collagen degradation |
DE4225038C2 (de) | 1992-07-29 | 1995-11-30 | Boehringer Mannheim Gmbh | Herstellung und Verwendung von Antikörpern gegen Kollagen |
ATE277946T1 (de) * | 1992-12-28 | 2004-10-15 | David J Baylink | Methode zur messung der knochenresorption |
DE59406512D1 (de) | 1993-07-28 | 1998-08-27 | Boehringer Mannheim Gmbh | Immunoassay zum nachweis von kollagen typ i oder kollagenfragmenten davon |
DK104093D0 (da) | 1993-09-17 | 1993-09-17 | Osteometer A S | Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen |
GB9506050D0 (en) | 1995-03-24 | 1995-05-10 | Osteometer A S | Assaying collagen fragments in body fluids |
WO1996012193A1 (en) | 1994-10-17 | 1996-04-25 | Osteometer Bio Tech A/S | Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen |
JPH08100000A (ja) | 1994-09-30 | 1996-04-16 | Morinaga & Co Ltd | ヒトiv型コラーゲンに対する抗体及びその利用 |
EP0718309B1 (de) * | 1994-12-23 | 1999-04-07 | Roche Diagnostics GmbH | Antigene und Antikörper zum Nachweis von Kollagen I |
US5763272A (en) | 1994-12-23 | 1998-06-09 | Boehringer Mannheim Gmbh | Hybridoma for producing antibody for collagen I |
US5750647A (en) * | 1995-05-19 | 1998-05-12 | Washington Research Foundation | Synthetic peptide analogs of NTx |
JPH0921803A (ja) * | 1995-07-07 | 1997-01-21 | Teijin Ltd | 2型コラーゲンテロペプチドの測定方法 |
US6107047A (en) * | 1996-03-21 | 2000-08-22 | Osteometer Biotech A/S | Assaying protein fragments in body fluids |
GB9617616D0 (en) * | 1996-08-22 | 1996-10-02 | Osteometer Biotech As | Assaying protein fragments in body fluids |
JP3446493B2 (ja) | 1996-09-13 | 2003-09-16 | トヨタ自動車株式会社 | エキゾーストマニホルド |
EP0829724A1 (en) * | 1996-09-17 | 1998-03-18 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Assay for detecting collagen degradation |
JP3913787B2 (ja) * | 1996-12-09 | 2007-05-09 | オステオメーター・ビオテク・エー/エス | I型コラーゲン断片のサンドウイッチ測定法 |
GB9702252D0 (en) * | 1997-02-06 | 1997-03-26 | Univ Sheffield Medical The Sch | Collagen assay |
-
1997
- 1997-12-05 JP JP52618698A patent/JP3913787B2/ja not_active Expired - Fee Related
- 1997-12-05 US US09/319,539 patent/US6660481B2/en not_active Expired - Lifetime
- 1997-12-05 EP EP97953745A patent/EP0944833B1/en not_active Expired - Lifetime
- 1997-12-05 AU AU57542/98A patent/AU5754298A/en not_active Abandoned
- 1997-12-05 WO PCT/EP1997/006803 patent/WO1998026286A2/en active IP Right Grant
- 1997-12-05 DE DE69705423T patent/DE69705423T2/de not_active Expired - Lifetime
- 1997-12-05 ES ES97953745T patent/ES2160985T3/es not_active Expired - Lifetime
- 1997-12-05 AT AT97953745T patent/ATE202632T1/de not_active IP Right Cessation
-
2003
- 2003-12-09 US US10/730,070 patent/US7195883B2/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003515170A (ja) * | 1999-11-26 | 2003-04-22 | オステオミーター・ビオテク・エー/エス | 異性化及び/又は光学的反転したタンパク質及びタンパク質断片の測定法 |
JP4688392B2 (ja) * | 1999-11-26 | 2011-05-25 | オステオミーター・ビオテク・エー/エス | 異性化及び/又は光学的反転したタンパク質及びタンパク質断片の測定法 |
WO2022202876A1 (ja) * | 2021-03-24 | 2022-09-29 | 積水メディカル株式会社 | I型コラーゲンc末端テロペプチドの免疫学的分析方法 |
WO2023068249A1 (ja) * | 2021-10-20 | 2023-04-27 | 積水メディカル株式会社 | I型コラーゲン架橋n-テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法 |
Also Published As
Publication number | Publication date |
---|---|
EP0944833B1 (en) | 2001-06-27 |
JP3913787B2 (ja) | 2007-05-09 |
WO1998026286A2 (en) | 1998-06-18 |
DE69705423D1 (de) | 2001-08-02 |
EP0944833A2 (en) | 1999-09-29 |
US20040224375A1 (en) | 2004-11-11 |
ATE202632T1 (de) | 2001-07-15 |
ES2160985T3 (es) | 2001-11-16 |
US20030148272A1 (en) | 2003-08-07 |
DE69705423T2 (de) | 2002-05-16 |
US7195883B2 (en) | 2007-03-27 |
WO1998026286A3 (en) | 1998-08-13 |
AU5754298A (en) | 1998-07-03 |
US6660481B2 (en) | 2003-12-09 |
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