DE69705423D1 - Sandwichtest zum nachweis von kollagenfragmenten - Google Patents

Sandwichtest zum nachweis von kollagenfragmenten

Info

Publication number
DE69705423D1
DE69705423D1 DE69705423T DE69705423T DE69705423D1 DE 69705423 D1 DE69705423 D1 DE 69705423D1 DE 69705423 T DE69705423 T DE 69705423T DE 69705423 T DE69705423 T DE 69705423T DE 69705423 D1 DE69705423 D1 DE 69705423D1
Authority
DE
Germany
Prior art keywords
sandweight
test
collagen fragments
detecting collagen
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69705423T
Other languages
English (en)
Other versions
DE69705423T2 (de
Inventor
Christian Rosenquist
Per Qvist
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunodiagnostic Systems Nordic AS
Original Assignee
Osteometer Biotech AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625559.1A external-priority patent/GB9625559D0/en
Priority claimed from GBGB9705687.3A external-priority patent/GB9705687D0/en
Application filed by Osteometer Biotech AS filed Critical Osteometer Biotech AS
Application granted granted Critical
Publication of DE69705423D1 publication Critical patent/DE69705423D1/de
Publication of DE69705423T2 publication Critical patent/DE69705423T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
DE69705423T 1996-12-09 1997-12-05 Sandwichtest zum nachweis von kollagenfragmenten Expired - Lifetime DE69705423T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9625559.1A GB9625559D0 (en) 1996-12-09 1996-12-09 Sandwish assays for collagen type I fragments
GBGB9705687.3A GB9705687D0 (en) 1997-03-19 1997-03-19 Sandwich assays for collagen type i fragments
PCT/EP1997/006803 WO1998026286A2 (en) 1996-12-09 1997-12-05 Sandwich assays for collagen type i fragments

Publications (2)

Publication Number Publication Date
DE69705423D1 true DE69705423D1 (de) 2001-08-02
DE69705423T2 DE69705423T2 (de) 2002-05-16

Family

ID=26310589

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69705423T Expired - Lifetime DE69705423T2 (de) 1996-12-09 1997-12-05 Sandwichtest zum nachweis von kollagenfragmenten

Country Status (8)

Country Link
US (2) US6660481B2 (de)
EP (1) EP0944833B1 (de)
JP (1) JP3913787B2 (de)
AT (1) ATE202632T1 (de)
AU (1) AU5754298A (de)
DE (1) DE69705423T2 (de)
ES (1) ES2160985T3 (de)
WO (1) WO1998026286A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
EP0944833B1 (de) * 1996-12-09 2001-06-27 Osteometer Biotech AS Sandwichtest zum nachweis von kollagenfragmenten
GB9928052D0 (en) * 1999-11-26 2000-01-26 Osteometer Biotech As Assay of isomerised and/or optically inverted proteins and protein fragments
US7354723B2 (en) 1999-11-26 2008-04-08 Nordic Bioscience Dagnostics A/S Assay of isomerised and/or optically inverted proteins and protein fragments
WO2002008722A2 (en) * 2000-07-12 2002-01-31 Werner Naser Direct assessment of relative concentrations of variants of an epitope on a dimeric molecule
EP1451357A4 (de) * 2001-11-01 2005-10-26 Univ California Biokatalytische sol-gel-mikroarrays
US20050124071A1 (en) * 2003-09-30 2005-06-09 Kraus Virginia B. Methods and compositions for diagnosing musculoskeletal, arthritic and joint disorders by biomarker dating
US20090221441A1 (en) * 2005-11-01 2009-09-03 Rensselaer Polytechnic Institute Three-dimensional cellular array chip and platform for toxicology assays
US20100298329A1 (en) * 2007-09-19 2010-11-25 Massachusette Institute Of Technology Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers
EP2223112A2 (de) * 2007-12-21 2010-09-01 Siemens Healthcare Diagnostics Inc. Zirkulierender epha2-rezeptor
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
USRE49477E1 (en) 2012-04-20 2023-03-28 Thomas Jefferson University Engineered antibody for inhibition of fibrosis
US9753030B2 (en) * 2013-03-06 2017-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection
ES2687220B1 (es) * 2017-03-23 2019-08-08 Servicio Andaluz De Salud Método de obtención de datos útiles para el cribado y diagnóstico de la osteoporosis
EP4317172A1 (de) * 2021-03-24 2024-02-07 Sekisui Medical Co., Ltd. Immunologisches analyseverfahren für typ-i-kollagen-c-terminales tlopeptid
WO2023068249A1 (ja) * 2021-10-20 2023-04-27 積水メディカル株式会社 Ｉ型コラーゲン架橋ｎ－テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6716836A (de) 1967-12-11 1969-06-13
DE2816841A1 (de) 1978-04-18 1979-10-31 Max Planck Gesellschaft Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii)
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
DE3209149A1 (de) 1982-03-13 1983-10-06 Hoechst Ag Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum
CA1251729A (en) 1982-05-19 1989-03-28 Steffen Gay In vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
US4628027A (en) 1982-05-19 1986-12-09 Molecular Engineering Associates, Ltd. Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
SE8304836D0 (sv) 1983-09-09 1983-09-09 Pharmacia Ab Sett att bestemma forendringar i ledbrosk
US5001225A (en) 1986-12-08 1991-03-19 Georgetown University Monoclonal antibodies to a pan-malarial antigen
JPS63209318A (ja) 1987-02-26 1988-08-30 Sony Corp 受信機
US5679583A (en) 1987-05-02 1997-10-21 Hoechst Aktiengesellschaft Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids
DE3714634A1 (de) 1987-05-02 1988-11-17 Hoechst Ag Verfahren zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in koerperfluessigkeiten und mittel zu dessen durchfuehrung
GB2205643B (en) 1987-05-08 1991-03-13 Farmos Group Limited Type iii collagen degradation assay
US4973666A (en) 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5300434A (en) 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
US5320970A (en) 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
ATE115963T1 (de) 1988-04-27 1995-01-15 Hoechst Ag Monoklonaler antikörper zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in körperflüssigkeiten.
GB8815174D0 (en) 1988-06-25 1988-08-03 Rowett Research Inst Method of monitoring collagen degradation
WO1990004417A1 (en) 1988-10-24 1990-05-03 Bruce Caterson Methods of and compositions for diagnosing, monitoring and treating the early stages of osteoarthritis
WO1990008195A1 (en) 1989-01-13 1990-07-26 President And Fellows Of Harvard College Monoclonal antibody to human type ix collagen
ZA909755B (en) 1989-12-07 1991-09-25 Res Dev Foundation Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
GB9014220D0 (en) 1990-06-26 1990-08-15 Farmos Yhtymy Oy Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen
GB9105893D0 (en) 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation
DE4225038C2 (de) 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Herstellung und Verwendung von Antikörpern gegen Kollagen
ATE277946T1 (de) * 1992-12-28 2004-10-15 David J Baylink Methode zur messung der knochenresorption
ATE168779T1 (de) 1993-07-28 1998-08-15 Boehringer Mannheim Gmbh Immunoassay zum nachweis von kollagen typ i oder kollagenfragmenten davon
DK104093D0 (da) 1993-09-17 1993-09-17 Osteometer A S Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen
GB9506050D0 (en) * 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
WO1996012193A1 (en) * 1994-10-17 1996-04-25 Osteometer Bio Tech A/S Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen
JPH08100000A (ja) 1994-09-30 1996-04-16 Morinaga & Co Ltd ヒトｉｖ型コラーゲンに対する抗体及びその利用
EP0718309B1 (de) 1994-12-23 1999-04-07 Roche Diagnostics GmbH Antigene und Antikörper zum Nachweis von Kollagen I
US5763272A (en) 1994-12-23 1998-06-09 Boehringer Mannheim Gmbh Hybridoma for producing antibody for collagen I
US5750647A (en) 1995-05-19 1998-05-12 Washington Research Foundation Synthetic peptide analogs of NTx
JPH0921803A (ja) * 1995-07-07 1997-01-21 Teijin Ltd ２型コラーゲンテロペプチドの測定方法
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) * 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
JP3446493B2 (ja) 1996-09-13 2003-09-16 トヨタ自動車株式会社 エキゾーストマニホルド
EP0829724A1 (de) * 1996-09-17 1998-03-18 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Verfahren zum Nachweis von Kollagenabbau
EP0944833B1 (de) * 1996-12-09 2001-06-27 Osteometer Biotech AS Sandwichtest zum nachweis von kollagenfragmenten
GB9702252D0 (en) * 1997-02-06 1997-03-26 Univ Sheffield Medical The Sch Collagen assay

Also Published As

Publication number Publication date
ES2160985T3 (es) 2001-11-16
WO1998026286A3 (en) 1998-08-13
EP0944833B1 (de) 2001-06-27
ATE202632T1 (de) 2001-07-15
US20040224375A1 (en) 2004-11-11
JP2001506000A (ja) 2001-05-08
US20030148272A1 (en) 2003-08-07
DE69705423T2 (de) 2002-05-16
JP3913787B2 (ja) 2007-05-09
AU5754298A (en) 1998-07-03
US6660481B2 (en) 2003-12-09
EP0944833A2 (de) 1999-09-29
US7195883B2 (en) 2007-03-27
WO1998026286A2 (en) 1998-06-18

Similar Documents

Publication Publication Date Title
DE69705423D1 (de) Sandwichtest zum nachweis von kollagenfragmenten
BR8807567A (pt) Teste imuno-enzimatico simultaneo para a deteccao de antigeno e/ou anticorpo em humanos
TW366279B (en) Method for assessing disposable absorbent articles with improved skin dryness performance and with improved skin aeration
DK234789D0 (da) Antistoffer mod latente human papillomavirusproteiner, diagnostiske systemer og diagnostiske metoder
DE58905081D1 (de) Verfahren zur bestimmung eines proteins nach dem prinzip des fluoreszenz-polarisations immunoassays.
ATE168779T1 (de) Immunoassay zum nachweis von kollagen typ i oder kollagenfragmenten davon
ES2148353T3 (es) Ensayo para la determinacion de proteina en una muestra biologica.
NO20010362L (no) Nukleinsyrer kodende for proteiner som er involvert i sensorisk transduksjon
NO982715D0 (no) Endotel celle-proliferasjonsinhibitor og fremgangsmÕte for anvendelse
ES2136598T3 (es) Inmunoanalisis de deteccion de anticuerpos monoclonales contra los peptidos de activacion de protrombina y sus productos de degradacion.
BR9506455A (pt) Reagente de detecção para uso em um ensaio de teste artigo de manufatura útil em um imunoensaio processo para capturar um parceiro de ligação de uma imunoglobina imunoensaio do tipo que emprega uma pluralidade de parceiros de ligação e kit
ATA120395A (de) In einen probenanalysator einsetzbare reagenzienflaschen
DE69716305T2 (de) Peptidereagenz zum nachweis von humanem cytomegalovirus (cmv)
ES537228A0 (es) Un metodo de inmunoensayo para determinar la lidocaina o un derivado relacionado de la misma en una muestra a ensayar
KR930700548A (ko) 자궁내막 항체 측정방법 및 측정용 자궁내막 항원, 조성물, 테스트킷
DE69121861D1 (de) Peptide von sm-d-antigen, deren benützung zum nachweis von disseminierten lupus-erythemateux
DK130689D0 (da) Undersoegelsesmetode til bestemmelse af sulfamethazin i naturlig proeve og kit til anvendelse herved
BR9407504A (pt) Dispositivo de teste para ensaio kit para realizar um ensaio e processo para determinar a presença de um anólito em um individuo em teste
DE69009098D1 (de) Dichtheitsprüfverfahren von Behältern für Waren, insbesondere lose Zerealien.
DE68906742D1 (de) Testsatz zum nachweis von denaturierten lipoproteinen.
DE3786037D1 (de) Tracer zur benutzung in immunologischen fluoreszenz-polarisationsverfahren zum nachweis von flecainid.
AU5990286A (en) Test for determining false positive reactions in a testing procedure to detect the presence of antibody to microorganisms
ATA291287A (de) Vorrichtung zum messen von belastungen in verbundkoerpern
IT1227006B (it) Test immunoenzimatico per la ricerca e determinazione degli anticorpi antigliadina nel siero
IT8906606A0 (it) Test immunoenzimatico per la ricerca e determinazione degli anticorpi anticaseina bovina nel siero

Legal Events

Date Code Title Description
8364 No opposition during term of opposition