ES2157979T3 - Titulacion inmunologica competitiva por medio de una proteina de union utilizada en una estructura de anticuerpos multiclonal. - Google Patents
Titulacion inmunologica competitiva por medio de una proteina de union utilizada en una estructura de anticuerpos multiclonal.Info
- Publication number
- ES2157979T3 ES2157979T3 ES94908805T ES94908805T ES2157979T3 ES 2157979 T3 ES2157979 T3 ES 2157979T3 ES 94908805 T ES94908805 T ES 94908805T ES 94908805 T ES94908805 T ES 94908805T ES 2157979 T3 ES2157979 T3 ES 2157979T3
- Authority
- ES
- Spain
- Prior art keywords
- degree
- protein used
- antibody structure
- competitive immunological
- multiclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 230000002860 competitive effect Effects 0.000 title 1
- 230000001900 immune effect Effects 0.000 title 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 abstract 1
- 229940014144 folate Drugs 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- 230000001976 improved effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/971—Capture of complex after antigen-antibody reaction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
UN METODO MEJORADO PARA PREFORMAR INMUNOENSAYOS EN DONDE PROTEINAS DE FIJACION ESPECIFICAS DE VITAMINA B12, FOLATO Y OTRAS ANALITAS DIANA SE UTILIZAN CON ANTICUERPOS CON DIFERENTES ESPECIFICIDADES PARA LAS PROTEINAS DE FIJACION. LOS ANTICUERPOS HACEN DE PUENTE DE LA PROTEINA DE FIJACION ESPECIFICA DIRECTA O INDIRECTAMENTE PARA UN MATERIAL CAPTURABLE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/021,942 US5434087A (en) | 1993-02-24 | 1993-02-24 | Folate immunoassay utilizing folate binding protein in a multiclonal antibody format |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2157979T3 true ES2157979T3 (es) | 2001-09-01 |
Family
ID=21806985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94908805T Expired - Lifetime ES2157979T3 (es) | 1993-02-24 | 1994-02-24 | Titulacion inmunologica competitiva por medio de una proteina de union utilizada en una estructura de anticuerpos multiclonal. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5434087A (es) |
EP (1) | EP0686263B1 (es) |
JP (1) | JP3392868B2 (es) |
AU (1) | AU6176594A (es) |
CA (1) | CA2156736C (es) |
DE (1) | DE69427122T2 (es) |
ES (1) | ES2157979T3 (es) |
WO (1) | WO1994019695A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19713088C1 (de) * | 1997-03-27 | 1998-11-26 | Reiner Dr Probst | Verfahren und Blutabnahmegefäß zur Aufbereitung von Blutproben für die Homocystein- und/oder Folatbestimmung |
GB9719140D0 (en) * | 1997-09-09 | 1997-11-12 | Ortho Clinical Diagnostics | Ligand binding sufaces |
CN100399030C (zh) | 1999-11-16 | 2008-07-02 | 杰南技术公司 | 用于vegf的elisa |
US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
CH697021A5 (de) * | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
CN100483134C (zh) * | 2003-06-30 | 2009-04-29 | 希森美康株式会社 | 免疫层析装置 |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8652788B2 (en) * | 2009-12-02 | 2014-02-18 | Abbott Laboratories | Assay for diagnosis of cardiac myocyte damage |
US8835120B2 (en) * | 2009-12-02 | 2014-09-16 | Abbott Laboratories | Assay for cardiac troponin-T (cTnT) |
US10059710B2 (en) | 2016-02-17 | 2018-08-28 | Merck & Cie | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid |
JP6946926B2 (ja) * | 2017-10-23 | 2021-10-13 | 東ソー株式会社 | ビタミン類の遊離に使用する凍結乾燥試薬 |
CN113933502B (zh) * | 2021-10-19 | 2024-02-02 | 青岛汉唐生物科技有限公司 | 一种免疫荧光层析法定量检测叶酸的检测卡及试剂盒 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4028465A (en) * | 1975-11-10 | 1977-06-07 | Bio-Rad Laboratories | Assay method for serum folate |
US4146602A (en) * | 1977-01-27 | 1979-03-27 | Becton, Dickinson & Company | Simultaneous radioassay of folate and vitamin B12 |
US4271140A (en) * | 1978-01-23 | 1981-06-02 | Baxter Travenol Laboratories, Inc. | Method and composition for double receptor, specific binding assays |
US4188189A (en) * | 1978-04-04 | 1980-02-12 | University Patents, Inc. | Quantitative testing for vitamin B12 |
US4351822A (en) * | 1978-04-04 | 1982-09-28 | University Patents, Inc. | Quantitative testing for vitamin B12 |
US4423154A (en) * | 1978-06-26 | 1983-12-27 | Becton Dickinson And Company | Simultaneous radioassay of folate and vitamin B12 |
US4517288A (en) * | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
US4418151A (en) * | 1981-03-30 | 1983-11-29 | Rohm And Haas Company | Assay process with non-boiling denaturation |
US4451571A (en) * | 1981-04-06 | 1984-05-29 | University Patents, Inc. | Preparation of samples for vitamin B12 and/or folate assay and assay |
US4399228A (en) * | 1981-07-30 | 1983-08-16 | Corning Glass Works | Polate competitive protein binding assay |
US4350659A (en) * | 1981-07-30 | 1982-09-21 | Corning Glass Works | Stabilization of sensitive biologically active intermediate metabolites such as folic acid derivatives |
US5011771A (en) * | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
GB2161165A (en) * | 1984-06-12 | 1986-01-08 | Cambridge Patent Dev | Secondary antibodies |
US4950612A (en) * | 1987-12-16 | 1990-08-21 | Microgenics Corporation | Peroxy acid pretreatment in vitamin B12 assay |
WO1989007271A1 (en) * | 1988-01-28 | 1989-08-10 | E.I. Du Pont De Nemours And Company | Immunoassays using monoclonal antibodies directed against natural binding proteins |
US5244630A (en) * | 1988-04-22 | 1993-09-14 | Abbott Laboratories | Device for performing solid-phase diagnostic assay |
JP3267614B2 (ja) * | 1991-05-30 | 2002-03-18 | アボツト・ラボラトリーズ | カルボキシメチルアミロースに結合させた結合メンバーを使用するイオン捕獲アッセイ |
JPH06508217A (ja) * | 1992-01-06 | 1994-09-14 | デイド、ベーリング、インコーポレイテッド | 結合蛋白質捕捉アッセイ |
-
1993
- 1993-02-24 US US08/021,942 patent/US5434087A/en not_active Expired - Lifetime
-
1994
- 1994-02-24 CA CA002156736A patent/CA2156736C/en not_active Expired - Fee Related
- 1994-02-24 ES ES94908805T patent/ES2157979T3/es not_active Expired - Lifetime
- 1994-02-24 EP EP94908805A patent/EP0686263B1/en not_active Expired - Lifetime
- 1994-02-24 JP JP51930594A patent/JP3392868B2/ja not_active Expired - Fee Related
- 1994-02-24 DE DE69427122T patent/DE69427122T2/de not_active Expired - Lifetime
- 1994-02-24 WO PCT/US1994/002073 patent/WO1994019695A1/en active IP Right Grant
- 1994-02-24 AU AU61765/94A patent/AU6176594A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0686263B1 (en) | 2001-04-18 |
JPH08507603A (ja) | 1996-08-13 |
WO1994019695A1 (en) | 1994-09-01 |
CA2156736A1 (en) | 1994-09-01 |
CA2156736C (en) | 2008-01-29 |
DE69427122D1 (de) | 2001-05-23 |
EP0686263A1 (en) | 1995-12-13 |
US5434087A (en) | 1995-07-18 |
AU6176594A (en) | 1994-09-14 |
EP0686263A4 (en) | 1998-06-10 |
DE69427122T2 (de) | 2002-01-03 |
JP3392868B2 (ja) | 2003-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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