ES2157979T3 - Titulacion inmunologica competitiva por medio de una proteina de union utilizada en una estructura de anticuerpos multiclonal. - Google Patents

Titulacion inmunologica competitiva por medio de una proteina de union utilizada en una estructura de anticuerpos multiclonal.

Info

Publication number
ES2157979T3
ES2157979T3 ES94908805T ES94908805T ES2157979T3 ES 2157979 T3 ES2157979 T3 ES 2157979T3 ES 94908805 T ES94908805 T ES 94908805T ES 94908805 T ES94908805 T ES 94908805T ES 2157979 T3 ES2157979 T3 ES 2157979T3
Authority
ES
Spain
Prior art keywords
degree
protein used
antibody structure
competitive immunological
multiclonal antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908805T
Other languages
English (en)
Inventor
Michael J Beggs
Linda J Sohn
Robert J Herrmann
Stephen C Hsu
David J Hawksworth
Mary S Pinkus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2157979T3 publication Critical patent/ES2157979T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN METODO MEJORADO PARA PREFORMAR INMUNOENSAYOS EN DONDE PROTEINAS DE FIJACION ESPECIFICAS DE VITAMINA B12, FOLATO Y OTRAS ANALITAS DIANA SE UTILIZAN CON ANTICUERPOS CON DIFERENTES ESPECIFICIDADES PARA LAS PROTEINAS DE FIJACION. LOS ANTICUERPOS HACEN DE PUENTE DE LA PROTEINA DE FIJACION ESPECIFICA DIRECTA O INDIRECTAMENTE PARA UN MATERIAL CAPTURABLE.
ES94908805T 1993-02-24 1994-02-24 Titulacion inmunologica competitiva por medio de una proteina de union utilizada en una estructura de anticuerpos multiclonal. Expired - Lifetime ES2157979T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/021,942 US5434087A (en) 1993-02-24 1993-02-24 Folate immunoassay utilizing folate binding protein in a multiclonal antibody format

Publications (1)

Publication Number Publication Date
ES2157979T3 true ES2157979T3 (es) 2001-09-01

Family

ID=21806985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908805T Expired - Lifetime ES2157979T3 (es) 1993-02-24 1994-02-24 Titulacion inmunologica competitiva por medio de una proteina de union utilizada en una estructura de anticuerpos multiclonal.

Country Status (8)

Country Link
US (1) US5434087A (es)
EP (1) EP0686263B1 (es)
JP (1) JP3392868B2 (es)
AU (1) AU6176594A (es)
CA (1) CA2156736C (es)
DE (1) DE69427122T2 (es)
ES (1) ES2157979T3 (es)
WO (1) WO1994019695A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713088C1 (de) * 1997-03-27 1998-11-26 Reiner Dr Probst Verfahren und Blutabnahmegefäß zur Aufbereitung von Blutproben für die Homocystein- und/oder Folatbestimmung
GB9719140D0 (en) * 1997-09-09 1997-11-12 Ortho Clinical Diagnostics Ligand binding sufaces
CN100399030C (zh) 1999-11-16 2008-07-02 杰南技术公司 用于vegf的elisa
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
CH697021A5 (de) * 2003-06-26 2008-03-31 Merck Eprova Ag Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat.
CN100483134C (zh) * 2003-06-30 2009-04-29 希森美康株式会社 免疫层析装置
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US7654956B2 (en) 2004-07-13 2010-02-02 Dexcom, Inc. Transcutaneous analyte sensor
US8652788B2 (en) * 2009-12-02 2014-02-18 Abbott Laboratories Assay for diagnosis of cardiac myocyte damage
US8835120B2 (en) * 2009-12-02 2014-09-16 Abbott Laboratories Assay for cardiac troponin-T (cTnT)
US10059710B2 (en) 2016-02-17 2018-08-28 Merck & Cie Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid
JP6946926B2 (ja) * 2017-10-23 2021-10-13 東ソー株式会社 ビタミン類の遊離に使用する凍結乾燥試薬
CN113933502B (zh) * 2021-10-19 2024-02-02 青岛汉唐生物科技有限公司 一种免疫荧光层析法定量检测叶酸的检测卡及试剂盒

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028465A (en) * 1975-11-10 1977-06-07 Bio-Rad Laboratories Assay method for serum folate
US4146602A (en) * 1977-01-27 1979-03-27 Becton, Dickinson & Company Simultaneous radioassay of folate and vitamin B12
US4271140A (en) * 1978-01-23 1981-06-02 Baxter Travenol Laboratories, Inc. Method and composition for double receptor, specific binding assays
US4188189A (en) * 1978-04-04 1980-02-12 University Patents, Inc. Quantitative testing for vitamin B12
US4351822A (en) * 1978-04-04 1982-09-28 University Patents, Inc. Quantitative testing for vitamin B12
US4423154A (en) * 1978-06-26 1983-12-27 Becton Dickinson And Company Simultaneous radioassay of folate and vitamin B12
US4517288A (en) * 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4418151A (en) * 1981-03-30 1983-11-29 Rohm And Haas Company Assay process with non-boiling denaturation
US4451571A (en) * 1981-04-06 1984-05-29 University Patents, Inc. Preparation of samples for vitamin B12 and/or folate assay and assay
US4399228A (en) * 1981-07-30 1983-08-16 Corning Glass Works Polate competitive protein binding assay
US4350659A (en) * 1981-07-30 1982-09-21 Corning Glass Works Stabilization of sensitive biologically active intermediate metabolites such as folic acid derivatives
US5011771A (en) * 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
GB2161165A (en) * 1984-06-12 1986-01-08 Cambridge Patent Dev Secondary antibodies
US4950612A (en) * 1987-12-16 1990-08-21 Microgenics Corporation Peroxy acid pretreatment in vitamin B12 assay
WO1989007271A1 (en) * 1988-01-28 1989-08-10 E.I. Du Pont De Nemours And Company Immunoassays using monoclonal antibodies directed against natural binding proteins
US5244630A (en) * 1988-04-22 1993-09-14 Abbott Laboratories Device for performing solid-phase diagnostic assay
JP3267614B2 (ja) * 1991-05-30 2002-03-18 アボツト・ラボラトリーズ カルボキシメチルアミロースに結合させた結合メンバーを使用するイオン捕獲アッセイ
JPH06508217A (ja) * 1992-01-06 1994-09-14 デイド、ベーリング、インコーポレイテッド 結合蛋白質捕捉アッセイ

Also Published As

Publication number Publication date
EP0686263B1 (en) 2001-04-18
JPH08507603A (ja) 1996-08-13
WO1994019695A1 (en) 1994-09-01
CA2156736A1 (en) 1994-09-01
CA2156736C (en) 2008-01-29
DE69427122D1 (de) 2001-05-23
EP0686263A1 (en) 1995-12-13
US5434087A (en) 1995-07-18
AU6176594A (en) 1994-09-14
EP0686263A4 (en) 1998-06-10
DE69427122T2 (de) 2002-01-03
JP3392868B2 (ja) 2003-03-31

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