ATE202632T1 - Sandwichtest zum nachweis von kollagenfragmenten - Google Patents

Sandwichtest zum nachweis von kollagenfragmenten

Info

Publication number
ATE202632T1
ATE202632T1 AT97953745T AT97953745T ATE202632T1 AT E202632 T1 ATE202632 T1 AT E202632T1 AT 97953745 T AT97953745 T AT 97953745T AT 97953745 T AT97953745 T AT 97953745T AT E202632 T1 ATE202632 T1 AT E202632T1
Authority
AT
Austria
Prior art keywords
sandwight
test
collagen fragments
detecting collagen
antibody
Prior art date
Application number
AT97953745T
Other languages
German (de)
English (en)
Inventor
Christian Rosenquist
Per Qvist
Original Assignee
Osteometer Biotech As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625559.1A external-priority patent/GB9625559D0/en
Priority claimed from GBGB9705687.3A external-priority patent/GB9705687D0/en
Application filed by Osteometer Biotech As filed Critical Osteometer Biotech As
Application granted granted Critical
Publication of ATE202632T1 publication Critical patent/ATE202632T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Paints Or Removers (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT97953745T 1996-12-09 1997-12-05 Sandwichtest zum nachweis von kollagenfragmenten ATE202632T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9625559.1A GB9625559D0 (en) 1996-12-09 1996-12-09 Sandwish assays for collagen type I fragments
GBGB9705687.3A GB9705687D0 (en) 1997-03-19 1997-03-19 Sandwich assays for collagen type i fragments
PCT/EP1997/006803 WO1998026286A2 (en) 1996-12-09 1997-12-05 Sandwich assays for collagen type i fragments

Publications (1)

Publication Number Publication Date
ATE202632T1 true ATE202632T1 (de) 2001-07-15

Family

ID=26310589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97953745T ATE202632T1 (de) 1996-12-09 1997-12-05 Sandwichtest zum nachweis von kollagenfragmenten

Country Status (8)

Country Link
US (2) US6660481B2 (enExample)
EP (1) EP0944833B1 (enExample)
JP (1) JP3913787B2 (enExample)
AT (1) ATE202632T1 (enExample)
AU (1) AU5754298A (enExample)
DE (1) DE69705423T2 (enExample)
ES (1) ES2160985T3 (enExample)
WO (1) WO1998026286A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
ES2160985T3 (es) * 1996-12-09 2001-11-16 Osteometer Biotech As Ensayos de tipo sandwich para fragmentos de colageno.
US7354723B2 (en) 1999-11-26 2008-04-08 Nordic Bioscience Dagnostics A/S Assay of isomerised and/or optically inverted proteins and protein fragments
GB9928052D0 (en) * 1999-11-26 2000-01-26 Osteometer Biotech As Assay of isomerised and/or optically inverted proteins and protein fragments
AU2001276395A1 (en) * 2000-07-12 2002-02-05 Werner Naser Direct assessment of relative concentrations of variants of an epitope on a dimeric molecule
WO2003038404A2 (en) * 2001-11-01 2003-05-08 Rensselaer Polytechnic Institute In vitro metabolic engineering on microscale devices
US20050124071A1 (en) * 2003-09-30 2005-06-09 Kraus Virginia B. Methods and compositions for diagnosing musculoskeletal, arthritic and joint disorders by biomarker dating
WO2007053561A2 (en) * 2005-11-01 2007-05-10 Rensselaer Polytechnic Institute Three-dimensional cellular array chip and platform for toxicology assays
US20100298329A1 (en) * 2007-09-19 2010-11-25 Massachusette Institute Of Technology Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers
EP2223112A2 (en) * 2007-12-21 2010-09-01 Siemens Healthcare Diagnostics Inc. Circulating epha2 receptor
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
USRE49477E1 (en) 2012-04-20 2023-03-28 Thomas Jefferson University Engineered antibody for inhibition of fibrosis
US9753030B2 (en) * 2013-03-06 2017-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection
ES2687220B1 (es) * 2017-03-23 2019-08-08 Servicio Andaluz De Salud Método de obtención de datos útiles para el cribado y diagnóstico de la osteoporosis
US20240125784A1 (en) * 2021-03-24 2024-04-18 Sekisui Medical Co., Ltd. Immunological analysis method for type-i collagen c-terminal telopeptide
JPWO2023068249A1 (enExample) * 2021-10-20 2023-04-27

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6716836A (enExample) 1967-12-11 1969-06-13
DE2816841A1 (de) 1978-04-18 1979-10-31 Max Planck Gesellschaft Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii)
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
DE3209149A1 (de) 1982-03-13 1983-10-06 Hoechst Ag Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum
US4628027A (en) 1982-05-19 1986-12-09 Molecular Engineering Associates, Ltd. Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
CA1251729A (en) 1982-05-19 1989-03-28 Steffen Gay In vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
SE8304836D0 (sv) 1983-09-09 1983-09-09 Pharmacia Ab Sett att bestemma forendringar i ledbrosk
US5001225A (en) 1986-12-08 1991-03-19 Georgetown University Monoclonal antibodies to a pan-malarial antigen
JPS63209318A (ja) 1987-02-26 1988-08-30 Sony Corp 受信機
US5679583A (en) 1987-05-02 1997-10-21 Hoechst Aktiengesellschaft Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids
DE3714634A1 (de) 1987-05-02 1988-11-17 Hoechst Ag Verfahren zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in koerperfluessigkeiten und mittel zu dessen durchfuehrung
GB2205643B (en) 1987-05-08 1991-03-13 Farmos Group Limited Type iii collagen degradation assay
US5300434A (en) 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
US4973666A (en) 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5320970A (en) 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
EP0339443B1 (de) 1988-04-27 1994-12-21 Hoechst Aktiengesellschaft Monoklonaler Antikörper zur selektiven immunologischen Bestimmung von intaktem Prokollagen Peptid (Typ III) und Prokollagen (Typ III) in Körperflüssigkeiten
GB8815174D0 (en) 1988-06-25 1988-08-03 Rowett Research Inst Method of monitoring collagen degradation
JPH04502854A (ja) 1988-10-24 1992-05-28 カターソン，ブルース 変形性関節症の初期段階の診断、モニタリングならびに治療の方法および組成物
WO1990008195A1 (en) 1989-01-13 1990-07-26 President And Fellows Of Harvard College Monoclonal antibody to human type ix collagen
ZA909755B (en) 1989-12-07 1991-09-25 Res Dev Foundation Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
GB9014220D0 (en) 1990-06-26 1990-08-15 Farmos Yhtymy Oy Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen
GB9105893D0 (en) 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation
DE4225038C2 (de) 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Herstellung und Verwendung von Antikörpern gegen Kollagen
EP0675903B1 (en) 1992-12-28 2004-09-29 David J Baylink Bone resorption assay
EP0711415B1 (de) 1993-07-28 1998-07-22 Boehringer Mannheim Gmbh Immunoassay zum nachweis von kollagen typ i oder kollagenfragmenten davon
DK104093D0 (da) * 1993-09-17 1993-09-17 Osteometer A S Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen
WO1996012193A1 (en) 1994-10-17 1996-04-25 Osteometer Bio Tech A/S Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen
GB9506050D0 (en) 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
JPH08100000A (ja) 1994-09-30 1996-04-16 Morinaga & Co Ltd ヒトｉｖ型コラーゲンに対する抗体及びその利用
DE59505585D1 (de) * 1994-12-23 1999-05-12 Roche Diagnostics Gmbh Antigene und Antikörper zum Nachweis von Kollagen I
US5763272A (en) 1994-12-23 1998-06-09 Boehringer Mannheim Gmbh Hybridoma for producing antibody for collagen I
US5750647A (en) * 1995-05-19 1998-05-12 Washington Research Foundation Synthetic peptide analogs of NTx
JPH0921803A (ja) * 1995-07-07 1997-01-21 Teijin Ltd ２型コラーゲンテロペプチドの測定方法
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) * 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
JP3446493B2 (ja) 1996-09-13 2003-09-16 トヨタ自動車株式会社 エキゾーストマニホルド
EP0829724A1 (en) * 1996-09-17 1998-03-18 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Assay for detecting collagen degradation
ES2160985T3 (es) * 1996-12-09 2001-11-16 Osteometer Biotech As Ensayos de tipo sandwich para fragmentos de colageno.
GB9702252D0 (en) * 1997-02-06 1997-03-26 Univ Sheffield Medical The Sch Collagen assay

Also Published As

Publication number Publication date
US20040224375A1 (en) 2004-11-11
WO1998026286A2 (en) 1998-06-18
DE69705423T2 (de) 2002-05-16
ES2160985T3 (es) 2001-11-16
EP0944833B1 (en) 2001-06-27
JP3913787B2 (ja) 2007-05-09
DE69705423D1 (de) 2001-08-02
US7195883B2 (en) 2007-03-27
WO1998026286A3 (en) 1998-08-13
AU5754298A (en) 1998-07-03
US20030148272A1 (en) 2003-08-07
JP2001506000A (ja) 2001-05-08
EP0944833A2 (en) 1999-09-29
US6660481B2 (en) 2003-12-09

Similar Documents

Publication Publication Date Title
DE69705423D1 (de) Sandwichtest zum nachweis von kollagenfragmenten
BR8807567A (pt) Teste imuno-enzimatico simultaneo para a deteccao de antigeno e/ou anticorpo em humanos
TW366279B (en) Method for assessing disposable absorbent articles with improved skin dryness performance and with improved skin aeration
DK234789A (da) Antistoffer mod latente human papillomavirusproteiner, diagnostiske systemer og diagnostiske metoder
ES2145924T3 (es) Procedimiento para detectar anticuerpos.
DE59406512D1 (de) Immunoassay zum nachweis von kollagen typ i oder kollagenfragmenten davon
ATE209356T1 (de) Ein verfahren zur bestimmung von kollagenfragmenten in körperflüssigkeiten, ein testkit und mittel zur durchführung des verfahrens, und seine verwendung zur feststellung von mit dem kollagenmetabolismus assoziierten störungen
DE58905081D1 (de) Verfahren zur bestimmung eines proteins nach dem prinzip des fluoreszenz-polarisations immunoassays.
ATE195807T1 (de) Test zum nachweis von proteinen in einer biologischen probe
ATA120395A (de) In einen probenanalysator einsetzbare reagenzienflaschen
NO20010362L (no) Nukleinsyrer kodende for proteiner som er involvert i sensorisk transduksjon
PT869970E (pt) Inibidor da proliferacao de celulas endoteliais e sua utilizacao
BR9506455A (pt) Reagente de detecção para uso em um ensaio de teste artigo de manufatura útil em um imunoensaio processo para capturar um parceiro de ligação de uma imunoglobina imunoensaio do tipo que emprega uma pluralidade de parceiros de ligação e kit
DK0594576T3 (da) Immunoafprøvninger for og monoklonale antistoffer over for prothrombin-aktivering-peptider og deres nedbrydningsprodukter
DE59510064D1 (de) Elektrochemischer messfühler zur bestimmung von stickoxiden in gasgemischen
DE69716305D1 (de) Peptidereagenz zum nachweis von humanem cytomegalovirus (cmv)
ES537228A0 (es) Un metodo de inmunoensayo para determinar la lidocaina o un derivado relacionado de la misma en una muestra a ensayar
NZ306622A (en) Method for diagnosing a patient for chlamydia
ES2052913T3 (es) Ensayo inmunoquimico en cuanto al factor estimulante de colonias de granulocitos-macrofagos.
KR930700548A (ko) 자궁내막 항체 측정방법 및 측정용 자궁내막 항원, 조성물, 테스트킷
DE69121861D1 (de) Peptide von sm-d-antigen, deren benützung zum nachweis von disseminierten lupus-erythemateux
DK130689D0 (da) Undersoegelsesmetode til bestemmelse af sulfamethazin i naturlig proeve og kit til anvendelse herved
BR9407504A (pt) Dispositivo de teste para ensaio kit para realizar um ensaio e processo para determinar a presença de um anólito em um individuo em teste
DE69009098D1 (de) Dichtheitsprüfverfahren von Behältern für Waren, insbesondere lose Zerealien.
FI905350A7 (fi) Leimattua streptokokki-vasta-ainetta sisältävä koostumus, testipakkaus ja analyysimenetelmä, jossa sitä käytetään

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee