ATE202632T1 - Sandwichtest zum nachweis von kollagenfragmenten - Google Patents

Sandwichtest zum nachweis von kollagenfragmenten

Info

Publication number
ATE202632T1
ATE202632T1 AT97953745T AT97953745T ATE202632T1 AT E202632 T1 ATE202632 T1 AT E202632T1 AT 97953745 T AT97953745 T AT 97953745T AT 97953745 T AT97953745 T AT 97953745T AT E202632 T1 ATE202632 T1 AT E202632T1
Authority
AT
Austria
Prior art keywords
sandwight
test
collagen fragments
detecting collagen
antibody
Prior art date
Application number
AT97953745T
Other languages
German (de)
English (en)
Inventor
Christian Rosenquist
Per Qvist
Original Assignee
Osteometer Biotech As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625559.1A external-priority patent/GB9625559D0/en
Priority claimed from GBGB9705687.3A external-priority patent/GB9705687D0/en
Application filed by Osteometer Biotech As filed Critical Osteometer Biotech As
Application granted granted Critical
Publication of ATE202632T1 publication Critical patent/ATE202632T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Paints Or Removers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT97953745T 1996-12-09 1997-12-05 Sandwichtest zum nachweis von kollagenfragmenten ATE202632T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9625559.1A GB9625559D0 (en) 1996-12-09 1996-12-09 Sandwish assays for collagen type I fragments
GBGB9705687.3A GB9705687D0 (en) 1997-03-19 1997-03-19 Sandwich assays for collagen type i fragments
PCT/EP1997/006803 WO1998026286A2 (en) 1996-12-09 1997-12-05 Sandwich assays for collagen type i fragments

Publications (1)

Publication Number Publication Date
ATE202632T1 true ATE202632T1 (de) 2001-07-15

Family

ID=26310589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97953745T ATE202632T1 (de) 1996-12-09 1997-12-05 Sandwichtest zum nachweis von kollagenfragmenten

Country Status (8)

Country Link
US (2) US6660481B2 (enExample)
EP (1) EP0944833B1 (enExample)
JP (1) JP3913787B2 (enExample)
AT (1) ATE202632T1 (enExample)
AU (1) AU5754298A (enExample)
DE (1) DE69705423T2 (enExample)
ES (1) ES2160985T3 (enExample)
WO (1) WO1998026286A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
DE69705423T2 (de) * 1996-12-09 2002-05-16 Osteometer Biotech As Herlev Sandwichtest zum nachweis von kollagenfragmenten
GB9928052D0 (en) * 1999-11-26 2000-01-26 Osteometer Biotech As Assay of isomerised and/or optically inverted proteins and protein fragments
US7354723B2 (en) 1999-11-26 2008-04-08 Nordic Bioscience Dagnostics A/S Assay of isomerised and/or optically inverted proteins and protein fragments
AU2001276395A1 (en) * 2000-07-12 2002-02-05 Werner Naser Direct assessment of relative concentrations of variants of an epitope on a dimeric molecule
EP2287330A1 (en) * 2001-11-01 2011-02-23 Rensselaer Polytechnic Institute Biocatalytic Solgel Microarrays
US20050124071A1 (en) * 2003-09-30 2005-06-09 Kraus Virginia B. Methods and compositions for diagnosing musculoskeletal, arthritic and joint disorders by biomarker dating
CA2628219C (en) * 2005-11-01 2012-11-27 Rensselaer Polytechnic Institute Three-dimensional cellular array chip and platform for toxicology assays
WO2009038771A2 (en) * 2007-09-19 2009-03-26 Massachusetts Institute Of Technology Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers
US20110281279A1 (en) * 2007-12-21 2011-11-17 Siemens Healthcare Diagnostics Inc. CIRCULATING Epha2 RECEPTOR
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
WO2013158217A1 (en) * 2012-04-20 2013-10-24 Thomas Jefferson University Engineered antibody for inhibition of fibrosis
US9753030B2 (en) * 2013-03-06 2017-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection
ES2687220B1 (es) * 2017-03-23 2019-08-08 Servicio Andaluz De Salud Método de obtención de datos útiles para el cribado y diagnóstico de la osteoporosis
WO2022202876A1 (ja) * 2021-03-24 2022-09-29 積水メディカル株式会社 Ｉ型コラーゲンｃ末端テロペプチドの免疫学的分析方法
WO2023068249A1 (ja) * 2021-10-20 2023-04-27 積水メディカル株式会社 Ｉ型コラーゲン架橋ｎ－テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6716836A (enExample) 1967-12-11 1969-06-13
DE2816841A1 (de) 1978-04-18 1979-10-31 Max Planck Gesellschaft Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii)
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
DE3209149A1 (de) 1982-03-13 1983-10-06 Hoechst Ag Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum
US4628027A (en) 1982-05-19 1986-12-09 Molecular Engineering Associates, Ltd. Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
CA1251729A (en) 1982-05-19 1989-03-28 Steffen Gay In vitro diagnostic methods using monoclonal antibodies against connective tissue proteins
SE8304836D0 (sv) 1983-09-09 1983-09-09 Pharmacia Ab Sett att bestemma forendringar i ledbrosk
US5001225A (en) 1986-12-08 1991-03-19 Georgetown University Monoclonal antibodies to a pan-malarial antigen
JPS63209318A (ja) 1987-02-26 1988-08-30 Sony Corp 受信機
US5679583A (en) 1987-05-02 1997-10-21 Hoechst Aktiengesellschaft Monoclonal antibodies for the selective immunological determination of intact procollagen peptide (type III) and procollagen (type III) in body fluids
DE3714634A1 (de) 1987-05-02 1988-11-17 Hoechst Ag Verfahren zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in koerperfluessigkeiten und mittel zu dessen durchfuehrung
GB2205643B (en) 1987-05-08 1991-03-13 Farmos Group Limited Type iii collagen degradation assay
US5320970A (en) 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
US4973666A (en) 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5300434A (en) 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
ATE115963T1 (de) 1988-04-27 1995-01-15 Hoechst Ag Monoklonaler antikörper zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in körperflüssigkeiten.
GB8815174D0 (en) 1988-06-25 1988-08-03 Rowett Research Inst Method of monitoring collagen degradation
WO1990004417A1 (en) 1988-10-24 1990-05-03 Bruce Caterson Methods of and compositions for diagnosing, monitoring and treating the early stages of osteoarthritis
WO1990008195A1 (en) 1989-01-13 1990-07-26 President And Fellows Of Harvard College Monoclonal antibody to human type ix collagen
ZA909755B (en) 1989-12-07 1991-09-25 Res Dev Foundation Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
GB9014220D0 (en) 1990-06-26 1990-08-15 Farmos Yhtymy Oy Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen
GB9105893D0 (en) 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation
DE4225038C2 (de) 1992-07-29 1995-11-30 Boehringer Mannheim Gmbh Herstellung und Verwendung von Antikörpern gegen Kollagen
DE69333641T2 (de) 1992-12-28 2005-11-03 Baylink, David Jeston, Redlands Methode zur messung der knochenresorption
DE59406512D1 (de) 1993-07-28 1998-08-27 Boehringer Mannheim Gmbh Immunoassay zum nachweis von kollagen typ i oder kollagenfragmenten davon
DK104093D0 (da) 1993-09-17 1993-09-17 Osteometer A S Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen
GB9506050D0 (en) * 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
JPH08100000A (ja) 1994-09-30 1996-04-16 Morinaga & Co Ltd ヒトｉｖ型コラーゲンに対する抗体及びその利用
ES2154739T3 (es) 1994-10-17 2001-04-16 Osteometer Biotech As Estimacion del modelo de fragmentacion del colageno en fluidos corporales y el diagnostico de trastornos asociados con el metabolismo del colageno.
US5763272A (en) 1994-12-23 1998-06-09 Boehringer Mannheim Gmbh Hybridoma for producing antibody for collagen I
DE59505585D1 (de) 1994-12-23 1999-05-12 Roche Diagnostics Gmbh Antigene und Antikörper zum Nachweis von Kollagen I
US5750647A (en) 1995-05-19 1998-05-12 Washington Research Foundation Synthetic peptide analogs of NTx
JPH0921803A (ja) * 1995-07-07 1997-01-21 Teijin Ltd ２型コラーゲンテロペプチドの測定方法
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
GB9617616D0 (en) * 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
JP3446493B2 (ja) 1996-09-13 2003-09-16 トヨタ自動車株式会社 エキゾーストマニホルド
EP0829724A1 (en) * 1996-09-17 1998-03-18 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Assay for detecting collagen degradation
DE69705423T2 (de) * 1996-12-09 2002-05-16 Osteometer Biotech As Herlev Sandwichtest zum nachweis von kollagenfragmenten
GB9702252D0 (en) * 1997-02-06 1997-03-26 Univ Sheffield Medical The Sch Collagen assay

Also Published As

Publication number Publication date
EP0944833B1 (en) 2001-06-27
WO1998026286A2 (en) 1998-06-18
US7195883B2 (en) 2007-03-27
US6660481B2 (en) 2003-12-09
WO1998026286A3 (en) 1998-08-13
EP0944833A2 (en) 1999-09-29
ES2160985T3 (es) 2001-11-16
AU5754298A (en) 1998-07-03
JP3913787B2 (ja) 2007-05-09
US20030148272A1 (en) 2003-08-07
DE69705423T2 (de) 2002-05-16
US20040224375A1 (en) 2004-11-11
JP2001506000A (ja) 2001-05-08
DE69705423D1 (de) 2001-08-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee