ATE209356T1 - Ein verfahren zur bestimmung von kollagenfragmenten in körperflüssigkeiten, ein testkit und mittel zur durchführung des verfahrens, und seine verwendung zur feststellung von mit dem kollagenmetabolismus assoziierten störungen - Google Patents
Ein verfahren zur bestimmung von kollagenfragmenten in körperflüssigkeiten, ein testkit und mittel zur durchführung des verfahrens, und seine verwendung zur feststellung von mit dem kollagenmetabolismus assoziierten störungenInfo
- Publication number
- ATE209356T1 ATE209356T1 AT94926817T AT94926817T ATE209356T1 AT E209356 T1 ATE209356 T1 AT E209356T1 AT 94926817 T AT94926817 T AT 94926817T AT 94926817 T AT94926817 T AT 94926817T AT E209356 T1 ATE209356 T1 AT E209356T1
- Authority
- AT
- Austria
- Prior art keywords
- collagen
- fragments
- carrying
- test kit
- body fluid
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title abstract 5
- 108010035532 Collagen Proteins 0.000 title abstract 5
- 229920001436 collagen Polymers 0.000 title abstract 5
- 239000012634 fragment Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 210000001124 body fluid Anatomy 0.000 title abstract 3
- 239000010839 body fluid Substances 0.000 title abstract 3
- 230000007691 collagen metabolic process Effects 0.000 title 1
- 230000001900 immune effect Effects 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/108—Osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK931040A DK104093D0 (da) | 1993-09-17 | 1993-09-17 | Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen |
PCT/DK1994/000348 WO1995008115A1 (en) | 1993-09-17 | 1994-09-19 | A method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE209356T1 true ATE209356T1 (de) | 2001-12-15 |
Family
ID=8100323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94926817T ATE209356T1 (de) | 1993-09-17 | 1994-09-19 | Ein verfahren zur bestimmung von kollagenfragmenten in körperflüssigkeiten, ein testkit und mittel zur durchführung des verfahrens, und seine verwendung zur feststellung von mit dem kollagenmetabolismus assoziierten störungen |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP0742902B2 (de) |
JP (2) | JP3423720B2 (de) |
AT (1) | ATE209356T1 (de) |
AU (1) | AU7652194A (de) |
DE (1) | DE69429192T3 (de) |
DK (1) | DK104093D0 (de) |
WO (1) | WO1995008115A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962639A (en) * | 1987-11-06 | 1999-10-05 | Washington Research Foundation | Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites |
GB9506050D0 (en) * | 1995-03-24 | 1995-05-10 | Osteometer A S | Assaying collagen fragments in body fluids |
DE69520111T2 (de) | 1994-10-17 | 2001-09-06 | Osteometer Biotech As Herlev | Schätzung des Fragmentierungsmusters von Kollagen in Körperflüssigkeiten und Diagnose von mit dem Kollagenmetabolismus zusammenhängenden Störungen |
US5750647A (en) * | 1995-05-19 | 1998-05-12 | Washington Research Foundation | Synthetic peptide analogs of NTx |
US6107047A (en) * | 1996-03-21 | 2000-08-22 | Osteometer Biotech A/S | Assaying protein fragments in body fluids |
GB9617616D0 (en) * | 1996-08-22 | 1996-10-02 | Osteometer Biotech As | Assaying protein fragments in body fluids |
EP0829724A1 (de) * | 1996-09-17 | 1998-03-18 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Verfahren zum Nachweis von Kollagenabbau |
WO1998026286A2 (en) * | 1996-12-09 | 1998-06-18 | Osteometer Biotech A/S | Sandwich assays for collagen type i fragments |
JPH10300749A (ja) * | 1997-04-28 | 1998-11-13 | Mitsubishi Chem Corp | コラーゲン断片を認識する抗体 |
JP2001512143A (ja) * | 1997-07-31 | 2001-08-21 | メトラ バイオシステムズ, インコーポレイテッド | コラーゲン−ペプチドアッセイ法 |
AU9312598A (en) * | 1997-09-10 | 1999-03-29 | Allegheny University Of The Health Sciences | Inhibitors of collagen assembly |
US6117646A (en) * | 1997-09-22 | 2000-09-12 | Osteometer Biotech A/S | Assaying protein fragments in body fluids |
US6916903B2 (en) | 1998-06-19 | 2005-07-12 | Washington Research Foundation | Collagen type III synthetic peptides for collagen resorption assays |
US6602980B1 (en) | 1998-06-19 | 2003-08-05 | Washington Research Foundation | Collagen type III synthetic peptides for collagen resorption assays |
US6348320B1 (en) | 1998-06-19 | 2002-02-19 | Washington Research Foundation | Cartilage resorption assays measuring type II collagen fragments |
US6255056B1 (en) | 1998-06-19 | 2001-07-03 | Washington Research Foundation | Cartilage resorption assays |
DE19919982C2 (de) * | 1999-04-30 | 2001-06-28 | Pe Diagnostik Gmbh | Verfahren zur Ermittlung osteoporotischer Prozesse |
ES2229805T3 (es) * | 1999-06-17 | 2005-04-16 | Washington Research Foundation | Ensayos de resorcion de cartilago. |
JP2003002845A (ja) * | 2001-04-03 | 2003-01-08 | Univ Nihon | 哺乳類の硬組織治療用組成物及びその治療方法 |
JP2006517789A (ja) * | 2003-01-10 | 2006-08-03 | アブリンクス エン.ヴェー. | 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用 |
FI20050814A0 (fi) * | 2005-08-11 | 2005-08-11 | Procollagen Oy | Menetelmä nivelreumassa muodostuvien kollageeniautovasta-aineiden havaitsemiseksi |
EP2538221A3 (de) * | 2007-11-05 | 2013-04-24 | Nordic Bioscience A/S | Biochemische Marker zur Bewertung des CVD-Risikos |
DE102010037622B4 (de) | 2010-09-17 | 2012-07-12 | Lophius Biosciences Gmbh | Verfahren zum Nachweis, Differenzieren und Quantifizieren von T-Zellpopulationen mittels der Reverse Transkription quantitativen Real-Time PCR (RT-qPCR) Technologie |
GB201016050D0 (en) * | 2010-09-24 | 2010-11-10 | Nordic Bioscience As | Assay for a type II collagen biomarker in serum |
CA2863190A1 (en) * | 2012-03-09 | 2013-09-12 | Basf Se | Means and methods for assessing hyperthyroidism |
JP7341774B2 (ja) * | 2019-07-30 | 2023-09-11 | オリエンタル酵母工業株式会社 | 骨質の評価方法 |
WO2023068249A1 (ja) * | 2021-10-20 | 2023-04-27 | 積水メディカル株式会社 | I型コラーゲン架橋n-テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法 |
WO2023068248A1 (ja) * | 2021-10-20 | 2023-04-27 | 積水メディカル株式会社 | I型コラーゲン架橋n-テロペプチドの免疫測定方法及び免疫測定キット、並びに抗体又はその抗体断片 |
WO2023182353A1 (ja) * | 2022-03-25 | 2023-09-28 | 積水メディカル株式会社 | 免疫学的検出方法及び免疫学的検出キット |
WO2023182343A1 (ja) * | 2022-03-25 | 2023-09-28 | 積水メディカル株式会社 | 免疫学的検出方法及び免疫学的検出キット |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3209149A1 (de) * | 1982-03-13 | 1983-10-06 | Hoechst Ag | Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum |
US5300434A (en) † | 1987-11-06 | 1994-04-05 | Washington Research Foundation | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
US4973666A (en) * | 1987-11-06 | 1990-11-27 | Washington Research Foundation | Peptide fragments containing HP and LP cross-links |
GB9105893D0 (en) * | 1991-03-20 | 1991-05-08 | Orion Yhtymae Oy | Bone resorption assay based on a peptide liberated during collagen degradation |
JPH07504896A (ja) * | 1992-01-31 | 1995-06-01 | ベイリンク,デビッド ジェイ. | アミノプロコラーゲン1(1)ペプチド |
DE4225038C2 (de) * | 1992-07-29 | 1995-11-30 | Boehringer Mannheim Gmbh | Herstellung und Verwendung von Antikörpern gegen Kollagen |
JPH08505149A (ja) * | 1992-12-28 | 1996-06-04 | ジェイ. ベイリンク,デビッド | 骨再吸収検定法 |
US5750647A (en) * | 1995-05-19 | 1998-05-12 | Washington Research Foundation | Synthetic peptide analogs of NTx |
-
1993
- 1993-09-17 DK DK931040A patent/DK104093D0/da not_active Application Discontinuation
-
1994
- 1994-09-19 AU AU76521/94A patent/AU7652194A/en not_active Abandoned
- 1994-09-19 EP EP94926817A patent/EP0742902B2/de not_active Expired - Lifetime
- 1994-09-19 DE DE69429192T patent/DE69429192T3/de not_active Expired - Lifetime
- 1994-09-19 AT AT94926817T patent/ATE209356T1/de not_active IP Right Cessation
- 1994-09-19 WO PCT/DK1994/000348 patent/WO1995008115A1/en active IP Right Grant
- 1994-09-19 JP JP50883995A patent/JP3423720B2/ja not_active Expired - Lifetime
- 1994-09-19 EP EP01101773A patent/EP1104887A3/de not_active Withdrawn
-
2002
- 2002-09-10 JP JP2002264031A patent/JP3790727B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0742902B2 (de) | 2007-06-13 |
JP3423720B2 (ja) | 2003-07-07 |
EP1104887A2 (de) | 2001-06-06 |
WO1995008115A1 (en) | 1995-03-23 |
DK104093D0 (da) | 1993-09-17 |
EP1104887A3 (de) | 2009-08-26 |
DE69429192T2 (de) | 2002-07-18 |
EP0742902A1 (de) | 1996-11-20 |
DE69429192D1 (de) | 2002-01-03 |
EP0742902B1 (de) | 2001-11-21 |
AU7652194A (en) | 1995-04-03 |
JPH09509736A (ja) | 1997-09-30 |
JP2003202338A (ja) | 2003-07-18 |
DE69429192T3 (de) | 2008-01-17 |
JP3790727B2 (ja) | 2006-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE209356T1 (de) | Ein verfahren zur bestimmung von kollagenfragmenten in körperflüssigkeiten, ein testkit und mittel zur durchführung des verfahrens, und seine verwendung zur feststellung von mit dem kollagenmetabolismus assoziierten störungen | |
DE69733560D1 (de) | TESTVERFAHREN UND REAGENZIEN ZUR QUANTIFIZIERUNG VON hBNP | |
DE59903915D1 (de) | Verfahren zur frühen diagnose von carcinomen | |
ATE151883T1 (de) | Verfahren zum nachweis freier igf-i, igf-ii, und gh spiegel in körperflüssigkeiten | |
ATE438657T1 (de) | Charakterisierung von granulozytischer ehrlichia und methoden für ihre verwendung. | |
ATE258310T1 (de) | Testverfahren für collagenpeptid | |
DE69928507D1 (de) | Festphasenverfahren und testsatz zur antigen- und antikörperprüfung in der blutgruppen-serologie | |
ATE328281T1 (de) | Methode zur diagnose von abnormalem knochenstoffwechsel | |
NO924912D0 (no) | Fremgangsmaate ved paavisning av analyttvarianter, samt sett for utfoerelse av fremgangsmaaten | |
GR3018371T3 (en) | Method for identifying or determining proteins and applications therefor. | |
ATE111533T1 (de) | Verfahren zur bestimmung von nukleinsäuren. | |
DE3850249D1 (de) | Nachweis von analyt in partikel enthaltenden proben. | |
DE69716305T2 (de) | Peptidereagenz zum nachweis von humanem cytomegalovirus (cmv) | |
ATE167301T1 (de) | Gruppe von getrennten peptiden | |
DE69733957D1 (de) | Verfahren zur bestimmung der gegenwart des gehirnspezifischen proteins s-100 beta | |
DE69629976D1 (de) | Typ I Prokollagen aminoterminales Propeptid, dessen Antikörper und Testverfahren unter Verwendung davon | |
WO1998029726A3 (en) | Method of detecting and determining the concentration of total troponin i in a biological sample | |
DE69526056D1 (de) | Immunologisches Testverfahren zur Quantifizierung von PEG-modifiziertem humanem Granulozyten-Kolonie-Stimulierender-Faktor | |
WO1999027366A3 (en) | Method of detecting prostate specific antigen activation peptide | |
Pena et al. | Reagent strip for semiquantitative total and specific IgE measurement: A comparison to radioisotopic methods | |
ATE228249T1 (de) | Immuntest zum nachweis von menschlichen cytomegalovirus spezifischen igm | |
ES2056191T3 (es) | Un metodo para la deteccion de una substancia de union especifica en la sangre y kit de ensayo para llevar a cabo dicho metodo. | |
ATE193376T1 (de) | Verfahren zur immunologischen bestimmung von proteinen, kit zur durchführung des verfahrens und für ein solches verfahren geeignete teströhrchen | |
ATE64466T1 (de) | Immuntest. | |
ATE347108T1 (de) | Zusammensetzungen und verfahren zum bestimmen von aa4rp |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |