WO1998029726A3 - Method of detecting and determining the concentration of total troponin i in a biological sample - Google Patents
Method of detecting and determining the concentration of total troponin i in a biological sample Download PDFInfo
- Publication number
- WO1998029726A3 WO1998029726A3 PCT/US1997/023529 US9723529W WO9829726A3 WO 1998029726 A3 WO1998029726 A3 WO 1998029726A3 US 9723529 W US9723529 W US 9723529W WO 9829726 A3 WO9829726 A3 WO 9829726A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- troponin
- determining
- detecting
- concentration
- biological sample
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention provides a method for detecting myocardial necrosis by incubating a sample with a natural binding partner (troponin C) for troponin I and antibodies to troponin C and troponin I; and determining the resultant immune complex formed in proportion to the total concentration of troponin I in the sample.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77721996A | 1996-12-27 | 1996-12-27 | |
US08/777,219 | 1996-12-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998029726A2 WO1998029726A2 (en) | 1998-07-09 |
WO1998029726A3 true WO1998029726A3 (en) | 1999-01-28 |
Family
ID=25109624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/023529 WO1998029726A2 (en) | 1996-12-27 | 1997-12-18 | Method of detecting and determining the concentration of total troponin i in a biological sample |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1998029726A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI20030652A0 (en) * | 2003-04-30 | 2003-04-30 | Susann Eriksson | Improved immune determination |
CN103380377B (en) * | 2011-02-25 | 2016-01-27 | 美迪恩斯生命科技株式会社 | The assay method of cardiac troponin |
US10670611B2 (en) | 2014-09-26 | 2020-06-02 | Somalogic, Inc. | Cardiovascular risk event prediction and uses thereof |
CN110554198A (en) * | 2019-09-18 | 2019-12-10 | 潍坊市康华生物技术有限公司 | Troponin I detection test method |
CN111073901B (en) * | 2019-12-18 | 2023-04-28 | 美康生物科技股份有限公司 | Preparation method of troponin I detection kit calibrator |
CN113125745B (en) * | 2019-12-31 | 2022-10-28 | 瑞博奥(广州)生物科技股份有限公司 | Cardiac function detection kit |
CN113985032A (en) * | 2021-09-14 | 2022-01-28 | 广州万孚生物技术股份有限公司 | Double-label immunodetection method containing internal reference and application thereof |
CN114994304B (en) * | 2022-05-18 | 2023-03-24 | 厦门宝太生物科技股份有限公司 | cTnI dry-type homogeneous phase chemiluminescence detection kit |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2275774A (en) * | 1993-02-23 | 1994-09-07 | Pasteur Sanofi Diagnostics | Stabilized composition of troponin |
WO1994027156A1 (en) * | 1993-05-17 | 1994-11-24 | Fortron Bioscience, Inc. | Assay for cardiac troponin i |
WO1997026534A1 (en) * | 1996-01-15 | 1997-07-24 | Finnish-Russian Joint Biotechnology Laboratory | Detection of cardiac muscle necrosis by immunoassay and appropriate antibodies therefor |
-
1997
- 1997-12-18 WO PCT/US1997/023529 patent/WO1998029726A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2275774A (en) * | 1993-02-23 | 1994-09-07 | Pasteur Sanofi Diagnostics | Stabilized composition of troponin |
WO1994027156A1 (en) * | 1993-05-17 | 1994-11-24 | Fortron Bioscience, Inc. | Assay for cardiac troponin i |
WO1997026534A1 (en) * | 1996-01-15 | 1997-07-24 | Finnish-Russian Joint Biotechnology Laboratory | Detection of cardiac muscle necrosis by immunoassay and appropriate antibodies therefor |
Non-Patent Citations (1)
Title |
---|
A G KATRUKHA, A V BEREZNIKOVA, T V ESAKOVA, K PETTERSSON, T LÖVGREN, M E SEVERINA, K PULKKI, L-M VUOPIO-PULKKI, N B GUSEV: "Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex", CLINICAL CHEMISTRY, vol. 43, no. 8, August 1997 (1997-08-01), pages 1379 - 1385, XP002085081 * |
Also Published As
Publication number | Publication date |
---|---|
WO1998029726A2 (en) | 1998-07-09 |
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