WO1998029726A3 - Method of detecting and determining the concentration of total troponin i in a biological sample - Google Patents

Method of detecting and determining the concentration of total troponin i in a biological sample Download PDF

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Publication number
WO1998029726A3
WO1998029726A3 PCT/US1997/023529 US9723529W WO9829726A3 WO 1998029726 A3 WO1998029726 A3 WO 1998029726A3 US 9723529 W US9723529 W US 9723529W WO 9829726 A3 WO9829726 A3 WO 9829726A3
Authority
WO
WIPO (PCT)
Prior art keywords
troponin
determining
detecting
concentration
biological sample
Prior art date
Application number
PCT/US1997/023529
Other languages
French (fr)
Other versions
WO1998029726A2 (en
Inventor
Stephan G Thompson
Original Assignee
Coulter Int Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Int Corp filed Critical Coulter Int Corp
Publication of WO1998029726A2 publication Critical patent/WO1998029726A2/en
Publication of WO1998029726A3 publication Critical patent/WO1998029726A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction

Abstract

The present invention provides a method for detecting myocardial necrosis by incubating a sample with a natural binding partner (troponin C) for troponin I and antibodies to troponin C and troponin I; and determining the resultant immune complex formed in proportion to the total concentration of troponin I in the sample.
PCT/US1997/023529 1996-12-27 1997-12-18 Method of detecting and determining the concentration of total troponin i in a biological sample WO1998029726A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77721996A 1996-12-27 1996-12-27
US08/777,219 1996-12-27

Publications (2)

Publication Number Publication Date
WO1998029726A2 WO1998029726A2 (en) 1998-07-09
WO1998029726A3 true WO1998029726A3 (en) 1999-01-28

Family

ID=25109624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023529 WO1998029726A2 (en) 1996-12-27 1997-12-18 Method of detecting and determining the concentration of total troponin i in a biological sample

Country Status (1)

Country Link
WO (1) WO1998029726A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20030652A0 (en) * 2003-04-30 2003-04-30 Susann Eriksson Improved immune determination
KR101975993B1 (en) * 2011-02-25 2019-05-07 가부시키가이샤 엘에스아이 메디엔스 Method for measuring myocardial troponin
US10670611B2 (en) 2014-09-26 2020-06-02 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
CN110554198A (en) * 2019-09-18 2019-12-10 潍坊市康华生物技术有限公司 Troponin I detection test method
CN111073901B (en) * 2019-12-18 2023-04-28 美康生物科技股份有限公司 Preparation method of troponin I detection kit calibrator
CN113125745B (en) * 2019-12-31 2022-10-28 瑞博奥(广州)生物科技股份有限公司 Cardiac function detection kit
CN113985032A (en) * 2021-09-14 2022-01-28 广州万孚生物技术股份有限公司 Double-label immunodetection method containing internal reference and application thereof
CN114994304B (en) * 2022-05-18 2023-03-24 厦门宝太生物科技股份有限公司 cTnI dry-type homogeneous phase chemiluminescence detection kit

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2275774A (en) * 1993-02-23 1994-09-07 Pasteur Sanofi Diagnostics Stabilized composition of troponin
WO1994027156A1 (en) * 1993-05-17 1994-11-24 Fortron Bioscience, Inc. Assay for cardiac troponin i
WO1997026534A1 (en) * 1996-01-15 1997-07-24 Finnish-Russian Joint Biotechnology Laboratory Detection of cardiac muscle necrosis by immunoassay and appropriate antibodies therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2275774A (en) * 1993-02-23 1994-09-07 Pasteur Sanofi Diagnostics Stabilized composition of troponin
WO1994027156A1 (en) * 1993-05-17 1994-11-24 Fortron Bioscience, Inc. Assay for cardiac troponin i
WO1997026534A1 (en) * 1996-01-15 1997-07-24 Finnish-Russian Joint Biotechnology Laboratory Detection of cardiac muscle necrosis by immunoassay and appropriate antibodies therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A G KATRUKHA, A V BEREZNIKOVA, T V ESAKOVA, K PETTERSSON, T LÖVGREN, M E SEVERINA, K PULKKI, L-M VUOPIO-PULKKI, N B GUSEV: "Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex", CLINICAL CHEMISTRY, vol. 43, no. 8, August 1997 (1997-08-01), pages 1379 - 1385, XP002085081 *

Also Published As

Publication number Publication date
WO1998029726A2 (en) 1998-07-09

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