DE69632224T2 - Reduzierung von Gelation von Fettsäureacylierten Proteinen unter Nutzung von Zitratpuffer - Google Patents

Reduzierung von Gelation von Fettsäureacylierten Proteinen unter Nutzung von Zitratpuffer Download PDF

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Publication number
DE69632224T2
DE69632224T2 DE69632224T DE69632224T DE69632224T2 DE 69632224 T2 DE69632224 T2 DE 69632224T2 DE 69632224 T DE69632224 T DE 69632224T DE 69632224 T DE69632224 T DE 69632224T DE 69632224 T2 DE69632224 T2 DE 69632224T2
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DE
Germany
Prior art keywords
fatty acid
acylated
protein
insulin
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69632224T
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German (de)
English (en)
Other versions
DE69632224D1 (de
Inventor
Jeffrey Clayton Indianapolis Baker
Jose M. Martinsville Hanquier
Warren E. Indianapolis Shrader
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Eli Lilly and Co
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Eli Lilly and Co
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Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69632224D1 publication Critical patent/DE69632224D1/de
Application granted granted Critical
Publication of DE69632224T2 publication Critical patent/DE69632224T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
DE69632224T 1995-06-07 1996-05-31 Reduzierung von Gelation von Fettsäureacylierten Proteinen unter Nutzung von Zitratpuffer Expired - Fee Related DE69632224T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,545 US5631347A (en) 1995-06-07 1995-06-07 Reducing gelation of a fatty acid-acylated protein
US484545 1995-06-07

Publications (2)

Publication Number Publication Date
DE69632224D1 DE69632224D1 (de) 2004-05-27
DE69632224T2 true DE69632224T2 (de) 2005-04-14

Family

ID=23924602

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632224T Expired - Fee Related DE69632224T2 (de) 1995-06-07 1996-05-31 Reduzierung von Gelation von Fettsäureacylierten Proteinen unter Nutzung von Zitratpuffer

Country Status (10)

Country Link
US (1) US5631347A (https=)
EP (1) EP0747390B1 (https=)
JP (1) JP3962430B2 (https=)
AT (1) ATE264867T1 (https=)
AU (1) AU5951596A (https=)
CA (1) CA2223531A1 (https=)
DE (1) DE69632224T2 (https=)
DK (1) DK0747390T3 (https=)
ES (1) ES2218569T3 (https=)
WO (1) WO1996040188A1 (https=)

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US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
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RU2527893C2 (ru) * 2004-07-19 2014-09-10 Биокон Лимитед Инсулин-олигомерные конъюгаты, их препараты и применения
PL1789434T3 (pl) 2004-08-31 2014-07-31 Novo Nordisk As Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek
MX2007005521A (es) 2004-11-12 2007-05-18 Novo Nordisk As Formulaciones estables de peptidos insulinotropicos.
BRPI0710503A2 (pt) * 2006-04-07 2011-08-16 Merrion Res Iii Ltd uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral
JP2009539862A (ja) * 2006-06-09 2009-11-19 メリオン リサーチ Ｉｉｉ リミテッド 強化剤を含む固体経口投与剤形
RU2453332C2 (ru) * 2007-10-16 2012-06-20 Байокон Лимитид Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц
RU2517135C2 (ru) * 2008-05-07 2014-05-27 Меррион Рисерч Iii Лимитед Композиции пептидов и способы их получения
CA2751854A1 (en) * 2009-02-25 2010-09-02 Merrion Research Iii Limited Composition and drug delivery of bisphosphonates
WO2011064316A2 (en) 2009-11-25 2011-06-03 Paolo Botti Mucosal delivery of peptides
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
US9089484B2 (en) * 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
KR20140026354A (ko) 2011-01-07 2014-03-05 메리온 리서치 Ⅲ 리미티드 경구 투여용 철의 제약 조성물
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
JP7211704B2 (ja) 2015-01-29 2023-01-24 ノヴォ ノルディスク アー／エス Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤
WO2018157150A1 (en) 2017-02-27 2018-08-30 Duke University In vivo protein n-acylation
KR102665710B1 (ko) 2017-08-24 2024-05-14 노보 노르디스크 에이/에스 Glp-1 조성물 및 그 용도
JP7761567B2 (ja) 2020-02-18 2025-10-28 ノヴォ ノルディスク アー／エス 医薬製剤

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Also Published As

Publication number Publication date
JP3962430B2 (ja) 2007-08-22
EP0747390A3 (en) 1997-06-04
ES2218569T3 (es) 2004-11-16
CA2223531A1 (en) 1996-12-19
EP0747390B1 (en) 2004-04-21
DE69632224D1 (de) 2004-05-27
US5631347A (en) 1997-05-20
EP0747390A2 (en) 1996-12-11
AU5951596A (en) 1996-12-30
WO1996040188A1 (en) 1996-12-19
JPH11506739A (ja) 1999-06-15
DK0747390T3 (da) 2004-07-26
ATE264867T1 (de) 2004-05-15

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee