DE69630691T2 - Liposomal p-Ethoxy Oligonucleotides - Google Patents
Liposomal p-Ethoxy Oligonucleotides Download PDFInfo
- Publication number
- DE69630691T2 DE69630691T2 DE69630691T DE69630691T DE69630691T2 DE 69630691 T2 DE69630691 T2 DE 69630691T2 DE 69630691 T DE69630691 T DE 69630691T DE 69630691 T DE69630691 T DE 69630691T DE 69630691 T2 DE69630691 T2 DE 69630691T2
- Authority
- DE
- Germany
- Prior art keywords
- oligos
- oligonucleotides
- liposomal
- antisense
- oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 108091034117 Oligonucleotide Proteins 0.000 title claims abstract description 127
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
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- Biotechnology (AREA)
- Wood Science & Technology (AREA)
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- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| US520385 | 1995-08-29 | ||
| PCT/US1996/014146 WO1997007784A2 (en) | 1995-08-29 | 1996-08-26 | LIPOSOMAL PHOSPHODIESTER, PHOSPHOROTHIOATE, AND p-ETHOXY OLIGONUCLEOTIDES |
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| DE69630691D1 DE69630691D1 (de) | 2003-12-18 |
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| ES (1) | ES2210385T3 (enExample) |
| PT (1) | PT847272E (enExample) |
| WO (1) | WO1997007784A2 (enExample) |
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- 1996-08-26 AU AU69129/96A patent/AU6912996A/en not_active Abandoned
- 1996-08-26 JP JP51064297A patent/JP4291412B2/ja not_active Expired - Fee Related
- 1996-08-26 ES ES96929888T patent/ES2210385T3/es not_active Expired - Lifetime
- 1996-08-26 WO PCT/US1996/014146 patent/WO1997007784A2/en not_active Ceased
- 1996-08-26 DE DE69630691T patent/DE69630691T2/de not_active Expired - Lifetime
- 1996-08-26 PT PT96929888T patent/PT847272E/pt unknown
- 1996-08-26 DK DK96929888T patent/DK0847272T3/da active
- 1996-08-26 CA CA2228944A patent/CA2228944C/en not_active Expired - Fee Related
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1998
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-
2003
- 2003-06-16 US US10/462,172 patent/US7176302B2/en not_active Expired - Fee Related
-
2007
- 2007-02-13 US US11/674,563 patent/US7754872B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE253897T1 (de) | 2003-11-15 |
| JP4291412B2 (ja) | 2009-07-08 |
| CA2228944A1 (en) | 1997-03-06 |
| AU6912996A (en) | 1997-03-19 |
| US20070202157A1 (en) | 2007-08-30 |
| DK0847272T3 (da) | 2004-03-22 |
| DE69630691D1 (de) | 2003-12-18 |
| US7176302B2 (en) | 2007-02-13 |
| EP0847272A2 (en) | 1998-06-17 |
| ES2210385T3 (es) | 2004-07-01 |
| US5855911A (en) | 1999-01-05 |
| EP0847272B1 (en) | 2003-11-12 |
| CA2228944C (en) | 2011-10-18 |
| JPH11512099A (ja) | 1999-10-19 |
| US20040005353A1 (en) | 2004-01-08 |
| WO1997007784A2 (en) | 1997-03-06 |
| US6042846A (en) | 2000-03-28 |
| PT847272E (pt) | 2004-04-30 |
| WO1997007784A3 (en) | 1997-04-24 |
| US7754872B2 (en) | 2010-07-13 |
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