DE69627683T2 - Substituierte pyrazolyl-benzolsulfonamide für veterinäre anwendung als entzündungshemmende mittel - Google Patents

Substituierte pyrazolyl-benzolsulfonamide für veterinäre anwendung als entzündungshemmende mittel

Info

Publication number
DE69627683T2
DE69627683T2 DE69627683T DE69627683T DE69627683T2 DE 69627683 T2 DE69627683 T2 DE 69627683T2 DE 69627683 T DE69627683 T DE 69627683T DE 69627683 T DE69627683 T DE 69627683T DE 69627683 T2 DE69627683 T2 DE 69627683T2
Authority
DE
Germany
Prior art keywords
benzolsulfonamides
substituted pyrazolyl
veterinary application
flamming
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69627683T
Other languages
English (en)
Other versions
DE69627683D1 (de
Inventor
C Isakson
J Talley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24138015&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69627683(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69627683D1 publication Critical patent/DE69627683D1/de
Publication of DE69627683T2 publication Critical patent/DE69627683T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/63Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69627683T 1995-09-29 1996-09-27 Substituierte pyrazolyl-benzolsulfonamide für veterinäre anwendung als entzündungshemmende mittel Expired - Lifetime DE69627683T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/536,318 US5756529A (en) 1995-09-29 1995-09-29 Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
PCT/US1996/015538 WO1997011704A1 (en) 1995-09-29 1996-09-27 Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies as antiinflammatory agents

Publications (2)

Publication Number Publication Date
DE69627683D1 DE69627683D1 (de) 2003-05-28
DE69627683T2 true DE69627683T2 (de) 2003-12-18

Family

ID=24138015

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69627683T Expired - Lifetime DE69627683T2 (de) 1995-09-29 1996-09-27 Substituierte pyrazolyl-benzolsulfonamide für veterinäre anwendung als entzündungshemmende mittel

Country Status (21)

Country Link
US (1) US5756529A (de)
EP (1) EP0854723B1 (de)
JP (1) JPH11514991A (de)
KR (1) KR100498730B1 (de)
CN (1) CN1202828A (de)
AT (1) ATE238058T1 (de)
AU (1) AU718300B2 (de)
BR (1) BR9610974A (de)
CA (1) CA2233620C (de)
CZ (1) CZ297183B6 (de)
DE (1) DE69627683T2 (de)
DK (1) DK0854723T3 (de)
ES (1) ES2197954T3 (de)
IL (1) IL123635A (de)
NO (1) NO321157B1 (de)
NZ (1) NZ320919A (de)
PL (1) PL191934B1 (de)
PT (1) PT854723E (de)
RO (1) RO120408B1 (de)
RU (1) RU2253456C2 (de)
WO (1) WO1997011704A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492411B1 (en) * 1993-11-30 2002-12-10 G. D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
EP0828718A1 (de) 1995-06-02 1998-03-18 G.D. SEARLE & CO. Heterocyclo-substituierte hydroxaminsäurederivate als cyclooxygenase-2 und 5-lipoxygenase inhibitoren
US6087381A (en) * 1997-05-22 2000-07-11 G. D. Searle & Company Pyrazole derivatives as p38 kinase inhibitors
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
TNSN99111A1 (fr) * 1998-06-11 2005-11-10 Pfizer Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
US6294558B1 (en) 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6727238B2 (en) * 1998-06-11 2004-04-27 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
SA99191255B1 (ar) * 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
EP1158977B1 (de) * 1999-03-10 2005-10-12 G.D. Searle LLC Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere
ATE361748T1 (de) 1999-06-16 2007-06-15 Univ Temple 1-(4-sulfamylphenyl)-3-trifluormethyl-5-aryl-2- pyrazoline als cyclooxygenase-2 inhibitoren
DK1104758T3 (da) * 1999-12-03 2003-10-20 Pfizer Prod Inc Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler
CA2392931A1 (en) 1999-12-03 2001-06-07 Pfizer Products Inc. Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
ES2208227T3 (es) 1999-12-03 2004-06-16 Pfizer Products Inc. Compuestos de heteroarilfenilpirazol como agentes antiinflamatorios/analgesicos.
DE60001623T2 (de) 1999-12-03 2003-12-18 Pfizer Prod Inc Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel
CZ20012875A3 (cs) * 1999-12-08 2002-02-13 Pharmacia Corporation Polymorfní krystalické formy celecoxibu
KR100793668B1 (ko) * 1999-12-08 2008-01-10 파마시아 코포레이션 강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브
PT1239857E (pt) * 1999-12-22 2006-07-31 Pharmacia Corp Composicoes de libertacao dupla de um inibidor de ciclo-oxigenase-2
AU2001253418A1 (en) * 2000-04-12 2001-10-30 Smith Kline Beecham Corporation Compounds and methods
CA2406226A1 (en) * 2000-04-18 2001-10-25 Pharmacia Corporation Rapid-onset formulation of a selective cyclooxigenase-2
WO2001081332A2 (en) * 2000-04-25 2001-11-01 Pharmacia Corporation 2-fluorobenzenesulfonyl compounds for the treatment of inflammation
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US20030219461A1 (en) * 2000-09-12 2003-11-27 Britten Nancy J. Parenteral combination therapy for infective conditions
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US7695736B2 (en) 2001-04-03 2010-04-13 Pfizer Inc. Reconstitutable parenteral composition
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
ES2241964T3 (es) 2001-07-05 2005-11-01 Pfizer Products Inc. Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos.
US7076539B2 (en) * 2001-07-30 2006-07-11 Hewlett-Packard Development Company, L.P. Network connectivity establishment at user log-in
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
EP1427706B1 (de) * 2001-09-19 2007-05-30 Pharmacia Corporation Substituierte pyrazoloverbindungen zur behandlung von entzündungen
JP2005506983A (ja) 2001-09-19 2005-03-10 ファルマシア・コーポレーション 炎症の治療のための置換ピラゾリル化合物
GT200200183A (es) 2001-09-28 2003-05-23 Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
WO2003037330A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors
CA2464944A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. An efficient synthesis of 5-heteroatom-containing-pyrazoles
WO2003037351A1 (en) 2001-11-02 2003-05-08 Pfizer Products Inc. Heterocyclo-alkylsulfonyl pyrazoles and their use as cox-2 inhibitors
WO2003037335A1 (en) * 2001-11-02 2003-05-08 Pfizer Products Inc. 5-heteroatom-substituted pyrazoles
EP1499597A4 (de) * 2002-04-08 2006-01-25 Univ Ohio State Res Found Verbindungen und verfahren zur induktion von apoptose in proliferierenden zellen
EP1539679A4 (de) 2002-06-28 2007-07-04 Nitromed Inc Oxim- und/oder hydrazonhaltige, nitrosierte und/oder nitrosylierte cyclooxigenase-2-selektive inhibitoren, zusammensetzungen und anwendungsverfahren
UA79804C2 (en) 2002-07-03 2007-07-25 Janssen Pharmaceutica Nv Cck-1 receptor modulators
US7803787B2 (en) * 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US20080003258A1 (en) * 2002-10-16 2008-01-03 Marcum Frank D Composition and Method for Treating Rheumatoid Arthritis
US20080153894A1 (en) * 2002-12-19 2008-06-26 Pharmacia Corporation Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
US20050009931A1 (en) * 2003-03-20 2005-01-13 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20050004098A1 (en) * 2003-03-20 2005-01-06 Britten Nancy Jean Dispersible formulation of an anti-inflammatory agent
DK1608407T3 (da) * 2003-03-20 2006-12-04 Pharmacia Corp Dispergébar formulering af et antiinflammatorisk middel
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
EP1534305B9 (de) 2003-05-07 2007-03-07 Osteologix A/S Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
US20050131028A1 (en) * 2003-09-11 2005-06-16 Pharmacia Corporation Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders
US7659426B2 (en) * 2003-12-01 2010-02-09 Reverse Proteomics Research Institute Co., Ltd. Target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto
US7250434B2 (en) 2003-12-22 2007-07-31 Janssen Pharmaceutica N.V. CCK-1 receptor modulators
ITMI20041032A1 (it) * 2004-05-24 2004-08-24 Neuroscienze S C A R L Compositi farmaceutici
US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
US8128460B2 (en) * 2006-09-14 2012-03-06 The Material Works, Ltd. Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell
TW200911240A (en) * 2007-06-11 2009-03-16 Kyowa Hakko Kogyo Kk Anti-tumor agent
US9186375B2 (en) 2007-06-21 2015-11-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan compositions in combination with stem cells
EP2560966B1 (de) 2010-03-30 2021-01-06 Verseon International Corporation Mehrfach substituierte aromatische verbindungen als thrombinhemmer
CA2825519A1 (en) * 2011-02-03 2012-09-08 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nachr
CN103242233B (zh) * 2012-02-08 2014-07-30 北京博爱汇康医药科技有限责任公司 制备塞来昔布的新方法
WO2014012074A2 (en) * 2012-07-12 2014-01-16 Euclises Pharmaceuticals, Inc. No-releasing nonoate (nitrogen-bound) sulfonamide-linked-coxib anti-cancer agents
LT2968297T (lt) 2013-03-15 2019-01-10 Verseon Corporation Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai
EP2970141B1 (de) 2013-03-15 2020-02-26 Verseon Corporation Halogenpyrazole als thrombinhemmer
EP2886104A1 (de) 2013-12-11 2015-06-24 Patir, Suleyman Intraartikuläres Gel
CA2960790A1 (en) 2014-09-17 2016-03-24 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
EP3261639B1 (de) 2015-02-27 2022-08-24 Verseon International Corporation Substituierte pyrazolylverbindungen als serinproteaseinhibitoren
CN107686465B (zh) * 2017-09-02 2020-10-27 东北农业大学 地拉考昔的制备方法
CN114292235B (zh) * 2021-12-29 2023-04-14 江苏天和制药有限公司 一种地拉考昔的制备和提纯方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940418A (en) * 1972-04-07 1976-02-24 G. D. Searle & Co. Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds
GB8814587D0 (en) * 1988-06-20 1988-07-27 Erba Carlo Spa Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5134155A (en) * 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
IL104311A (en) * 1992-02-05 1997-07-13 Fujisawa Pharmaceutical Co Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5434178A (en) * 1993-11-30 1995-07-18 G.D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
ES2193609T3 (es) * 1993-11-30 2003-11-01 Searle & Co Pirazolil-bencenosulfonamidas sustituidas y su uso como inhibidores de la ciclooxigenasa ii.
US5475018A (en) * 1993-11-30 1995-12-12 G. D. Searle & Co. 1,5-diphenyl pyrazole compounds for treatment of inflammation
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5401765A (en) * 1993-11-30 1995-03-28 G. D. Searle 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders

Also Published As

Publication number Publication date
CZ297183B6 (cs) 2006-09-13
IL123635A0 (en) 1998-10-30
ES2197954T3 (es) 2004-01-16
AU7376896A (en) 1997-04-17
DK0854723T3 (da) 2003-08-11
NO981392L (no) 1998-05-25
RO120408B1 (ro) 2006-01-30
CN1202828A (zh) 1998-12-23
PT854723E (pt) 2003-08-29
EP0854723A1 (de) 1998-07-29
US5756529A (en) 1998-05-26
RU2253456C2 (ru) 2005-06-10
WO1997011704A1 (en) 1997-04-03
NO321157B1 (no) 2006-03-27
EP0854723B1 (de) 2003-04-23
IL123635A (en) 2003-06-24
BR9610974A (pt) 1999-07-13
KR100498730B1 (ko) 2005-09-09
CA2233620C (en) 2011-11-22
PL325952A1 (en) 1998-08-17
NZ320919A (en) 1999-10-28
NO981392D0 (no) 1998-03-27
DE69627683D1 (de) 2003-05-28
PL191934B1 (pl) 2006-07-31
CZ89798A3 (cs) 1999-04-14
AU718300B2 (en) 2000-04-13
JPH11514991A (ja) 1999-12-21
KR19990063874A (ko) 1999-07-26
ATE238058T1 (de) 2003-05-15
CA2233620A1 (en) 1997-04-03

Similar Documents

Publication Publication Date Title
DE69627683T2 (de) Substituierte pyrazolyl-benzolsulfonamide für veterinäre anwendung als entzündungshemmende mittel
MY119711A (en) Method of inhibiting photoaging of skin
DE69325366T2 (de) Verfahren zur hautpflege und mittel
HK1013194A1 (en) Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
ZA904971B (en) Stable,cosmetically acceptable topical gel formulation and method of treatment for acne
DE69612731D1 (de) Elektrophoretischer apparat und verfahren zur anwendung von therapeutischen-, kosmetischen- und farblösungen im haar
NO973900L (no) Nitrogenoksyd syntase inhibitor
PT880350E (pt) Tratamento de esclerose multipla
EP0681831A3 (de) Verwendung von Extracten aus filamentösen Bakterien als kosmetische Mittel gegen Hautaltern.
ATE267583T1 (de) Arzneizubereitungen zur behandlung sexueller funktionsstörungen
DE69508764T2 (de) Alkoholisches feuchtigkeitsspendendes after shave lotion
FR2751541B1 (fr) Composition dermo-cosmetique contenant un alcaloide du quinquina et methode de traitement cosmetique de l'alopecie
NO984446L (no) FremgangsmÕte for behandling av smerte
ATE234614T1 (de) Verwendung von selegilin zur behandlung von gehörverlust bei säugetieren
NO950925L (no) Preparat og fremgangsmåte for behandling av hårtap
DE69711779D1 (de) Neue Melatonin-Derivaten als Wirkstoff gegen freien Radikale sowie diese enthaltende Präparate
DE69608683D1 (de) Analytisches und therapeutisches mittel
DE59702322D1 (de) Kombination aus cis-4-hydroxy-l-prolin und n-methyl-cis-4-hydroxy-l-prolin zur anwendung als therapeutischer wirkstoff insbesondere für die krebstherapie
ES2099613T3 (es) Empleo de hidroxinaftalinas en agentes colorantes.
MX9700626A (es) USO DE AZASPIRANOS EN LA REPARACIaN DE COMPOSICIONES PARA TRATAR INFECCIONES OPORTUNISTAS.
ATE103811T1 (de) Oestradiol enthaltende mittel und verfahren zur topischen anwendung.
UA15164A (uk) Спосіб детоксикації при захворюваhhях оргаhів гепатопаhкреатобіліарhої зоhи запальhого геhезу
BG98985U (bg) Средство за подобряване регенерацията на кожата
DK0621785T3 (da) Anvendelse af vandige opløsninger indeholdende peroxobisulfationer til behandling af maligne celler
UA38987A (uk) Спосіб лікування піодермії

Legal Events

Date Code Title Description
8364 No opposition during term of opposition