DE69613833T2 - Substituierte oxime, hydrazone und olefine als neurokinin-antagonisten - Google Patents
Substituierte oxime, hydrazone und olefine als neurokinin-antagonistenInfo
- Publication number
- DE69613833T2 DE69613833T2 DE69613833T DE69613833T DE69613833T2 DE 69613833 T2 DE69613833 T2 DE 69613833T2 DE 69613833 T DE69613833 T DE 69613833T DE 69613833 T DE69613833 T DE 69613833T DE 69613833 T2 DE69613833 T2 DE 69613833T2
- Authority
- DE
- Germany
- Prior art keywords
- heteroaryl
- alkyl
- image
- hydrazone
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43274095A | 1995-05-02 | 1995-05-02 | |
US46081995A | 1995-06-01 | 1995-06-01 | |
PCT/US1996/005659 WO1996034857A1 (en) | 1995-05-02 | 1996-05-01 | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69613833D1 DE69613833D1 (de) | 2001-08-16 |
DE69613833T2 true DE69613833T2 (de) | 2002-04-04 |
Family
ID=27029621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69613833T Expired - Lifetime DE69613833T2 (de) | 1995-05-02 | 1996-05-01 | Substituierte oxime, hydrazone und olefine als neurokinin-antagonisten |
Country Status (23)
Country | Link |
---|---|
US (2) | US5696267A (de) |
EP (1) | EP0823896B1 (de) |
JP (1) | JP3255421B2 (de) |
KR (1) | KR100248921B1 (de) |
CN (1) | CN1134414C (de) |
AT (1) | ATE203014T1 (de) |
AU (1) | AU706526B2 (de) |
BR (1) | BR9608269A (de) |
CA (1) | CA2218913C (de) |
CZ (1) | CZ342497A3 (de) |
DE (1) | DE69613833T2 (de) |
DK (1) | DK0823896T3 (de) |
ES (1) | ES2158314T3 (de) |
GR (1) | GR3036676T3 (de) |
HK (1) | HK1008221A1 (de) |
HU (1) | HU222048B1 (de) |
MX (1) | MX9708415A (de) |
NO (1) | NO310189B1 (de) |
NZ (1) | NZ307715A (de) |
PL (1) | PL323088A1 (de) |
PT (1) | PT823896E (de) |
SK (1) | SK147197A3 (de) |
WO (1) | WO1996034857A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5688960A (en) * | 1995-05-02 | 1997-11-18 | Schering Corporation | Substituted oximes, hydrazones and olefins useful as neurokinin antagonists |
US5945428A (en) * | 1996-11-01 | 1999-08-31 | Schering Corporation | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
US6265614B1 (en) | 1997-10-27 | 2001-07-24 | Schering Corporation | Optically active intermediates for the preparation of optically active substituted oximes, hydrazones and olefins useful as neurokinin antagonists |
CA2308073A1 (en) * | 1997-10-27 | 1999-05-06 | Schering Corporation | Optically active intermediates for the preparation of optically active substituted oximes, hydrazones and olefins useful as neurokinin antagonists |
BR9814987A (pt) * | 1997-11-21 | 2000-10-03 | Schering Corp | "oximas substituìdas como antagonistas da neurocinina" |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
US6221880B1 (en) | 1998-10-09 | 2001-04-24 | Schering Corporation | Composition and method for treating allergic diseases |
US6103735A (en) * | 1998-10-09 | 2000-08-15 | Schering Corporation | Composition and method for treating allergic diseases |
US6063926A (en) * | 1998-11-18 | 2000-05-16 | Schering Corporation | Substituted oximes as neurokinin antagonists |
PE20001353A1 (es) * | 1998-12-23 | 2000-12-07 | Schering Corp | Oximas e hidrazonas sustituidas como antagonistas de neuroquinina |
US6204265B1 (en) | 1998-12-23 | 2001-03-20 | Schering Corporation | Substituted oximes and hydrazones as neurokinin antagonists |
US6348504B1 (en) | 1999-03-30 | 2002-02-19 | Richard E. Olson | Oxime ethers as IIb/IIa antagonists |
SE9902987D0 (sv) * | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
GB0011838D0 (en) * | 2000-05-17 | 2000-07-05 | Astrazeneca Ab | Chemical compounds |
CA2412355A1 (en) * | 2000-06-12 | 2001-12-20 | University Of Rochester | Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist |
GB0104050D0 (en) * | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0107228D0 (en) * | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
GB0108046D0 (en) * | 2001-03-30 | 2001-05-23 | Astrazeneca Ab | Chemical compounds |
WO2002089802A2 (en) * | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
IL159256A0 (en) | 2001-07-02 | 2004-06-01 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
UA75425C2 (en) * | 2001-07-09 | 2006-04-17 | Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds | |
GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
WO2003022835A1 (en) * | 2001-09-06 | 2003-03-20 | Schering Corporation | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
ATE471315T1 (de) * | 2001-10-17 | 2010-07-15 | Schering Corp | Piperidin- und piperazinacetamide als inhibitoren der 17beta-hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten |
SE0103818D0 (sv) * | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
ME00804B (me) | 2002-03-13 | 2012-03-20 | Biogen Idec Inc | Anti-alpha v beta 6 antitela |
SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
US7494987B2 (en) | 2002-11-25 | 2009-02-24 | Mochida Pharmaceutical Co., Ltd. | Agent for treating respiratory diseases containing 4-hydroxypiperidine derivative as active ingredient |
SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
SE0301369D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
MX2007006233A (es) | 2004-11-24 | 2007-11-23 | Medpointe Healthcare Inc | Composiciones que comprenden azelastina y metodos de uso de la misma. |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
CN104072614B (zh) | 2005-07-08 | 2017-04-26 | 生物基因Ma公司 | 抗-αvβ6 抗体及其用途 |
CA2615650A1 (en) | 2005-07-21 | 2007-01-25 | Astrazeneca Ab | Novel piperidine derivatives |
MX2008002014A (es) * | 2005-08-15 | 2008-03-27 | Hoffmann La Roche | Derivados de piperidina y piperazina como antagonistas de p2x3. |
WO2007053498A1 (en) * | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
WO2007053495A2 (en) * | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
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US20070116818A1 (en) * | 2005-11-22 | 2007-05-24 | Toyo Seikan Kaisha, Ltd. | Extract containing beta-cryptoxanthin component from persimmon fruit |
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EP2046374A4 (de) | 2006-07-10 | 2010-05-05 | Biogen Idec Inc | Zusammensetzungen und verfahren zur wachstumshemmung von smad4-defizienten tumoren |
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CN101925383A (zh) | 2007-12-11 | 2010-12-22 | 赛特帕斯凡德株式会社 | 甲酰胺化合物及其作为趋化因子受体激动剂的应用 |
KR20150046259A (ko) | 2012-08-23 | 2015-04-29 | 앨리오스 바이오파마 인크. | 파라믹소바이러스 바이러스성 감염의 치료용 화합물 |
US10035860B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
WO2014144466A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
EP3151820A4 (de) * | 2014-06-06 | 2017-11-22 | Flexus Biosciences, Inc. | Immunregulatorische wirkstoffe |
JP6615212B2 (ja) * | 2014-11-03 | 2019-12-04 | オロン ソシエタ ペル アチオニ | 1−(2−ハロゲン−エチル)−4−ピぺリジンカルボン酸エチルエステルの製法 |
EP3061501A1 (de) | 2015-02-27 | 2016-08-31 | Rottapharm Ltd. | Zusammensetzung zur behandlung von akne |
EP3117825A1 (de) | 2015-07-16 | 2017-01-18 | Rottapharm S.p.A. | Orale formulierung mit berberin und morus-alba-extrakt |
CN105481623B (zh) * | 2015-12-01 | 2017-10-27 | 上海澄厚菲贸易有限公司 | 一种羟乙基苯胺酯化物(iii)的合成工艺 |
JP7256509B2 (ja) * | 2016-08-22 | 2023-04-12 | エルゴン ファーマシューティカルズ エルエルシー | Bcat1阻害剤を使用する組成物及び治療方法 |
US11548893B2 (en) | 2017-07-15 | 2023-01-10 | Arisan Therapeutics Inc. | Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection |
CN113087689B (zh) * | 2021-03-10 | 2023-09-29 | 中国人民解放军空军军医大学 | 5-氨基-γ-内酯衍生物的简便合成方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2473518A1 (fr) * | 1980-01-16 | 1981-07-17 | Unicler | Derives du phenyl-1 morpholino-4 butene-1 ol-3, leur preparation et leur application en therapeutique |
IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical preparations containing them |
DE69208088T2 (de) * | 1991-07-05 | 1996-11-14 | Merck Sharp & Dohme | Aromatische verbindungen, diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische anwendung |
US5472978A (en) * | 1991-07-05 | 1995-12-05 | Merck Sharp & Dohme Ltd. | Aromatic compounds, pharmaceutical compositions containing them and their use in therapy |
DK0641328T3 (da) * | 1992-05-18 | 2002-05-21 | Pfizer | Broforbundne, azabicykliske derivater som substans P-antagonister |
GB9321557D0 (en) * | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
FR2700472B1 (fr) * | 1993-01-19 | 1995-02-17 | Rhone Poulenc Rorer Sa | Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2. |
DK0687268T3 (da) * | 1993-03-04 | 1998-10-12 | Pfizer | Spiroazacykliske derivater som substans P-antagonister |
GB9310713D0 (en) * | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Aryl substituted heterocycles |
CA2163995A1 (en) * | 1993-06-07 | 1994-12-22 | Malcolm Maccoss | Spiro-substituted azacycles as neurokinin antagonists |
GB9317104D0 (en) * | 1993-08-17 | 1993-09-29 | Zeneca Ltd | Therapeutic heterocycles |
GB9322643D0 (en) * | 1993-11-03 | 1993-12-22 | Zeneca Ltd | Lactam derivatives |
FR2717802B1 (fr) * | 1994-03-25 | 1996-06-21 | Sanofi Sa | Nouveaux composés aromatiques, procédé pour leur préparation et compositions pharmaceutiques en contenant. |
GB9408872D0 (en) * | 1994-05-03 | 1994-06-22 | Zeneca Ltd | Heterocyclic compounds |
CA2154116A1 (en) * | 1994-07-22 | 1996-01-23 | Philip Arthur Hipskind | 1-aryl-2-acetamidopentanone derivatives for use as tachykinin receptor antagonists |
-
1996
- 1996-04-30 US US08/641,384 patent/US5696267A/en not_active Expired - Lifetime
- 1996-05-01 CA CA002218913A patent/CA2218913C/en not_active Expired - Fee Related
- 1996-05-01 CZ CZ973424A patent/CZ342497A3/cs unknown
- 1996-05-01 WO PCT/US1996/005659 patent/WO1996034857A1/en not_active Application Discontinuation
- 1996-05-01 NZ NZ307715A patent/NZ307715A/xx unknown
- 1996-05-01 PL PL96323088A patent/PL323088A1/xx unknown
- 1996-05-01 AT AT96915341T patent/ATE203014T1/de not_active IP Right Cessation
- 1996-05-01 ES ES96915341T patent/ES2158314T3/es not_active Expired - Lifetime
- 1996-05-01 SK SK1471-97A patent/SK147197A3/sk unknown
- 1996-05-01 DK DK96915341T patent/DK0823896T3/da active
- 1996-05-01 AU AU57140/96A patent/AU706526B2/en not_active Ceased
- 1996-05-01 PT PT96915341T patent/PT823896E/pt unknown
- 1996-05-01 CN CNB961951729A patent/CN1134414C/zh not_active Expired - Fee Related
- 1996-05-01 KR KR1019970707757A patent/KR100248921B1/ko not_active IP Right Cessation
- 1996-05-01 EP EP96915341A patent/EP0823896B1/de not_active Expired - Lifetime
- 1996-05-01 DE DE69613833T patent/DE69613833T2/de not_active Expired - Lifetime
- 1996-05-01 HU HU9800840A patent/HU222048B1/hu not_active IP Right Cessation
- 1996-05-01 BR BR9608269A patent/BR9608269A/pt not_active Application Discontinuation
- 1996-05-01 JP JP53335496A patent/JP3255421B2/ja not_active Expired - Fee Related
- 1996-05-01 MX MX9708415A patent/MX9708415A/es not_active IP Right Cessation
-
1997
- 1997-07-25 US US08/901,028 patent/US5840725A/en not_active Expired - Lifetime
- 1997-10-31 NO NO19975029A patent/NO310189B1/no not_active IP Right Cessation
-
1998
- 1998-07-17 HK HK98109217A patent/HK1008221A1/xx not_active IP Right Cessation
-
2001
- 2001-09-20 GR GR20010401533T patent/GR3036676T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1996034857A1 (en) | 1996-11-07 |
PT823896E (pt) | 2001-11-30 |
ATE203014T1 (de) | 2001-07-15 |
EP0823896B1 (de) | 2001-07-11 |
NO310189B1 (no) | 2001-06-05 |
DK0823896T3 (da) | 2001-09-24 |
JP3255421B2 (ja) | 2002-02-12 |
AU5714096A (en) | 1996-11-21 |
HUP9800840A3 (en) | 1998-09-28 |
CA2218913C (en) | 2003-03-04 |
SK147197A3 (en) | 1998-08-05 |
GR3036676T3 (en) | 2001-12-31 |
HU222048B1 (hu) | 2003-04-28 |
MX9708415A (es) | 1998-02-28 |
DE69613833D1 (de) | 2001-08-16 |
ES2158314T3 (es) | 2001-09-01 |
KR19990008231A (ko) | 1999-01-25 |
NZ307715A (en) | 2000-01-28 |
CZ342497A3 (cs) | 1998-07-15 |
JPH10506923A (ja) | 1998-07-07 |
AU706526B2 (en) | 1999-06-17 |
BR9608269A (pt) | 1999-02-17 |
EP0823896A1 (de) | 1998-02-18 |
US5696267A (en) | 1997-12-09 |
KR100248921B1 (ko) | 2000-04-01 |
NO975029D0 (no) | 1997-10-31 |
HK1008221A1 (en) | 1999-05-07 |
NO975029L (no) | 1997-12-30 |
CA2218913A1 (en) | 1996-11-07 |
CN1189821A (zh) | 1998-08-05 |
HUP9800840A2 (hu) | 1998-08-28 |
CN1134414C (zh) | 2004-01-14 |
PL323088A1 (en) | 1998-03-02 |
US5840725A (en) | 1998-11-24 |
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