ES2172767T3 - 7-amino-2-heptenoatos y su utilizacion en la preparacion de metilfenidato. - Google Patents

7-amino-2-heptenoatos y su utilizacion en la preparacion de metilfenidato.

Info

Publication number
ES2172767T3
ES2172767T3 ES97908413T ES97908413T ES2172767T3 ES 2172767 T3 ES2172767 T3 ES 2172767T3 ES 97908413 T ES97908413 T ES 97908413T ES 97908413 T ES97908413 T ES 97908413T ES 2172767 T3 ES2172767 T3 ES 2172767T3
Authority
ES
Spain
Prior art keywords
methylphenidate
heptenoatos
amino
preparation
cooch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97908413T
Other languages
English (en)
Inventor
Martin Edward Fox
Jane Marie Paul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celltech Pharma Europe Ltd
Original Assignee
Medeva Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medeva Europe Ltd filed Critical Medeva Europe Ltd
Application granted granted Critical
Publication of ES2172767T3 publication Critical patent/ES2172767T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE FORMULA Y SUP,1 Y 2 N - (CH 2 ) 4 - CH = C(PH) - X, DONDE Y 1 E Y 2 SON INDEPENDIENTEMENTE H O UN GRUPO BLOQUEANTE ELIMINABLE, O Y 1 E Y 2 CONJUNTAMENTE SON UN GRU PO BLOQUEANTE DIVALENTE ELIMINABLE; Y X ES COOCH 3 O UN GRUPO CONVERTIBLE EN EL MISMO. DICHO COMPUESTO SE PUEDE CICLIZAR MEDIANTE ADICION DE MICHAEL, PRODUCIENDO METILFENIDATO, SI ES NECESARIO TRAS LA ELIMINACION DEL GRUPO O GRUPOS BLOQUEANTES Y LA CONVERSION DE X EN COOCH 3 .
ES97908413T 1996-03-27 1997-03-21 7-amino-2-heptenoatos y su utilizacion en la preparacion de metilfenidato. Expired - Lifetime ES2172767T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9606417.5A GB9606417D0 (en) 1996-03-27 1996-03-27 Asymmetric cyclisation

Publications (1)

Publication Number Publication Date
ES2172767T3 true ES2172767T3 (es) 2002-10-01

Family

ID=10791096

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97908413T Expired - Lifetime ES2172767T3 (es) 1996-03-27 1997-03-21 7-amino-2-heptenoatos y su utilizacion en la preparacion de metilfenidato.

Country Status (14)

Country Link
US (1) US6031124A (es)
EP (1) EP0889874B1 (es)
JP (1) JP2000507263A (es)
KR (1) KR100472753B1 (es)
AT (1) ATE212616T1 (es)
AU (1) AU703927B2 (es)
CA (1) CA2243544C (es)
DE (1) DE69710181T2 (es)
DK (1) DK0889874T3 (es)
ES (1) ES2172767T3 (es)
GB (1) GB9606417D0 (es)
MX (1) MX202731B (es)
PT (1) PT889874E (es)
WO (1) WO1997035836A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
EP0860426A1 (en) * 1997-02-19 1998-08-26 Takasago International Corporation 7-(n-substituted amino)-2-phenylheptanoic acid derivative and process for manufacturing the same
US5859249A (en) * 1997-02-19 1999-01-12 Takasago International Corporation 2-phenyl-2-(2'-piperidinylidene)acetate derivative, process for manufacturing the same, and process for manufacturing optically active 2-phenyl-2-(2'-piperidinyl)acetate derivative by asymmetrically hydrogenating the same
US6962997B1 (en) 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
US6100401A (en) * 1998-04-20 2000-08-08 Novartris Ag Process for preparing the d-threo isomer of methylphenidate hydrochloride
US6025502A (en) * 1999-03-19 2000-02-15 The Trustees Of The University Of Pennsylvania Enantopselective synthesis of methyl phenidate
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
CA2591247A1 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment of patients suffering from a disease having a family history or diagnosis of tics or tourette's syndrome with d-threo methylphenidate
US9603809B2 (en) 2011-03-23 2017-03-28 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US8916588B2 (en) 2011-03-23 2014-12-23 Ironshore Pharmaceuticals & Development, Inc. Methods for treatment of attention deficit hyperactivity disorder
US9498447B2 (en) 2011-03-23 2016-11-22 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9283214B2 (en) 2011-03-23 2016-03-15 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
EP4011364B1 (en) 2011-03-23 2023-12-13 Ironshore Pharmaceuticals & Development, Inc. Methods and compositions for treatment of attention deficit disorder
US10905652B2 (en) 2011-03-23 2021-02-02 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US10292937B2 (en) 2011-03-23 2019-05-21 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US9119809B2 (en) 2011-03-23 2015-09-01 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US11241391B2 (en) 2011-03-23 2022-02-08 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US8927010B2 (en) 2011-03-23 2015-01-06 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2957880A (en) * 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers
JPS537627A (en) * 1976-07-07 1978-01-24 Teijin Ltd Optically active unsaturated esters and their preparation

Also Published As

Publication number Publication date
US6031124A (en) 2000-02-29
CA2243544A1 (en) 1997-10-02
MX202731B (en) 2001-06-29
PT889874E (pt) 2002-06-28
AU703927B2 (en) 1999-04-01
EP0889874B1 (en) 2002-01-30
ATE212616T1 (de) 2002-02-15
CA2243544C (en) 2002-11-19
GB9606417D0 (en) 1996-06-05
MX9807879A (en) 1999-02-28
WO1997035836A1 (en) 1997-10-02
AU2038697A (en) 1997-10-17
DE69710181T2 (de) 2002-08-14
DK0889874T3 (da) 2002-05-06
EP0889874A1 (en) 1999-01-13
DE69710181D1 (de) 2002-03-14
JP2000507263A (ja) 2000-06-13
KR100472753B1 (ko) 2005-07-07
KR19990087826A (ko) 1999-12-27

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