MY114455A - Substituted oximes, hydrazones and olefins as neurokinin antagonists - Google Patents

Substituted oximes, hydrazones and olefins as neurokinin antagonists

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Publication number
MY114455A
MY114455A MYPI97001119A MYPI19971119A MY114455A MY 114455 A MY114455 A MY 114455A MY PI97001119 A MYPI97001119 A MY PI97001119A MY PI19971119 A MYPI19971119 A MY PI19971119A MY 114455 A MY114455 A MY 114455A
Authority
MY
Malaysia
Prior art keywords
formula
heteroaryl
alkyl
substituted
cycloalkyl
Prior art date
Application number
MYPI97001119A
Inventor
Lupo Andrew
Ganguly Ashit
D Mccormick Kevin
J Piwinski John
C Ting Pauline
I Carruthers Nicholas
Mangiaracina Pietro
A Reichard Gregory
P Kirkup Michael
Shankar Bandarpalle
Shih Neng-Yang
M Spitler James
A Alaimo Cheryl
G Aslanian Robert
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to MYPI97001119A priority Critical patent/MY114455A/en
Publication of MY114455A publication Critical patent/MY114455A/en

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Abstract

COMPOUND REPRESENTED BY THE STRUCTURAL FORMULA (FORMULA 1) OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, WHEREIN: A IS 0, 1, 2, OR 3; B, D AND E ARE INDEPENDENTLY 0, 1 OR 2; R IS H, C1-6 ALKYL, -OH OR C2-C6 HYDROXYALKYL;A IS AN OPTIONALLY SUBSTITUTED OXIME, HYDRAZONE OR OLEFIN; X IS A BOND, -C(O)-, -O-, -NR6, -S(O)E-, -N(R6)C(O)-, -C(O)N(R6)-, -OC(O)NR6-, -OC(=S)NR6-, -N(R6)C(=S)O-, -C(=NOR1)-, -S(O)2N(R6)-, -N(R6)S(O)2-, -N(R6)C(O)O-, OR -OC(O)-; T IS H, PHTHALIMIDYL, ARYL, HETEROCYCLOALKYL, HETEROARYL, CYCLOALKYL OR BRIDGED CYCLOALKYL; Q IS -SR6, -N(R6)(R7), -OR6, PHENYL, NAPHTHYLOR HETEROARYL; R6A, R7A, R8A, R9A, R6 AND R7 ARE H, C1-6 ALKYL, C2-C6 HYDROXYALKYL, C1-C6 ALKOXY-C1-C6 ALKYL, PHENYL OR BENZYL; OR R6 AND R7, TOGETHER WITH THE NITROGEN TO WHICH THEY ARE ATTACHED, FORM A RING; R9A IS R6 OR -OR6; Z IS MORPHOLINYL, OPTIONALLY N-SUBSTITUTED PIPERAZINYL, OPTIONALLYSUBSTITUTED, ( FORMULA ) OR SUBSTITUTED ( FORMULA ) G IS 0-3 AND H IS 1-4, PROVIDED THE SUM OF H AND G IS 1-7; WHEREIN ARYL, HETEROCYCLOALKYL, HETEROARYL, CYCLOALKYL AND BRIDGED CYCLOALKYL GROUPS ARE OPTIONALLY SUBSTITUTED; METHODS OF TREATING ASTHMA, COUGH, BRONCHOSPASM, IMFLAMMATORY DISEASES, AND GASTROINTESTINAL DISORDERS WITH SAID COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS ARE DISCLOSED.
MYPI97001119A 1997-03-17 1997-03-17 Substituted oximes, hydrazones and olefins as neurokinin antagonists MY114455A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MYPI97001119A MY114455A (en) 1997-03-17 1997-03-17 Substituted oximes, hydrazones and olefins as neurokinin antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI97001119A MY114455A (en) 1997-03-17 1997-03-17 Substituted oximes, hydrazones and olefins as neurokinin antagonists

Publications (1)

Publication Number Publication Date
MY114455A true MY114455A (en) 2002-10-31

Family

ID=79646308

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI97001119A MY114455A (en) 1997-03-17 1997-03-17 Substituted oximes, hydrazones and olefins as neurokinin antagonists

Country Status (1)

Country Link
MY (1) MY114455A (en)

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