DE69530701D1 - Verwendung von 2,7,8-Trimethyl-2-( beta-Carboxyethyl )-6-Hydroxy-Chroman (LLU-alpha) - Google Patents
Verwendung von 2,7,8-Trimethyl-2-( beta-Carboxyethyl )-6-Hydroxy-Chroman (LLU-alpha)Info
- Publication number
- DE69530701D1 DE69530701D1 DE69530701T DE69530701T DE69530701D1 DE 69530701 D1 DE69530701 D1 DE 69530701D1 DE 69530701 T DE69530701 T DE 69530701T DE 69530701 T DE69530701 T DE 69530701T DE 69530701 D1 DE69530701 D1 DE 69530701D1
- Authority
- DE
- Germany
- Prior art keywords
- llu
- chroman
- carboxyethyl
- trimethyl
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Read Only Memory (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/290,430 US6150402A (en) | 1994-08-15 | 1994-08-15 | Natriuretic compounds |
PCT/US1995/010411 WO1996005191A1 (en) | 1994-08-15 | 1995-08-15 | Natriuretic cyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69530701D1 true DE69530701D1 (de) | 2003-06-12 |
Family
ID=23115959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530701T Expired - Lifetime DE69530701D1 (de) | 1994-08-15 | 1995-08-15 | Verwendung von 2,7,8-Trimethyl-2-( beta-Carboxyethyl )-6-Hydroxy-Chroman (LLU-alpha) |
Country Status (7)
Country | Link |
---|---|
US (2) | US6150402A (de) |
EP (1) | EP0792270B1 (de) |
JP (2) | JPH10506383A (de) |
AT (1) | ATE239465T1 (de) |
AU (1) | AU3327795A (de) |
DE (1) | DE69530701D1 (de) |
WO (1) | WO1996005191A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6120432A (en) | 1997-04-23 | 2000-09-19 | Vascular Science Inc. | Medical grafting methods and apparatus |
JP2002501018A (ja) | 1998-01-26 | 2002-01-15 | マイトコー | ミトコンドリア関連疾患を処置するためのミトコンドリア保護剤 |
US6048891A (en) * | 1998-12-17 | 2000-04-11 | Loma Linda University Medical Center | Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease |
US6426362B1 (en) | 1999-10-08 | 2002-07-30 | Galileo Laboratories, Inc. | Formulations of tocopherols and methods of making and using them |
ES2346181T3 (es) * | 2000-03-31 | 2010-10-13 | EISAI R&D MANAGEMENT CO., LTD. | Uso de gamma-tocotrienol como diuretico. |
US7034054B2 (en) * | 2000-12-15 | 2006-04-25 | Galileo Pharmaceuticals, Inc. | Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols |
US20030144219A1 (en) | 2001-11-15 | 2003-07-31 | Phinney Stephen Dodge | Formulations and methods for treatment or amelioration of inflammatory conditions |
JP4118623B2 (ja) * | 2002-07-23 | 2008-07-16 | 松下電器産業株式会社 | 不揮発性半導体記憶装置 |
AU2003291012A1 (en) * | 2002-11-15 | 2004-06-15 | Galileo Pharmaceuticals, Inc. | Chroman derivatives for the reduction of inflammation symptoms |
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
CA2580584C (en) | 2003-09-19 | 2015-07-28 | Galileo Pharmaceuticals, Inc. | Use of alpha-tocotrienol for treatment of mitochondrial diseases |
US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
NZ550441A (en) * | 2004-05-05 | 2009-07-31 | Hoffmann La Roche | Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both |
GB2433815B (en) * | 2004-10-26 | 2009-02-25 | Spansion Llc | Non-volatile memory device |
ATE448216T1 (de) * | 2004-12-21 | 2009-11-15 | Hoffmann La Roche | Tetralin- und indanderivate und anwendungen davon |
JP4738418B2 (ja) | 2004-12-21 | 2011-08-03 | エフ.ホフマン−ラ ロシュ アーゲー | クロマン誘導体及びcns障害の処置におけるその使用 |
KR100889185B1 (ko) * | 2004-12-21 | 2009-03-16 | 에프. 호프만-라 로슈 아게 | 테트랄린 및 인단 유도체 및 5-ht 길항제로서의 이의용도 |
SI1831159T1 (sl) * | 2004-12-21 | 2010-04-30 | Hoffmann La Roche | Derivati tetralina in indana ter njune uporabe |
MX2007007480A (es) * | 2004-12-21 | 2007-07-20 | Hoffmann La Roche | Derivados de cromano y su uso como ligandos del receptor 5-ht. |
EP1871355A1 (de) * | 2005-04-22 | 2008-01-02 | Wyeth | Neue therapeutische kombinationen zur behandlung oder prävention von depression |
MX2007013179A (es) * | 2005-04-22 | 2008-01-16 | Wyeth Corp | Formas cristalinas de clorhidrato de {[(2r)-7-(diclorofenil)-5- fluoro-2,3-dihidro-1-benzofurano-2-il]metil}amina. |
RU2007139541A (ru) * | 2005-04-22 | 2009-05-27 | Вайет (Us) | Производные хромана и хромена и их применение |
CA2610152C (en) * | 2005-06-01 | 2018-04-10 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
SI1933821T1 (sl) * | 2005-09-15 | 2020-11-30 | Ptc Therapeutics, Inc. | Repne variante redoks-aktivnih terapevtikov za zdravljenje mitohondrijskih bolezni in drugih bolezni ter modulacijo energijskih biooznačevalcev |
RU2008115032A (ru) * | 2005-11-03 | 2009-12-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | Арилсульфонилхроманы в качестве ингибиторов 5-нт6 |
EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
AU2007233123A1 (en) * | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
DK2001518T3 (da) * | 2006-03-30 | 2013-10-07 | Palatin Technologies Inc | Cykliske natriuretiske peptidfremstillinger |
US8580746B2 (en) * | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
BRPI0713736A2 (pt) * | 2006-06-20 | 2014-11-18 | Hoffmann La Roche | Derivados de tetralina e indano e emprego destes |
JP2009541249A (ja) * | 2006-06-20 | 2009-11-26 | エフ.ホフマン−ラ ロシュ アーゲー | アリールスルホニルナフタレン誘導体およびその使用 |
CN101472883A (zh) * | 2006-06-20 | 2009-07-01 | 弗·哈夫曼-拉罗切有限公司 | 芳基磺酰氨基四氢萘衍生物以及其应用 |
MX2010004622A (es) | 2007-11-06 | 2010-05-20 | Edison Pharmaceuticals Inc | Derivados de 4-(p-quinonil)-2-hidroxibutanamida para tratamiento de enfermedades mitocondriales. |
WO2010030607A1 (en) | 2008-09-10 | 2010-03-18 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
US20120277155A1 (en) | 2011-02-25 | 2012-11-01 | Medtronic, Inc. | Therapy for kidney disease and/or heart failure |
EP2750697A4 (de) | 2011-09-02 | 2015-03-25 | Medtronic Inc | Chimäre natriuretische peptidzusammensetzungen und verfahren zu ihrer herstellung |
JP2016520621A (ja) * | 2013-05-31 | 2016-07-14 | エジソン ファーマシューティカルズ, インコーポレイテッド | 酸化ストレス障害の処置のためのカルボン酸誘導体 |
RU2770091C2 (ru) | 2014-12-16 | 2022-04-14 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Полиморфные и аморфные формы (r)-2-гидрокси-2-метил-4-(2,4,5-триметил-3,6-диоксоциклогекса-1,4-диенил)бутанамида |
CA3008849A1 (en) | 2015-12-17 | 2017-06-22 | Bioelectron Technology Corporation | Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
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NL112041C (de) * | 1954-03-08 | |||
GB947885A (en) * | 1961-04-12 | 1964-01-29 | Vitamins Ltd | Improvements in or relating to the preparation of chromanols |
GB949715A (en) * | 1961-04-12 | 1964-02-19 | Vitamins Ltd | Improvements in or relating to chromanols |
US3726904A (en) * | 1970-11-16 | 1973-04-10 | Ciba Geigy Corp | 2,3-dihydro-5-(2-nitro-1-alkenyl)-benzofuran-2-carboxylic acid and pharmaceutically acceptable salts |
US3947473A (en) * | 1972-12-22 | 1976-03-30 | Hoffman-La Roche Inc. | Antioxidant chroman compounds |
US4018799A (en) * | 1973-11-19 | 1977-04-19 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
US4026907A (en) * | 1973-11-19 | 1977-05-31 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
US4003919A (en) * | 1973-11-19 | 1977-01-18 | Hoffmann-La Roche Inc. | Antioxidant chroman compounds |
US4100294A (en) * | 1976-12-06 | 1978-07-11 | Merck & Co., Inc. | 5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives |
US4127608A (en) * | 1977-05-17 | 1978-11-28 | Hoffmann-La Roche Inc. | Synthesis of Vitamin E |
DE2861183D1 (en) * | 1978-01-30 | 1981-12-24 | Hoffmann La Roche | Process for the preparation of chromane derivatives |
US4237130A (en) * | 1979-06-21 | 1980-12-02 | Merck & Co., Inc. | 2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids |
DE3010504A1 (de) * | 1980-03-19 | 1981-10-01 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von 2-hydroxyalkylchromanen |
US4321270A (en) * | 1981-01-29 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Substituted chromans |
JPS57145871A (en) * | 1981-03-05 | 1982-09-09 | Eisai Co Ltd | Chromanolcarboxylic derivative |
JPS6163671A (ja) * | 1984-09-05 | 1986-04-01 | Shionogi & Co Ltd | 2,3−ジヒドロベンゾフラン−5−スルホンアミド誘導体および降圧利尿剤 |
US4728650A (en) * | 1985-05-13 | 1988-03-01 | Kuraray Co., Ltd. | 3,4-dihydrobenzopyran derivatives and medicinal uses thereof |
US4791209A (en) * | 1985-05-22 | 1988-12-13 | Chugai Seiyako Kabushiki Kaisha | Furobenzisoxazole derivatives |
DK36389A (da) * | 1988-02-05 | 1989-08-06 | Eastman Kodak Co | Praeparat og fremgangsmaade til at forebygge vaevskader ved reperfusion |
JPH01303467A (ja) * | 1988-05-31 | 1989-12-07 | Mita Ind Co Ltd | 画像形成装置の中間調制御装置 |
EP0369082A1 (de) * | 1988-11-14 | 1990-05-23 | Merrell Dow Pharmaceuticals Inc. | Herzschutz-Tocopherolanaloge |
IT1231341B (it) * | 1989-08-18 | 1991-11-28 | Foscama Biomed Chim Farma | 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche. |
JP3029840B2 (ja) * | 1990-01-18 | 2000-04-10 | 旭電化工業株式会社 | 光学活性なクロマン―2―エタノール誘導体の製造方法およびその中間体 |
FR2676056B1 (fr) * | 1991-05-03 | 1993-07-16 | Adir | Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
DE4121468A1 (de) * | 1991-06-28 | 1993-01-14 | Deutsches Primatenzentrum Gmbh | Antivirale substanzen und diese enthaltende arzneimittel |
-
1994
- 1994-08-15 US US08/290,430 patent/US6150402A/en not_active Expired - Lifetime
-
1995
- 1995-08-15 AT AT95929559T patent/ATE239465T1/de not_active IP Right Cessation
- 1995-08-15 DE DE69530701T patent/DE69530701D1/de not_active Expired - Lifetime
- 1995-08-15 JP JP8507600A patent/JPH10506383A/ja active Pending
- 1995-08-15 AU AU33277/95A patent/AU3327795A/en not_active Abandoned
- 1995-08-15 EP EP95929559A patent/EP0792270B1/de not_active Expired - Lifetime
- 1995-08-15 WO PCT/US1995/010411 patent/WO1996005191A1/en active IP Right Grant
-
1996
- 1996-07-09 JP JP9507600A patent/JPH10510656A/ja active Pending
-
1998
- 1998-04-09 US US09/057,731 patent/US6083982A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0792270A1 (de) | 1997-09-03 |
US6150402A (en) | 2000-11-21 |
US6083982A (en) | 2000-07-04 |
JPH10506383A (ja) | 1998-06-23 |
EP0792270B1 (de) | 2003-05-07 |
AU3327795A (en) | 1996-03-07 |
ATE239465T1 (de) | 2003-05-15 |
WO1996005191A1 (en) | 1996-02-22 |
JPH10510656A (ja) | 1998-10-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |