DE69529601D1 - Selbst adressierbare und sich selbst zusammensetzende mikroelektronische systeme und vorrichtungen zur molekularen biologischen tralyse und diagnose - Google Patents

Selbst adressierbare und sich selbst zusammensetzende mikroelektronische systeme und vorrichtungen zur molekularen biologischen tralyse und diagnose

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Publication number
DE69529601D1
DE69529601D1 DE69529601T DE69529601T DE69529601D1 DE 69529601 D1 DE69529601 D1 DE 69529601D1 DE 69529601 T DE69529601 T DE 69529601T DE 69529601 T DE69529601 T DE 69529601T DE 69529601 D1 DE69529601 D1 DE 69529601D1
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nucleic acid
self
selector
cell
sample
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J Heller
Eugene Tu
A Evans
G Sosnowski
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Nanogen Inc
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Nanogen Inc
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DE69529601T 1994-07-07 1995-07-05 Selbst adressierbare und sich selbst zusammensetzende mikroelektronische systeme und vorrichtungen zur molekularen biologischen tralyse und diagnose Expired - Lifetime DE69529601D1 (de)

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US08/271,882 US6017696A (en) 1993-11-01 1994-07-07 Methods for electronic stringency control for molecular biological analysis and diagnostics
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Publication number Priority date Publication date Assignee Title
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US6197508B1 (en) 1990-09-12 2001-03-06 Affymetrix, Inc. Electrochemical denaturation and annealing of nucleic acid
US6652808B1 (en) * 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US6569382B1 (en) * 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US6048690A (en) * 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6401267B1 (en) * 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
US6315953B1 (en) 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US7172864B1 (en) 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
US6068818A (en) * 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US7314708B1 (en) 1998-08-04 2008-01-01 Nanogen, Inc. Method and apparatus for electronic synthesis of molecular structures
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US6306348B1 (en) * 1993-11-01 2001-10-23 Nanogen, Inc. Inorganic permeation layer for micro-electric device
US6129828A (en) 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US7101661B1 (en) 1993-11-01 2006-09-05 Nanogen, Inc. Apparatus for active programmable matrix devices
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6468742B2 (en) * 1993-11-01 2002-10-22 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
US6726880B1 (en) 1993-11-01 2004-04-27 Nanogen, Inc. Electronic device for performing active biological operations and method of using same
US6309602B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6254827B1 (en) 1993-11-01 2001-07-03 Nanogen, Inc. Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6207373B1 (en) 1998-02-25 2001-03-27 Nanogen, Inc. Methods for determining nature of repeat units in DNA
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US7857957B2 (en) * 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US5544268A (en) 1994-09-09 1996-08-06 Deacon Research Display panel with electrically-controlled waveguide-routing
US20040086917A1 (en) * 1995-09-27 2004-05-06 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US6048691A (en) * 1996-05-13 2000-04-11 Motorola, Inc. Method and system for performing a binding assay
US6355436B1 (en) 1996-05-17 2002-03-12 L'ecole Centrale De Lyon Method for analyzing biological substances in a conductive liquid medium
JP2000515508A (ja) * 1996-07-12 2000-11-21 ベルトリング,ボルフ 分子を精製し濃縮するための方法および装置
US7169556B2 (en) * 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP1019711A4 (de) * 1996-09-06 2001-06-13 Nanogen Inc Verfahren und materialien zur optimierung der elektronischen hybridisierungsreaktion
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
DE19646505A1 (de) 1996-11-12 1998-05-14 Itt Ind Gmbh Deutsche Vorrichtung zur Durchführung von Untersuchungen an Zellproben und dergleichen
EP0938674B1 (de) * 1996-11-16 2005-06-01 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung
GB2319771B (en) * 1996-11-29 2001-09-26 Imperial College Process
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
CA2294449A1 (en) * 1997-06-20 1998-12-30 New York University Electrospraying solutions of substances for mass fabrication of chips and libraries
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19753850A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Probennahmevorrichtung
DE19753847A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit Kapillarkanal
DE19819735A1 (de) * 1998-05-02 1999-11-04 Novartis Ag Vorrichtung und Verfahren zur Herstellung einer Anordnung von Kettenmolekülen auf einem Trägermaterial
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
US6387632B2 (en) * 1998-06-11 2002-05-14 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
US6761816B1 (en) * 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6281006B1 (en) 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6638716B2 (en) 1998-08-24 2003-10-28 Therasense, Inc. Rapid amperometric verification of PCR amplification of DNA
KR100369694B1 (ko) * 1998-09-17 2003-01-29 인터내셔널 비지네스 머신즈 코포레이션 화학적 태그의 합성 방법
US7135283B1 (en) 1998-11-17 2006-11-14 Nanogen, Inc. Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms
DE19854946C2 (de) * 1998-11-27 2002-01-03 Guenter Von Kiedrowski Klonieren und Kopieren an Oberflächen
US20030032029A1 (en) * 1998-12-21 2003-02-13 Nanogen, Inc. Three dimensional apparatus and method for integrating sample preparation and multiplex assays
US6514768B1 (en) 1999-01-29 2003-02-04 Surmodics, Inc. Replicable probe array
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6410231B1 (en) * 1999-02-26 2002-06-25 Incyte Genomics, Inc. SNP detection
AU772213C (en) * 1999-02-26 2004-12-09 Exact Sciences Corporation Biochemical purification devices with immobilized capture probes and their uses
EP1039291A1 (de) * 1999-03-26 2000-09-27 Sony International (Europe) GmbH Optochemischer Fühler and Herstellungsmethode
EP1177423A4 (de) * 1999-04-12 2004-10-27 Nanogen Becton Dickinson Partn Verstärkung und trennung von nukleinsäuresequenzen mittels strangverschiebeverstärkung und bioelektronischer
US6309833B1 (en) 1999-04-12 2001-10-30 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
US6326173B1 (en) * 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
WO2000061805A1 (en) * 1999-04-12 2000-10-19 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6531302B1 (en) * 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
CA2644688C (en) * 1999-04-20 2012-11-13 Kankyo Engineering Co., Ltd. Method for determining a concentration of target nucleic acid molecules, nucleic acid probes for the method, and method for analysing data obtained by the method
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6423536B1 (en) 1999-08-02 2002-07-23 Molecular Dynamics, Inc. Low volume chemical and biochemical reaction system
AU7730500A (en) * 1999-09-30 2001-04-30 Nanogen, Inc. Biomolecular attachment sites on microelectronic arrays and methods thereof
WO2001027327A2 (en) * 1999-10-08 2001-04-19 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US6824664B1 (en) 1999-11-04 2004-11-30 Princeton University Electrode-less dielectrophorises for polarizable particles
ES2225264T3 (es) * 1999-11-12 2005-03-16 Clinical Micro Sensors, Inc. Tecnicas de aceleracion de union para la deteccion de analitos.
US6451191B1 (en) * 1999-11-18 2002-09-17 3M Innovative Properties Company Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same
EP3379591A1 (de) * 1999-12-01 2018-09-26 The Trustees of Princeton University Komplexe der formel l2mx
DE19960076C2 (de) * 1999-12-13 2002-12-05 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Nachweis und zur Quantifizierung von Biomolekülen
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
JP3757412B2 (ja) * 2000-02-22 2006-03-22 横河電機株式会社 バイオチップ
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
EP1134294A3 (de) * 2000-03-16 2004-06-30 Kabushiki Kaisha Toshiba Verfahren zur Synthese eines immobilisierten Nukleinsäurestranges
DE10013990C2 (de) * 2000-03-22 2003-12-04 Invitek Biotechnik & Biodesign Polyfunktionelles Trägermaterial für die komplexe Nukleinsäureanalytik
AU2000267888A1 (en) * 2000-03-28 2001-10-08 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
DE10015547C2 (de) * 2000-03-30 2002-02-14 Aventis Res & Tech Gmbh & Co Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren
DE10015818A1 (de) 2000-03-30 2001-10-18 Infineon Technologies Ag Biosensor und Verfahren zum Ermitteln makromolekularer Biopolymere mit einem Biosensor
CA2302827A1 (en) * 2000-04-12 2001-10-12 Michelle Furtado Oligonucleotide and dna de-hybridization on surfaces
US6413792B1 (en) 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US7001792B2 (en) * 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US8232582B2 (en) 2000-04-24 2012-07-31 Life Technologies Corporation Ultra-fast nucleic acid sequencing device and a method for making and using the same
CA2407973C (en) * 2000-05-03 2011-06-07 Jen-Jr Gau Biological identification system with integrated sensor chip
US6790330B2 (en) * 2000-06-14 2004-09-14 Board Of Regents, The University Of Texas System Systems and methods for cell subpopulation analysis
CA2413634A1 (en) * 2000-06-14 2001-12-20 Peter R. C. Gascoyne Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures
WO2001096024A2 (en) * 2000-06-14 2001-12-20 Board Of Regents, The University Of Texas System Apparatus and method for fluid injection
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DE60117556T2 (de) * 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
CN1137999C (zh) * 2000-07-04 2004-02-11 清华大学 集成式微阵列装置
JP2004514418A (ja) * 2000-07-11 2004-05-20 ホーガン カーク 周術期ゲノムプロファイリングの方法および組成物
EP1349956A2 (de) * 2000-08-02 2003-10-08 SurModics, Inc. Replizierbarer sondenarray
DE10038237A1 (de) * 2000-08-04 2002-02-14 Aventis Res & Tech Gmbh & Co Verfahren zum Nachweis von Mutationen in Nucleotidsequenzen
AU2001287440A1 (en) * 2000-08-30 2002-03-13 National Research Council Of Canada A method for spatial distribution of chemical groups on a semiconductor surface
US6780584B1 (en) * 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US7060442B2 (en) * 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
DE60141171D1 (de) 2000-11-27 2010-03-11 Intelligent Medical Devices Ll Klinische intelligente diagnostische vorrichtungen und verfahren
EP1346208A2 (de) * 2000-11-28 2003-09-24 Nanogen, Inc. Vorrichtung im mikrotiterplattenformat und verfahren zur trennung unterschiedlich geladener moleküle unter verwendung eines elektrischen felds
US20020127855A1 (en) * 2001-01-04 2002-09-12 Sauer Jon Robert Method for fabricating a pattern in a mask on a surface of an object and product manufactured thereby
JPWO2002066969A1 (ja) * 2001-02-19 2004-06-24 協和メデックス株式会社 荷電成分検出装置及びその使用方法並びに検出パネル
DE10109777A1 (de) * 2001-03-01 2002-09-19 Infineon Technologies Ag Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren
DE10109779A1 (de) * 2001-03-01 2002-09-19 Infineon Technologies Ag Vorrichtung und Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren
WO2002070789A2 (en) * 2001-03-02 2002-09-12 William Marsh Rice University Electrical potential-assisted assembly of molecular devices
DE10112778A1 (de) * 2001-03-16 2002-10-02 Infineon Technologies Ag Biosensor, Vorrichtung und Verfahren zum Erfassen von Nukleinsäuren mittels mindestens zwei Einheiten zum Immobilisieren von Nukleinsäuren
DE10113550A1 (de) * 2001-03-20 2002-10-02 Infineon Technologies Ag Verfahren zum Erfassen von makromolekularen Biopolymeren mittels einer Elektrodenanordnung
US20040171002A1 (en) * 2001-04-26 2004-09-02 Gert Desmet Method for acceleration and intensification of target-receptor binding and devices therefor
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
DE60222427T2 (de) * 2001-07-16 2008-06-12 Protein Forest, Inc., Waltham Puffer-arrays zum nachweis von biomolekülen anhand ihres isoelektrischen punktes
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
DE60208801T8 (de) * 2001-07-25 2007-09-20 Posco, Pohang Nachweisverfahren der nukleinsäurehybridisierung
DE10137342A1 (de) * 2001-07-31 2003-03-06 Infineon Technologies Ag Biosensor und Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren
US20030148314A1 (en) * 2001-08-01 2003-08-07 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer
US20030040000A1 (en) * 2001-08-08 2003-02-27 Connolly Dennis M. Methods for attaching nucleic acid molecules to electrically conductive surfaces
US20030119028A1 (en) * 2001-08-08 2003-06-26 Graves David J. Device and methods for enhanced microarray hybridization reactions
US7666661B2 (en) 2001-08-27 2010-02-23 Platypus Technologies, Llc Substrates, devices, and methods for quantitative liquid crystal assays
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
JP3848226B2 (ja) * 2001-08-31 2006-11-22 株式会社東芝 生体物質検出装置及び生体物質検出素子
US7198754B2 (en) 2001-08-31 2007-04-03 Kabushiki Kaisha Toshiba Biological material detection element, biological material detection method and apparatus, charged material moving apparatus
KR100449069B1 (ko) * 2001-09-12 2004-09-18 한국전자통신연구원 미소전극, 미소전극 어레이 및 미소전극 제조 방법
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
US7108975B2 (en) * 2001-09-21 2006-09-19 Regents Of The University Of Michigan Atlastin
US7582425B2 (en) * 2001-09-21 2009-09-01 The Regents Of The University Of Michigan Atlastin
ES2661167T3 (es) 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US7074519B2 (en) * 2001-10-26 2006-07-11 The Regents Of The University Of California Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device
WO2003038131A1 (en) * 2001-11-01 2003-05-08 Rensselaer Polytechnic Institute Biocatalytic solgel microarrays
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
DE10155892A1 (de) * 2001-11-14 2003-05-28 Infineon Technologies Ag Verfahren zum Erfassen von makromolekularen Biopolymeren mittels mindestens einer Einheit zum Immobilisieren von makromolekularen Biopolymeren und Biosensor zum Erfassen von makromolekularen Biopolymeren
US7413859B2 (en) * 2001-11-14 2008-08-19 Siemens Aktiengesellschaft Method and biosensors for detecting macromolecular biopolymers
US6703819B2 (en) 2001-12-03 2004-03-09 Board Of Regents, The University Of Texas System Particle impedance sensor
US6960298B2 (en) 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
US6866762B2 (en) * 2001-12-20 2005-03-15 Board Of Regents, University Of Texas System Dielectric gate and methods for fluid injection and control
US20030119057A1 (en) * 2001-12-20 2003-06-26 Board Of Regents Forming and modifying dielectrically-engineered microparticles
EP1333281A3 (de) * 2002-01-31 2004-01-14 Fuji Photo Film Co., Ltd. Verfahren und Reaktor zur Durchführung von Rezeptor-Ligand Bindungsreaktionen
US7255986B2 (en) * 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
JP3888947B2 (ja) * 2002-02-01 2007-03-07 日清紡績株式会社 生体分子の担体への固定法
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
US20030148362A1 (en) * 2002-02-07 2003-08-07 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Diagnostic microarray and method of use thereof
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
JP3856214B2 (ja) * 2002-03-11 2006-12-13 横河電機株式会社 蛍光強度増強ビーズ
DE10214719A1 (de) * 2002-04-03 2003-11-20 Infineon Technologies Ag Sensor zur qualitativen und quantitativen Bestimmung von (bio)organischen Oligomeren und Polymeren, Analyseverfahren hierzu sowie Verfahren zur Herstellung des Sensors
US20040038260A1 (en) * 2002-04-18 2004-02-26 Imedd, Inc. Nanopump device for analyzing DNA sequences
US20040009516A1 (en) * 2002-05-08 2004-01-15 Nelson Bryce P. Arrayed SPR prism
US6878523B2 (en) * 2002-05-08 2005-04-12 Gentel Bio Surfaces, Inc. Molecular interaction assays on a solid surface
US20030211478A1 (en) * 2002-05-08 2003-11-13 Gentel Corporation Transcription factor profiling on a solid surface
US6841379B2 (en) * 2002-05-15 2005-01-11 Beckman Coulter, Inc. Conductive microplate
US8268614B2 (en) * 2002-05-22 2012-09-18 Platypus Technologies, Llc Method for assaying cell movement
JP2006501860A (ja) 2002-05-22 2006-01-19 プラティパス テクノロジーズ エルエルシー 細胞をアッセイするための基体、装置および方法
DE10224150B4 (de) * 2002-05-27 2004-04-01 Siemens Ag Reaktor zur Behandlung eines Probenmediums
US20030222905A1 (en) * 2002-06-04 2003-12-04 Argonaut Technologies, Inc. Recipe recorder for automated chemistry
DE10229210A1 (de) * 2002-06-28 2004-01-29 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung zur Detektion eines Analyten
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
CN100577811C (zh) 2002-07-20 2010-01-06 美国艾森生物科学公司 基于阻抗分析细胞和颗粒的装置和方法
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7468255B2 (en) 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7732127B2 (en) 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
JP3917640B2 (ja) * 2002-07-26 2007-05-23 株式会社東芝 核酸プローブ固定化基体を用いた標的核酸の存在を検出する方法
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
EP1546392A4 (de) 2002-08-02 2006-05-24 Stratatech Corp Spezies-spezifischer dna-nachweis
US7153687B2 (en) 2002-08-13 2006-12-26 Hong Kong Dna Chips Limited Apparatus and methods for detecting DNA in biological samples
US7267751B2 (en) * 2002-08-20 2007-09-11 Nanogen, Inc. Programmable multiplexed active biologic array
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US6863731B2 (en) * 2002-10-18 2005-03-08 Controls Corporation Of America System for deposition of inert barrier coating to increase corrosion resistance
US7217542B2 (en) * 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
US20040086872A1 (en) * 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
JP3956389B2 (ja) * 2002-12-11 2007-08-08 横河電機株式会社 ハイブリダイゼーション法およびハイブリダイゼーション用装置
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
JP4230457B2 (ja) 2002-12-18 2009-02-25 サード・ウェーブ・テクノロジーズ・インク 低分子核酸の検出方法
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
GB0302058D0 (en) * 2003-01-29 2003-02-26 Univ Cranfield Replication of nucleic acid arrays
US20050014134A1 (en) * 2003-03-06 2005-01-20 West Jason Andrew Appleton Viral identification by generation and detection of protein signatures
US20050009066A1 (en) * 2003-05-15 2005-01-13 Connolly Dennis M. Methods for localizing target molecules in a flowing fluid sample
US7384792B1 (en) * 2003-05-27 2008-06-10 Opto Trace Technologies, Inc. Method of fabricating nano-structured surface and configuration of surface enhanced light scattering probe
US7341841B2 (en) 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
AU2004273783A1 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
US20050064395A1 (en) 2003-07-25 2005-03-24 Platypus Technologies, Llc Liquid crystal based analyte detection
GB0318808D0 (en) * 2003-08-11 2003-09-10 Toshiba Res Europ Ltd An encoded carrier
WO2005029705A2 (en) * 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
AU2004276761B2 (en) * 2003-09-22 2009-12-24 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
JP4328168B2 (ja) * 2003-10-02 2009-09-09 ソニー株式会社 毛細管現象を利用する物質間の相互作用検出部と該検出部を用いる方法及びバイオアッセイ用基板
US7390622B2 (en) * 2003-10-16 2008-06-24 Hai Kang Life Corporation Limited Apparatus and methods for detecting nucleic acid in biological samples
AU2004286252A1 (en) * 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20070207055A1 (en) * 2003-10-31 2007-09-06 Commissariat A L'energie Atomique Operating Device Comprising A Localized Zone For The Capture Of A Drop A Liquid Of Interest
FR2861608B1 (fr) * 2003-10-31 2005-12-23 Commissariat Energie Atomique Dispositif de travail comportant des zones de travail bordees, laboratoire sur puce et microsysteme
CA2550274A1 (en) 2003-11-12 2005-05-26 Acea Biosciences, Inc. Real time electronic cell sensing systems and applications for cell-based assays
US20070140912A1 (en) * 2004-01-22 2007-06-21 Minot Michael J Fiber optic interrogated microfluidic device
US7358113B2 (en) * 2004-01-28 2008-04-15 Zettacore, Inc. Processing systems and methods for molecular memory
US7432057B2 (en) * 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
US7384779B2 (en) * 2004-04-12 2008-06-10 Corning Incorporated Porous substrate plates and the use thereof
US7462451B2 (en) * 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
NZ582558A (en) * 2004-05-13 2012-06-29 Anita Goel Nano-PCR: Methods and devices for nucleic acid amplification and detection
US8974652B2 (en) * 2004-05-28 2015-03-10 Board Of Regents, The University Of Texas System Programmable fluidic processors
JP3952042B2 (ja) * 2004-06-07 2007-08-01 ソニー株式会社 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるdnaチップ
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
FR2872809B1 (fr) * 2004-07-09 2006-09-15 Commissariat Energie Atomique Methode d'adressage d'electrodes
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CA2513340A1 (en) * 2004-08-25 2006-02-25 F. Hoffmann-La Roche Ag Reusable substrate for dna microarray production
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
US7524672B2 (en) * 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
US7314542B2 (en) * 2004-09-23 2008-01-01 Nanogen, Inc. Methods and materials for optimization of electronic transportation and hybridization reactions
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
JP5897780B2 (ja) 2005-01-28 2016-03-30 デューク ユニバーシティ プリント回路基板上の液滴操作装置及び方法
US7875426B2 (en) * 2005-02-04 2011-01-25 University Of South Florida DNA biochip and methods of use
WO2006089268A2 (en) * 2005-02-18 2006-08-24 The University Of North Carolina At Chapel Hill Gene and cognate protein profiles and methods to determine connective tissue markers in normal and pathologic conditions
US20070034513A1 (en) 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US7439055B1 (en) 2005-05-03 2008-10-21 Sandia Corporation Biomolecular detection device
US7939257B2 (en) * 2005-05-12 2011-05-10 Third Wave Technologies, Inc. Polymorphic GHSR nucleic acids and uses thereof
TW200741960A (en) * 2005-05-13 2007-11-01 Cambrios Technologies Corp Seed layers, cap layers, and thin films and methods of making thereof
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US7410762B1 (en) 2005-06-27 2008-08-12 Sandia Corporation Method for detecting biomolecules
EP1749917B1 (de) * 2005-07-25 2013-09-25 BERNINA International AG Vorrichtung zum Sichern der Oberfadenschlaufe nach dem Einfädeln
US7662572B2 (en) 2005-08-25 2010-02-16 Platypus Technologies, Llc. Compositions and liquid crystals
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US20070207455A1 (en) * 2005-11-17 2007-09-06 Third Wave Technologies, Inc. Compositions and methods for detecting an HCV-1 subtype
MX2008006945A (es) 2005-11-30 2008-10-02 Massachusetts Inst Technology Biosensor de deteccion de patogeno.
US20070231805A1 (en) * 2006-03-31 2007-10-04 Baynes Brian M Nucleic acid assembly optimization using clamped mismatch binding proteins
CA2646309C (en) 2006-04-21 2016-07-26 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
US7674924B2 (en) * 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
JP5260503B2 (ja) 2006-06-01 2013-08-14 サード ウェーブ テクノロジーズ,インコーポレーテッド 核酸の検出
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US7842499B2 (en) * 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
EP2057277B1 (de) 2006-08-07 2018-06-13 Platypus Technologies, LLC Substrate, vorrichtungen und verfahren für zelluläre assays
US20100056388A1 (en) * 2006-08-21 2010-03-04 Cnvgenes, Inc. Nucleic acid array having fixed nucleic acid anti-probes and complementary free nucleic acid probes
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
US20080057586A1 (en) * 2006-09-05 2008-03-06 Light James P Fluorescent Cartridge for Calibration of a Microarray Reader
US8041515B2 (en) 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
WO2009012112A1 (en) 2007-07-13 2009-01-22 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus using electric field for improved biological assays
US8268246B2 (en) * 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
US9968935B2 (en) * 2007-08-20 2018-05-15 Platypus Technologies, Llc Devices for cell assays
WO2009039208A1 (en) * 2007-09-17 2009-03-26 Twof, Inc. Supramolecular nanostamping printing device
CA2702276C (en) * 2007-10-09 2019-04-02 Hsueh-Chia Chang Microfluidic platforms for multi-target detection
WO2009117327A2 (en) * 2008-03-15 2009-09-24 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
WO2009132667A1 (de) * 2008-04-30 2009-11-05 Micronas Gmbh Verfahren zum nachweisen und/oder bestimmen der konzentration eines liganden
CA2723223C (en) 2008-05-05 2017-06-06 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
US8472683B2 (en) * 2008-05-09 2013-06-25 General Electric Company Motion correction in tomographic images
JP4997181B2 (ja) * 2008-06-13 2012-08-08 株式会社日立ハイテクノロジーズ 核酸分析デバイス及び核酸分析装置
WO2010031047A2 (en) 2008-09-15 2010-03-18 Platypus Technologies, Llc Detection of vapor phase compounds by changes in physical properties of a liquid crystal
US8945912B2 (en) * 2008-09-29 2015-02-03 The Board Of Trustees Of The University Of Illinois DNA sequencing and amplification systems using nanoscale field effect sensor arrays
GB2467338A (en) * 2009-01-30 2010-08-04 Sharp Kk Electrical analyte sensor with optical output
EP2401388A4 (de) * 2009-02-23 2012-12-05 Univ Georgetown Sequenzspezifischer nachweis von nukleotidsequenzen
WO2010124257A2 (en) * 2009-04-24 2010-10-28 Colby Pharmaceutical Company Methods and kits for determining oxygen free radical (ofr) levels in animal and human tissues as a prognostic marker for cancer and other pathophysiologies
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
US9216414B2 (en) 2009-11-25 2015-12-22 Gen9, Inc. Microfluidic devices and methods for gene synthesis
CN102103112B (zh) * 2009-12-16 2013-05-01 中国科学院电子学研究所 一种识别残留农药的光寻址分子印迹阵列传感器
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
US9927434B2 (en) 2010-01-20 2018-03-27 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
CA3132011A1 (en) 2010-11-12 2012-06-14 Gen9, Inc. Methods and devices for nucleic acids synthesis
ES2551922T3 (es) 2011-03-07 2015-11-24 Accelerate Diagnostics, Inc. Sistemas rápidos de purificación celular
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
CN103797108B (zh) 2011-08-05 2015-12-09 株式会社东芝 多核酸扩增反应用具
EP2562536B1 (de) * 2011-08-22 2018-08-01 Nxp B.V. Analytbestimmungsverfahren und Analytbestimmungsgerät
JP2014526899A (ja) 2011-08-26 2014-10-09 ジェン9・インコーポレイテッド 核酸の高忠実度アセンブリのための組成物および方法
US10150993B2 (en) * 2011-12-22 2018-12-11 Ibis Biosciences, Inc. Macromolecule positioning by electrical potential
CA3191015A1 (en) 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US20150087628A1 (en) 2012-04-10 2015-03-26 The Regents Of The University Of California Compositions and methods for treating cancer
US10081807B2 (en) 2012-04-24 2018-09-25 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
WO2014004393A1 (en) 2012-06-25 2014-01-03 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
JP5981667B2 (ja) 2013-02-15 2016-08-31 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー 増幅された電気化学発光検出のための方法および組成物
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Kras g12c之抑制劑
CA3171807A1 (en) 2013-12-19 2015-06-25 Illumina, Inc. Substrates comprising nano-patterning surfaces and methods of preparing thereof
US10537889B2 (en) 2013-12-31 2020-01-21 Illumina, Inc. Addressable flow cell using patterned electrodes
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
AR102094A1 (es) 2014-09-25 2017-02-01 Araxes Pharma Llc Inhibidores de proteínas kras con una mutación g12c
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
ES2898765T3 (es) 2015-04-10 2022-03-08 Araxes Pharma Llc Compuestos de quinazolina sustituidos y métodos de uso de los mismos
EP3283462B1 (de) 2015-04-15 2020-12-02 Araxes Pharma LLC Kondensierte tricyclische inhibitoren von kras und anwendungsverfahren dafür
EP3112841A1 (de) 2015-06-30 2017-01-04 Gnothis Holding SA Einzelmolekülanalyse in einem elektrischen feld
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
US10882847B2 (en) 2015-09-28 2021-01-05 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10875842B2 (en) 2015-09-28 2020-12-29 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058902A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058915A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058768A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058805A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
JP2018533939A (ja) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Rasの阻害剤をスクリーニングするための方法
EA038635B9 (ru) 2015-11-16 2021-10-26 Араксис Фарма Ллк 2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
WO2017172979A1 (en) 2016-03-30 2017-10-05 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
US11513076B2 (en) 2016-06-15 2022-11-29 Ludwig-Maximilians-Universität München Single molecule detection or quantification using DNA nanotechnology
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CN110036010A (zh) 2016-09-29 2019-07-19 亚瑞克西斯制药公司 Kras g12c突变蛋白的抑制剂
EP3523289A1 (de) 2016-10-07 2019-08-14 Araxes Pharma LLC Heterocyclische verbindungen als ras-inhibitoren und verfahren zur verwendung davon
BR112019012263A2 (pt) 2016-12-15 2020-01-28 Univ California composições e métodos para tratar câncer
CN110352234A (zh) 2016-12-29 2019-10-18 Ador诊断有限公司 用于电泳应用的电泳芯片
EP3573970A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(6-(3-hydroxynaphthalin-1-yl)chinazolin-2-yl)azetidin-1-yl)prop-2-en-1-on-derivate und ähnliche verbindungen wie kras g12c-inhibitoren zur behandlung von krebs
EP3573971A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-on-derivate und ähnliche verbindungen als kras-g12c-modulatoren zur behandlung von krebs
US11358959B2 (en) 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
EP3573954A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC Fusionierte bicyclische benzoheteroaromatische verbindungen und verfahren zur verwendung davon
WO2018140600A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused hetero-hetero bicyclic compounds and methods of use thereof
CN110582569B (zh) 2017-03-03 2024-04-02 安捷伦科技有限公司 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统
TW201900633A (zh) 2017-05-25 2019-01-01 美商亞瑞克西斯製藥公司 Kras之共價抑制劑
WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
EP3630746A1 (de) 2017-05-25 2020-04-08 Araxes Pharma LLC Verbindungen und verwendungsverfahren dafür zur behandlung von krebs
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
US11584956B2 (en) * 2018-12-21 2023-02-21 Microsoft Technology Licensing, Llc Selectively controllable cleavable linkers
US10520437B1 (en) 2019-05-24 2019-12-31 Raytheon Company High sensitivity sensor utilizing ultra-fast laser pulse excitation and time delayed detector
US11773422B2 (en) 2019-08-16 2023-10-03 Microsoft Technology Licensing, Llc Regulation of polymerase using cofactor oxidation states
US11896945B2 (en) 2019-10-09 2024-02-13 Microsoft Technology Licensing, Llc High surface area coatings for solid-phase synthesis
US11873484B2 (en) * 2019-11-27 2024-01-16 Microsoft Technology Licensing, Llc Oligonucleotide assembly using electrically controlled hybridization
CN112625890B (zh) * 2020-12-23 2021-08-31 广州和实生物技术有限公司 一种核酸poct检测装置及其检测方法
EP4298246A1 (de) 2021-02-26 2024-01-03 Avery Digital Data, Inc. Halbleiterchipanordnungen und verfahren zur polynukleotidsynthese

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5036087A (de) * 1973-07-13 1975-04-04
US3995190A (en) * 1974-09-19 1976-11-30 Butler, Binion, Rice, Cook & Knapp Mobile ion film memory
US4283773A (en) 1977-08-30 1981-08-11 Xerox Corporation Programmable master controller communicating with plural controllers
US4225410A (en) 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
US4580895A (en) * 1983-10-28 1986-04-08 Dynatech Laboratories, Incorporated Sample-scanning photometer
DK557884A (da) 1983-11-25 1985-05-26 Mars Inc Automatisk testudstyr
US4661451A (en) 1984-02-06 1987-04-28 Ortho Diagnostic Systems, Inc. Methods for immobilizing and translocating biological cells
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4828979A (en) 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4584075A (en) * 1984-11-26 1986-04-22 Ionics Incorporated Process and apparatus for electrically desorbing components selectively sorbed on an electrolytically conducting barrier
GB8432118D0 (en) * 1984-12-19 1985-01-30 Malcolm A D B Sandwich hybridisation technique
US4594135A (en) * 1985-02-20 1986-06-10 Ionics Incorporated Process and apparatus for electrically desorbing components selectively sorbed on granules
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US4751177A (en) * 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US4816418A (en) * 1985-07-22 1989-03-28 Sequoia-Turner Corporation Method and apparatus for performing automated, multi-sequential immunoassays
EP0213825A3 (de) * 1985-08-22 1989-04-26 Molecular Devices Corporation Chemisch-modulierte Mehrfachkapazitanz
US4822566A (en) * 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
EP0228075B1 (en) * 1986-01-03 1991-04-03 Molecular Diagnostics, Inc. Eucaryotic genomic dna dot-blot hybridization method
US5242797A (en) 1986-03-21 1993-09-07 Myron J. Block Nucleic acid assay method
US5125748A (en) * 1986-03-26 1992-06-30 Beckman Instruments, Inc. Optical detection module for use in an automated laboratory work station
DE3750503T2 (de) 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
YU57087A (en) * 1987-04-01 1990-08-31 Centar Za Genticko Inzenjerstv Process for obtaining genome by hebridization and oligonucleotidic tests
US5114674A (en) 1987-05-01 1992-05-19 Biotronic Systems Corporation Added array of molecular chains for interfering with electrical fields
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US5074977A (en) 1987-05-05 1991-12-24 The Washington Technology Center Digital biosensors and method of using same
US4936963A (en) 1987-05-27 1990-06-26 Abbott Laboratories Polycationic buffers and method for gel electrophoresis of nucleic acids
US5766960A (en) 1987-07-27 1998-06-16 Australian Membrane And Biotechnology Research Institute Receptor membranes
DE3852036T2 (de) * 1987-07-27 1995-03-09 Commw Scient Ind Res Org Rezeptormembranen.
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5075077A (en) * 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
WO1990001564A1 (en) * 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
AU633839B2 (en) * 1988-08-18 1993-02-11 Ambri Limited Improvements in sensitivity and selectivity of ion channel membrane biosensors
WO1990002327A1 (en) * 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
US5096669A (en) 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5219726A (en) * 1989-06-02 1993-06-15 The Salk Institute For Biological Studies Physical mapping of complex genomes
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6984487B1 (en) 1989-08-22 2006-01-10 Hsc Research Development Corporation Cystic fibrosis gene
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5750015A (en) * 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
WO1991015758A1 (en) 1990-04-11 1991-10-17 Ludwig Institute For Cancer Research Methods and apparatus allowing sequential chemical reactions
US5064519A (en) 1990-06-29 1991-11-12 E. I. Du Pont De Nemours And Company Neutral and positively charged dyes for electrophoresis sample loading solutions
US5166063A (en) * 1990-06-29 1992-11-24 Eli Lilly And Company Immobolization of biomolecules by enhanced electrophoretic precipitation
US5527670A (en) 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
WO1992004470A1 (en) * 1990-09-12 1992-03-19 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
GB2247889A (en) 1990-09-12 1992-03-18 Scient Generics Ltd DNA denaturation by an electric potential
US5227265A (en) * 1990-11-30 1993-07-13 Eastman Kodak Company Migration imaging system
US5110434A (en) 1990-12-20 1992-05-05 Bio-Rad Laboratories, Inc. Use of zwitterions to mobilize isoelectrically focused ampholyte zones
WO1992019960A1 (en) 1991-05-09 1992-11-12 Nanophore, Inc. Methods for the electrophoretic separation of nucleic acids and other linear macromolecules in gel media with restrictive pore diameters
DE69225227T2 (de) * 1991-06-27 1998-10-29 Genelabs Tech Inc Screeningtest für den nachweis von dna-bindenden molekülen
US5726014A (en) * 1991-06-27 1998-03-10 Genelabs Technologies, Inc. Screening assay for the detection of DNA-binding molecules
DE69233391D1 (de) 1991-11-07 2004-09-02 Nanotronics Inc Hybridisierung von mit Chromophoren und Fluorophoren konjugierten Polynukleotiden zur Erzeugung eines Donor-Donor Energietransfersystems
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
JPH05236997A (ja) * 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
WO1993022457A1 (en) * 1992-04-24 1993-11-11 Massachusetts Institute Of Technology Screening for genetic variation
US5667667A (en) 1992-04-24 1997-09-16 Isis Innovation Limited Electrochemical treatment of surfaces
GB9208921D0 (en) * 1992-04-24 1992-06-10 Isis Innovation Electrochemical treatment of surfaces
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5747265A (en) * 1992-10-30 1998-05-05 T Cell Diagnostics, Inc. Method for measuring the amount of a cell-associated molecule
FR2703359B1 (fr) 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
US5433819A (en) 1993-05-26 1995-07-18 Pressac, Inc. Method of making circuit boards
US5789167A (en) * 1993-09-10 1998-08-04 Genevue, Inc. Optical detection of position of oligonucleotides on large DNA molecules
US7101661B1 (en) 1993-11-01 2006-09-05 Nanogen, Inc. Apparatus for active programmable matrix devices
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US5445525A (en) 1994-05-12 1995-08-29 Intel Corporation Interconnection scheme for integrated circuit card with auxiliary contacts
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5464517A (en) 1995-01-30 1995-11-07 Bio-Rad Laboratories Electrophoresis in low conductivity buffers
US5660701A (en) 1996-02-29 1997-08-26 Bio-Rad Laboratories, Inc. Protein separations by capillary electrophoresis using amino acid-containing buffers
ZA975891B (en) 1996-07-05 1998-07-23 Combimatrix Corp Electrochemical solid phase synthesis of polymers
US6780584B1 (en) 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics

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AU2966195A (en) 1996-02-09
JPH09503307A (ja) 1997-03-31
WO1996001836A1 (en) 1996-01-25
CA2169852A1 (en) 1996-01-25
CN1135220A (zh) 1996-11-06
FI961034A0 (fi) 1996-03-06
CN1151374C (zh) 2004-05-26
NZ289731A (en) 1998-09-24
US20100173792A1 (en) 2010-07-08
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US7947486B2 (en) 2011-05-24
JP2007020568A (ja) 2007-02-01
EP0717749B1 (de) 2003-02-12
FI961034A (fi) 1996-05-02
EP0717749A4 (de) 1998-07-01
ATE232604T1 (de) 2003-02-15
CN1550556A (zh) 2004-12-01
AU708677B2 (en) 1999-08-12
EP0717749A1 (de) 1996-06-26
US6238624B1 (en) 2001-05-29
CA2169852C (en) 2008-09-23
BR9506035A (pt) 1997-10-14
US6017696A (en) 2000-01-25

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