DE69514497D1 - Modafinilpartikel mit definierter Korngrössenverteilung - Google Patents

Modafinilpartikel mit definierter Korngrössenverteilung

Info

Publication number
DE69514497D1
DE69514497D1 DE69514497T DE69514497T DE69514497D1 DE 69514497 D1 DE69514497 D1 DE 69514497D1 DE 69514497 T DE69514497 T DE 69514497T DE 69514497 T DE69514497 T DE 69514497T DE 69514497 D1 DE69514497 D1 DE 69514497D1
Authority
DE
Germany
Prior art keywords
size distribution
grain size
defined grain
modafinil particles
modafinil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69514497T
Other languages
English (en)
Other versions
DE69514497T2 (de
Inventor
E Grebow
Vincent Corvari
David Stong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23240954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69514497(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cephalon LLC filed Critical Cephalon LLC
Publication of DE69514497D1 publication Critical patent/DE69514497D1/de
Application granted granted Critical
Publication of DE69514497T2 publication Critical patent/DE69514497T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Paints Or Removers (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Laminated Bodies (AREA)
  • Slot Machines And Peripheral Devices (AREA)
  • Packaging For Recording Disks (AREA)
DE69514497T 1994-10-06 1995-10-04 Modafinilpartikel mit definierter Korngrössenverteilung Expired - Lifetime DE69514497T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/319,124 US5618845A (en) 1994-10-06 1994-10-06 Acetamide derivative having defined particle size
PCT/US1995/012944 WO1996011001A1 (en) 1994-10-06 1995-10-04 Modafinil having defined particle size

Publications (2)

Publication Number Publication Date
DE69514497D1 true DE69514497D1 (de) 2000-02-17
DE69514497T2 DE69514497T2 (de) 2000-08-10

Family

ID=23240954

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69520161T Expired - Lifetime DE69520161T2 (de) 1994-10-06 1995-10-04 Modafinilpartikel mit definierter Korngrössenverteilung
DE69514497T Expired - Lifetime DE69514497T2 (de) 1994-10-06 1995-10-04 Modafinilpartikel mit definierter Korngrössenverteilung
DE69535786T Expired - Lifetime DE69535786D1 (de) 1994-10-06 1995-10-04 Modafinil mit definierter Korngrössenverteilung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69520161T Expired - Lifetime DE69520161T2 (de) 1994-10-06 1995-10-04 Modafinilpartikel mit definierter Korngrössenverteilung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69535786T Expired - Lifetime DE69535786D1 (de) 1994-10-06 1995-10-04 Modafinil mit definierter Korngrössenverteilung

Country Status (34)

Country Link
US (2) US5618845A (de)
EP (3) EP0731698B1 (de)
JP (1) JP2915146B2 (de)
KR (1) KR100249360B1 (de)
AT (3) ATE400260T1 (de)
AU (1) AU703087B2 (de)
BG (1) BG62952B1 (de)
BR (1) BR9509257A (de)
CA (2) CA2201967C (de)
CZ (1) CZ291700B6 (de)
DE (3) DE69520161T2 (de)
DK (3) DK0966962T3 (de)
EE (1) EE9700082A (de)
ES (3) ES2142499T3 (de)
FI (1) FI121454B (de)
GB (1) GB2293103B (de)
GR (2) GR3033152T3 (de)
HK (3) HK1003561A1 (de)
HU (1) HU226411B1 (de)
IS (1) IS1987B (de)
LT (1) LT4303B (de)
LV (1) LV11852B (de)
MD (1) MD970143A (de)
MX (1) MX9602176A (de)
NO (1) NO318818B1 (de)
NZ (1) NZ295869A (de)
PL (1) PL181523B1 (de)
PT (3) PT731698E (de)
RO (1) RO118928B1 (de)
RU (1) RU2287987C2 (de)
SI (1) SI9520106B (de)
SK (1) SK283632B6 (de)
UA (1) UA42023C2 (de)
WO (1) WO1996011001A1 (de)

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US6821975B1 (en) 1999-08-03 2004-11-23 Lilly Icos Llc Beta-carboline drug products
UA71629C2 (en) * 1999-08-03 2004-12-15 Lilli Icos Llc Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction
US6346548B1 (en) 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation
FR2804322B1 (fr) * 2000-01-31 2002-04-19 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies
US20010034373A1 (en) * 2000-02-09 2001-10-25 Matthew Miller Low dose modafinil for enhancement of cognitive function
US6492396B2 (en) 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
CZ2003529A3 (cs) * 2000-07-27 2003-09-17 Teva Pharmaceutical Industries Ltd. Krystalický a čistý modafinil a postup jeho přípravy
US6489363B2 (en) * 2000-10-11 2002-12-03 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
CA2425338C (en) * 2000-10-11 2010-04-20 Cephalon, Inc. Compositions comprising modafinil compounds
US6919378B2 (en) * 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
CZ306618B6 (cs) * 2000-10-11 2017-04-05 Cephalon, Inc. Kompozice obsahující sloučeniny modafinylu
US7704975B2 (en) * 2000-12-19 2010-04-27 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US7141555B2 (en) 2000-12-19 2006-11-28 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US20080058424A1 (en) * 2002-05-23 2008-03-06 Cephalon, Inc. Novel pharmaceutical formulations of modafinil
KR100911779B1 (ko) * 2001-05-25 2009-08-12 세파론, 인코포레이티드 모다피닐을 포함하는 고형 제약 제제
US7576133B2 (en) 2002-03-11 2009-08-18 Carl Henry Lawyer Methods and compositions for nasal administration of modafinil
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
MY137846A (en) 2002-07-08 2009-03-31 Ranbaxy Lab Ltd Processes for the preparation of oral dosage formulations of modafinil
US20040048931A1 (en) * 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US20080044468A1 (en) * 2002-07-25 2008-02-21 Romi Barat Singh Processes For The Preparation Of Oral Dosage Formulations Of Modafinil
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
CA2420180A1 (en) * 2003-02-28 2004-08-28 Bernard Charles Sherman Tablets comprising modafinil
DK1610796T3 (da) * 2003-03-17 2014-07-21 Neurohealing Pharmaceuticals Inc Højpotent dopaminerg behandling af neurologisk svækkelse, som er forbundet med hjerneskade
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
ES2330321T3 (es) * 2003-05-16 2009-12-09 Cephalon France Procedimiento de sintesis de modafinilo.
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US20050137264A1 (en) * 2003-12-22 2005-06-23 Patel Ashish A. Modafinil compositions
EP2292213A1 (de) 2004-02-06 2011-03-09 Cephalon, Inc. Armodafinil Polymorph enthaltende Zusammensetzungen
US20060024370A1 (en) * 2004-07-29 2006-02-02 Cephalon France Modafinil oral lyophilizate
GT200600008A (es) * 2005-01-18 2006-08-09 Formulacion de compresion directa y proceso
EP1909573A4 (de) * 2005-07-21 2010-09-22 Neurohealing Pharmaceuticals I Kurzfristig wirksame modafinilzusammensetzungen mit rascher anfangswirkung, und verfahren zu ihrer verwendung
EP1951197A4 (de) * 2005-11-10 2011-12-21 Alphapharm Pty Ltd Verfahren zur kontrolle der teilchengrösse
US20080317843A1 (en) * 2006-07-12 2008-12-25 Elan Corporation Plc Nanoparticulate formulations of modafinil
US7884135B2 (en) * 2006-08-14 2011-02-08 Neurohealing Pharmaceuticals, Inc. Modafinil-based treatment for premature ejaculation
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
EP2476418A1 (de) 2006-12-21 2012-07-18 Alphapharm Pty Ltd. Pharmaceutischer Wirkstoff und Zusammensetzung für die Verwendung in der Behandlung vonTyp II Diabetes enthaltend Rosiglitazon in einer bestimmten Partikelgrösse
US8173169B2 (en) * 2007-07-11 2012-05-08 Hikma Pharmaceuticals Formulation and process for the preparation of modafinil
US20090325999A1 (en) * 2008-06-27 2009-12-31 Jie Du Personalized pharmaceutical kits, packaging and compositions for the treatment of allergic conditions
US20110206770A1 (en) * 2008-07-25 2011-08-25 Alphapharm Pty. Ltd. Atovaquone with a particle size diameter range (d90) of greater than 3 microns to about 10 microns
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
EP2238973A1 (de) 2009-04-07 2010-10-13 Cephalon France Lyophilisierte Präparate von Proteasominhibitoren
FR2987265B1 (fr) * 2012-02-28 2014-02-28 Debregeas Et Associes Pharma Composition pharmaceutique sous forme de sirop a base de modafinil, son procede de fabrication et son application
FR2987267B1 (fr) * 2012-02-28 2015-01-16 Debregeas Et Associes Pharma Application du modafinil dans le traitement de substitution des cacainomanes
FR2987266B1 (fr) * 2012-02-28 2014-12-19 Debregeas Et Associes Pharma Procede d'obtention d'une composition pharmaceutique a base de modafinil, composition pharmaceutique ainsi obtenue et son application
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith

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Also Published As

Publication number Publication date
PT1088549E (pt) 2008-09-23
USRE37516E1 (en) 2002-01-15
PT966962E (pt) 2001-06-29
PL319480A1 (en) 1997-08-04
DE69535786D1 (de) 2008-08-21
LV11852B (en) 1998-03-20
FI971417A (fi) 1997-04-04
HK1034676A1 (en) 2001-11-02
EP0731698A1 (de) 1996-09-18
PT731698E (pt) 2000-05-31
NZ295869A (en) 1998-02-26
HUT77778A (hu) 1998-08-28
DK1088549T3 (da) 2008-11-17
CA2201967A1 (en) 1996-04-18
DK0966962T3 (da) 2001-03-19
PL181523B1 (en) 2001-08-31
EP0966962B1 (de) 2001-02-21
EP0966962A1 (de) 1999-12-29
CZ103297A3 (en) 1997-09-17
LT97060A (en) 1997-10-27
GR3033152T3 (en) 2000-08-31
ES2308960T3 (es) 2008-12-16
HK1003561A1 (en) 1998-10-30
ATE188607T1 (de) 2000-01-15
IS1987B (is) 2005-02-15
GR3035451T3 (en) 2001-05-31
LV11852A (lv) 1997-10-20
EE9700082A (et) 1997-10-15
NO971541L (no) 1997-06-04
GB2293103B (en) 1997-05-07
WO1996011001A1 (en) 1996-04-18
RO118928B1 (ro) 2004-01-30
ATE199216T1 (de) 2001-03-15
UA42023C2 (uk) 2001-10-15
GB9524328D0 (en) 1996-01-31
CA2382275A1 (en) 1996-04-18
ATE400260T1 (de) 2008-07-15
ES2156457T3 (es) 2001-06-16
GB2293103A (en) 1996-03-20
EP0731698B1 (de) 2000-01-12
BG101389A (en) 1997-12-30
US5618845A (en) 1997-04-08
IS4451A (is) 1997-03-24
BG62952B1 (bg) 2000-12-29
FI121454B (fi) 2010-11-30
DE69520161T2 (de) 2001-08-02
HU226411B1 (en) 2008-11-28
EP1088549A1 (de) 2001-04-04
NO318818B1 (no) 2005-05-09
HK1024625A1 (en) 2000-10-20
AU3951495A (en) 1996-05-02
BR9509257A (pt) 1998-07-07
RU2287987C2 (ru) 2006-11-27
LT4303B (lt) 1998-03-25
DE69514497T2 (de) 2000-08-10
EP1088549B1 (de) 2008-07-09
SK283632B6 (sk) 2003-11-04
FI971417A0 (fi) 1997-04-04
JPH09511754A (ja) 1997-11-25
SK44597A3 (en) 1997-09-10
MX9602176A (es) 1997-05-31
NO971541D0 (no) 1997-04-04
DE69520161D1 (de) 2001-03-29
JP2915146B2 (ja) 1999-07-05
ES2142499T3 (es) 2000-04-16
SI9520106A (sl) 1998-02-28
SI9520106B (sl) 2003-12-31
AU703087B2 (en) 1999-03-18
DK0731698T3 (da) 2000-05-08
CA2201967C (en) 2002-12-10
CA2382275C (en) 2003-12-16
KR100249360B1 (ko) 2000-04-01
CZ291700B6 (cs) 2003-05-14
MD970143A (ro) 1998-12-31

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