DE69433692D1 - Verfahren zur herstellung von poly-beta-1-4-n-acetylglukosamin - Google Patents

Verfahren zur herstellung von poly-beta-1-4-n-acetylglukosamin

Info

Publication number
DE69433692D1
DE69433692D1 DE69433692T DE69433692T DE69433692D1 DE 69433692 D1 DE69433692 D1 DE 69433692D1 DE 69433692 T DE69433692 T DE 69433692T DE 69433692 T DE69433692 T DE 69433692T DE 69433692 D1 DE69433692 D1 DE 69433692D1
Authority
DE
Germany
Prior art keywords
glcnac
beta
relates
present
acetylglucosamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69433692T
Other languages
English (en)
Other versions
DE69433692T2 (de
Inventor
N Vournakis
Sergio Finkielsztein
R Pariser
Mike Helton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marine Polymer Technologies Inc
Original Assignee
Marine Polymer Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marine Polymer Technologies Inc filed Critical Marine Polymer Technologies Inc
Publication of DE69433692D1 publication Critical patent/DE69433692D1/de
Application granted granted Critical
Publication of DE69433692T2 publication Critical patent/DE69433692T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C12N1/125—Unicellular algae isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/89—Algae ; Processes using algae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
DE69433692T 1993-12-01 1994-12-01 Verfahren zur herstellung von poly-beta-1-4-n-acetylglukosamin Expired - Lifetime DE69433692T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/160,569 US5622834A (en) 1993-12-01 1993-12-01 Method of isolating poly-β-1-4-N-acetylglucosamine from microalgal culture
US160569 1993-12-01
PCT/US1994/013706 WO1995015343A1 (en) 1993-12-01 1994-12-01 POLY-β-1→4-N-ACETYLGLUCOSAMINE

Publications (2)

Publication Number Publication Date
DE69433692D1 true DE69433692D1 (de) 2004-05-13
DE69433692T2 DE69433692T2 (de) 2005-03-10

Family

ID=22577431

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69433692T Expired - Lifetime DE69433692T2 (de) 1993-12-01 1994-12-01 Verfahren zur herstellung von poly-beta-1-4-n-acetylglukosamin

Country Status (15)

Country Link
US (2) US5622834A (de)
EP (2) EP0731812B1 (de)
JP (3) JP3993633B2 (de)
CN (1) CN1142833B (de)
AT (1) ATE263785T1 (de)
AU (1) AU695850B2 (de)
CA (1) CA2177823C (de)
DE (1) DE69433692T2 (de)
DK (1) DK0731812T3 (de)
ES (1) ES2219659T3 (de)
IL (1) IL111825A0 (de)
NZ (1) NZ277662A (de)
PT (1) PT731812E (de)
TW (1) TW458987B (de)
WO (1) WO1995015343A1 (de)

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US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
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WO2004076637A2 (en) 2003-02-24 2004-09-10 Marine Polymer Technologies, Inc. Cell-polymer fiber compositions and use thereof
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EP3000487B8 (de) 2007-02-19 2022-06-15 Marine Polymer Technologies, Inc. Blutstillende zusammensetzungen und therapieansätze
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
ES2466916T3 (es) 2007-06-27 2014-06-11 Admune Therapeutics Llc Complejos de IL-15 e IL-15R alfa y usos de los mismos
US8486033B2 (en) * 2007-07-18 2013-07-16 Marine Polymer Technologies, Inc. Application of polymeric materials to screens to facilitate hemostasis and wound healing
CA2688196C (en) * 2007-07-18 2014-01-07 Marine Polymer Technologies, Inc. Application of polymeric materials to screens to facilitate hemostasis and wound healing
EP2310002B1 (de) * 2008-04-24 2016-11-02 Medtronic, Inc Schutzgel auf basis von chitosan und oxidiertem polysaccharid
CN102159220A (zh) * 2008-04-24 2011-08-17 麦德托尼克公司 硫醇化的壳聚糖凝胶
JP2011518837A (ja) 2008-04-24 2011-06-30 メドトロニック，インコーポレイテッド 再水和可能なチオール化多糖粒子およびスポンジ
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JP6532452B2 (ja) * 2013-03-14 2019-06-19 マリン ポリマー テクノロジーズ，インコーポレーテッド ポリ−ｎ−アセチルグルコサミンナノファイバーを有する疾患の処置
CN104056298B (zh) * 2013-03-18 2017-04-26 李锋 无规共聚物的伤口应用
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Also Published As

Publication number Publication date
JP2009079223A (ja) 2009-04-16
JPH09506126A (ja) 1997-06-17
DE69433692T2 (de) 2005-03-10
JP3993633B2 (ja) 2007-10-17
AU695850B2 (en) 1998-08-27
ATE263785T1 (de) 2004-04-15
IL111825A0 (en) 1995-01-24
EP0731812A4 (de) 1997-06-18
CA2177823C (en) 2002-04-30
CN1142833A (zh) 1997-02-12
JP2004211101A (ja) 2004-07-29
TW458987B (en) 2001-10-11
ES2219659T3 (es) 2004-12-01
PT731812E (pt) 2004-08-31
EP0731812B1 (de) 2004-04-07
EP1452546A3 (de) 2004-10-13
EP1452546A2 (de) 2004-09-01
CN1142833B (zh) 2010-06-02
EP0731812A1 (de) 1996-09-18
DK0731812T3 (da) 2004-08-02
US5622834A (en) 1997-04-22
US5623064A (en) 1997-04-22
AU1296995A (en) 1995-06-19
CA2177823A1 (en) 1995-06-08
WO1995015343A1 (en) 1995-06-08
NZ277662A (en) 1998-04-27

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