DE69430919T2 - Eine phosphoenolpyruvat-carboxylasevariante, ihr gen und verfahren zur herstellung von aminosäuren - Google Patents
Eine phosphoenolpyruvat-carboxylasevariante, ihr gen und verfahren zur herstellung von aminosäurenInfo
- Publication number
- DE69430919T2 DE69430919T2 DE69430919T DE69430919T DE69430919T2 DE 69430919 T2 DE69430919 T2 DE 69430919T2 DE 69430919 T DE69430919 T DE 69430919T DE 69430919 T DE69430919 T DE 69430919T DE 69430919 T2 DE69430919 T2 DE 69430919T2
- Authority
- DE
- Germany
- Prior art keywords
- gene
- phosphoenolpyruvate carboxylase
- version
- production
- carboxylase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/20—Aspartic acid; Asparagine
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20977693 | 1993-08-24 | ||
JP20977593 | 1993-08-24 | ||
JP15387694 | 1994-07-05 | ||
PCT/JP1994/001365 WO1995006114A1 (fr) | 1993-08-24 | 1994-08-17 | Allele de phosphenolpyruvate carboxylase, gene de cet allele et procede de production de l'acide amine |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430919D1 DE69430919D1 (de) | 2002-08-08 |
DE69430919T2 true DE69430919T2 (de) | 2003-02-27 |
Family
ID=27320552
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430919T Expired - Lifetime DE69430919T2 (de) | 1993-08-24 | 1994-08-17 | Eine phosphoenolpyruvat-carboxylasevariante, ihr gen und verfahren zur herstellung von aminosäuren |
Country Status (15)
Country | Link |
---|---|
US (2) | US5876983A (de) |
EP (1) | EP0723011B1 (de) |
KR (2) | KR100337959B1 (de) |
CN (1) | CN1179043C (de) |
AT (1) | ATE220099T1 (de) |
AU (1) | AU682547B2 (de) |
BR (1) | BR9407625A (de) |
CA (1) | CA2169170C (de) |
CZ (1) | CZ289051B6 (de) |
DE (1) | DE69430919T2 (de) |
HU (1) | HU219600B (de) |
MY (1) | MY112250A (de) |
PL (1) | PL181380B1 (de) |
SK (1) | SK283369B6 (de) |
WO (1) | WO1995006114A1 (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6969782B2 (en) | 1993-10-06 | 2005-11-29 | Ajinomoto Co., Inc. | Method of producing transgenic plants having improved amino acid composition |
JPH09285294A (ja) * | 1996-04-23 | 1997-11-04 | Ajinomoto Co Inc | 発酵法によるl−グルタミン酸の製造法 |
EP1584679B1 (de) * | 1997-07-18 | 2008-12-10 | Ajinomoto Co., Inc. | Verfahren zur Produktion von Purinnukleosiden durch Fermentation |
WO1999018228A2 (de) | 1997-10-04 | 1999-04-15 | Forschungszentrum Jülich GmbH | Verfahren zur mikrobiellen herstellung von aminosäuren der aspartat- und/oder glutamatfamilie und im verfahren einsetzbare mittel |
AU756507B2 (en) * | 1998-03-18 | 2003-01-16 | Ajinomoto Co., Inc. | L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
ATE458040T1 (de) * | 1998-04-13 | 2010-03-15 | Univ Georgia | Pyruvate carboxylase überexpression zur verstärkten produktion von oxalacetat abgeleiteten verbindungen in mikrobiellen zellen |
US20030087381A1 (en) * | 1998-04-13 | 2003-05-08 | University Of Georgia Research Foundation, Inc. | Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals |
WO2000039305A1 (en) * | 1998-12-23 | 2000-07-06 | Massachusetts Institute Of Technology | PYRUVATE CARBOXYLASE FROM $i(CORYNEBACTERIUM GLUTAMICUM) |
US6171833B1 (en) | 1998-12-23 | 2001-01-09 | Massachusetts Institute Of Technology | Pyruvate carboxylase from corynebacterium glutamicum |
US6599732B1 (en) | 1999-06-29 | 2003-07-29 | Archer-Daniels-Midland Company | Regulation of carbon assimilation |
KR20020015708A (ko) * | 1999-06-29 | 2002-02-28 | 추후제출 | 탄소 동화의 조절 |
DE60027161D1 (de) | 1999-07-02 | 2006-05-18 | Ajinomoto Kk | Für das saccharose-pts-enzym ii kodierende dna |
DE19931314A1 (de) * | 1999-07-07 | 2001-01-11 | Degussa | L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin |
WO2001027258A2 (en) * | 1999-10-13 | 2001-04-19 | The University Of Georgia Research Foundation, Inc. | High yield protein expression system and methods |
US6727411B2 (en) | 1999-12-13 | 2004-04-27 | Ajinomoto Co., Inc. | Method of producing transgenic plants having improved amino acid composition |
CN1230525C (zh) * | 1999-12-24 | 2005-12-07 | 味之素株式会社 | 生产l-氨基酸的方法和新型基因 |
US6927046B1 (en) * | 1999-12-30 | 2005-08-09 | Archer-Daniels-Midland Company | Increased lysine production by gene amplification using coryneform bacteria |
ES2313878T3 (es) | 2000-01-21 | 2009-03-16 | Ajinomoto Co., Inc. | Procedimiento para la produccion de l-lisina. |
KR100397423B1 (ko) * | 2001-02-13 | 2003-09-13 | 씨제이 주식회사 | L-쓰레오닌의 제조방법 |
US7368266B2 (en) | 2001-02-13 | 2008-05-06 | Cj Corporation | Method for L-threonine production |
US20030115638A1 (en) * | 2001-08-17 | 2003-06-19 | Ajinomoto Co., Inc. | Plants having increased amino acids content and methods for producing the same |
AU2003205041A1 (en) * | 2002-07-12 | 2004-01-29 | Ajinomoto Co., Inc. | Method for producing target substance by fermentation |
BR0304860A (pt) * | 2002-11-11 | 2004-08-31 | Ajinomoto Kk | Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia |
KR100498971B1 (ko) * | 2003-04-04 | 2005-07-04 | 씨제이 주식회사 | 염색체 내 tdcBC 및 pckA 유전자가 불활성화된 미생물 및 이를 이용하여 L-쓰레오닌을 제조하는 방법 |
JP2007532114A (ja) * | 2004-04-09 | 2007-11-15 | ジェネンコー・インターナショナル・インク | バチルスにおけるpckA修飾および増強されたタンパク質発現 |
KR100768748B1 (ko) | 2004-12-30 | 2007-10-19 | 씨제이 주식회사 | 외래의 nadp 의존적 글리세르알데히드-3-포스페이트디히드로게나제 유전자를 포함하는 에세리키아 종 또는코리네박리움 종 미생물 및 그를 이용하여 l-라이신을생산하는 방법 |
WO2007017710A1 (en) | 2005-08-11 | 2007-02-15 | Metabolic Explorer | Process for the preparation of aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, homoserine, or valine employing a microorganism with enhanced isocitrate lyase and/or malate synthase expression |
WO2007086618A1 (en) | 2006-01-30 | 2007-08-02 | Ajinomoto Co., Inc. | L-amino acid producing bacterium and method of producing l-amino acid |
JP2009118740A (ja) | 2006-03-03 | 2009-06-04 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2010017082A (ja) | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2010041920A (ja) | 2006-12-19 | 2010-02-25 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2010515465A (ja) * | 2007-01-12 | 2010-05-13 | ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド,ア ボディー コーポレート | 微生物によって生成される有機化学物質の生成に対する耐性を高めるための組成物および方法 |
JP2010088301A (ja) | 2007-02-01 | 2010-04-22 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2010110216A (ja) | 2007-02-20 | 2010-05-20 | Ajinomoto Co Inc | L−アミノ酸または核酸の製造方法 |
US8883453B2 (en) * | 2007-04-30 | 2014-11-11 | University Of Maryland | Codon specific mutagenesis |
EP2192170B1 (de) | 2007-09-04 | 2017-02-15 | Ajinomoto Co., Inc. | Aminosäureproduzierender mikroorganismus und verfahren zur aminosäureproduktion |
US8048624B1 (en) | 2007-12-04 | 2011-11-01 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
JP2011067095A (ja) | 2008-01-10 | 2011-04-07 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
KR20100120663A (ko) | 2008-01-23 | 2010-11-16 | 아지노모토 가부시키가이샤 | L-아미노산의 제조법 |
JP5598329B2 (ja) | 2008-09-08 | 2014-10-01 | 味の素株式会社 | L−アミノ酸を生産する微生物及びl−アミノ酸の製造法 |
JP2012029565A (ja) | 2008-11-27 | 2012-02-16 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
CN102471790B (zh) | 2009-07-29 | 2014-10-29 | 味之素株式会社 | 产生l-氨基酸的方法 |
JP2012223091A (ja) | 2009-08-25 | 2012-11-15 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
JP2012223092A (ja) | 2009-08-28 | 2012-11-15 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
GB2473755B (en) | 2009-09-27 | 2011-09-07 | Opx Biotechnologies Inc | Method for producing 3-hydroxypropionic acid and other products |
US8809027B1 (en) | 2009-09-27 | 2014-08-19 | Opx Biotechnologies, Inc. | Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase |
JP2013013329A (ja) | 2009-11-06 | 2013-01-24 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
WO2011063363A2 (en) * | 2009-11-20 | 2011-05-26 | Opx Biotechnologies, Inc. | Production of an organic acid and/or related chemicals |
US9084467B2 (en) | 2010-02-11 | 2015-07-21 | Metabolix, Inc. | Process for gamma-butyrolactone production |
US9605285B2 (en) | 2011-01-25 | 2017-03-28 | Cargill, Incorporated | Compositions and methods for succinate production |
WO2012103263A2 (en) * | 2011-01-25 | 2012-08-02 | Finley Kenneth R | Compositions and methods for malate and fumarate production |
EP2495317A1 (de) | 2011-03-01 | 2012-09-05 | Technische Universität Hamburg-Harburg | Modifizierte Phosphoenolpyruvate-Carboxylase aus Corynebacterium glutamicum und Verwendungen derselben |
WO2012170793A1 (en) | 2011-06-08 | 2012-12-13 | Metabolix, Inc. | Biorefinery process for thf production |
WO2013023140A1 (en) | 2011-08-10 | 2013-02-14 | Metabolix, Inc. | Post process purification for gamma-butyrolactone production |
US9850507B2 (en) | 2012-07-25 | 2017-12-26 | Cargill, Incorporated | Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P)+ transhydrogenase enzyme |
CN109182238A (zh) | 2012-08-10 | 2019-01-11 | 嘉吉有限公司 | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 |
CA2905602A1 (en) | 2013-03-15 | 2014-09-18 | Sarah M. Hoyt | Flash evaporation for product purification and recovery |
WO2014146026A1 (en) | 2013-03-15 | 2014-09-18 | Opx Biotechnologies, Inc. | Bioproduction of chemicals |
CN105008532B (zh) | 2013-05-13 | 2017-07-21 | 味之素株式会社 | L‑氨基酸的制造方法 |
JP2016165225A (ja) | 2013-07-09 | 2016-09-15 | 味の素株式会社 | 有用物質の製造方法 |
WO2015010103A2 (en) | 2013-07-19 | 2015-01-22 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
JP2016192903A (ja) | 2013-09-17 | 2016-11-17 | 味の素株式会社 | 海藻由来バイオマスからのl−アミノ酸の製造方法 |
BR112016007286B1 (pt) | 2013-10-02 | 2021-07-20 | Ajinomoto Co., Inc | Métodos de controle de amônia e para produção de uma substância alvo, e, aparelho para controle de amônia |
WO2015060314A1 (ja) | 2013-10-21 | 2015-04-30 | 味の素株式会社 | L-アミノ酸の製造法 |
JP6519476B2 (ja) | 2013-10-23 | 2019-05-29 | 味の素株式会社 | 目的物質の製造法 |
EP2993228B1 (de) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Herstellung von fettsäureestern |
CN105132388B (zh) * | 2015-09-06 | 2018-02-23 | 江南大学 | 一种酶活性提高的丙酮酸羧化酶突变体r485p及其应用 |
CN105907730B (zh) * | 2016-05-11 | 2019-06-21 | 江南大学 | 一种酶活性提高的丙酮酸羧化酶突变体n1078f及其应用 |
CN110494566A (zh) | 2017-02-02 | 2019-11-22 | 嘉吉公司 | 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞 |
CN111094571B (zh) * | 2017-09-01 | 2023-10-27 | 国立大学法人新潟大学 | 龙涎香醇的有效制备方法 |
CN116113699A (zh) * | 2020-12-24 | 2023-05-12 | 武汉远大弘元股份有限公司 | 改造的磷酸烯醇丙酮酸羧化酶及其在提高谷氨酸棒杆菌氨基酸产量中的应用 |
CN115806962A (zh) * | 2021-09-15 | 2023-03-17 | 中国科学院天津工业生物技术研究所 | 磷酸烯醇式丙酮酸羧化酶突变体及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2223754B (en) * | 1988-09-12 | 1992-07-22 | Degussa | Dna encoding phosphoenolpyruvate carboxylase |
JPH07108228B2 (ja) * | 1990-10-15 | 1995-11-22 | 味の素株式会社 | 温度感受性プラスミド |
-
1994
- 1994-08-17 HU HU9600240A patent/HU219600B/hu not_active IP Right Cessation
- 1994-08-17 CA CA002169170A patent/CA2169170C/en not_active Expired - Fee Related
- 1994-08-17 BR BR9407625A patent/BR9407625A/pt not_active IP Right Cessation
- 1994-08-17 CZ CZ1996524A patent/CZ289051B6/cs not_active IP Right Cessation
- 1994-08-17 KR KR1019960700741A patent/KR100337959B1/ko not_active IP Right Cessation
- 1994-08-17 CN CNB941939057A patent/CN1179043C/zh not_active Expired - Fee Related
- 1994-08-17 PL PL94313119A patent/PL181380B1/pl not_active IP Right Cessation
- 1994-08-17 AT AT94924384T patent/ATE220099T1/de not_active IP Right Cessation
- 1994-08-17 WO PCT/JP1994/001365 patent/WO1995006114A1/ja active IP Right Grant
- 1994-08-17 US US08/596,366 patent/US5876983A/en not_active Expired - Lifetime
- 1994-08-17 DE DE69430919T patent/DE69430919T2/de not_active Expired - Lifetime
- 1994-08-17 AU AU80991/94A patent/AU682547B2/en not_active Ceased
- 1994-08-17 SK SK204-96A patent/SK283369B6/sk not_active IP Right Cessation
- 1994-08-17 EP EP94924384A patent/EP0723011B1/de not_active Expired - Lifetime
- 1994-08-23 MY MYPI94002202A patent/MY112250A/en unknown
-
1996
- 1996-02-14 KR KR1019960700074A patent/KR960704029A/ko not_active Application Discontinuation
-
1997
- 1997-11-10 US US08/967,104 patent/US5919694A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
HUT73690A (en) | 1996-09-30 |
PL181380B1 (pl) | 2001-07-31 |
MY112250A (en) | 2001-05-31 |
EP0723011A4 (de) | 1996-05-21 |
HU219600B (hu) | 2001-05-28 |
CN1179043C (zh) | 2004-12-08 |
WO1995006114A1 (fr) | 1995-03-02 |
SK283369B6 (sk) | 2003-06-03 |
CZ52496A3 (en) | 1996-06-12 |
CN1133615A (zh) | 1996-10-16 |
DE69430919D1 (de) | 2002-08-08 |
KR960704029A (ko) | 1996-08-31 |
KR100337959B1 (ko) | 2002-11-23 |
CA2169170C (en) | 2007-01-09 |
ATE220099T1 (de) | 2002-07-15 |
EP0723011A1 (de) | 1996-07-24 |
AU682547B2 (en) | 1997-10-09 |
AU8099194A (en) | 1995-03-21 |
CA2169170A1 (en) | 1995-03-02 |
EP0723011B1 (de) | 2002-07-03 |
US5919694A (en) | 1999-07-06 |
HU9600240D0 (en) | 1996-03-28 |
BR9407625A (pt) | 1997-01-21 |
CZ289051B6 (cs) | 2001-10-17 |
US5876983A (en) | 1999-03-02 |
PL313119A1 (en) | 1996-06-10 |
SK20496A3 (en) | 1996-11-06 |
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