DE69429928D1 - Zweiphasige zusammensetzung in kapselnform - Google Patents

Zweiphasige zusammensetzung in kapselnform

Info

Publication number
DE69429928D1
DE69429928D1 DE69429928T DE69429928T DE69429928D1 DE 69429928 D1 DE69429928 D1 DE 69429928D1 DE 69429928 T DE69429928 T DE 69429928T DE 69429928 T DE69429928 T DE 69429928T DE 69429928 D1 DE69429928 D1 DE 69429928D1
Authority
DE
Germany
Prior art keywords
capsule composition
formulations
phase capsule
fill compositions
prevented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69429928T
Other languages
English (en)
Other versions
DE69429928T2 (de
Inventor
Stephen George Barnwell
Simon Higginbottom
Ian Peter Whelan
Stephen John Burns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PII Drug Delivery LLC
Original Assignee
Provalis UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provalis UK Ltd filed Critical Provalis UK Ltd
Application granted granted Critical
Publication of DE69429928D1 publication Critical patent/DE69429928D1/de
Publication of DE69429928T2 publication Critical patent/DE69429928T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Package Specialized In Special Use (AREA)
  • Closures For Containers (AREA)
DE69429928T 1993-12-13 1994-12-12 Zweiphasige zusammensetzung in kapselnform Expired - Fee Related DE69429928T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939325445A GB9325445D0 (en) 1993-12-13 1993-12-13 Pharmaceutical formulations
PCT/GB1994/002703 WO1995016438A1 (en) 1993-12-13 1994-12-12 Biphasic capsule formulation

Publications (2)

Publication Number Publication Date
DE69429928D1 true DE69429928D1 (de) 2002-03-28
DE69429928T2 DE69429928T2 (de) 2002-11-28

Family

ID=10746512

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429928T Expired - Fee Related DE69429928T2 (de) 1993-12-13 1994-12-12 Zweiphasige zusammensetzung in kapselnform

Country Status (16)

Country Link
US (4) US6153218A (de)
EP (1) EP0734253B1 (de)
JP (1) JPH09506606A (de)
CN (1) CN1137235A (de)
AT (1) ATE213406T1 (de)
AU (1) AU702464B2 (de)
BR (1) BR9408294A (de)
DE (1) DE69429928T2 (de)
DK (1) DK0734253T3 (de)
ES (1) ES2172576T3 (de)
GB (1) GB9325445D0 (de)
NZ (1) NZ277074A (de)
PT (1) PT734253E (de)
SG (1) SG64292A1 (de)
WO (1) WO1995016438A1 (de)
ZA (1) ZA949931B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9325445D0 (en) * 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
EP0898961A1 (de) * 1997-08-27 1999-03-03 Herta-Maria Dr. Sahlender Pharmazeutische Zubereitung zur verbesserten Schmerztherapie bei akutem, postoperativem oder chronischem Schmerz
FR2781373B1 (fr) * 1998-07-07 2001-09-21 Pf Medicament Formulations thixotropes pour le remplissage de gelules
CA2391707C (en) * 1999-07-30 2010-05-11 Smithkline Beecham Plc Multi-component pharmaceutical dosage form
DE19951617A1 (de) * 1999-10-26 2001-05-03 Basf Ag Zubereitungen pharmazeutische Wirkstoffe
US7842308B2 (en) 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
GB0102342D0 (en) 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US7883721B2 (en) 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
US20040156903A1 (en) * 2002-05-22 2004-08-12 Abrams Andrew L.. Metering and packaging of controlled release medication
US7670612B2 (en) * 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
TWI336260B (en) 2002-07-25 2011-01-21 Glaxo Group Ltd Dosage form suitable for retaining drug substance
US20040162333A1 (en) * 2003-02-19 2004-08-19 Naima Mezaache Rapid absorption selective 5-HT agonist formulations
TW200526274A (en) 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
WO2005053727A2 (en) * 2003-11-29 2005-06-16 Sangstat Medical Corporation Pharmaceutical compositions for bioactive peptide agents
PE20060003A1 (es) 2004-03-12 2006-03-01 Smithkline Beecham Plc Formulacion farmaceutica polimerica para moldear por inyeccion
AU2005292243B2 (en) * 2004-10-01 2011-03-10 Telecommunication Systems, Inc. Off board navigation solution
DK1836665T3 (da) 2004-11-19 2013-04-15 Glaxosmithkline Llc Fremgangsmåde til specialtilpasset afgivelse af medikamentkombinationsprodukter med variabel dosis til individualisering af terapier
CN100350899C (zh) * 2005-05-23 2007-11-28 江西本草天工科技有限责任公司 冠心丹参双相胶囊及其制备方法
CN100350898C (zh) * 2005-05-23 2007-11-28 江西本草天工科技有限责任公司 复方三七双相胶囊及其制备方法
CN100350900C (zh) * 2005-05-23 2007-11-28 江西本草天工科技有限责任公司 复方降香双相胶囊及其制备方法
WO2008132727A2 (en) * 2007-04-26 2008-11-06 Technion Research And Development Foundation Ltd Oral delivery of proteins and peptides
US20080306506A1 (en) * 2007-06-11 2008-12-11 Leatherman Dennis A Self-inflating and deflating intragastric balloon implant device
US20090087483A1 (en) * 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
CN101827571A (zh) 2007-10-15 2010-09-08 葛兰素集团有限公司 用于释放一种或多种药物成分的多部分剂型的连接件及所得剂型
JP2011503048A (ja) 2007-11-08 2011-01-27 グラクソ グループ リミテッド 医薬製剤
US8834922B2 (en) 2008-01-21 2014-09-16 Brian S. Banks Methodology and apparatus for oral dual delivery of homeopathic products and non-homeopathic products
EP3431128A1 (de) 2010-01-05 2019-01-23 MicroDose Therapeutx, Inc. Inhalationsvorrichtung
EP2720686A4 (de) * 2011-06-15 2014-12-17 Orient Pharma Co Ltd Mehrschichtige kapsel und herstellungsverfahren dafür
AU2012296358B2 (en) * 2011-08-17 2016-04-21 Board Of Regents, The University Of Texas System Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system
CN103784664B (zh) * 2014-01-27 2017-03-08 贵州师范大学 一种防治慢性盆腔炎的双相胶囊及其制备方法和检测方法
US10653622B1 (en) 2015-04-13 2020-05-19 Pharmacoustics Technologies LLC Individualized solid dosage products and a system and method for the globally integrated pharmaceutical manufacturing and its monitoring thereof
JP6195280B2 (ja) * 2015-12-18 2017-09-13 オリエント ファーマ シーオー．，エルティーディー． 多層カプセルおよびその製造方法

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB285091A (en) 1927-02-12 1929-06-10 Siegwart Hermann Process for the production of pills and pastilles for the small intestine
US1746984A (en) 1927-10-31 1930-02-11 William C Bausch Vehicle for acetyl-salicylic acid tablets
US2011587A (en) 1934-03-24 1935-08-20 Kelp Ol Lab Inc Coating for medical compound
US2071511A (en) 1934-10-01 1937-02-23 Reed & Carnrick Enteric coating
US2714084A (en) 1954-10-11 1955-07-26 Victor M Hermelin Enteric coated tablets and methods of making the same
US3033754A (en) 1959-12-21 1962-05-08 Lakeside Lab Inc Tablets containing hydrazine derivatives
US3115441A (en) 1962-06-06 1963-12-24 Victor M Hermelin Timed release pharmaceutical preparations and method of making the same
FR1396710A (fr) 1964-06-15 1965-04-23 Diwag Chemische Fabriken G M B Procédé pour la fabrication de charges ou supports perfectionnés et produits obtenus
DE1492077A1 (de) 1965-10-19 1969-06-26 Othmer Ekkehard Verfahren zur Herstellung eines regulatorisch-gegenregulatorisch wirkenden Arzneimittels zur Erreichung optimaler physiologischer Regulationsverlaeufe
FR1480744A (fr) 1966-05-23 1967-05-12 Double gélule
US4237118A (en) 1972-03-06 1980-12-02 Howard Alan N Dietary supplement and dietary methods employing said supplement for the treatment of obesity
US4147783A (en) 1974-02-28 1979-04-03 Akzona Incorporated Oral pharmaceutical preparation
US4181716A (en) 1974-03-28 1980-01-01 Beecham Group Limited Antibiotics
US3922339A (en) 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
US4137300A (en) 1976-08-20 1979-01-30 Ciba-Geigy Corporation Sustained action dosage forms
EP0001247A1 (de) 1977-09-14 1979-04-04 Kanebo, Ltd. Nifedipine enthaltendes Arzneipräparat und Verfahren zu seiner Herstellung.
AU523040B2 (en) 1978-05-15 1982-07-08 Kanebo Limited Calcium -antagonistic composition
GB1600639A (en) 1978-05-23 1981-10-21 Kali Chemie Pharma Gmbh Medicament preparation having resorption properties and method of producing the same
US4341563A (en) 1978-11-17 1982-07-27 Sankyo Company Limited Protective coating compositions
JPS5655310A (en) 1979-10-15 1981-05-15 Mitsubishi Paper Mills Ltd Production of double-layered capsule
JPS6056122B2 (ja) 1980-05-21 1985-12-09 塩野義製薬株式会社 徐放性製剤
US4366145A (en) 1981-06-24 1982-12-28 Sandoz, Inc. Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation
JPS58208215A (ja) 1982-05-31 1983-12-03 Sato Seiyaku Kk 脂溶性ビタミン配合油溶組成物
JPS59131355A (ja) 1983-01-17 1984-07-28 森下仁丹株式会社 多重軟カプセルの製法
GB8308126D0 (en) 1983-03-24 1983-05-05 Bloch M Pharmaceutical compositions
GB2142824B (en) 1983-07-07 1987-02-11 American Home Prod Pharmaceutical composition containing a liquid lubricant
US4620974A (en) 1983-07-07 1986-11-04 American Home Products Corporation Pharmaceutical composition containing a liquid lubricant
CH661878A5 (de) 1983-11-04 1987-08-31 Warner Lambert Co Kapsel-dosierungsformen.
DE3346526C2 (de) 1983-12-22 1986-12-11 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
DE3432881A1 (de) 1984-09-07 1986-03-20 Roshdy Dipl.-Chem. Dr. 5000 Köln Ismail Vitamin a + e enthaltende kapsel mit lecithin
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4609403A (en) * 1984-03-12 1986-09-02 Warner-Lambert Company Foam soft gelatin capsules and their method of manufacture
DE3421644A1 (de) 1984-06-09 1985-12-12 Richard 7880 Bad Säckingen Hau Diaetetische zusammensetzung
US4588717A (en) 1984-06-13 1986-05-13 David C. Mitchell Medical Research Institute Compounds and vitamin supplements and methods for making same
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
WO1986004501A1 (en) * 1985-01-31 1986-08-14 Fujisawa Pharmaceutical Co., Ltd. Soft multi-chamber capsule and method of and apparatus for manufacturing same
GB8522453D0 (en) 1985-09-11 1985-10-16 Lilly Industries Ltd Chewable capsules
GB8524421D0 (en) 1985-10-03 1985-11-06 Boots Co Plc Therapeutic agents
US4853249A (en) 1985-11-15 1989-08-01 Taisho Pharmaceutical Co., Ltd. Method of preparing sustained-release pharmaceutical/preparation
US4892742A (en) 1985-11-18 1990-01-09 Hoffmann-La Roche Inc. Controlled release compositions with zero order release
IL77186A0 (en) 1985-11-29 1986-04-29 Touitou Elka Pharmaceutical insulin composition
DE3600084A1 (de) 1986-01-03 1987-07-09 Scherer Gmbh R P Formkoerper sowie verfahren und vorrichtung zur herstellung eines solchen formkoerpers
NL8600050A (nl) 1986-01-13 1987-08-03 Sanico Nv Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.
US4795642A (en) 1986-05-01 1989-01-03 Pharmacaps, Inc. Gelatin-encapsulated controlled-release composition
CA1257199A (en) 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
US4738850A (en) 1986-05-27 1988-04-19 E. R. Squibb & Sons, Inc. Controlled release formulation and method
JPS6327424A (ja) 1986-07-17 1988-02-05 Shionogi & Co Ltd 徐放性製剤およびその製造法
IT1200178B (it) * 1986-07-23 1989-01-05 Alfa Farmaceutici Spa Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica
US5071643A (en) 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
US5599840A (en) 1986-11-26 1997-02-04 Bar Ilan University Physiologically active and nutritional composition
GB8630273D0 (en) 1986-12-18 1987-01-28 Til Medical Ltd Pharmaceutical delivery systems
GB8701332D0 (en) 1987-01-21 1987-02-25 Lilly Industries Ltd Capsule filling
HU196559B (en) 1987-04-17 1988-12-28 Biogal Gyogyszergyar Process for production of capsules of big stability from mild gelatine for medical purpuses containing as active substance of oils of natural origin
GB8716975D0 (en) 1987-07-17 1987-08-26 Boots Co Plc Therapeutic agents
US5004613A (en) 1987-07-27 1991-04-02 Mcneil-Ppc, Inc. Oral sustained release pharmaceutical formulation and process
US4820522A (en) 1987-07-27 1989-04-11 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
DE3727894A1 (de) * 1987-08-21 1989-03-02 Stephan Dieter Kapsel fuer pharmazeutisch wirksame inhaltsstoffe einer droge
DE3738236A1 (de) 1987-11-11 1989-05-24 Euro Celtique Sa Beisskapsel
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
GB8822857D0 (en) 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
JPH02237922A (ja) 1989-01-24 1990-09-20 Green Cross Corp:The 抗ウィルス剤
GB8904182D0 (en) 1989-02-23 1989-04-05 Glaxo Canada Pharmaceutical compositions
US5372823A (en) 1989-03-16 1994-12-13 Bristol-Myers Squibb Company Direct compression cholestyramine tablet and solvent-free coating thereof
GB8909022D0 (en) * 1989-04-20 1989-06-07 Cortecs Ltd Pharmaceutical compositions
DE3924887A1 (de) * 1989-07-27 1990-04-05 Kubin Herbert Dipl Ing Fh Oralschluckkapsel mit insulinfuellung fuer insulinpflichtige diabetiker
WO1991002520A1 (en) 1989-08-17 1991-03-07 Cortecs Limited Pharmaceutical formulations
US5532002A (en) 1989-08-17 1996-07-02 Cortecs Limited Gelatin pharmaceutical formulations
JP3078859B2 (ja) 1990-02-23 2000-08-21 武田薬品工業株式会社 安定な放出制御性製剤用コーティング剤
IE64128B1 (en) 1990-02-26 1995-07-12 Byrne Rynne Holdings Ltd A pharmaceutical composition
JP3249147B2 (ja) 1990-06-01 2002-01-21 キリン−アムジエン・インコーポレーテツド 生理活性蛋白含有経口製剤
GB9012651D0 (en) 1990-06-06 1990-07-25 Efamol Holdings Essential fatty acid treatment
IE61651B1 (en) 1990-07-04 1994-11-16 Zambon Spa Programmed release oral solid pharmaceutical dosage form
GB9022788D0 (en) * 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
BR9106965A (pt) 1990-11-16 1994-01-25 Pfizer Pre-misturas de semduranicin
US5387421A (en) * 1991-01-31 1995-02-07 Tsrl, Inc. Multi stage drug delivery system
US5108754A (en) 1991-02-08 1992-04-28 Michael Wilburn Orthomolecular method of treating sickle cell disease
JP2829794B2 (ja) 1991-02-08 1998-12-02 エスエス製薬 株式会社 徐放性経口投与型プラノプロフェン製剤
GB9111900D0 (en) 1991-06-03 1991-07-24 Efamol Holdings Fatty acid compositions
US5198229A (en) 1991-06-05 1993-03-30 Alza Corporation Self-retaining gastrointestinal delivery device
US5206219A (en) 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
DE4201179A1 (de) 1992-01-17 1993-07-22 Alfatec Pharma Gmbh Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung
EP0573978B1 (de) 1992-06-12 1999-04-21 Kao Corporation Badezusatzzusammensetzung enthaltend oberflächenaktive Mittel enthaltende nahtlose Kapsel und Verfahren zur Herrstellung der Kapsel
US5310555A (en) 1992-07-24 1994-05-10 Midwestern Bio-Ag Products And Services, Inc. Oral nutritional and dietary composition
US5501857A (en) 1992-07-24 1996-03-26 Midwestern Bio-Ag Products & Services, Inc. Oral nutritional and dietary composition
US5888541A (en) 1992-08-21 1999-03-30 Scotia Holdings Plc Fatty acid treatment
GB9217780D0 (en) 1992-08-21 1992-10-07 Efamol Holdings Fatty acid treatment
JP2650578B2 (ja) 1992-08-27 1997-09-03 日本エランコ株式会社 硬質カプセル用ゼラチン皮膜組成物及び易溶性硬質ゼラチンカプセル
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
IL103224A (en) 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
AU683027B2 (en) 1993-01-27 1997-10-30 Scotia Holdings Plc Triglycerides
US5310538A (en) 1993-03-11 1994-05-10 Sterling Winthrop Inc. Compositions of iodophenoxy alkylene ethers in film-forming materials for visualization of the gastrointestinal tract
SE9300937L (sv) 1993-03-19 1994-09-20 Anne Fjellestad Paulsen Komposition för oral administrering av peptider
WO1996010996A1 (en) 1993-07-21 1996-04-18 The University Of Kentucky Research Foundation A multicompartment hard capsule with control release properties
US5505961A (en) 1993-08-05 1996-04-09 R. P. Scherer Corporation Gelatin capsules containing a highly concentrated acetaminophen solution
US6054136A (en) 1993-09-30 2000-04-25 Gattefosse S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
GB9325445D0 (en) 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
US5447936A (en) 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
JP4157969B2 (ja) 1994-03-18 2008-10-01 スパーナス ファーマシューティカルズ インコーポレイテッド 乳化薬物送達システム
US5484608A (en) 1994-03-28 1996-01-16 Pharmavene, Inc. Sustained-release drug delivery system
US5447729A (en) 1994-04-07 1995-09-05 Pharmavene, Inc. Multilamellar drug delivery systems
US5468754A (en) 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5597829A (en) 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5869084A (en) 1994-06-20 1999-02-09 K-V Pharmaceuticals Co. Multi-vitamin and mineral supplements for women
US5938990A (en) 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby
US5571441A (en) 1994-11-01 1996-11-05 The Procter & Gamble Company Nutrient supplement compositions providing physiologic feedback
DE19509354A1 (de) 1994-12-08 1996-06-13 Klett Loch Lore M Kombinationspräparat zur Förderung des Haarwachstums und ggf. des Haut- und Nagelwachstums sowie zur Verhinderung bzw. zur Beseitigung von Haarausfall
CA2220451A1 (en) 1995-05-17 1996-11-21 Cedars-Sinai Medical Center Methods and compositions for improving digestion and absorption in the small intestine
US6008228A (en) 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
US5882715A (en) 1995-06-20 1999-03-16 Pharma-Vinci A/S Method of preparing an oral preparation provided on the outer side with an enteric coating, as well as an oral preparation obtained by the method
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5670640A (en) 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
US6024980A (en) 1996-06-28 2000-02-15 Mcneil-Ppc, Inc. Multiphase soft gelatin dosage form
US5798333A (en) 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
US6028067A (en) 1997-12-05 2000-02-22 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
US6063762A (en) 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
US6057289A (en) 1999-04-30 2000-05-02 Pharmasolutions, Inc. Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system

Also Published As

Publication number Publication date
BR9408294A (pt) 1997-08-26
US6613353B1 (en) 2003-09-02
DK0734253T3 (da) 2002-07-01
ATE213406T1 (de) 2002-03-15
AU1196795A (en) 1995-07-03
GB9325445D0 (en) 1994-02-16
ZA949931B (en) 1996-06-13
SG64292A1 (en) 1999-04-27
US20070202161A1 (en) 2007-08-30
ES2172576T3 (es) 2002-10-01
CN1137235A (zh) 1996-12-04
NZ277074A (en) 1998-01-26
AU702464B2 (en) 1999-02-25
JPH09506606A (ja) 1997-06-30
DE69429928T2 (de) 2002-11-28
EP0734253A1 (de) 1996-10-02
EP0734253B1 (de) 2002-02-20
US6153218A (en) 2000-11-28
PT734253E (pt) 2002-08-30
US20050191347A1 (en) 2005-09-01
WO1995016438A1 (en) 1995-06-22

Similar Documents

Publication Publication Date Title
DE69429928D1 (de) Zweiphasige zusammensetzung in kapselnform
MX9203373A (es) 3-amino-1-hidroxi-propan-1,1-difosfonato disodico y composiciones farmaceuticas que lo contienen.
ITRM920361A1 (it) Composizioni farmaceutiche contenenti un composto allilamminico quale principio attivo.
IL128425A0 (en) Taxane derivatives their preparation and pharmaceutical compositions containing them
DE3585294D1 (de) Molekularsiebzusammensetzungen.
WO2001098328A3 (en) Glycopeptide phosphonate derivatives
DK0548114T5 (da) Mometason-furoat-monohydrat, fremgangsmåde til fremtilling deraf og farmaceutiske præparater indeholdende dette
AU2001289438A1 (en) Pharmaceutical semi-solid composition of isotretinoin
DK0959872T3 (da) Fremgangsmåder, præparater og dentale afgivelsessystemer til beskyttelse af tandflader
ES2018478B3 (es) Un sistema para preparar una composicion desensibilizante dental.
BR0209489A (pt) Composições farmacêuticas
WO1992014696A3 (en) SUBSTITUTED α-AMINOALDEHYDES AND DERIVATIVES
DE69221994D1 (de) Härtbare, gefüllte Polysiloxanzusammensetzungen
DE69406766D1 (de) Polyoxymetalate-Gruppen enthaltende Organosiloxan-Zusammensetzungen
IL146284A0 (en) Androgen glycosides and pharmaceutical compositions containing the same
ATE235832T1 (de) Hartkaramellen mit verbesserter lagerstabilität
AU6849198A (en) Neurotrypsin
IL109866A (en) Crystalline 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine(+)L-hydrogentartrate its preparation and pharmaceutical compositions containing it
ZA918381B (en) Pharmaceutical compositions.
CA2179041A1 (en) Biphasic capsule formulation
CA2154871A1 (en) Farnesyl:protein transferase inhibitors as anticancer agents
EP0640659A3 (de) Einkomponenten-Polysiloxanmassen.
IT9048066A0 (it) 2- amminotetraline-6, 7-sostituite attive come immunomodulanti e composizioni farmaceutiche che le contengono.
ATE208627T1 (de) Orale zusammensetzungen mit niedrigdosierten zytotoxischen proteinen
MX9205362A (es) Composiciones herbicidas sinergisticas.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PII DRUG DELIVERY, LLC, HUNT VALLEY, MD., US

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee