DE69421939T2 - Nichttoxisches schleimhautadjuvans - Google Patents
Nichttoxisches schleimhautadjuvansInfo
- Publication number
- DE69421939T2 DE69421939T2 DE69421939T DE69421939T DE69421939T2 DE 69421939 T2 DE69421939 T2 DE 69421939T2 DE 69421939 T DE69421939 T DE 69421939T DE 69421939 T DE69421939 T DE 69421939T DE 69421939 T2 DE69421939 T2 DE 69421939T2
- Authority
- DE
- Germany
- Prior art keywords
- toxic
- mucutine
- adjuvans
- mucosal adjuvant
- administrable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002671 adjuvant Substances 0.000 title abstract 3
- 231100000252 nontoxic Toxicity 0.000 title abstract 3
- 230000003000 nontoxic effect Effects 0.000 title abstract 3
- 230000006229 amino acid addition Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/832—Drug, bio-affecting and body treating compositions involving bacterial toxin that has modified amino acid sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939326174A GB9326174D0 (en) | 1993-12-22 | 1993-12-22 | Mucosal adjuvant |
GB9326174 | 1993-12-22 | ||
PCT/IB94/00068 | 1994-03-24 | ||
IB9400068 | 1994-03-24 | ||
PCT/IB1995/000013 WO1995017211A1 (en) | 1993-12-22 | 1994-12-22 | Non-toxic mucosal adjuvant |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69421939D1 DE69421939D1 (de) | 2000-01-05 |
DE69421939T2 true DE69421939T2 (de) | 2000-06-15 |
DE69421939T3 DE69421939T3 (de) | 2009-11-05 |
Family
ID=10747021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69421939T Expired - Lifetime DE69421939T3 (de) | 1993-12-22 | 1994-12-22 | Nichttoxisches schleimhautadjuvans |
Country Status (13)
Country | Link |
---|---|
US (3) | US20020187154A1 (de) |
EP (1) | EP0732937B2 (de) |
JP (2) | JP4283889B2 (de) |
AT (1) | ATE187078T1 (de) |
AU (1) | AU1278595A (de) |
CA (1) | CA2179771C (de) |
DE (1) | DE69421939T3 (de) |
DK (1) | DK0732937T4 (de) |
ES (1) | ES2139879T5 (de) |
GB (1) | GB9326174D0 (de) |
GR (1) | GR3032497T3 (de) |
PT (1) | PT732937E (de) |
WO (1) | WO1995017211A1 (de) |
Families Citing this family (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9513371D0 (en) * | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
EP0725653B2 (de) | 1993-10-05 | 2008-04-02 | UCB Pharma Limited | Impfstoffzusammensetzungen |
GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
JP5148577B2 (ja) * | 1993-12-22 | 2013-02-20 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 非毒性の粘膜アジュバント |
US6436407B1 (en) | 1994-08-26 | 2002-08-20 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic adjuvant |
US6019982A (en) * | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
GB9603314D0 (en) * | 1996-02-16 | 1996-04-17 | Biocine Spa | Immunogenic detoxified mutant toxins |
US20070043215A1 (en) * | 1996-08-27 | 2007-02-22 | Heath David G | Recombinant f1-v plague vaccine |
GB9622660D0 (en) * | 1996-10-31 | 1997-01-08 | Biocine Spa | Immunogenic detoxified mutant toxin |
US5980898A (en) * | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
CN101002727A (zh) * | 1996-11-14 | 2007-07-25 | (由国防部长代表的)美利坚合众国政府 | 经皮免疫之佐剂 |
US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
AU755465C (en) * | 1998-06-01 | 2004-01-29 | Fidia Farmaceutici S.P.A. | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
US6824793B1 (en) | 1998-06-01 | 2004-11-30 | Chiron Corporation | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
US6576244B1 (en) | 1998-06-19 | 2003-06-10 | Acambis, Inc. | LT and CT in parenteral immunization methods against helicobacter infection |
US6693087B1 (en) | 1998-08-20 | 2004-02-17 | Aventis Pasteur Limited | Nucleic acid molecules encoding POMP91A protein of Chlamydia |
US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
AU5366099A (en) | 1998-08-20 | 2000-03-14 | Connaught Laboratories Limited | Nucleic acid molecules encoding inclusion membrane protein of (chlamydia) |
AU774649B2 (en) * | 1998-10-21 | 2004-07-01 | Kitasato Daiichi Sankyo Vaccine Co.,Ltd. | Vaccine preparations containing attenuated toxin |
DE69942774D1 (de) * | 1999-02-26 | 2010-10-28 | Novartis Vaccines & Diagnostic | Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen |
US7115730B1 (en) | 1999-04-27 | 2006-10-03 | Chiron Srl | Immunogenic detoxified mutant E. coli LT-A-toxin |
US7384640B1 (en) | 1999-09-30 | 2008-06-10 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant |
WO2001030382A1 (en) | 1999-10-22 | 2001-05-03 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
JP2003171291A (ja) * | 1999-10-29 | 2003-06-17 | Takeda Schering-Plough Animal Health Kk | 乳房炎用粘膜予防剤 |
EP1246646A2 (de) * | 2000-01-05 | 2002-10-09 | Aventis Pasteur Limited | Verstärkung der immunreaktion gegen ein antigen durch eine vorsensibilisierung mit einem induzierenden agens vor der immunisierung mit dem induzierenden agens und dem antigen |
EP1792995A3 (de) | 2000-05-08 | 2007-06-13 | Sanofi Pasteur Limited | Chlamydia Antigene, entsprechende DNS Fragmente und ihre Verwendungen |
ATE346925T1 (de) | 2000-05-10 | 2006-12-15 | Sanofi Pasteur Ltd | Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen |
AU2001271268A1 (en) | 2000-05-19 | 2001-12-03 | The Administrators Of The Tulane Educational Fund | Hybrid lt-a/ct-b holotoxin for use as an adjuvant |
ATE357461T1 (de) | 2000-08-25 | 2007-04-15 | Aventis Pasteur | Innen-kern oligosaccharide epitopes aus lipopolysacchariden von haemophilus influenza als vakzinen in der prophylaktischen behandlung von haemophilus influenzae infektionen |
EP2198882A3 (de) | 2001-01-12 | 2010-10-13 | Novartis Vaccines and Diagnostics, Inc. | Nukleinsäure mukosale Immunisierung |
GB0108024D0 (en) | 2001-03-30 | 2001-05-23 | Chiron Spa | Bacterial toxins |
ES2399420T3 (es) | 2001-05-22 | 2013-04-01 | The Government Of The United States Of America, As Represented By The Secretary, The Department Of | Desarrollo de mutaciones útiles para atenuar virus del dengue y virus del dengue quiméricos |
CA2449670A1 (en) * | 2001-06-07 | 2002-12-12 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
CN1977971A (zh) | 2001-06-07 | 2007-06-13 | 惠氏控股有限公司 | 作为佐剂的霍乱全毒素的突变体形式 |
ATE513560T1 (de) * | 2002-05-14 | 2011-07-15 | Novartis Vaccines & Diagnostic | Kombinationsimpfstoff gegen bakterielle meningitis, der über die schleimhaut appliziert wird |
GB0220205D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Neisseria toxin |
JPWO2004028561A1 (ja) * | 2002-09-30 | 2006-01-19 | アステラス製薬株式会社 | 免疫応答誘導方法 |
US20050031587A1 (en) * | 2002-10-04 | 2005-02-10 | Yamanouchi Pharmaceutical Co., Ltd. | Immune response induction method |
HUE031886T2 (en) | 2002-10-11 | 2017-08-28 | Glaxosmithkline Biologicals Sa | Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines |
CA3042073C (en) | 2003-01-30 | 2022-09-13 | Novartis Vaccines And Diagnostics S.R.L. | Injectable vaccines against multiple meningococcal serogroups |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
WO2005032583A2 (en) | 2003-10-02 | 2005-04-14 | Chiron Srl | Liquid vaccines for multiple meningococcal serogroups |
US20080254065A1 (en) | 2004-03-09 | 2008-10-16 | Chiron Corporation | Influenza Virus Vaccines |
RU2379052C2 (ru) | 2004-04-30 | 2010-01-20 | Чирон С.Р.Л. | Вакцинация менингококковыми конъюгатами |
GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
GB0410866D0 (en) | 2004-05-14 | 2004-06-16 | Chiron Srl | Haemophilius influenzae |
EP2811027A1 (de) | 2004-05-21 | 2014-12-10 | Novartis Vaccines and Diagnostics, Inc. | Alphavirus-Vektoren für RSV- und PIV-Impfstoffe |
WO2006078318A2 (en) | 2004-07-29 | 2006-07-27 | Novartis Vaccines And Diagnostics Inc. | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
EP2351772B1 (de) | 2005-02-18 | 2016-07-13 | GlaxoSmithKline Biologicals SA | Proteine und Nukleinsäuren von meningitis-/sepsis-assoziierten Escherichia coli |
CA2598488A1 (en) | 2005-02-18 | 2006-08-31 | Novartis Vaccines And Diagnostics, Inc. | Immunogens from uropathogenic escherichia coli |
JP2009511636A (ja) | 2005-10-18 | 2009-03-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | アルファウイルスレプリコン粒子による粘膜免疫および全身免疫 |
WO2007052057A2 (en) * | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Adminstration routes for priming/boosting with influenza vaccines |
PT2368572T (pt) | 2005-11-04 | 2020-06-16 | Seqirus Uk Ltd | Vacinas com adjuvante dotadas de antigénios não-virião preparados a partir de vírus da gripe cultivado em cultura celular |
WO2007081447A2 (en) | 2005-11-22 | 2007-07-19 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and sapovirus antigens |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
PL2478916T3 (pl) | 2006-01-27 | 2020-11-16 | Seqirus UK Limited | Szczepionki przeciw grypie zawierające hemaglutyninę i białka macierzy |
EP2502999A3 (de) | 2006-03-03 | 2013-01-23 | Amorfix Life Sciences Ltd. | Verfahren und Zusammensetzungen zum Behandeln und Erkennen von missgefaltetem SOD 1-herbeigeführte Erkrankungen |
EP2010537B1 (de) | 2006-03-23 | 2011-12-28 | Novartis AG | Imidazochinoxalinverbindungen als immunmodulatoren |
CN101448523A (zh) | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
EP2019686B1 (de) | 2006-03-31 | 2012-07-11 | Novartis AG | Kombinierte mukosale und parenterale immunisierung gegen hiv |
ATE522541T1 (de) | 2006-06-09 | 2011-09-15 | Novartis Ag | Bakterielle adhäsine konformere |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
WO2008020330A2 (en) | 2006-08-16 | 2008-02-21 | Novartis Ag | Immunogens from uropathogenic escherichia coli |
EA200970271A1 (ru) | 2006-09-11 | 2010-02-26 | Новартис Аг | Получение вакцин против вируса гриппа без использования куриных эмбрионов |
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GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
BRPI0721702A2 (pt) | 2007-05-23 | 2013-01-15 | Uab Research Foundation | neuraminidase pneumocàcica destoxificada ou uma porÇço antigÊnica da mesma, composiÇço, mÉtodos para reduzir ou prevenir a portabilidade nasal pneumocàcica em um indivÍduo, e para reduzir ou prevenir a infecÇço pneumocàcica em um indivÍduo, e, recipiente |
WO2009001217A2 (en) | 2007-06-27 | 2008-12-31 | Novartis Ag | Low-additive influenza vaccines |
GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
ES2534671T3 (es) | 2007-09-11 | 2015-04-27 | University Of Guelph | Inmunógenos polisacáridos de la Clostridium difficile |
KR101621837B1 (ko) | 2007-09-12 | 2016-05-17 | 노파르티스 아게 | Gas57 돌연변이 항원 및 gas57 항체 |
GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
WO2009081274A2 (en) | 2007-12-21 | 2009-07-02 | Novartis Ag | Mutant forms of streptolysin o |
ES2532946T3 (es) | 2008-02-21 | 2015-04-06 | Novartis Ag | Polipéptidos PUfH meningocócicos |
EP2889042A3 (de) | 2008-03-18 | 2015-10-14 | Novartis AG | Verbesserungen bei der Herstellung von Influenzavirusimpfstoffantigenen |
EP2376089B1 (de) * | 2008-11-17 | 2018-03-14 | The Regents of the University of Michigan | Krebsvakzine-zusammensetzungen und anwendungsverfahren dafür |
BRPI0923649A2 (pt) | 2008-12-24 | 2016-01-19 | Netherlands Vaccine Inst | polipeptídeos de pneumolisina (ply) de streptococcus pneumoniae modificados. |
BRPI1005670A8 (pt) | 2009-01-05 | 2017-12-26 | Epitogenesis Inc | composições adjuvantes e processos de uso. |
US8465751B2 (en) | 2009-01-12 | 2013-06-18 | Novartis Ag | Cna—B domain antigens in vaccines against gram positive bacteria |
CN102438650A (zh) | 2009-03-06 | 2012-05-02 | 诺华有限公司 | 衣原体抗原 |
WO2010119343A2 (en) | 2009-04-14 | 2010-10-21 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
WO2010146414A1 (en) | 2009-06-15 | 2010-12-23 | National University Of Singapore | Influenza vaccine, composition, and methods of use |
JP2012532600A (ja) | 2009-07-07 | 2012-12-20 | ノバルティス アーゲー | 保存された大腸菌免疫原 |
SG178026A1 (en) | 2009-07-15 | 2012-03-29 | Novartis Ag | Rsv f protein compositions and methods for making same |
CN102770443A (zh) | 2009-07-16 | 2012-11-07 | 诺华有限公司 | 脱毒大肠杆菌免疫原 |
CN102596240B (zh) | 2009-08-27 | 2015-02-04 | 诺华股份有限公司 | 包括脑膜炎球菌fHBP序列的杂交多肽 |
BR112012008338A2 (pt) | 2009-09-10 | 2019-09-24 | Novartis Ag | combinação de vacinas contra doenças do trato respiratório. |
GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
GB0917002D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Improved shigella blebs |
US8974799B2 (en) | 2009-09-30 | 2015-03-10 | Novartis Ag | Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides |
AU2010302344A1 (en) | 2009-09-30 | 2012-04-26 | Novartis Ag | Expression of meningococcal fhbp polypeptides |
GB0918392D0 (en) | 2009-10-20 | 2009-12-02 | Novartis Ag | Diagnostic and therapeutic methods |
EP2493499A1 (de) | 2009-10-27 | 2012-09-05 | Novartis AG | Modifizierte meningokokken-fhbp-polypeptide |
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-
1993
- 1993-12-22 GB GB939326174A patent/GB9326174D0/en active Pending
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1994
- 1994-12-22 PT PT95903889T patent/PT732937E/pt unknown
- 1994-12-22 JP JP51730095A patent/JP4283889B2/ja not_active Expired - Fee Related
- 1994-12-22 EP EP95903889A patent/EP0732937B2/de not_active Expired - Lifetime
- 1994-12-22 AT AT95903889T patent/ATE187078T1/de active
- 1994-12-22 AU AU12785/95A patent/AU1278595A/en not_active Abandoned
- 1994-12-22 ES ES95903889T patent/ES2139879T5/es not_active Expired - Lifetime
- 1994-12-22 DE DE69421939T patent/DE69421939T3/de not_active Expired - Lifetime
- 1994-12-22 DK DK95903889T patent/DK0732937T4/da active
- 1994-12-22 CA CA002179771A patent/CA2179771C/en not_active Expired - Fee Related
- 1994-12-22 WO PCT/IB1995/000013 patent/WO1995017211A1/en active IP Right Grant
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2000
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2002
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2005
- 2005-11-18 JP JP2005335023A patent/JP2006143729A/ja not_active Withdrawn
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US20020187154A1 (en) | 2002-12-12 |
PT732937E (pt) | 2000-05-31 |
DK0732937T3 (da) | 2000-05-01 |
CA2179771C (en) | 2001-02-20 |
US7485304B2 (en) | 2009-02-03 |
WO1995017211A1 (en) | 1995-06-29 |
US7070781B2 (en) | 2006-07-04 |
CA2179771A1 (en) | 1995-06-29 |
GR3032497T3 (en) | 2000-05-31 |
DK0732937T4 (da) | 2009-06-08 |
DE69421939T3 (de) | 2009-11-05 |
ES2139879T3 (es) | 2000-02-16 |
ATE187078T1 (de) | 1999-12-15 |
ES2139879T5 (es) | 2009-06-10 |
DE69421939D1 (de) | 2000-01-05 |
AU1278595A (en) | 1995-07-10 |
EP0732937A1 (de) | 1996-09-25 |
US20040028690A1 (en) | 2004-02-12 |
US20060177469A1 (en) | 2006-08-10 |
JP4283889B2 (ja) | 2009-06-24 |
EP0732937B1 (de) | 1999-12-01 |
EP0732937B2 (de) | 2009-03-18 |
GB9326174D0 (en) | 1994-02-23 |
JP2006143729A (ja) | 2006-06-08 |
JPH10500099A (ja) | 1998-01-06 |
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