AU2001271268A1 - Hybrid lt-a/ct-b holotoxin for use as an adjuvant - Google Patents

Hybrid lt-a/ct-b holotoxin for use as an adjuvant

Info

Publication number
AU2001271268A1
AU2001271268A1 AU2001271268A AU7126801A AU2001271268A1 AU 2001271268 A1 AU2001271268 A1 AU 2001271268A1 AU 2001271268 A AU2001271268 A AU 2001271268A AU 7126801 A AU7126801 A AU 7126801A AU 2001271268 A1 AU2001271268 A1 AU 2001271268A1
Authority
AU
Australia
Prior art keywords
holotoxin
adjuvant
hybrid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001271268A
Inventor
John D. Clements
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Publication of AU2001271268A1 publication Critical patent/AU2001271268A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AU2001271268A 2000-05-19 2001-05-21 Hybrid lt-a/ct-b holotoxin for use as an adjuvant Abandoned AU2001271268A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20596900P 2000-05-19 2000-05-19
US60/205,969 2000-05-19
PCT/US2001/016542 WO2001089456A2 (en) 2000-05-19 2001-05-21 Hybrid lt-a/ct-b holotoxin for use as an adjuvant

Publications (1)

Publication Number Publication Date
AU2001271268A1 true AU2001271268A1 (en) 2001-12-03

Family

ID=22764426

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001271268A Abandoned AU2001271268A1 (en) 2000-05-19 2001-05-21 Hybrid lt-a/ct-b holotoxin for use as an adjuvant

Country Status (3)

Country Link
US (1) US7063852B2 (en)
AU (1) AU2001271268A1 (en)
WO (1) WO2001089456A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513371D0 (en) * 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
US20030072774A1 (en) * 1994-06-10 2003-04-17 Diane M. Gajewczyk Proteinaceous adjuvants
US7384640B1 (en) * 1999-09-30 2008-06-10 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant
CA2449663A1 (en) * 2001-06-07 2002-12-12 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
AU2002322380B2 (en) 2001-06-07 2006-11-02 Government Of The United States Of America As Represented By The Uniformed Services University Of The Health Sciences Mutant forms of cholera holotoxin as an adjuvant
WO2005011733A1 (en) * 2003-07-21 2005-02-10 Akzo Nobel N.V. Hybrid toxins comprising shiga-like toxin subunits fused to escherichia coli heat labile enterotoxin subunits and vaccines thereof
US8188244B2 (en) 2004-02-11 2012-05-29 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Carcinoembryonic antigen fusions and uses thereof
CN100445743C (en) * 2005-11-30 2008-12-24 东北农业大学 Recombined prokaryotic expression detection antigen for detecting local trichina nematode antibody and producing method thereof
CN100460013C (en) * 2006-09-05 2009-02-11 重庆康卫生物科技有限公司 Oral administration recombinant helicobacterpylori vaccine and preparing method thereof
WO2009133882A1 (en) 2008-05-02 2009-11-05 出光興産株式会社 Bacterial toxin vaccine
US7927586B2 (en) * 2008-07-08 2011-04-19 South Dakota State University Vaccine for porcine post-weaning diarrhea caused by enterotoxigenic Escherichia coli
CN110075290A (en) * 2018-01-25 2019-08-02 吴夙钦 Influenza mucosal vaccine composition and the preparation method and application thereof
US20210187064A1 (en) * 2018-05-07 2021-06-24 Administrators Of The Tulane Educational Fund Mutated e. coli enterotoxins as anti-inflammatory agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328209A (en) 1979-04-11 1982-05-04 Board Of Regents, The University Of Texas System Cholera vaccine
JP2849632B2 (en) 1988-04-08 1999-01-20 社団法人北里研究所 Vaccine preparation
IL101715A (en) 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
IT1253009B (en) 1991-12-31 1995-07-10 Sclavo Ricerca S R L DETOXIFIED IMMUNOGENIC MUTANTS OF COLERIC TOXIN AND TOXIN LT, THEIR PREPARATION AND USE FOR THE PREPARATION OF VACCINES
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
SE9501682D0 (en) * 1995-05-05 1995-05-05 Jan Holmgren Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits

Also Published As

Publication number Publication date
WO2001089456A2 (en) 2001-11-29
WO2001089456A3 (en) 2002-04-11
US20030113345A1 (en) 2003-06-19
WO2001089456A9 (en) 2003-01-16
US7063852B2 (en) 2006-06-20

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