DE69334141D1 - Schweinevirus, Erreger der sich vermehrenden Erkrankung der Atemwege, Impstoffe und seine virale DNA - Google Patents

Schweinevirus, Erreger der sich vermehrenden Erkrankung der Atemwege, Impstoffe und seine virale DNA

Info

Publication number
DE69334141D1
DE69334141D1 DE69334141T DE69334141T DE69334141D1 DE 69334141 D1 DE69334141 D1 DE 69334141D1 DE 69334141 T DE69334141 T DE 69334141T DE 69334141 T DE69334141 T DE 69334141T DE 69334141 D1 DE69334141 D1 DE 69334141D1
Authority
DE
Germany
Prior art keywords
vaccines
viral dna
respiratory disease
causative agent
swine virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69334141T
Other languages
English (en)
Other versions
DE69334141T2 (de
Inventor
Prem S Paul
Patrick G Halbur
Xiang-Jin Meng
Melissa A Lum
Young S Lyoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Iowa State University Research Foundation ISURF
Original Assignee
University of Iowa Research Foundation UIRF
Solvay Animal Health Inc
Iowa State University Research Foundation ISURF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26829656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69334141(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Iowa Research Foundation UIRF, Solvay Animal Health Inc, Iowa State University Research Foundation ISURF filed Critical University of Iowa Research Foundation UIRF
Publication of DE69334141D1 publication Critical patent/DE69334141D1/de
Application granted granted Critical
Publication of DE69334141T2 publication Critical patent/DE69334141T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/543Mucosal route intranasal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10021Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/815Viral vaccine for porcine species, e.g. swine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
DE1993634141 1992-10-30 1993-10-29 Schweinevirus, Erreger der sich vermehrenden Erkrankung der Atemwege, Impstoffe und seine virale DNA Expired - Lifetime DE69334141T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US96907192A 1992-10-30 1992-10-30
US969071 1992-10-30
US08/131,625 US5695766A (en) 1992-10-30 1993-10-05 Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US131625 1993-10-05

Publications (2)

Publication Number Publication Date
DE69334141D1 true DE69334141D1 (de) 2007-07-05
DE69334141T2 DE69334141T2 (de) 2008-01-24

Family

ID=26829656

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1993634141 Expired - Lifetime DE69334141T2 (de) 1992-10-30 1993-10-29 Schweinevirus, Erreger der sich vermehrenden Erkrankung der Atemwege, Impstoffe und seine virale DNA

Country Status (12)

Country Link
US (4) US5695766A (de)
EP (1) EP0595436B1 (de)
JP (1) JP4125385B2 (de)
CN (1) CN1087175C (de)
AU (1) AU672825B2 (de)
BR (1) BR9304453A (de)
CA (1) CA2102036C (de)
DE (1) DE69334141T2 (de)
DK (1) DK0595436T3 (de)
ES (1) ES2286815T3 (de)
MX (1) MXPA93006804A (de)
TW (2) TW517085B (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2103460C (en) 1991-06-06 2000-09-26 Gert Wensvoort Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US6042830A (en) * 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US6380376B1 (en) * 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6773908B1 (en) 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6251397B1 (en) 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
CZ289743B6 (cs) * 1993-02-08 2002-03-13 Bayer Corporation Izolát viru vepřového reprodukčního a respiračního syndromu PRRSV, způsob kultivace PRRSV, tkáňová kultura, způsob přípravy vakcíny a vakcína obsahující PRRSV izolát
CA2158651C (en) * 1993-03-29 2009-09-01 David S. Roberts Multicomponent clostridial vaccines using saponin adjuvants
GB2289279B (en) * 1994-05-13 1998-09-16 Iberica Cyanamid Diagnostic kits and vaccines containing recombinant PRRSV proteins
ES2078187B1 (es) * 1994-05-13 1996-07-16 Cynamid Iberica S A Proteinas recombinantes de prrs, kits de diagnostico y vacunas que contienen dichas proteinas recombinantes.
DE69535061T2 (de) * 1994-08-05 2007-01-25 Regents Of The University Of Minnesota, Minneapolis Virale nukleotidsequenz vr-2332 und nutzungsverfahren
US5690940A (en) * 1995-06-21 1997-11-25 Regents Of The University Of Minnesota Low pathogencity PRRS live virus vaccines and methods of preparation thereof
DE69636112T2 (de) * 1995-08-30 2006-12-14 Toray Industries, Inc. Verfahren zum testen von myocarditis und cardiomyopathie
JP3135069B2 (ja) * 1996-03-01 2001-02-13 シェーリング コーポレイション ブタ生殖および呼吸症候群ワクチン
US5866401A (en) * 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US6015663A (en) * 1996-03-01 2000-01-18 The United States Of America As Represented By The Secretary Of Agriculture Restriction enzyme screen for differentiating porcine reproductive and respiratory syndrome virus strains
PT835930E (pt) * 1996-10-09 2001-06-29 Akzo Nobel Nv Estirpes europeias de vacina do virus do sindroma reprodutivo e respiratorio porcino (prrsv)
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (de) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Ansteckende Klone von RNA-Viren und darauf basierende Impfstoffe und diagnostisches Verfahren
DE69837992T2 (de) 1997-05-06 2008-03-20 Boehringer Ingelheim Vetmedica Gmbh Prrsv-antigene, die auf peptidsequenzen des prrs-virus basieren, für die verwendung als impfstoff und für diagnostische tests
ZA991641B (en) * 1998-03-02 2000-09-01 Lilly Co Eli Treatment of viral disease in swine.
NZ501264A (en) 1998-12-22 2001-09-28 Pfizer Prod Inc Polynucleotide DNA sequence encoding an infectious RNA molecule encoding a North American PRRS
EP1157121B1 (de) * 1999-03-08 2013-04-24 Boehringer Ingelheim Vetmedica GmbH Prrsv replikon
MXPA01010681A (es) 1999-04-22 2003-08-20 Us Agriculture Vacuna de sindrome respiratorio y reproductiva porcina a base de ja-142 aislado.
GB9930359D0 (en) * 1999-12-22 2000-02-09 Glaxo Group Ltd Novel polypeptides
DK1255815T3 (da) * 2000-02-08 2006-10-30 Univ Minnesota Porcint reproduktivt og respiratorisk syndromvirus til fremgangsmåder til anvendelse
AU2002249852A1 (en) * 2000-11-09 2002-08-12 Board Of Trustees Of The University Of Illinois Enhancement of immune response to vaccine by interferon alpha
US6740490B2 (en) * 2001-01-29 2004-05-25 Kansas State University Research Foundation Identification and applications of porcine reproductive and respiratory syndrome virus host susceptibility factor(s) for improved swine breeding
EP1357943A2 (de) * 2001-01-30 2003-11-05 The Lauridsen Group Incorporated Verfahren und zusammensetzungen zur modulation des immunsystems in tieren
EP1397498A1 (de) * 2001-05-21 2004-03-17 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Deletionen in arterivirus replikons
US7479482B2 (en) * 2001-11-21 2009-01-20 New York University Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid β, prion protein, amylin, α-synuclein, or polyglutamine repeats for induction of an immune response thereto
US6841364B2 (en) 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
US20040197845A1 (en) * 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
WO2004110370A2 (en) * 2003-06-03 2004-12-23 Iowa State University Research Foundation, Inc. Etiologic agnet for sow infertility syndrome
AR049924A1 (es) * 2004-06-18 2006-09-13 Univ Minnesota Identificacion de organismos viralmente infectados y vacunados
US7632636B2 (en) * 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
CA2894069C (en) 2005-06-24 2019-02-26 Regents Of The University Of Minnesota Prrs viruses, infectious clones, mutants thereof, and methods of use
CN106075422B (zh) * 2005-11-29 2021-05-28 衣阿华州立大学研究基金公司 猪繁殖与呼吸综合征病毒(prrsv)的保护性抗原决定子的鉴定及其用途
AR064888A1 (es) * 2007-01-12 2009-04-29 Univ Illinois Celulas no simias para el crecimiento del virus del sindrome reproductor y respiratorio porcino (prrs)
AU2008294036A1 (en) * 2007-05-30 2009-03-05 Wyeth Llc Raccoon poxvirus expressing genes of porcine virus
US7666585B2 (en) * 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
JP2010531143A (ja) * 2007-06-25 2010-09-24 サウス ダコタ ステート ユニバーシティー 組換え北アメリカ1型ブタ生殖器呼吸器症候群ウイルス及び使用方法
WO2010025109A1 (en) * 2008-08-25 2010-03-04 Boehringer Ingelheim Vetmedia, Inc. Vaccine against highly pathogenic porcine reproductive and respiratory syndrome (hp prrs)
EP2230246A1 (de) * 2009-03-19 2010-09-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Arterivirus-Glykoprotein-5-artige Partikel
WO2010129674A2 (en) 2009-05-05 2010-11-11 New York University Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
TWI627281B (zh) * 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物
ES2600929T3 (es) 2009-09-10 2017-02-13 Merial, Inc. Nuevas formulaciones de vacuna que comprenden adyuvantes que contienen saponina
CA2800824A1 (en) * 2010-06-02 2011-12-08 Virginia Tech Intellectual Properties, Inc. Novel modified live-attenuated vaccines (mlv) and subunit vaccines created by dna shuffling against porcine reproductive and respiratory syndrome virus (prrsv)
PL2675475T3 (pl) 2011-02-17 2015-12-31 Boehringer Ingelheim Vetmedica Gmbh Nowy europejski szczep prrs
US9944902B2 (en) 2011-02-17 2018-04-17 Boehringer Ingelheim Vetmedica Gmbh Commercial scale process for production of PRRSV
WO2013013056A1 (en) 2011-07-19 2013-01-24 New York University Method for treating amyloid disease
US9926353B2 (en) 2011-07-19 2018-03-27 New York University Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides
US9315781B2 (en) 2011-07-29 2016-04-19 Boehringer Ingelheim Vetmedica Gmbh Infectious CDNA clone of european PRRS virus and uses thereof
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
DK2741740T3 (en) 2011-08-12 2017-06-06 Merial Inc VACUUM-SUPPORTED CONSERVATION OF BIOLOGICAL PRODUCTS, IN PARTICULAR OF VACCINES
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
US10279028B2 (en) 2012-04-24 2019-05-07 Ohio State Innovation Foundation Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome
ES2932952T3 (es) 2012-04-24 2023-01-30 Ohio State Innovation Foundation Composiciones y métodos para tratar y prevenir el síndrome reproductivo y respiratorio porcino
RU2494760C1 (ru) * 2012-04-26 2013-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ижевская государственная сельскохозяйственная академия" Способ получения гипериммунной сыворотки против цирковирусной инфекции, репродуктивно-респираторного синдрома и гемофилеза свиней
EP2968513A2 (de) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Prrs-virus, zusammensetzungen, impfstoff und verfahren zur verwendung
MX2020010248A (es) 2013-12-20 2020-10-16 Boehringer Ingelheim Vetmedica Gmbh Variante del virus prrs, clon de adnc del virus europeo y sus usos.
TWI745278B (zh) 2014-10-10 2021-11-11 以色列商艾畢克生物實驗有限公司 發泡性降低之疫苗組合物
CN104561092B (zh) * 2014-12-19 2018-12-11 中国农业科学院上海兽医研究所 表达猪瘟病毒e2蛋白重组prrs病毒基因工程疫苗的构建方法和应用
KR20190044052A (ko) 2016-06-17 2019-04-29 메리얼 인코포레이티드 선형 또는 분지형 폴리아크릴산 폴리머 아쥬반트를 포함하는 신규한 면역원성 제형
DK3534939T3 (da) 2016-11-03 2023-04-24 Boehringer Ingelheim Vetmedica Gmbh Vaccine mod porcin parvovirus og porcin reproduktions- og respirationssyndromvirus og fremgangsmåder til fremstilling deraf
CN113684318A (zh) * 2021-09-16 2021-11-23 天津农学院 猪繁殖与呼吸综合征病毒m蛋白基因的荧光pcr检测试剂盒

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442205A (en) * 1981-09-22 1984-04-10 The United States Of America As Represented By The Department Of Health And Human Services Simian virus recombinant that directs the synthesis of hepatitis B surface antigen
US5213759A (en) * 1988-05-05 1993-05-25 Elopak Systems A.G. Sterilization
US5212057A (en) * 1988-10-26 1993-05-18 University Of Florida Biological system for constructing and testing viral vaccines
US5431160A (en) * 1989-07-19 1995-07-11 University Of New Mexico Miniature implantable refillable glucose sensor and material therefor
US5213795A (en) * 1990-10-24 1993-05-25 Oxford Encephalomyocarditis virus vaccine
CA2103460C (en) * 1991-06-06 2000-09-26 Gert Wensvoort Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US5846805A (en) * 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
ATE144144T1 (de) * 1991-08-26 1996-11-15 James Edward Collins Vakzine gegen und diagnosemethode für das schweine-unfruchtbarkeits- und atmungs-syndrom (suas)
US6042830A (en) * 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
CA2076744C (en) * 1991-08-26 2000-06-27 Danny W. Chladek Viral agent associated with mystery swine disease
WO1993006211A1 (en) * 1991-09-16 1993-04-01 Collins James E Vaccine for mystery swine disease and method for diagnosis thereof
EP0610250B2 (de) * 1991-10-14 2008-10-29 Intervet International BV Impstoff und diagnostik für das fortpflanzungs- und atmungssyndrom bei schweinen (prrs) und diagnose
FR2686097B1 (fr) * 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
TW289731B (de) * 1992-07-09 1996-11-01 Akzo Nv
US6380376B1 (en) * 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6251397B1 (en) 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
US5419907A (en) * 1992-11-10 1995-05-30 Iowa State University Research Foundation, Inc. Pathogenic porcine respiratory coronavirus
CZ289743B6 (cs) * 1993-02-08 2002-03-13 Bayer Corporation Izolát viru vepřového reprodukčního a respiračního syndromu PRRSV, způsob kultivace PRRSV, tkáňová kultura, způsob přípravy vakcíny a vakcína obsahující PRRSV izolát
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
EP0659885A1 (de) * 1993-12-21 1995-06-28 Akzo Nobel N.V. Impstoffe gegen von Antikörper abhängende Vergrösserung (ADE) der Virus-Infektivität
DE4407489A1 (de) * 1994-03-07 1995-09-14 Bayer Ag Vakzine zur Prävention von Respirations- und Reproduktionserkrankungen des Schweines
ES2165405T3 (es) * 1994-04-11 2002-03-16 Akzo Nobel Nv Cepas de vacuna europeas del virus del sindrome reproductor y respiratorio porcino (prrsv).
GB2289279B (en) * 1994-05-13 1998-09-16 Iberica Cyanamid Diagnostic kits and vaccines containing recombinant PRRSV proteins
DE69535061T2 (de) 1994-08-05 2007-01-25 Regents Of The University Of Minnesota, Minneapolis Virale nukleotidsequenz vr-2332 und nutzungsverfahren
ATE268783T1 (de) * 1995-03-14 2004-06-15 Akzo Nobel Nv Expression in der selben zelle von polypeptide vom schweinen reproduktiven und respiratorischen syndrom
ES2102971B1 (es) * 1996-01-25 1998-03-01 Hipra Lab Sa Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.
US6015663A (en) * 1996-03-01 2000-01-18 The United States Of America As Represented By The Secretary Of Agriculture Restriction enzyme screen for differentiating porcine reproductive and respiratory syndrome virus strains
US5866401A (en) * 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US5976537A (en) * 1996-07-02 1999-11-02 The United States Of America As Represented By The Secretary Of Agriculture Porcine reproductive and respiratory syndrome vaccine
PT835930E (pt) * 1996-10-09 2001-06-29 Akzo Nobel Nv Estirpes europeias de vacina do virus do sindroma reprodutivo e respiratorio porcino (prrsv)
DE69837992T2 (de) * 1997-05-06 2008-03-20 Boehringer Ingelheim Vetmedica Gmbh Prrsv-antigene, die auf peptidsequenzen des prrs-virus basieren, für die verwendung als impfstoff und für diagnostische tests
US5970537A (en) * 1998-02-03 1999-10-26 Hickory Springs Manufacturing Co. Folding bed frame structure and method of fabricating same
US6403102B1 (en) * 1998-10-29 2002-06-11 Connaught Laboratories Limited Chlamydia antigens and corresponding DNA fragments and uses thereof

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EP0595436B1 (de) 2007-05-23
EP0595436A2 (de) 1994-05-04
US20070269445A1 (en) 2007-11-22
CN1087175C (zh) 2002-07-10
JP4125385B2 (ja) 2008-07-30
JPH07138186A (ja) 1995-05-30
CN1096223A (zh) 1994-12-14
ES2286815T3 (es) 2007-12-01
AU5037593A (en) 1994-05-12
DE69334141T2 (de) 2008-01-24
US6110467A (en) 2000-08-29
AU672825B2 (en) 1996-10-17
EP0595436A3 (de) 1994-11-23
US7517976B2 (en) 2009-04-14
CA2102036A1 (en) 1994-05-01
MXPA93006804A (es) 2003-05-30
TW497973B (en) 2002-08-11
TW517085B (en) 2003-01-11
BR9304453A (pt) 1994-06-14
CA2102036C (en) 2004-02-24
US5695766A (en) 1997-12-09
DK0595436T3 (da) 2007-09-03
US6251404B1 (en) 2001-06-26

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