DE69333345T2 - Verfahren zur herstellung von mikrokapseln - Google Patents

Verfahren zur herstellung von mikrokapseln Download PDF

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Publication number
DE69333345T2
DE69333345T2 DE69333345T DE69333345T DE69333345T2 DE 69333345 T2 DE69333345 T2 DE 69333345T2 DE 69333345 T DE69333345 T DE 69333345T DE 69333345 T DE69333345 T DE 69333345T DE 69333345 T2 DE69333345 T2 DE 69333345T2
Authority
DE
Germany
Prior art keywords
microspheres
wall
forming material
microsphere
producing microcapsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69333345T
Other languages
English (en)
Other versions
DE69333345D1 (de
Inventor
Andrew Derek Sutton
Richard Alan Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
Quadrant Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10723265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69333345(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quadrant Drug Delivery Ltd filed Critical Quadrant Drug Delivery Ltd
Publication of DE69333345D1 publication Critical patent/DE69333345D1/de
Application granted granted Critical
Publication of DE69333345T2 publication Critical patent/DE69333345T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Gyroscopes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Sorption Type Refrigeration Machines (AREA)
  • Luminescent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69333345T 1992-10-10 1993-10-08 Verfahren zur herstellung von mikrokapseln Revoked DE69333345T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929221329A GB9221329D0 (en) 1992-10-10 1992-10-10 Preparation of further diagnostic agents
PCT/GB1993/002091 WO1994008627A1 (en) 1992-10-10 1993-10-08 Preparation of further diagnostic agents

Publications (2)

Publication Number Publication Date
DE69333345D1 DE69333345D1 (de) 2004-01-22
DE69333345T2 true DE69333345T2 (de) 2004-10-07

Family

ID=10723265

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69334304T Expired - Lifetime DE69334304D1 (de) 1992-10-10 1993-10-08 Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäure
DE69333345T Revoked DE69333345T2 (de) 1992-10-10 1993-10-08 Verfahren zur herstellung von mikrokapseln

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69334304T Expired - Lifetime DE69334304D1 (de) 1992-10-10 1993-10-08 Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäure

Country Status (11)

Country Link
US (7) US6344182B1 (de)
EP (2) EP0663840B1 (de)
JP (2) JPH08505366A (de)
AT (2) ATE451127T1 (de)
CA (1) CA2146783C (de)
DE (2) DE69334304D1 (de)
DK (1) DK0663840T3 (de)
ES (2) ES2214477T3 (de)
GB (4) GB9221329D0 (de)
HK (3) HK1007960A1 (de)
WO (1) WO1994008627A1 (de)

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ATE255911T1 (de) 2003-12-15
DE69333345D1 (de) 2004-01-22
EP1226832B1 (de) 2009-12-09
EP0663840B1 (de) 2003-12-10
GB2302650A (en) 1997-01-29
DK0663840T3 (da) 2004-03-29
CA2146783C (en) 2009-05-26
EP1226832A3 (de) 2004-01-02
GB2302649B (en) 1997-04-09
ATE451127T1 (de) 2009-12-15
GB9507191D0 (en) 1995-05-31
GB9221329D0 (en) 1992-11-25
GB2286122A (en) 1995-08-09
EP1226832A2 (de) 2002-07-31
US6015546A (en) 2000-01-18
ES2214477T3 (es) 2004-09-16
CA2146783A1 (en) 1994-04-28
US6416741B1 (en) 2002-07-09
US20050238586A1 (en) 2005-10-27
US6939530B2 (en) 2005-09-06
HK1007959A1 (en) 1999-04-30
GB9616116D0 (en) 1996-09-11
US6348186B1 (en) 2002-02-19
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JPH08505366A (ja) 1996-06-11
US6344182B1 (en) 2002-02-05
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US20030133876A1 (en) 2003-07-17
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US5957848A (en) 1999-09-28
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