DE69332987T2 - Verbindungen verwendbar für die Behandlung von Allergien und Entzündungskrankheiten - Google Patents
Verbindungen verwendbar für die Behandlung von Allergien und Entzündungskrankheiten Download PDFInfo
- Publication number
- DE69332987T2 DE69332987T2 DE69332987T DE69332987T DE69332987T2 DE 69332987 T2 DE69332987 T2 DE 69332987T2 DE 69332987 T DE69332987 T DE 69332987T DE 69332987 T DE69332987 T DE 69332987T DE 69332987 T2 DE69332987 T2 DE 69332987T2
- Authority
- DE
- Germany
- Prior art keywords
- cyano
- methoxyphenyl
- cis
- cyclohexane
- cyclopropylmethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- -1 2 -cyclopropyl- Chemical group 0.000 claims description 227
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims description 30
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 15
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 11
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 125000005843 halogen group Chemical group 0.000 claims description 7
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86203092A | 1992-04-02 | 1992-04-02 | |
| US862030 | 1992-04-02 | ||
| US96876292A | 1992-10-30 | 1992-10-30 | |
| US968762 | 1992-10-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69332987D1 DE69332987D1 (de) | 2003-06-18 |
| DE69332987T2 true DE69332987T2 (de) | 2004-05-19 |
Family
ID=27127661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69332987T Expired - Lifetime DE69332987T2 (de) | 1992-04-02 | 1993-03-05 | Verbindungen verwendbar für die Behandlung von Allergien und Entzündungskrankheiten |
| DE69330206T Expired - Lifetime DE69330206T2 (de) | 1992-04-02 | 1993-03-05 | Verbindungen zur behandlung von allergischen und entzündlichen erkrankungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69330206T Expired - Lifetime DE69330206T2 (de) | 1992-04-02 | 1993-03-05 | Verbindungen zur behandlung von allergischen und entzündlichen erkrankungen |
Country Status (16)
| Country | Link |
|---|---|
| EP (3) | EP1380571A1 (enExample) |
| JP (1) | JP2873090B2 (enExample) |
| KR (1) | KR950700731A (enExample) |
| AT (2) | ATE200980T1 (enExample) |
| AU (2) | AU705566B2 (enExample) |
| CY (2) | CY2331B1 (enExample) |
| DE (2) | DE69332987T2 (enExample) |
| DK (2) | DK0633776T3 (enExample) |
| ES (2) | ES2197421T3 (enExample) |
| MA (1) | MA22859A1 (enExample) |
| MY (1) | MY109561A (enExample) |
| OA (1) | OA10101A (enExample) |
| PH (1) | PH31379A (enExample) |
| PT (2) | PT919544E (enExample) |
| RO (1) | RO115872B1 (enExample) |
| RU (1) | RU2136656C1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005187458A (ja) * | 2003-12-04 | 2005-07-14 | Santen Pharmaceut Co Ltd | シロミラストまたはその塩を有効成分とする掻痒治療剤 |
| WO2005053672A1 (ja) * | 2003-12-04 | 2005-06-16 | Santen Pharmaceutical Co., Ltd. | シロミラストまたはその塩を有効成分とする掻痒治療剤 |
| UA106422C2 (uk) * | 2006-07-05 | 2014-08-26 | Такеда Гмбх | КОМБІНОВАНЕ ЗАСТОСУВАННЯ ІНГІБІТОРА PDE4 ТА ІНГІБІТОРА HMG-CоA-РЕДУКТАЗИ ДЛЯ ПРОФІЛАКТИКИ АБО ЗЦІЛЮВАЛЬНОГО ЛІКУВАННЯ ЗАПАЛЬНОГО ЗАХВОРЮВАННЯ ЛЕГЕНІВ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1793383C3 (de) * | 1968-09-10 | 1979-03-01 | Knoll Ag, 6700 Ludwigshafen | 4-Cyan-4-phenyl-aminocyclohexane und deren wasserlösliche Salze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4795757A (en) * | 1984-09-04 | 1989-01-03 | Rorer Pharmaceutical Corporation | Bisarylamines |
| DE3621581A1 (de) * | 1986-06-27 | 1988-01-07 | Merck Patent Gmbh | Polymerisierbare fluessigkristallmaterialien |
| US5096906A (en) * | 1986-12-31 | 1992-03-17 | University Of Virginia Alumni Patents Foundation | Method of inhibiting the activity of leukocyte derived cytokines |
| WO1993019751A1 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
| EP0634930A4 (en) * | 1992-04-02 | 1995-02-22 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases. |
| EP0633771A4 (en) * | 1992-04-02 | 1995-02-22 | Smithkline Beecham Corporation | Compounds. |
-
1993
- 1993-03-05 DK DK93907233T patent/DK0633776T3/da active
- 1993-03-05 DK DK98204466T patent/DK0919544T3/da active
- 1993-03-05 RO RO94-01601A patent/RO115872B1/ro unknown
- 1993-03-05 EP EP03076447A patent/EP1380571A1/en not_active Withdrawn
- 1993-03-05 EP EP98204466A patent/EP0919544B1/en not_active Expired - Lifetime
- 1993-03-05 DE DE69332987T patent/DE69332987T2/de not_active Expired - Lifetime
- 1993-03-05 ES ES98204466T patent/ES2197421T3/es not_active Expired - Lifetime
- 1993-03-05 AT AT93907233T patent/ATE200980T1/de active
- 1993-03-05 PT PT98204466T patent/PT919544E/pt unknown
- 1993-03-05 EP EP03076446A patent/EP1420011A1/en not_active Withdrawn
- 1993-03-05 AT AT98204466T patent/ATE240290T1/de active
- 1993-03-05 JP JP5517446A patent/JP2873090B2/ja not_active Expired - Lifetime
- 1993-03-05 PT PT93907233T patent/PT633776E/pt unknown
- 1993-03-05 ES ES93907233T patent/ES2157923T3/es not_active Expired - Lifetime
- 1993-03-05 RU RU94045291A patent/RU2136656C1/ru active
- 1993-03-05 DE DE69330206T patent/DE69330206T2/de not_active Expired - Lifetime
- 1993-03-29 PH PH45956A patent/PH31379A/en unknown
- 1993-03-31 MY MYPI93000561A patent/MY109561A/en unknown
- 1993-04-01 MA MA23150A patent/MA22859A1/fr unknown
-
1994
- 1994-09-29 OA OA60565A patent/OA10101A/en unknown
- 1994-10-04 KR KR1019940703523A patent/KR950700731A/ko active Granted
-
1997
- 1997-08-08 AU AU33229/97A patent/AU705566B2/en not_active Expired
-
1999
- 1999-06-24 AU AU36759/99A patent/AU724115B2/en not_active Expired
-
2002
- 2002-11-05 CY CY0200061A patent/CY2331B1/xx unknown
-
2004
- 2004-08-27 CY CY0400066A patent/CY2474B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY2474B1 (en) | 2005-06-03 |
| AU3675999A (en) | 1999-08-19 |
| AU705566B2 (en) | 1999-05-27 |
| RU94045291A (ru) | 1996-09-27 |
| OA10101A (en) | 1996-12-18 |
| DK0919544T3 (da) | 2003-09-15 |
| KR100344711B1 (enExample) | 2003-05-01 |
| PT633776E (pt) | 2001-10-31 |
| ES2197421T3 (es) | 2004-01-01 |
| ES2157923T3 (es) | 2001-09-01 |
| CY2331B1 (en) | 2004-02-06 |
| MY109561A (en) | 1997-02-28 |
| JPH07508508A (ja) | 1995-09-21 |
| ATE200980T1 (de) | 2001-05-15 |
| DE69330206T2 (de) | 2002-02-14 |
| EP1380571A1 (en) | 2004-01-14 |
| RO115872B1 (ro) | 2000-07-28 |
| HK1022467A1 (en) | 2000-08-11 |
| DK0633776T3 (da) | 2001-08-27 |
| RU2136656C1 (ru) | 1999-09-10 |
| AU3322997A (en) | 1997-10-23 |
| EP1420011A1 (en) | 2004-05-19 |
| HK1012263A1 (en) | 1999-07-30 |
| PT919544E (pt) | 2003-09-30 |
| EP0919544B1 (en) | 2003-05-14 |
| ATE240290T1 (de) | 2003-05-15 |
| MA22859A1 (fr) | 1993-12-31 |
| KR950700731A (ko) | 1995-02-20 |
| PH31379A (en) | 1998-10-29 |
| DE69330206D1 (de) | 2001-06-13 |
| EP0919544A1 (en) | 1999-06-02 |
| AU724115B2 (en) | 2000-09-14 |
| DE69332987D1 (de) | 2003-06-18 |
| JP2873090B2 (ja) | 1999-03-24 |
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| 8364 | No opposition during term of opposition |