DE69330206D1 - Verbindungen zur behandlung von allergischen und entzündlichen erkrankungen - Google Patents
Verbindungen zur behandlung von allergischen und entzündlichen erkrankungenInfo
- Publication number
- DE69330206D1 DE69330206D1 DE69330206T DE69330206T DE69330206D1 DE 69330206 D1 DE69330206 D1 DE 69330206D1 DE 69330206 T DE69330206 T DE 69330206T DE 69330206 T DE69330206 T DE 69330206T DE 69330206 D1 DE69330206 D1 DE 69330206D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- allergic
- connections
- useful
- inflammatory diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- External Artificial Organs (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86203092A | 1992-04-02 | 1992-04-02 | |
US96876292A | 1992-10-30 | 1992-10-30 | |
PCT/US1993/001991 WO1993019749A1 (en) | 1992-04-02 | 1993-03-05 | Compounds useful for treating allergic and inflammatory diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69330206D1 true DE69330206D1 (de) | 2001-06-13 |
DE69330206T2 DE69330206T2 (de) | 2002-02-14 |
Family
ID=27127661
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69332987T Expired - Lifetime DE69332987T2 (de) | 1992-04-02 | 1993-03-05 | Verbindungen verwendbar für die Behandlung von Allergien und Entzündungskrankheiten |
DE69330206T Expired - Lifetime DE69330206T2 (de) | 1992-04-02 | 1993-03-05 | Verbindungen zur behandlung von allergischen und entzündlichen erkrankungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69332987T Expired - Lifetime DE69332987T2 (de) | 1992-04-02 | 1993-03-05 | Verbindungen verwendbar für die Behandlung von Allergien und Entzündungskrankheiten |
Country Status (17)
Country | Link |
---|---|
EP (3) | EP0919544B1 (de) |
JP (1) | JP2873090B2 (de) |
KR (1) | KR950700731A (de) |
AT (2) | ATE240290T1 (de) |
AU (2) | AU705566B2 (de) |
CY (2) | CY2331B1 (de) |
DE (2) | DE69332987T2 (de) |
DK (2) | DK0919544T3 (de) |
ES (2) | ES2157923T3 (de) |
HK (2) | HK1012263A1 (de) |
MA (1) | MA22859A1 (de) |
MY (1) | MY109561A (de) |
OA (1) | OA10101A (de) |
PH (1) | PH31379A (de) |
PT (2) | PT633776E (de) |
RO (1) | RO115872B1 (de) |
RU (1) | RU2136656C1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005187458A (ja) * | 2003-12-04 | 2005-07-14 | Santen Pharmaceut Co Ltd | シロミラストまたはその塩を有効成分とする掻痒治療剤 |
WO2005053672A1 (ja) * | 2003-12-04 | 2005-06-16 | Santen Pharmaceutical Co., Ltd. | シロミラストまたはその塩を有効成分とする掻痒治療剤 |
CN101484166B (zh) * | 2006-07-05 | 2012-09-05 | 奈科明有限责任公司 | 用于治疗炎症性肺部疾病的HMG-CoA还原酶抑制剂与磷酸二酯酶4抑制剂的组合 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4795757A (en) * | 1984-09-04 | 1989-01-03 | Rorer Pharmaceutical Corporation | Bisarylamines |
US5096906A (en) * | 1986-12-31 | 1992-03-17 | University Of Virginia Alumni Patents Foundation | Method of inhibiting the activity of leukocyte derived cytokines |
EP0633771A4 (en) * | 1992-04-02 | 1995-02-22 | Smithkline Beecham Corporation | Compounds. |
WO1993019751A1 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
US5602173A (en) * | 1992-04-02 | 1997-02-11 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
-
1993
- 1993-03-05 RO RO94-01601A patent/RO115872B1/ro unknown
- 1993-03-05 DE DE69332987T patent/DE69332987T2/de not_active Expired - Lifetime
- 1993-03-05 EP EP98204466A patent/EP0919544B1/de not_active Expired - Lifetime
- 1993-03-05 AT AT98204466T patent/ATE240290T1/de active
- 1993-03-05 DK DK98204466T patent/DK0919544T3/da active
- 1993-03-05 PT PT93907233T patent/PT633776E/pt unknown
- 1993-03-05 PT PT98204466T patent/PT919544E/pt unknown
- 1993-03-05 ES ES93907233T patent/ES2157923T3/es not_active Expired - Lifetime
- 1993-03-05 JP JP5517446A patent/JP2873090B2/ja not_active Expired - Lifetime
- 1993-03-05 AT AT93907233T patent/ATE200980T1/de active
- 1993-03-05 DE DE69330206T patent/DE69330206T2/de not_active Expired - Lifetime
- 1993-03-05 EP EP03076446A patent/EP1420011A1/de not_active Withdrawn
- 1993-03-05 EP EP03076447A patent/EP1380571A1/de not_active Withdrawn
- 1993-03-05 ES ES98204466T patent/ES2197421T3/es not_active Expired - Lifetime
- 1993-03-05 DK DK93907233T patent/DK0633776T3/da active
- 1993-03-05 RU RU94045291A patent/RU2136656C1/ru active
- 1993-03-29 PH PH45956A patent/PH31379A/en unknown
- 1993-03-31 MY MYPI93000561A patent/MY109561A/en unknown
- 1993-04-01 MA MA23150A patent/MA22859A1/fr unknown
-
1994
- 1994-09-29 OA OA60565A patent/OA10101A/en unknown
- 1994-10-04 KR KR1019940703523A patent/KR950700731A/ko not_active IP Right Cessation
-
1997
- 1997-08-08 AU AU33229/97A patent/AU705566B2/en not_active Expired
-
1998
- 1998-12-15 HK HK98113533A patent/HK1012263A1/xx not_active IP Right Cessation
-
1999
- 1999-06-24 AU AU36759/99A patent/AU724115B2/en not_active Expired
- 1999-12-01 HK HK99105589A patent/HK1022467A1/xx not_active IP Right Cessation
-
2002
- 2002-11-05 CY CY0200061A patent/CY2331B1/xx unknown
-
2004
- 2004-08-27 CY CY0400066A patent/CY2474B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PT633776E (pt) | 2001-10-31 |
KR950700731A (ko) | 1995-02-20 |
JP2873090B2 (ja) | 1999-03-24 |
OA10101A (en) | 1996-12-18 |
HK1022467A1 (en) | 2000-08-11 |
AU3675999A (en) | 1999-08-19 |
ES2197421T3 (es) | 2004-01-01 |
EP0919544A1 (de) | 1999-06-02 |
KR100344711B1 (de) | 2003-05-01 |
CY2331B1 (en) | 2004-02-06 |
CY2474B1 (en) | 2005-06-03 |
EP1420011A1 (de) | 2004-05-19 |
DE69332987T2 (de) | 2004-05-19 |
DE69330206T2 (de) | 2002-02-14 |
DK0633776T3 (da) | 2001-08-27 |
AU3322997A (en) | 1997-10-23 |
ATE240290T1 (de) | 2003-05-15 |
EP1380571A1 (de) | 2004-01-14 |
ES2157923T3 (es) | 2001-09-01 |
MA22859A1 (fr) | 1993-12-31 |
ATE200980T1 (de) | 2001-05-15 |
DK0919544T3 (da) | 2003-09-15 |
HK1012263A1 (en) | 1999-07-30 |
AU705566B2 (en) | 1999-05-27 |
JPH07508508A (ja) | 1995-09-21 |
PT919544E (pt) | 2003-09-30 |
AU724115B2 (en) | 2000-09-14 |
MY109561A (en) | 1997-02-28 |
PH31379A (en) | 1998-10-29 |
DE69332987D1 (de) | 2003-06-18 |
RO115872B1 (ro) | 2000-07-28 |
RU94045291A (ru) | 1996-09-27 |
RU2136656C1 (ru) | 1999-09-10 |
EP0919544B1 (de) | 2003-05-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |