ATE197043T1 - Pyrimidinyl-essigsäureamide als elastase inhibitoren - Google Patents
Pyrimidinyl-essigsäureamide als elastase inhibitorenInfo
- Publication number
- ATE197043T1 ATE197043T1 AT92307389T AT92307389T ATE197043T1 AT E197043 T1 ATE197043 T1 AT E197043T1 AT 92307389 T AT92307389 T AT 92307389T AT 92307389 T AT92307389 T AT 92307389T AT E197043 T1 ATE197043 T1 AT E197043T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted heterocycles
- pyrimidinyl
- acid amides
- elastase inhibitors
- hle
- Prior art date
Links
- -1 PYRIMIDINYL ACID AMIDES Chemical class 0.000 title 1
- 239000003602 elastase inhibitor Substances 0.000 title 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 102100033174 Neutrophil elastase Human genes 0.000 abstract 3
- 102000052502 human ELANE Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Nonmetallic Welding Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919117641A GB9117641D0 (en) | 1991-08-15 | 1991-08-15 | Substituted heterocycles |
| GB929208378A GB9208378D0 (en) | 1992-04-16 | 1992-04-16 | Substituted heterocycles |
| GB929214447A GB9214447D0 (en) | 1992-07-08 | 1992-07-08 | Substituted heterocycles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE197043T1 true ATE197043T1 (de) | 2000-11-15 |
Family
ID=27265822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92307389T ATE197043T1 (de) | 1991-08-15 | 1992-08-12 | Pyrimidinyl-essigsäureamide als elastase inhibitoren |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5254558A (de) |
| EP (1) | EP0528633B1 (de) |
| JP (1) | JPH05286946A (de) |
| KR (1) | KR930004276A (de) |
| AT (1) | ATE197043T1 (de) |
| CA (1) | CA2076226C (de) |
| CZ (1) | CZ251792A3 (de) |
| DE (1) | DE69231513T2 (de) |
| FI (1) | FI923661A7 (de) |
| GB (1) | GB9216272D0 (de) |
| HU (1) | HUT61732A (de) |
| IE (1) | IE922586A1 (de) |
| IL (1) | IL102805A0 (de) |
| NO (1) | NO923197L (de) |
| NZ (1) | NZ243950A (de) |
| ZW (1) | ZW13292A1 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521179A (en) * | 1991-04-18 | 1996-05-28 | Zeneca Limited | Heterocyclic amides |
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| CA2133657A1 (en) * | 1992-04-16 | 1993-10-28 | Peter R. Bernstein | Substituted derivatives |
| US5486529A (en) * | 1992-04-16 | 1996-01-23 | Zeneca Limited | Certain pyridyl ketones for treating diseases involving leukocyte elastase |
| GB9211783D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
| GB9214053D0 (en) * | 1992-07-02 | 1992-08-12 | Ici Plc | Heterocyclic amides |
| US6100238A (en) * | 1994-11-21 | 2000-08-08 | Cortech Inc. | Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors |
| US6001811A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors--N-substituted derivatives |
| US6015791A (en) * | 1994-11-21 | 2000-01-18 | Cortech Inc. | Serine protease inhibitors-cycloheptane derivatives |
| US6001814A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Serine protease inhibitors |
| US6150334A (en) * | 1994-11-21 | 2000-11-21 | Cortech, Inc. | Serine protease inhibitors-tripeptoid analogs |
| US20020119985A1 (en) | 1994-11-21 | 2002-08-29 | Albert Gyorkos | Serine protease inhibitors |
| US6001813A (en) * | 1994-11-21 | 1999-12-14 | Cortech Inc. | Val-pro containing α-keto oxadiazoles as serine protease inhibitors |
| US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
| US5998379A (en) * | 1994-11-21 | 1999-12-07 | Cortech Inc. | Serine protease inhibitors-proline analogs |
| US5656645A (en) * | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
| US5658930A (en) * | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
| US5948785A (en) * | 1995-04-27 | 1999-09-07 | The Green Cross Corporation | Heterocyclic amide compounds and pharmaceutical use of the same |
| EP0936216A4 (de) | 1996-09-06 | 2003-01-02 | Nippon Kayaku Kk | Neue acetamid derivate und protease inhibitoren |
| US6080738A (en) * | 1996-10-25 | 2000-06-27 | Yoshitomi Pharmaceuticals Industries, Ltd. | Heterocyclic amide compounds and medicinal uses thereof |
| CN1247542A (zh) * | 1996-12-06 | 2000-03-15 | 康泰驰公司 | 丝氨酸蛋白酶抑制剂 |
| US6656910B2 (en) | 1997-12-04 | 2003-12-02 | Cortech, Inc. | Serine protease inhibitors |
| CA2321146A1 (en) | 1998-02-17 | 1999-08-19 | Nippon Kayaku Kabushiki Kaisha | Novel acetamide derivative and use thereof |
| AU2746999A (en) | 1998-03-11 | 1999-09-27 | Welfide Corporation | Ige antibody production inhibitors and autoimmune diseases inhibitors |
| KR20010078725A (ko) | 1998-06-03 | 2001-08-21 | 존 더블류. 갈루치 2세 | 세린 프로테아제 저해제로서의 펩토이드 및 비펩토이드를함유하는 알파-케토 옥사디아졸 |
| KR20020011970A (ko) * | 1999-03-12 | 2002-02-09 | 우에노 도시오 | 피리미딘 유도체 및 그 제조 방법 |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| WO2000078812A1 (en) * | 1999-06-17 | 2000-12-28 | Source Precision Medicine, Inc. | Method and compounds for inhibiting activity of serine elastases |
| HUP0203835A3 (en) * | 1999-09-27 | 2003-07-28 | Ono Pharmaceutical Co | Pyrimidine derivatives, process for preparing the derivatives and drugs containing the same as the active ingredient |
| US6852761B2 (en) | 2000-03-13 | 2005-02-08 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| CA2405306A1 (en) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| PT1268463E (pt) | 2000-04-05 | 2005-05-31 | Pharmacia Corp | 4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao |
| US20040171616A9 (en) | 2000-04-17 | 2004-09-02 | South Michael S. | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| AU2001222501A1 (en) * | 2000-05-18 | 2001-11-26 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| WO2002006242A2 (en) * | 2000-07-18 | 2002-01-24 | Neurogen Corporation | 5-substituted 2-aryl-4-pyrimidinones |
| JP2004517074A (ja) | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類 |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| WO2002051815A1 (en) * | 2000-12-26 | 2002-07-04 | Ono Pharmaceutical Co., Ltd. | Pyrimidine derivatives and process for preparing the same |
| CA2462305A1 (en) | 2001-10-03 | 2003-04-10 | Michael S. South | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| EP1432687A2 (de) | 2001-10-03 | 2004-06-30 | Pharmacia Corporation | Substitutierte fünfgliedrige polyzyclischen vebindungen für die selektive hemmung der koagulationskaskade |
| PL375647A1 (en) | 2002-09-10 | 2005-12-12 | Bayer Healthcare Ag | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes |
| TW200500341A (en) * | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
-
1992
- 1992-07-30 GB GB929216272A patent/GB9216272D0/en active Pending
- 1992-08-12 AT AT92307389T patent/ATE197043T1/de not_active IP Right Cessation
- 1992-08-12 DE DE69231513T patent/DE69231513T2/de not_active Expired - Fee Related
- 1992-08-12 EP EP92307389A patent/EP0528633B1/de not_active Expired - Lifetime
- 1992-08-14 ZW ZW132/92A patent/ZW13292A1/xx unknown
- 1992-08-14 US US07/930,568 patent/US5254558A/en not_active Expired - Lifetime
- 1992-08-14 CA CA002076226A patent/CA2076226C/en not_active Expired - Fee Related
- 1992-08-14 NZ NZ243950A patent/NZ243950A/en unknown
- 1992-08-14 HU HU9202640A patent/HUT61732A/hu unknown
- 1992-08-14 IL IL102805A patent/IL102805A0/xx unknown
- 1992-08-14 KR KR1019920014728A patent/KR930004276A/ko not_active Withdrawn
- 1992-08-14 NO NO92923197A patent/NO923197L/no unknown
- 1992-08-14 CZ CS922517A patent/CZ251792A3/cs unknown
- 1992-08-14 IE IE258692A patent/IE922586A1/en not_active IP Right Cessation
- 1992-08-14 FI FI923661A patent/FI923661A7/fi not_active Application Discontinuation
- 1992-08-17 JP JP4260490A patent/JPH05286946A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB9216272D0 (en) | 1992-09-09 |
| EP0528633A1 (de) | 1993-02-24 |
| US5254558A (en) | 1993-10-19 |
| IL102805A0 (en) | 1993-01-31 |
| FI923661A0 (fi) | 1992-08-14 |
| FI923661A7 (fi) | 1993-02-16 |
| HU9202640D0 (en) | 1992-10-28 |
| ZW13292A1 (en) | 1993-05-05 |
| HUT61732A (en) | 1993-03-01 |
| IE922586A1 (en) | 1993-02-24 |
| JPH05286946A (ja) | 1993-11-02 |
| NZ243950A (en) | 1995-05-26 |
| CA2076226C (en) | 2004-09-21 |
| KR930004276A (ko) | 1993-03-22 |
| CA2076226A1 (en) | 1993-02-16 |
| CZ251792A3 (en) | 1993-02-17 |
| DE69231513D1 (de) | 2000-11-23 |
| NO923197D0 (no) | 1992-08-14 |
| NO923197L (no) | 1993-02-16 |
| EP0528633B1 (de) | 2000-10-18 |
| DE69231513T2 (de) | 2001-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE197043T1 (de) | Pyrimidinyl-essigsäureamide als elastase inhibitoren | |
| TW262475B (en) | Heterocyclic amides, intermediates and process for their preparation and pharmaceutical compositions containing them | |
| DE69319238D1 (de) | Lactampeptide mit hfl inhibierender aktivität | |
| AU3959693A (en) | Alpha-aminoboronic acid peptides and their use as elastase inhibitors | |
| GB9307555D0 (en) | Heterocyclic compounds | |
| FI946202A0 (fi) | Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan | |
| GB9211783D0 (en) | Amide derivatives | |
| ATE105302T1 (de) | Fluoramid-derivate mit hemmender aktivitaet gegen menschliche leukozytenelastase. | |
| DE69010079D1 (de) | Trifluoroketopeptidderivate, benutzbar als Hemmer von menschlicher Elastase aus Leukozyten. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |