DE69326192T2 - Halichondrine: zytotoxische Polyäther-Makrolide - Google Patents

Halichondrine: zytotoxische Polyäther-Makrolide

Info

Publication number
DE69326192T2
DE69326192T2 DE69326192T DE69326192T DE69326192T2 DE 69326192 T2 DE69326192 T2 DE 69326192T2 DE 69326192 T DE69326192 T DE 69326192T DE 69326192 T DE69326192 T DE 69326192T DE 69326192 T2 DE69326192 T2 DE 69326192T2
Authority
DE
Germany
Prior art keywords
cytotoxic
halichondrine
macrolides
polyether
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69326192T
Other languages
English (en)
Other versions
DE69326192D1 (de
Inventor
Dolores Garcia C O Ph Gravalos
Robin John Lake
John Wilson Blunt
Murray Herbert Gibson Munro
Marc Stephane Philibe Litaudon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmamar SA filed Critical Pharmamar SA
Application granted granted Critical
Publication of DE69326192D1 publication Critical patent/DE69326192D1/de
Publication of DE69326192T2 publication Critical patent/DE69326192T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Dental Preparations (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69326192T 1992-03-23 1993-03-22 Halichondrine: zytotoxische Polyäther-Makrolide Expired - Fee Related DE69326192T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929206244A GB9206244D0 (en) 1992-03-23 1992-03-23 Cytotoxic compound from a marine sponge

Publications (2)

Publication Number Publication Date
DE69326192D1 DE69326192D1 (de) 1999-10-07
DE69326192T2 true DE69326192T2 (de) 2000-05-04

Family

ID=10712627

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69326192T Expired - Fee Related DE69326192T2 (de) 1992-03-23 1993-03-22 Halichondrine: zytotoxische Polyäther-Makrolide

Country Status (12)

Country Link
US (1) US5786492A (de)
EP (1) EP0572109B1 (de)
JP (1) JP3168098B2 (de)
AT (1) ATE184009T1 (de)
AU (1) AU671818B2 (de)
CA (1) CA2092108A1 (de)
DE (1) DE69326192T2 (de)
DK (1) DK0572109T3 (de)
ES (1) ES2138993T3 (de)
GB (1) GB9206244D0 (de)
GR (1) GR3031981T3 (de)
ZA (1) ZA932061B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
KR100798600B1 (ko) * 1998-06-17 2008-01-28 에자이 가부시키가이샤 마크로시클릭 유사체 및 그들의 이용 및 제조방법
US8097648B2 (en) 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
CA2567984C (en) 2004-06-03 2014-05-20 Eisai Co., Ltd. Intermediates for the preparation of analogs of halichondrin b
CN104311571B (zh) * 2007-10-03 2019-07-02 卫材R&D管理有限公司 用于合成软海绵素b类似物的中间体和方法
MX2010010902A (es) 2008-04-04 2010-12-21 Eisai R&D Man Co Ltd Analogos de halicondrina b.
BRPI0916446A2 (pt) * 2008-07-15 2018-09-11 Basf Corp dispositivo, sistema, composição e método para a distribuição de uma composição de dióxido de cloro substancialmente isenta de ânion de oxi- cloro a um tecido
CN102803254B (zh) 2010-01-26 2016-09-14 卫材R&D管理有限公司 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物
RU2710545C2 (ru) 2013-11-04 2019-12-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Реакции макроциклизации и промежуточные соединения и другие фрагменты, пригодные в получении аналогов халихондрина b
MX370611B (es) 2013-12-06 2019-12-18 Eisai R&D Man Co Ltd Metodos utiles en la sintesis de analogos de halicondrina b.
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
US10308661B2 (en) 2015-05-07 2019-06-04 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
MX2018009794A (es) 2016-02-12 2018-12-17 Eisai R&D Man Co Ltd Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados.
MX2018016329A (es) 2016-06-30 2019-09-18 Eisai R&D Man Co Ltd Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos.
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
TWI781163B (zh) 2017-04-05 2022-10-21 哈佛大學校長及研究員協會 巨環化合物及其用途
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
EP3649135B1 (de) 2017-07-06 2022-12-28 President and Fellows of Harvard College Synthese von halichondrinen
WO2019099646A1 (en) 2017-11-15 2019-05-23 President And Fellows Of Harvard College Macrocyclic compounds and uses thereof
US11419856B2 (en) 2017-11-20 2022-08-23 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
MX2020006945A (es) 2018-01-03 2020-11-09 Eisai R&D Man Co Ltd Reaccion de prins y compuestos utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos.

Also Published As

Publication number Publication date
ATE184009T1 (de) 1999-09-15
ZA932061B (en) 1993-10-19
EP0572109A1 (de) 1993-12-01
GB9206244D0 (en) 1992-05-06
JP3168098B2 (ja) 2001-05-21
ES2138993T3 (es) 2000-02-01
CA2092108A1 (en) 1993-09-24
EP0572109B1 (de) 1999-09-01
DK0572109T3 (da) 2000-03-27
US5786492A (en) 1998-07-28
AU3543393A (en) 1993-09-30
AU671818B2 (en) 1996-09-12
JPH06122687A (ja) 1994-05-06
DE69326192D1 (de) 1999-10-07
GR3031981T3 (en) 2000-03-31

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee