ES2138993T3 - Halicondrinas: macrolidos de polieter citotoxicos. - Google Patents

Halicondrinas: macrolidos de polieter citotoxicos.

Info

Publication number
ES2138993T3
ES2138993T3 ES93302148T ES93302148T ES2138993T3 ES 2138993 T3 ES2138993 T3 ES 2138993T3 ES 93302148 T ES93302148 T ES 93302148T ES 93302148 T ES93302148 T ES 93302148T ES 2138993 T3 ES2138993 T3 ES 2138993T3
Authority
ES
Spain
Prior art keywords
halicondrinas
citotoxicos
polyeter
macrolides
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93302148T
Other languages
English (en)
Inventor
Dolores Garcia Gravalos
Robin John Lake
John Wilson Blunt
Murray Herbert Gibson Munro
Marc Stephane Philibe Litaudon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmamar SA filed Critical Pharmamar SA
Application granted granted Critical
Publication of ES2138993T3 publication Critical patent/ES2138993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Dental Preparations (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

DERIVADOS DE HALICONDRINAS, ISOESTABLES DE UNA ESPONJA MARINA DE LA LISSODENDIX SP., QUE TIENE PREPARACIONES CITOTOXICAS Y SON DE FORMULA : EN LA QUE R1 Y R2 JUNTOS REPRESENTAN UN GRUPO DE LA FORMULA:
ES93302148T 1992-03-23 1993-03-22 Halicondrinas: macrolidos de polieter citotoxicos. Expired - Lifetime ES2138993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929206244A GB9206244D0 (en) 1992-03-23 1992-03-23 Cytotoxic compound from a marine sponge

Publications (1)

Publication Number Publication Date
ES2138993T3 true ES2138993T3 (es) 2000-02-01

Family

ID=10712627

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93302148T Expired - Lifetime ES2138993T3 (es) 1992-03-23 1993-03-22 Halicondrinas: macrolidos de polieter citotoxicos.

Country Status (12)

Country Link
US (1) US5786492A (es)
EP (1) EP0572109B1 (es)
JP (1) JP3168098B2 (es)
AT (1) ATE184009T1 (es)
AU (1) AU671818B2 (es)
CA (1) CA2092108A1 (es)
DE (1) DE69326192T2 (es)
DK (1) DK0572109T3 (es)
ES (1) ES2138993T3 (es)
GB (1) GB9206244D0 (es)
GR (1) GR3031981T3 (es)
ZA (1) ZA932061B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338865A (en) * 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
US8097648B2 (en) 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
WO1999065894A1 (en) * 1998-06-17 1999-12-23 Eisai Co., Ltd. Macrocyclic analogs and methods of their use and preparation
US6653341B1 (en) 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
USRE46965E1 (en) 2004-06-03 2018-07-24 Eisai R&D Management Co., Ltd. Intermediates for the preparation of analogs of Halichondrin B
BRPI0817909B1 (pt) * 2007-10-03 2022-06-21 Eisai R&D Management Co., Ltd Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos
SG189739A1 (en) 2008-04-04 2013-05-31 Eisai R&D Man Co Ltd Halichondrin b analogs
WO2010009140A2 (en) * 2008-07-15 2010-01-21 Basf Catalysts Llc Methods, systems and devices for administration of chlorine dioxide
US8203010B2 (en) 2010-01-26 2012-06-19 Eisai R&D Management Co., Ltd. Compounds useful in the synthesis of halichondrin B analogs
US9783549B2 (en) 2013-11-04 2017-10-10 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
US9303039B2 (en) 2013-12-06 2016-04-05 Eisai R&D Management Co., Ltd. Methods useful in the synthesis of halichondrin B analogs
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
US10344038B2 (en) 2015-04-30 2019-07-09 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
MX2021002629A (es) 2015-05-07 2022-05-13 Eisai R&D Man Co Ltd Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina.
MX2018009794A (es) 2016-02-12 2018-12-17 Eisai R&D Man Co Ltd Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados.
CN114805322A (zh) 2016-06-30 2022-07-29 卫材R&D管理有限公司 可用于合成软海绵素大环内酯类及其类似物的普林斯反应和中间体
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
PL3606928T3 (pl) 2017-04-05 2023-02-06 President And Fellows Of Harvard College Związek makrocykliczny i jego zastosowania
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
BR112020000141A2 (pt) 2017-07-06 2020-07-14 President And Fellows Of Harvard College síntese de halicondrinas
CN117924310A (zh) 2017-11-15 2024-04-26 哈佛大学的校长及成员们 大环化合物及其用途
EP3713565A1 (en) 2017-11-20 2020-09-30 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of neoplastic diseases
CN111868044B (zh) 2018-01-03 2024-07-19 卫材R&D管理有限公司 可用于合成软海绵素大环内酯及其类似物的普林斯反应和化合物

Also Published As

Publication number Publication date
US5786492A (en) 1998-07-28
CA2092108A1 (en) 1993-09-24
AU671818B2 (en) 1996-09-12
EP0572109B1 (en) 1999-09-01
DE69326192D1 (de) 1999-10-07
GR3031981T3 (en) 2000-03-31
DE69326192T2 (de) 2000-05-04
AU3543393A (en) 1993-09-30
EP0572109A1 (en) 1993-12-01
ATE184009T1 (de) 1999-09-15
JPH06122687A (ja) 1994-05-06
ZA932061B (en) 1993-10-19
JP3168098B2 (ja) 2001-05-21
DK0572109T3 (da) 2000-03-27
GB9206244D0 (en) 1992-05-06

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