DE69321134T2 - Plasminogen-derivate die durch thrombin aktivierbar sind - Google Patents

Plasminogen-derivate die durch thrombin aktivierbar sind

Info

Publication number
DE69321134T2
DE69321134T2 DE69321134T DE69321134T DE69321134T2 DE 69321134 T2 DE69321134 T2 DE 69321134T2 DE 69321134 T DE69321134 T DE 69321134T DE 69321134 T DE69321134 T DE 69321134T DE 69321134 T2 DE69321134 T2 DE 69321134T2
Authority
DE
Germany
Prior art keywords
thrombin
activated
amino acid
acid residue
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69321134T
Other languages
English (en)
Other versions
DE69321134D1 (de
Inventor
Richard James Gilbert
Michael George Hunter
Keith Martyn Dawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Publication of DE69321134D1 publication Critical patent/DE69321134D1/de
Application granted granted Critical
Publication of DE69321134T2 publication Critical patent/DE69321134T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE69321134T 1992-10-29 1993-10-28 Plasminogen-derivate die durch thrombin aktivierbar sind Expired - Lifetime DE69321134T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929222758A GB9222758D0 (en) 1992-10-29 1992-10-29 Proteins and nucleic acids
PCT/GB1993/002219 WO1994010318A1 (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives

Publications (2)

Publication Number Publication Date
DE69321134D1 DE69321134D1 (de) 1998-10-22
DE69321134T2 true DE69321134T2 (de) 1999-02-25

Family

ID=10724266

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69321134T Expired - Lifetime DE69321134T2 (de) 1992-10-29 1993-10-28 Plasminogen-derivate die durch thrombin aktivierbar sind

Country Status (15)

Country Link
EP (1) EP0666920B1 (de)
JP (1) JP3329340B2 (de)
AT (1) ATE171213T1 (de)
AU (1) AU674180B2 (de)
CA (1) CA2145749C (de)
DE (1) DE69321134T2 (de)
DK (1) DK0666920T3 (de)
ES (1) ES2123669T3 (de)
FI (1) FI114102B (de)
GB (1) GB9222758D0 (de)
HK (1) HK1008047A1 (de)
NO (1) NO317661B1 (de)
NZ (1) NZ257175A (de)
WO (1) WO1994010318A1 (de)
ZA (1) ZA938120B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
KR20000029755A (ko) * 1996-08-02 2000-05-25 로셰 디아그노스틱스 게엠베하 트롬빈에의해활성화될수있는플라스미노겐활성화제
DE60131450T2 (de) * 2000-12-21 2008-10-16 Thrombogenics N.V. Hefeexpressionsvektor und verfahren zur herstellung eines rekombinanten proteins durch expression in einer hefezelle
CA2475277A1 (en) * 2002-02-06 2003-08-14 Trommsdorff Gmbh & Co. Kg Arzneimittel Method for producing recombinant proteins in micro-organisms
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
CA2145749C (en) 2005-06-21
EP0666920A1 (de) 1995-08-16
NO317661B1 (no) 2004-11-29
EP0666920B1 (de) 1998-09-16
ATE171213T1 (de) 1998-10-15
HK1008047A1 (en) 1999-04-30
FI114102B (fi) 2004-08-13
DE69321134D1 (de) 1998-10-22
JP3329340B2 (ja) 2002-09-30
NZ257175A (en) 1996-07-26
AU5343294A (en) 1994-05-24
ES2123669T3 (es) 1999-01-16
CA2145749A1 (en) 1994-05-11
FI952071A0 (fi) 1995-04-28
FI952071A (fi) 1995-04-28
GB9222758D0 (en) 1992-12-09
AU674180B2 (en) 1996-12-12
DK0666920T3 (da) 1999-06-14
NO951648D0 (no) 1995-04-28
NO951648L (no) 1995-04-28
ZA938120B (en) 1994-08-01
WO1994010318A1 (en) 1994-05-11
JPH08504575A (ja) 1996-05-21

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Legal Events

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