FI952071A - Trombiinilla aktivoitava plasminogeenijohdoksia - Google Patents

Trombiinilla aktivoitava plasminogeenijohdoksia Download PDF

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Publication number
FI952071A
FI952071A FI952071A FI952071A FI952071A FI 952071 A FI952071 A FI 952071A FI 952071 A FI952071 A FI 952071A FI 952071 A FI952071 A FI 952071A FI 952071 A FI952071 A FI 952071A
Authority
FI
Finland
Prior art keywords
thrombin
amino acid
acid residue
thrombin activatable
activatable plasminogen
Prior art date
Application number
FI952071A
Other languages
English (en)
Swedish (sv)
Other versions
FI114102B (fi
FI952071A0 (fi
Inventor
Richard James Gilbert
Michael George Hulnter
Keith Martyn Dawson
Original Assignee
British Biotech Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharm filed Critical British Biotech Pharm
Publication of FI952071A publication Critical patent/FI952071A/fi
Publication of FI952071A0 publication Critical patent/FI952071A0/fi
Application granted granted Critical
Publication of FI114102B publication Critical patent/FI114102B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI952071A 1992-10-29 1995-04-28 Menetelmä trombiinin vaikutuksesta pilkkoutuvan plasminogeenianalogin valmistamiseksi FI114102B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9222758 1992-10-29
GB929222758A GB9222758D0 (en) 1992-10-29 1992-10-29 Proteins and nucleic acids
PCT/GB1993/002219 WO1994010318A1 (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives
GB9302219 1993-10-28

Publications (3)

Publication Number Publication Date
FI952071A true FI952071A (fi) 1995-04-28
FI952071A0 FI952071A0 (fi) 1995-04-28
FI114102B FI114102B (fi) 2004-08-13

Family

ID=10724266

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952071A FI114102B (fi) 1992-10-29 1995-04-28 Menetelmä trombiinin vaikutuksesta pilkkoutuvan plasminogeenianalogin valmistamiseksi

Country Status (15)

Country Link
EP (1) EP0666920B1 (fi)
JP (1) JP3329340B2 (fi)
AT (1) ATE171213T1 (fi)
AU (1) AU674180B2 (fi)
CA (1) CA2145749C (fi)
DE (1) DE69321134T2 (fi)
DK (1) DK0666920T3 (fi)
ES (1) ES2123669T3 (fi)
FI (1) FI114102B (fi)
GB (1) GB9222758D0 (fi)
HK (1) HK1008047A1 (fi)
NO (1) NO317661B1 (fi)
NZ (1) NZ257175A (fi)
WO (1) WO1994010318A1 (fi)
ZA (1) ZA938120B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
CN1226926A (zh) * 1996-08-02 1999-08-25 贝林格尔曼海姆股份有限公司 可凝血酶活化的血纤溶酶原激活物
DE60131450T2 (de) 2000-12-21 2008-10-16 Thrombogenics N.V. Hefeexpressionsvektor und verfahren zur herstellung eines rekombinanten proteins durch expression in einer hefezelle
JP2005525798A (ja) * 2002-02-06 2005-09-02 トロムスドルフ ゲーエムベーハー ウント コー．カーゲー アルツナイミッテル 微生物内での組み換えタンパク質の生産方法
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
EP0666920A1 (en) 1995-08-16
FI114102B (fi) 2004-08-13
HK1008047A1 (en) 1999-04-30
NO951648D0 (no) 1995-04-28
NO951648L (no) 1995-04-28
EP0666920B1 (en) 1998-09-16
ATE171213T1 (de) 1998-10-15
AU5343294A (en) 1994-05-24
DE69321134T2 (de) 1999-02-25
JP3329340B2 (ja) 2002-09-30
DE69321134D1 (de) 1998-10-22
CA2145749A1 (en) 1994-05-11
WO1994010318A1 (en) 1994-05-11
JPH08504575A (ja) 1996-05-21
ZA938120B (en) 1994-08-01
CA2145749C (en) 2005-06-21
ES2123669T3 (es) 1999-01-16
NO317661B1 (no) 2004-11-29
FI952071A0 (fi) 1995-04-28
AU674180B2 (en) 1996-12-12
DK0666920T3 (da) 1999-06-14
GB9222758D0 (en) 1992-12-09
NZ257175A (en) 1996-07-26

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