ES2123669T3 - Derivados del plasminogeno que se activan con trombina. - Google Patents

Derivados del plasminogeno que se activan con trombina.

Info

Publication number
ES2123669T3
ES2123669T3 ES93923634T ES93923634T ES2123669T3 ES 2123669 T3 ES2123669 T3 ES 2123669T3 ES 93923634 T ES93923634 T ES 93923634T ES 93923634 T ES93923634 T ES 93923634T ES 2123669 T3 ES2123669 T3 ES 2123669T3
Authority
ES
Spain
Prior art keywords
plasminogen
thrombin
derivatives
activated
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93923634T
Other languages
English (en)
Inventor
Richard James Gilbert
Michael George Hunter
Keith Martyn Dawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Application granted granted Critical
Publication of ES2123669T3 publication Critical patent/ES2123669T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN ANALOGO DE UN PLASMINOGEN ACTIVABLE CON TROMBINA PARA QUE TENGA LA ACTIVIDAD DE LA PLASMINA QUE CONTIENE LA SECUENCIA DEL LUGAR DE EXFOLIACION P4 - P3 - PRO - ARG - P1'' - P2'' DONDE P3 ES UN RESIDUO AMINOACIDO BASICO, P4 ES UN RESIDUO AMINOACIDO HIDROFOBICO Y CADA P1'' Y P2'' ES, INDEPENDIENTEMENTE, UN RESIDUO AMINOACIDO NO ACIDICO, EN DONDE DICHO LUGAR SE PUEDE EXFOLIAR CON LA TROMBINA ENTRE ARG Y P1''.
ES93923634T 1992-10-29 1993-10-28 Derivados del plasminogeno que se activan con trombina. Expired - Lifetime ES2123669T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929222758A GB9222758D0 (en) 1992-10-29 1992-10-29 Proteins and nucleic acids

Publications (1)

Publication Number Publication Date
ES2123669T3 true ES2123669T3 (es) 1999-01-16

Family

ID=10724266

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93923634T Expired - Lifetime ES2123669T3 (es) 1992-10-29 1993-10-28 Derivados del plasminogeno que se activan con trombina.

Country Status (15)

Country Link
EP (1) EP0666920B1 (es)
JP (1) JP3329340B2 (es)
AT (1) ATE171213T1 (es)
AU (1) AU674180B2 (es)
CA (1) CA2145749C (es)
DE (1) DE69321134T2 (es)
DK (1) DK0666920T3 (es)
ES (1) ES2123669T3 (es)
FI (1) FI114102B (es)
GB (1) GB9222758D0 (es)
HK (1) HK1008047A1 (es)
NO (1) NO317661B1 (es)
NZ (1) NZ257175A (es)
WO (1) WO1994010318A1 (es)
ZA (1) ZA938120B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
WO1998005762A1 (de) * 1996-08-02 1998-02-12 Roche Diagnostics Gmbh Thrombinaktivierbarer plasminogenaktivator
ATE378413T1 (de) 2000-12-21 2007-11-15 Thromb X N V Hefeexpressionsvektor und verfahren zur herstellung eines rekombinanten proteins durch expression in einer hefezelle
EP1472346A2 (de) * 2002-02-06 2004-11-03 N-Zyme BioTec GmbH Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
FI952071A0 (fi) 1995-04-28
ATE171213T1 (de) 1998-10-15
AU5343294A (en) 1994-05-24
ZA938120B (en) 1994-08-01
WO1994010318A1 (en) 1994-05-11
AU674180B2 (en) 1996-12-12
DE69321134T2 (de) 1999-02-25
EP0666920B1 (en) 1998-09-16
NO951648D0 (no) 1995-04-28
NO317661B1 (no) 2004-11-29
DE69321134D1 (de) 1998-10-22
CA2145749C (en) 2005-06-21
FI952071L (fi) 1995-04-28
GB9222758D0 (en) 1992-12-09
JPH08504575A (ja) 1996-05-21
EP0666920A1 (en) 1995-08-16
FI114102B (fi) 2004-08-13
JP3329340B2 (ja) 2002-09-30
DK0666920T3 (da) 1999-06-14
NZ257175A (en) 1996-07-26
CA2145749A1 (en) 1994-05-11
NO951648L (no) 1995-04-28
HK1008047A1 (en) 1999-04-30

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