EP0169465A3 - Mixture of pyrimido-pyrimidines and o-acetyl-salicylic acid, or their pharmacologically acceptable salts, and its use - Google Patents

Mixture of pyrimido-pyrimidines and o-acetyl-salicylic acid, or their pharmacologically acceptable salts, and its use Download PDF

Info

Publication number
EP0169465A3
EP0169465A3 EP85108761A EP85108761A EP0169465A3 EP 0169465 A3 EP0169465 A3 EP 0169465A3 EP 85108761 A EP85108761 A EP 85108761A EP 85108761 A EP85108761 A EP 85108761A EP 0169465 A3 EP0169465 A3 EP 0169465A3
Authority
EP
European Patent Office
Prior art keywords
pyrimido
pyrimidines
acetyl
mixture
acceptable salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP85108761A
Other languages
German (de)
Other versions
EP0169465B1 (en
EP0169465A2 (en
Inventor
Klaus Ulrich Dr. Weithmann
Dirk Dr. Seiffge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853515874 external-priority patent/DE3515874A1/en
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to AT85108761T priority Critical patent/ATE50497T1/en
Publication of EP0169465A2 publication Critical patent/EP0169465A2/en
Publication of EP0169465A3 publication Critical patent/EP0169465A3/en
Application granted granted Critical
Publication of EP0169465B1 publication Critical patent/EP0169465B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

O-acetylsalicylic acid and a pyrimido-pyrimidine as combination products.
EP85108761A 1984-07-21 1985-07-12 Mixture of pyrimido-pyrimidines and o-acetyl-salicylic acid, or their pharmacologically acceptable salts, and its use Expired - Lifetime EP0169465B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT85108761T ATE50497T1 (en) 1984-07-21 1985-07-12 COMBINATION PREPARATIVE OF PYRIMIDO-PYRIMIDINES AND O-ACETYLSALICYLIC ACID OR. THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS AND THEIR USE.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3426961 1984-07-21
DE3426961 1984-07-21
DE19853515874 DE3515874A1 (en) 1984-07-21 1985-05-03 COMBINATION PRODUCT MADE OF PYRIMIDO-PYRIMIDINES AND O-ACETYLSALICYL ACIDS OR THEIR PHARMACOLOGICALLY COMPATIBLE SALTS AND THE USE THEREOF
DE3515874 1985-05-03

Publications (3)

Publication Number Publication Date
EP0169465A2 EP0169465A2 (en) 1986-01-29
EP0169465A3 true EP0169465A3 (en) 1986-05-28
EP0169465B1 EP0169465B1 (en) 1990-02-28

Family

ID=25823162

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85108761A Expired - Lifetime EP0169465B1 (en) 1984-07-21 1985-07-12 Mixture of pyrimido-pyrimidines and o-acetyl-salicylic acid, or their pharmacologically acceptable salts, and its use

Country Status (14)

Country Link
US (1) US4694024A (en)
EP (1) EP0169465B1 (en)
JP (1) JPS6143117A (en)
AT (1) ATE50497T1 (en)
AU (1) AU574206B2 (en)
CA (1) CA1247529A (en)
DE (1) DE3576119D1 (en)
DK (1) DK164638C (en)
HU (1) HU193793B (en)
IE (1) IE58612B1 (en)
IL (1) IL75852A (en)
NZ (1) NZ212797A (en)
PH (1) PH22342A (en)
PT (1) PT80837B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3508097A1 (en) * 1984-07-21 1986-02-06 Hoechst Ag, 6230 Frankfurt COMBINATION PRODUCT MADE OF XANTHINE DERIVATIVES AND O-ACETYLSALICYL ACID OR THEIR PHARMACOLOGICALLY COMPATIBLE SALTS AND THE USE THEREOF
DE3627423A1 (en) * 1986-08-13 1988-02-18 Thomae Gmbh Dr K MEDICINAL PRODUCTS CONTAINING DIPYRIDAMOL OR MOPIDAMOL AND O-ACETYLSALICYL ACID OR THEIR PHYSIOLOGICALLY COMPATIBLE SALTS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR COMBATING THROMBUS FORMATION
US4917896A (en) * 1986-08-15 1990-04-17 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agents
DE3717337A1 (en) * 1987-05-22 1988-12-15 Hoechst Ag METHOD FOR DETECTING THE ANTIAGGREGATORY EFFECT OF VASOACTIVE SUBSTANCES, SPECIFICALLY OF PHOSPHODIESTERASE AND / OR CYCLOOXYGENASE INHIBITORS
AT393962B (en) * 1987-10-22 1992-01-10 Thomae Gmbh Dr K Synergistic pharmaceutical combination with a content of a phosphodiesterase inhibitor and the use thereof
US5041430A (en) * 1989-09-18 1991-08-20 Du Pont Mereck Pharmaceutical Company Oral anticoagulant/platelet inhibitor low dose formulation
FR2681596B1 (en) * 1991-09-23 1993-11-26 Thomas Andre PROCESS FOR THE PREPARATION OF ACETYLSALICYLATES OF PURIC AND PYRIMID BASES AND THEIR NUCLEOSIDES.
EP1093814A1 (en) * 1999-10-22 2001-04-25 Boehringer Ingelheim Pharma KG Use of dipyridamole or mopidamol in the manufacture of a medicament for the treatment and prevention of fibrin-dependent microcirculation disorders
JP2002255155A (en) * 2001-03-06 2002-09-11 Ricoh Elemex Corp Packing material
US7064130B2 (en) * 2001-04-20 2006-06-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of radical-scavenging compounds for treatment and prevention of NO-dependent microcirculation disorders
WO2004069254A2 (en) * 2003-02-07 2004-08-19 Boehringer Ingelheim International Gmbh Use of dipyridamole or mopidamole for treatment and prevention of mmp-9-dependent disorders
EP1820506B1 (en) 2006-02-09 2008-03-26 Teva Pharmaceutical Industries Ltd. Dipyridamole extended-release formulations and process for preparing same
ITRM20060460A1 (en) * 2006-08-31 2006-11-30 Univ Roma USE OF ACETYLICYLICYLIC ACID IN COMBINATION WITH MRP4 CHANNEL INHIBITORS FOR THE TREATMENT OF PATIENTS RESISTANT TO THESE ACETYLICYLIC ACID
WO2010036975A2 (en) * 2008-09-25 2010-04-01 Teva Pharmaceutical Industries Ltd. Dipyridamole and acetylsalicylic acid formulations and process for preparing same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368272A1 (en) * 1976-10-20 1978-05-19 Theramex Solid aspirin-dipyridamole compsns. - each sepd. from other by inert material, for reducing platelet aggregation
FR2390959A1 (en) * 1977-05-16 1978-12-15 Prugnaud Robert Synergistic pyrimido:pyrimidine and aspirin compsns. - are anti-aggregating agents and are useful for treating e.g. peripheral vascular disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3508097A1 (en) * 1984-07-21 1986-02-06 Hoechst Ag, 6230 Frankfurt COMBINATION PRODUCT MADE OF XANTHINE DERIVATIVES AND O-ACETYLSALICYL ACID OR THEIR PHARMACOLOGICALLY COMPATIBLE SALTS AND THE USE THEREOF

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368272A1 (en) * 1976-10-20 1978-05-19 Theramex Solid aspirin-dipyridamole compsns. - each sepd. from other by inert material, for reducing platelet aggregation
FR2390959A1 (en) * 1977-05-16 1978-12-15 Prugnaud Robert Synergistic pyrimido:pyrimidine and aspirin compsns. - are anti-aggregating agents and are useful for treating e.g. peripheral vascular disorders

Also Published As

Publication number Publication date
CA1247529A (en) 1988-12-28
DE3576119D1 (en) 1990-04-05
HUT38255A (en) 1986-05-28
PH22342A (en) 1988-08-12
IE58612B1 (en) 1993-10-20
DK164638B (en) 1992-07-27
PT80837A (en) 1985-08-01
DK330585D0 (en) 1985-07-19
DK164638C (en) 1992-12-14
US4694024A (en) 1987-09-15
IE851821L (en) 1986-01-21
IL75852A0 (en) 1985-11-29
PT80837B (en) 1987-10-20
JPH0564615B2 (en) 1993-09-16
DK330585A (en) 1986-01-22
EP0169465B1 (en) 1990-02-28
AU4519585A (en) 1986-01-23
JPS6143117A (en) 1986-03-01
NZ212797A (en) 1988-07-28
IL75852A (en) 1990-04-29
HU193793B (en) 1987-11-30
AU574206B2 (en) 1988-06-30
EP0169465A2 (en) 1986-01-29
ATE50497T1 (en) 1990-03-15

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