CA2145749A1 - Thrombin activatable plasminogen derivatives - Google Patents

Thrombin activatable plasminogen derivatives

Info

Publication number
CA2145749A1
CA2145749A1 CA002145749A CA2145749A CA2145749A1 CA 2145749 A1 CA2145749 A1 CA 2145749A1 CA 002145749 A CA002145749 A CA 002145749A CA 2145749 A CA2145749 A CA 2145749A CA 2145749 A1 CA2145749 A1 CA 2145749A1
Authority
CA
Canada
Prior art keywords
thrombin
amino acid
acid residue
thrombin activatable
activatable plasminogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002145749A
Other languages
French (fr)
Other versions
CA2145749C (en
Inventor
Richard James Gilbert
Michael George Hunter
Keith Martyn Dawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2145749A1 publication Critical patent/CA2145749A1/en
Application granted granted Critical
Publication of CA2145749C publication Critical patent/CA2145749C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

A plasminogen analogue activatable by thrombin to have plasmin activity which contains the cleavage site sequence P4-P3-Pro-Arg-P1'-P2' where P3 is a basic amino acid residue, P4 is a hydrophobic amino acid residue and each of P1' and P2' is independently a non-acidic amino acid residue, said site being cleavable by thrombin between Arg and P1'.
CA002145749A 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives Expired - Fee Related CA2145749C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929222758A GB9222758D0 (en) 1992-10-29 1992-10-29 Proteins and nucleic acids
GB9222758.6 1992-10-29
PCT/GB1993/002219 WO1994010318A1 (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives

Publications (2)

Publication Number Publication Date
CA2145749A1 true CA2145749A1 (en) 1994-05-11
CA2145749C CA2145749C (en) 2005-06-21

Family

ID=10724266

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002145749A Expired - Fee Related CA2145749C (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives

Country Status (15)

Country Link
EP (1) EP0666920B1 (en)
JP (1) JP3329340B2 (en)
AT (1) ATE171213T1 (en)
AU (1) AU674180B2 (en)
CA (1) CA2145749C (en)
DE (1) DE69321134T2 (en)
DK (1) DK0666920T3 (en)
ES (1) ES2123669T3 (en)
FI (1) FI114102B (en)
GB (1) GB9222758D0 (en)
HK (1) HK1008047A1 (en)
NO (1) NO317661B1 (en)
NZ (1) NZ257175A (en)
WO (1) WO1994010318A1 (en)
ZA (1) ZA938120B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
BR9711015A (en) * 1996-08-02 1999-08-17 Boehringer Mannheim Gmbh Plasminogen activator capable of being activated by thrombin
AU2002218890A1 (en) 2000-12-21 2002-07-01 Thromb-X N.V. A yeast expression vector and a method of making a recombinant protein by expression in a yeast cell
WO2003066842A2 (en) * 2002-02-06 2003-08-14 Trommsdorff Gmbh & Co. Kg Arzneimittel Method for producing recombinant proteins in micro-organisms
FR2841904B1 (en) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med THROMBIN CLAVABLE X FACTOR ANALOGS
PL213309B1 (en) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Method for the peptide bond hydrolysis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
GB9222758D0 (en) 1992-12-09
ES2123669T3 (en) 1999-01-16
NZ257175A (en) 1996-07-26
NO317661B1 (en) 2004-11-29
AU674180B2 (en) 1996-12-12
EP0666920A1 (en) 1995-08-16
DK0666920T3 (en) 1999-06-14
DE69321134D1 (en) 1998-10-22
EP0666920B1 (en) 1998-09-16
CA2145749C (en) 2005-06-21
NO951648D0 (en) 1995-04-28
DE69321134T2 (en) 1999-02-25
FI952071A (en) 1995-04-28
JP3329340B2 (en) 2002-09-30
JPH08504575A (en) 1996-05-21
ZA938120B (en) 1994-08-01
FI952071A0 (en) 1995-04-28
HK1008047A1 (en) 1999-04-30
WO1994010318A1 (en) 1994-05-11
ATE171213T1 (en) 1998-10-15
FI114102B (en) 2004-08-13
AU5343294A (en) 1994-05-24
NO951648L (en) 1995-04-28

Similar Documents

Publication Publication Date Title
CA2168113A1 (en) Therapeutic peptide derivatives
AU605124B2 (en) Novel peptide plasminogen activators
FI892507A0 (en) THERAPEUTIC PEPTIDER.
AU5846494A (en) Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
AU7690498A (en) Cleavage of fibrin(ogen) and cross-linked fibrin by fibrinolytic matrix metalloproteinases
WO1996020210A3 (en) Diastereomerically pure 3-oxo and 3-thioxo-4-aza-androstan derivatives and the use thereof as antiandrogens
AU3868097A (en) Novel peptide derivatives having thiazolyl-alanine residue
CA2145749A1 (en) Thrombin activatable plasminogen derivatives
CA2221865A1 (en) Bradykinin analogs as selective thrombin inhibitors
UA27132C2 (en) TWO-FUNCTIONAL UROKINASE VARIANTS WITH BIASED FIBRINOLYTIC activity and thrombin-inhibitory action
CS440889A2 (en) Method of bu-3608 antibiotics' complex n-alkyl derivatives production
AU5530286A (en) Peptides
GB2286190A (en) Thrombin activatable plasminogen derivatives
AU3674989A (en) Process for the preparation of 2,6-dichlorodiphenylaminoacetic acid derivatives
AU6180486A (en) Novel tissue plasminogen activator derivatives
AU4227189A (en) Cyclopeptide derivatives, usable as selective inhibitors of proteases with active serine
NZ211632A (en) Substituted aminothiol dipeptide derivatives and intermediates
AU7037591A (en) Stabilization of t-pa pro
AU4569385A (en) 2,5-pyrrolidinedione derivatives useful as antiarrhythmic agents

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed