DE69021885T2 - Mutanten des menschlichen plasminogenaktivator-inhibitors 1 (pai-1), ihre herstellung und verwendung. - Google Patents

Mutanten des menschlichen plasminogenaktivator-inhibitors 1 (pai-1), ihre herstellung und verwendung.

Info

Publication number
DE69021885T2
DE69021885T2 DE69021885T DE69021885T DE69021885T2 DE 69021885 T2 DE69021885 T2 DE 69021885T2 DE 69021885 T DE69021885 T DE 69021885T DE 69021885 T DE69021885 T DE 69021885T DE 69021885 T2 DE69021885 T2 DE 69021885T2
Authority
DE
Germany
Prior art keywords
pai
mutants
plasminogen activator
activator inhibitor
human plasminogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69021885T
Other languages
English (en)
Other versions
DE69021885D1 (de
Inventor
Hans Pannekoek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STICHTING CENTRAAL LAB
Original Assignee
STICHTING CENTRAAL LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STICHTING CENTRAAL LAB filed Critical STICHTING CENTRAAL LAB
Publication of DE69021885D1 publication Critical patent/DE69021885D1/de
Application granted granted Critical
Publication of DE69021885T2 publication Critical patent/DE69021885T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8132—Plasminogen activator inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69021885T 1989-10-03 1990-10-03 Mutanten des menschlichen plasminogenaktivator-inhibitors 1 (pai-1), ihre herstellung und verwendung. Expired - Fee Related DE69021885T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8902454A NL8902454A (nl) 1989-10-03 1989-10-03 Mutanten van de humane plasminogeen activator inhibitor 1 (pai-1), hun bereiding en toepassing, en recombinante polynucleotiden die voor deze mutanten coderende genetische informatie omvatten.
PCT/NL1990/000145 WO1991005048A1 (en) 1989-10-03 1990-10-03 Mutants of the human plasminogen activator inhibitor 1 (pai-1), their preparation and use

Publications (2)

Publication Number Publication Date
DE69021885D1 DE69021885D1 (de) 1995-09-28
DE69021885T2 true DE69021885T2 (de) 1996-05-02

Family

ID=19855387

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69021885T Expired - Fee Related DE69021885T2 (de) 1989-10-03 1990-10-03 Mutanten des menschlichen plasminogenaktivator-inhibitors 1 (pai-1), ihre herstellung und verwendung.

Country Status (8)

Country Link
EP (1) EP0494929B1 (de)
JP (1) JPH05503211A (de)
AT (1) ATE126828T1 (de)
DE (1) DE69021885T2 (de)
DK (1) DK0494929T3 (de)
ES (1) ES2078979T3 (de)
NL (1) NL8902454A (de)
WO (1) WO1991005048A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3742997A1 (de) * 1987-12-18 1989-06-29 Behringwerke Ag Peptide, verfahren zu ihrer herstellung, ihre verwendung zur gewinnung von antikoerpern sowie deren verwendung zur blockierung der pai-1-aktivitaet menschlichen blutes
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
DE4242655A1 (de) * 1992-12-17 1994-06-23 Behringwerke Ag Verwendung von Thrombin-Inhibitoren zur Inhibition okularer Fibrinbildung
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
US6750201B1 (en) * 1997-10-17 2004-06-15 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
WO1999020295A1 (en) * 1997-10-17 1999-04-29 Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
AU2002352115A1 (en) * 2001-11-27 2003-06-10 Bayer Aktiengesellschaft Polynucleotides encoding nexin-related serine protease inhibitor
US7939304B2 (en) 2002-10-02 2011-05-10 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity
AU2003227721A1 (en) * 2003-05-02 2004-11-23 Paion Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
CA2524573A1 (en) * 2003-05-02 2004-11-11 Paion Deutschland Gmbh Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
EP1735439B1 (de) 2004-04-12 2011-11-23 Catalyst Biosciences, Inc. Spaltung von vegf und vegf-rezeptoren durch wildtyp- und mutante mt-sp1
KR101476458B1 (ko) * 2006-07-05 2015-01-05 카탈리스트 바이오사이언시즈, 인코포레이티드 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제
ES2324192B1 (es) * 2008-01-30 2010-06-17 PUIG BEAUTY & FASHION GROUP, S.L. Derivados peptidicos utiles en el tratamiento, cuidado o limpieza de la piel, mucosa, cuero cabelludo o uñas.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3521226A1 (de) * 1985-02-08 1986-08-14 Hoechst Ag, 6230 Frankfurt Gene fuer biologisch aktive proteine
NL8602307A (nl) * 1986-09-12 1988-04-05 Stichting Centraal Lab Recombinant dna molekuul; werkwijze voor het bereiden van humane endotheliale plasminogeen activator remmer (pai) of een mutant daarvan; farmaceutisch preparaat; getransformeerde gastheercellen.
JPH01191687A (ja) * 1988-01-28 1989-08-01 Hoechst Japan Kk ヒトα↓２−プラスミンインヒビターまたはそれと類似の蛋白質から誘導される新規蛋白質

Also Published As

Publication number Publication date
WO1991005048A1 (en) 1991-04-18
ATE126828T1 (de) 1995-09-15
EP0494929B1 (de) 1995-08-23
DK0494929T3 (da) 1996-01-29
ES2078979T3 (es) 1996-01-01
DE69021885D1 (de) 1995-09-28
EP0494929A1 (de) 1992-07-22
NL8902454A (nl) 1991-05-01
JPH05503211A (ja) 1993-06-03

Similar Documents

Publication Publication Date Title
DE69021885D1 (de) Mutanten des menschlichen plasminogenaktivator-inhibitors 1 (pai-1), ihre herstellung und verwendung.
DE69018920T2 (de) Verwendung von dns-fragmenten, die ein signalpeptid kodieren zur sekretion von reifen proteinen in rekombinanten hefen, expressions-kassetten, transformierte hefen und verfahren zur herstellung dieser proteine.
IL191890A0 (en) Tissue inhibitor metalloproteinase type three (timp-3) and compositions thereof
EP1612272A3 (de) Antiangiogenische Polypeptide und Verfahren zur Angiogenesehemmung
EP0278696A3 (de) Arg-Serpin-Hemmer von menschlichem Plasminogen-Aktivator, bezeichnet als PAI-2
DE69034013D1 (de) Serpin-resistenter T-PA; Mutanten; Gene
ES8800347A1 (es) Metodo para preparar uroquinasa de una sola cadena resistente a proteasas
EP0205475A4 (de) Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu.
ATE70301T1 (de) Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
EP0641215A4 (de) Protease-resistente analoge des thrombomodulin.
DE69126049D1 (de) Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C
HK1005037A1 (en) Hybrid plasminogen activators
ATE121754T1 (de) Vakzine gegen bordetella.
ATE194624T1 (de) Mutanten von menschlichem antithrombin iii
HUT58811A (en) Process for producing new polypeptides
DE59008764D1 (de) t-PA-MUTANTE GK1L.
JPS6452769A (en) 1-fluoro-1-halogeno-3,6-dioxabicyclo(4,1,0)heptane, manufacture and use

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee