ATE194624T1 - Mutanten von menschlichem antithrombin iii - Google Patents
Mutanten von menschlichem antithrombin iiiInfo
- Publication number
- ATE194624T1 ATE194624T1 AT93105829T AT93105829T ATE194624T1 AT E194624 T1 ATE194624 T1 AT E194624T1 AT 93105829 T AT93105829 T AT 93105829T AT 93105829 T AT93105829 T AT 93105829T AT E194624 T1 ATE194624 T1 AT E194624T1
- Authority
- AT
- Austria
- Prior art keywords
- iii
- mutant
- mutants
- antithrombin iii
- amino acids
- Prior art date
Links
- 101000757319 Homo sapiens Antithrombin-III Proteins 0.000 title abstract 2
- 102000052834 human SERPINC1 Human genes 0.000 title abstract 2
- 229960004336 human antithrombin iii Drugs 0.000 title abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229960002897 heparin Drugs 0.000 abstract 2
- 229920000669 heparin Polymers 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 239000004019 antithrombin Substances 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9048892 | 1992-04-10 | ||
| JP03185593A JP3479539B2 (ja) | 1992-04-10 | 1993-02-22 | ヒトアンチトロンビンｉｉｉ変異体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE194624T1 true ATE194624T1 (de) | 2000-07-15 |
Family
ID=26370368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93105829T ATE194624T1 (de) | 1992-04-10 | 1993-04-08 | Mutanten von menschlichem antithrombin iii |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5420252A (de) |
| EP (1) | EP0568833B1 (de) |
| JP (1) | JP3479539B2 (de) |
| AT (1) | ATE194624T1 (de) |
| AU (1) | AU655723B2 (de) |
| CA (1) | CA2093575A1 (de) |
| DE (1) | DE69328992T2 (de) |
| DK (1) | DK0568833T3 (de) |
| ES (1) | ES2149788T3 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3479495A (en) * | 1994-09-30 | 1996-04-26 | Ppl Therapeutics (Scotland) Ltd | Alpha-1-antitrypsin and antithrombine-iii variants |
| KR20010052345A (ko) | 1998-05-12 | 2001-06-25 | 수잔 씨 복 | 인간 항트롬빈 3 및 그에 관련된 방법 |
| US6607724B2 (en) | 1998-10-08 | 2003-08-19 | Children's Hospital | Compositions and methods for inhibiting angiogenesis |
| JP4339962B2 (ja) | 1999-06-23 | 2009-10-07 | 武比古 小出 | ヒトアンチトロンビン変異体 |
| CA2487901A1 (en) | 2002-05-31 | 2003-12-11 | University Of Utah Research Foundation | Variants of antithrombin iii |
| CA2552894A1 (en) * | 2004-01-09 | 2005-08-04 | University Of Utah Research Foundation | Methods of using high affinity atiii variants |
| JP2010533684A (ja) * | 2007-07-20 | 2010-10-28 | ユニベルシテ パリ サッド １１ | 血液凝固異常の治療又は予防のための変異アンチトロンビンの使用 |
| WO2010081878A1 (en) * | 2009-01-16 | 2010-07-22 | Universite Paris-Sud Xi | Mutated antithrombins, a process for preparing the same and their use as drugs |
| TR201809898T4 (tr) | 2009-11-03 | 2018-07-23 | Grifols Therapeutics Llc | Alfa-1 protei̇naz i̇nhi̇bi̇törüne yöneli̇k bi̇leşi̇m, yöntem ve ki̇t. |
| ES2648249T3 (es) | 2009-11-24 | 2017-12-29 | Grifols Therapeutics Inc. | Procedimientos, composiciones y kits de liofilización |
| ES2374054B1 (es) * | 2010-07-03 | 2012-12-26 | Instituto De Salud Carlos Iii | Nuevo inhibidor de serina proteasa y su uso. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185431A (en) | 1988-08-31 | 1993-02-09 | Eisai Co., Ltd. | Recombinant natural killer cell activator |
| DE3901917A1 (de) | 1989-01-24 | 1990-07-26 | Behringwerke Ag | Mutanten von humanem antithrombin iii |
| IE902276A1 (en) | 1989-06-26 | 1991-01-16 | Akzo Nv | Serpin variants |
| US5102995A (en) * | 1989-10-20 | 1992-04-07 | Washington University | Dna encoding modified heparin cofactor ii |
-
1993
- 1993-02-22 JP JP03185593A patent/JP3479539B2/ja not_active Expired - Lifetime
- 1993-04-06 AU AU36761/93A patent/AU655723B2/en not_active Ceased
- 1993-04-07 CA CA002093575A patent/CA2093575A1/en not_active Abandoned
- 1993-04-08 AT AT93105829T patent/ATE194624T1/de not_active IP Right Cessation
- 1993-04-08 EP EP93105829A patent/EP0568833B1/de not_active Expired - Lifetime
- 1993-04-08 ES ES93105829T patent/ES2149788T3/es not_active Expired - Lifetime
- 1993-04-08 DK DK93105829T patent/DK0568833T3/da active
- 1993-04-08 DE DE69328992T patent/DE69328992T2/de not_active Expired - Lifetime
- 1993-04-09 US US08/046,431 patent/US5420252A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69328992T2 (de) | 2000-12-07 |
| DK0568833T3 (da) | 2000-09-18 |
| JPH05339292A (ja) | 1993-12-21 |
| US5420252A (en) | 1995-05-30 |
| AU3676193A (en) | 1993-10-14 |
| DE69328992D1 (de) | 2000-08-17 |
| CA2093575A1 (en) | 1993-10-11 |
| EP0568833A1 (de) | 1993-11-10 |
| ES2149788T3 (es) | 2000-11-16 |
| JP3479539B2 (ja) | 2003-12-15 |
| AU655723B2 (en) | 1995-01-05 |
| EP0568833B1 (de) | 2000-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |