DE69320490D1 - Fahrbare modulanlage für die entwicklung und herstellung von biotechnologischen produkten im versuchsmasstab - Google Patents

Fahrbare modulanlage für die entwicklung und herstellung von biotechnologischen produkten im versuchsmasstab

Info

Publication number
DE69320490D1
DE69320490D1 DE69320490T DE69320490T DE69320490D1 DE 69320490 D1 DE69320490 D1 DE 69320490D1 DE 69320490 T DE69320490 T DE 69320490T DE 69320490 T DE69320490 T DE 69320490T DE 69320490 D1 DE69320490 D1 DE 69320490D1
Authority
DE
Germany
Prior art keywords
development
manufacturing
modular system
test scale
mobile modular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69320490T
Other languages
English (en)
Other versions
DE69320490T2 (de
Inventor
Giovanni Cassani
Marina Lani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmadule Nacka Se AB
Original Assignee
Snamprogetti Biotecnologie SpA
Tecnogen SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Snamprogetti Biotecnologie SpA, Tecnogen SpA filed Critical Snamprogetti Biotecnologie SpA
Publication of DE69320490D1 publication Critical patent/DE69320490D1/de
Application granted granted Critical
Publication of DE69320490T2 publication Critical patent/DE69320490T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B01L1/52—Transportable laboratories; Field kits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/52—Mobile; Means for transporting the apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Manufacturing & Machinery (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Prostheses (AREA)
DE69320490T 1992-06-09 1993-05-29 Fahrbare modulanlage für die entwicklung und herstellung von biotechnologischen produkten im versuchsmasstab Expired - Lifetime DE69320490T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI921417A IT1258959B (it) 1992-06-09 1992-06-09 Impianto a moduli mobili per lo sviluppo e la produzione di prodotti biotecnologici su scala pilota
PCT/EP1993/001401 WO1993025657A1 (en) 1992-06-09 1993-05-29 Mobile-module plant for the developement and the production of biotechnological products on a pilot scale

Publications (2)

Publication Number Publication Date
DE69320490D1 true DE69320490D1 (de) 1998-09-24
DE69320490T2 DE69320490T2 (de) 1999-05-06

Family

ID=11363478

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69320490T Expired - Lifetime DE69320490T2 (de) 1992-06-09 1993-05-29 Fahrbare modulanlage für die entwicklung und herstellung von biotechnologischen produkten im versuchsmasstab

Country Status (7)

Country Link
US (1) US5656491A (de)
EP (1) EP0670889B1 (de)
AU (1) AU4322193A (de)
CA (1) CA2137671C (de)
DE (1) DE69320490T2 (de)
IT (1) IT1258959B (de)
WO (1) WO1993025657A1 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6176046B1 (en) * 1998-11-24 2001-01-23 Northstar Industries, Inc. Portable, pre-manufactured, modular natural gas delivery stations
DE50009879D1 (de) * 1999-08-10 2005-04-28 Siemens Ag Kraftwerk, insbesondere industriekraftwerk
FR2819536A1 (fr) * 2001-01-12 2002-07-19 Bernard Gaffet Laboratoire modulaire de niveau de confinement p2,p2+ ou p3
US7591107B2 (en) 2001-03-28 2009-09-22 The Timken Company Portable facility and process for reconditioning antifriction bearings
US6696018B2 (en) 2001-11-14 2004-02-24 Electron Process Company, Llc System and method for sterilization of biological connections
US20030226857A1 (en) * 2002-04-12 2003-12-11 Hyclone Laboratories, Inc. Systems for forming sterile fluid connections and methods of use
WO2003095765A1 (en) * 2002-05-08 2003-11-20 PETTUS, Candace, Gale Modular containment unit
ES2260984B1 (es) * 2003-12-02 2007-11-01 Horst Lutzow Estacion de ensayo integral para proyectos de investigacion, desarrollo e innovacion y/o para la industria.
CA2552717C (en) * 2004-01-07 2011-11-29 Levtech, Inc. Mixing bag with integral sparger and sensor receiver
EP1719025B1 (de) * 2004-02-03 2019-10-23 GE Healthcare Bio-Sciences Corp. System und verfahren zur herstellung
US7326355B2 (en) * 2004-03-31 2008-02-05 Hyclone Laboratories, Inc. Mobile filtration facility and methods of use
CN201080493Y (zh) * 2004-05-07 2008-07-02 Oc欧瑞康巴尔斯公司 移动的pvd/cvd涂装中心
DE102004026338A1 (de) * 2004-05-26 2005-12-15 Keller, Bernhard, Prof. Dr. Sicherheitslabor
ES2612212T5 (es) * 2004-06-04 2020-06-25 Global Life Sciences Solutions Usa Llc Sistemas y métodos de biorreactor desechable
DE202005012340U1 (de) * 2005-08-05 2006-12-07 Agraferm Technologies Ag Biogasanlage und Modul für eine Biogasanlage
US20070094946A1 (en) * 2005-09-30 2007-05-03 Ohio Transmission Corporation Modular industrial equipment facility
WO2008088379A2 (en) * 2006-07-14 2008-07-24 Xcellerex, Inc. Environmental containment systems
MX2009000712A (es) * 2006-07-21 2009-03-23 Xyleco Inc Sistemas para conversion de biomasa.
US8778668B1 (en) * 2006-08-07 2014-07-15 Mark K. Gaalswyk Self-contained deployable automatic factory built ethanol production plant
CA2596139C (en) * 2006-08-07 2013-10-15 Mark K. Gaalswyk Self-contained deployable automatic factory built ethanol production plant
US7511960B2 (en) * 2006-09-13 2009-03-31 Sun Microsystems, Inc. Balanced chilled fluid cooling system for a data center in a shipping container
US7856838B2 (en) * 2006-09-13 2010-12-28 Oracle America, Inc. Cooling air flow loop for a data center in a shipping container
US7854652B2 (en) * 2006-09-13 2010-12-21 Oracle America, Inc. Server rack service utilities for a data center in a shipping container
US7551971B2 (en) * 2006-09-13 2009-06-23 Sun Microsystems, Inc. Operation ready transportable data center in a shipping container
US8047904B2 (en) * 2006-09-13 2011-11-01 Oracle America, Inc. Cooling method for a data center in a shipping container
CA2668253C (en) * 2008-06-03 2016-07-26 Richard F. Ablett Plant waste bio-product pomace extract concentrates and processes of producing same
DE102008041950A1 (de) * 2008-09-10 2010-03-11 Evonik Degussa Gmbh System zur Bereitstellung einer universellen Infrastruktur für chemische Prozesse
CN102378945B (zh) 2008-12-23 2015-08-05 佐马美国有限公司 柔性制造系统
US9795957B2 (en) 2009-08-16 2017-10-24 G-Con Manufacturing, Inc. Modular, self-contained, mobile clean room
IN2012DN01645A (de) 2009-08-16 2015-06-05 G Con Llc
WO2011029898A1 (en) 2009-09-10 2011-03-17 Lonza Biologics Plc Method and system for polypeptide purification
DE102010007720A1 (de) * 2010-02-10 2011-08-11 Vivotecnia Research S.L. Labormodul
WO2011127456A2 (en) 2010-04-09 2011-10-13 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
WO2013130636A2 (en) 2012-02-28 2013-09-06 Hyclone Laboratories, Inc. Systems and containers for sterilizing a fluid
US9339026B2 (en) 2012-06-14 2016-05-17 Therapeutic Proteins International, LLC Pneumatically agitated and aerated single-use bioreactor
EP2900362A1 (de) * 2012-09-28 2015-08-05 Promethera Biosciences S.A. Bewegliche vorrichtung zur herstellung und verteilung medizinischer produkte auf zellbasis
US20140335566A1 (en) * 2013-05-10 2014-11-13 BioCapacity On Demand, LLC Mobile vessel or carrier for the manufacturing production and purification of biologics
KR101920129B1 (ko) * 2013-10-14 2018-11-19 지-콘 메뉴팩츄어링 인코포레이티드 모듈형 모바일 룸을 연결하기 위한 유닛
DE102013114816B4 (de) * 2013-12-23 2023-11-02 Gunter Grant GEIGER Krankenhaus
SG11201700155YA (en) * 2014-07-11 2017-02-27 G Con Mfg Inc Modular parts that supply utilities to cleanroom, isolation or containment cubicles, pods, or modules
KR20180074775A (ko) 2015-10-26 2018-07-03 론자 리미티드 생물약제의 생산을 위한 제조 설비
US11566052B2 (en) 2015-11-11 2023-01-31 Lonza Ltd. CRISPR-associated (Cas) proteins with reduced immunogenicity
PL3196136T3 (pl) * 2016-01-20 2019-07-31 Inversiones Hiki6, S.L. Sposób i modułowa, mobilna instalacja do mieszania i pakowania
US11377677B2 (en) 2016-03-02 2022-07-05 Lonza Ltd Fermentation process
US10689873B2 (en) 2016-03-10 2020-06-23 Lonza Ltd Customizable facility
US11236520B2 (en) 2016-03-10 2022-02-01 Lonza Ltd Customizable facility
WO2017207822A1 (en) 2016-06-03 2017-12-07 Lonza Limited Single use bioreactor
KR102451374B1 (ko) 2016-06-10 2022-10-11 론자 리미티드 단백질을 안정화시키는 방법
WO2017223269A1 (en) 2016-06-24 2017-12-28 Lonza Ltd. Variable diameter bioreactors
IL307217A (en) 2016-08-02 2023-11-01 Lonza Ag Customizable facility
WO2018031858A1 (en) 2016-08-12 2018-02-15 Lonza Ltd Proteomic analysis of host cell proteins
US10808216B2 (en) 2016-10-05 2020-10-20 Lonza Ltd Reactor surface finish remediation
WO2018093854A1 (en) 2016-11-17 2018-05-24 Lonza Ltd. Filter assembly with filter lock design
US10919715B2 (en) 2016-11-17 2021-02-16 Lonza Ltd Filter moving device
CN110225790A (zh) 2016-12-09 2019-09-10 龙沙有限公司 减少药物中病毒滴度的方法
CN110192053B (zh) 2016-12-09 2021-10-15 龙沙有限公司 生物反应器的破裂盘及其使用方法
CA3050477A1 (en) 2017-01-18 2018-07-26 Lonza Ltd Methods for evaluating monoclonality
WO2018144794A1 (en) 2017-02-03 2018-08-09 Lonza Ltd Methods of analyzing pluralities of cells and detecting protein sequence variants in biological product manufacturing
EP3565883A1 (de) 2017-02-10 2019-11-13 Lonza Ltd Zellkultursystem und -verfahren
US20190382718A1 (en) 2017-02-17 2019-12-19 Lonza Ltd A method for producing biologic product variants
CN111372946A (zh) 2017-02-17 2020-07-03 隆萨有限公司 难以表达的蛋白质的多位点特异性整合细胞
JP2020507331A (ja) 2017-02-17 2020-03-12 ロンザ リミテッドＬｏｎｚａ Ｌｉｍｉｔｅｄ アデノ随伴ウイルスを生産するための哺乳動物細胞
US10244406B2 (en) 2017-03-07 2019-03-26 Lonza Ltd. Wireless sensor information monitoring
ES2684630B2 (es) * 2017-03-30 2019-07-02 Inversiones Hiki6 S L Método, programa informático y planta multifuncional, modular y móvil de mezcla y envasado
CN110785494A (zh) 2017-06-16 2020-02-11 隆萨有限公司 用于生产生物制品的通用自调节哺乳动物细胞系平台
WO2019067966A1 (en) 2017-09-29 2019-04-04 Lonza Ltd. INFUSION APPARATUS FOR USE IN BIOREACTOR SYSTEMS
US11609120B2 (en) 2017-10-06 2023-03-21 Lonza Ltd Automated control of cell culture using Raman spectroscopy
CA3083124A1 (en) 2017-11-20 2019-05-23 Lonza Ltd. Process and system for propagating cell cultures while preventing lactate accumulation
AU2018381301A1 (en) 2017-12-05 2020-06-11 Lonza Ltd Methods of assaying tropolone
BR202017027731U2 (pt) 2017-12-21 2019-07-09 Elizabeth Regina Maccariello E Outros Disposição construtiva introduzida em contêiner
US20230174971A1 (en) 2018-02-02 2023-06-08 Lonza Ltd Methods of cell selection and modifying cell metabolism
WO2019206902A1 (en) * 2018-04-23 2019-10-31 Univercells S.A. Bioreactor with freeze-thaw capabilities to enhance product recovery and related methods
JP2021530225A (ja) 2018-07-13 2021-11-11 ロンザ リミテッドLonza Limited 内因性タンパク質のレベルを低下させることによって生物学的産物の産生を改善する方法
WO2020028616A1 (en) 2018-08-02 2020-02-06 Lonza Ltd Methods for manufacturing recombinant protein comprising a disulfide bond
WO2020041454A1 (en) 2018-08-21 2020-02-27 Lonza Ltd A process for creating reference data for predicting concentrations of quality attributes
DE102018121050A1 (de) * 2018-08-29 2020-03-05 Goffin Energy GmbH Modulare Biogasanlage, Verfahren zum Betrieb einer modularen Biogasanlage und System zur computergestützten, dezentralen Überwachung und Steuerung mindestens einer modularen Biogasanlage
SG11202103111TA (en) 2018-10-01 2021-04-29 Lonza Ag Ssi cells with predictable and stable transgene expression and methods of formation
GB201900741D0 (en) 2019-01-18 2019-03-06 Synpromics Ltd Liver-specifc inducible prometers and methods of use thereof
JP2022519313A (ja) 2019-02-11 2022-03-22 ロンザ リミテッド 緩衝液製剤の方法およびシステム
AU2020329233B2 (en) 2019-08-15 2022-07-07 G-Con Manufacturing, Inc. Removable panel roof for modular, self-contained, mobile clean room
JP2023502916A (ja) 2019-11-14 2023-01-26 ロンザ リミテッド 細胞の選択方法
IT201900025447A1 (it) 2019-12-27 2021-06-27 Rispa S R L Camera sterile
JP2023509585A (ja) 2020-01-10 2023-03-09 ロンザ ウォーカーズヴィル，インコーポレーテッド 生物学的プロセスおよび細胞集団を精製するためのフィルター装置および方法
FR3106841A1 (fr) * 2020-02-05 2021-08-06 Cesi Association Unité de fabrication modulaire et transportable offrant une haute sécurité industrielle notamment pour la fabrication additive métallique
US20210283565A1 (en) 2020-03-10 2021-09-16 Cellares Corporation Systems and methods for cell processing
AU2021240417A1 (en) 2020-03-26 2022-10-20 Asklepios Biopharmaceutical, Inc. Forskolin-inducible promoters and hypoxia-inducible promoters
EP4136237A1 (de) 2020-04-15 2023-02-22 Asklepios Biopharmaceutical, Inc. Durch forskolin induzierbare promotoren und durch hypoxie induzierbare promotoren
US11492795B2 (en) 2020-08-31 2022-11-08 G-Con Manufacturing, Inc. Ballroom-style cleanroom assembled from modular buildings
WO2022133105A1 (en) 2020-12-18 2022-06-23 Lonza Biologics Inc. Sterile disconnect for bioprocess systems and method for using same
DE102021101167A1 (de) 2021-01-20 2022-07-21 WAS Wirtschaftsagentur Martin Schroeder GmbH Verfahren und Vorrichtung zur Verwertung von organischen Materialien
NL2027815B1 (en) 2021-03-23 2022-10-07 Academisch Ziekenhuis Leiden Genomic integration
TW202405159A (zh) 2022-06-28 2024-02-01 美商安進公司 用於治療性產品製造的靈活的設施配置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8401637D0 (en) * 1984-01-21 1984-02-22 British Petroleum Co Plc Analytical unit
JPS60119552U (ja) * 1984-01-23 1985-08-13 アルプス電気株式会社 プリンタの手動紙送り機構
DE3426717A1 (de) * 1984-07-20 1986-01-23 Maschinen- und Fördertechnik GmbH, 5802 Wetter Transportable bio-gas-reaktoren als baukasten
JPS63111869A (ja) * 1986-10-29 1988-05-17 株式会社　青木建設 排水滅菌オ−トクレ−ブ装置
US5195922A (en) * 1990-08-29 1993-03-23 Intelligent Enclosures Corporation Environmental control system
US5366896A (en) * 1991-07-30 1994-11-22 University Of Virginia Alumni Patents Foundation Robotically operated laboratory system
US5259812A (en) * 1992-09-23 1993-11-09 Kleinsek Don A Clean room and clean room containment center

Also Published As

Publication number Publication date
EP0670889A1 (de) 1995-09-13
ITMI921417A1 (it) 1993-12-09
AU4322193A (en) 1994-01-04
CA2137671C (en) 1999-09-07
WO1993025657A1 (en) 1993-12-23
US5656491A (en) 1997-08-12
CA2137671A1 (en) 1993-12-23
ITMI921417A0 (it) 1992-06-09
DE69320490T2 (de) 1999-05-06
EP0670889B1 (de) 1998-08-19
IT1258959B (it) 1996-03-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMADULE EMTUNGA AB, NACKA, SE

8328 Change in the person/name/address of the agent

Representative=s name: PAE SPLANEMANN REITZNER BARONETZKY WESTENDORP, 804

8327 Change in the person/name/address of the patent owner

Owner name: PHARMADULE AB, NACKA, SE