DE69230525D1 - Technetium-99m markierte Polypeptide zur Bildformung - Google Patents

Technetium-99m markierte Polypeptide zur Bildformung

Info

Publication number
DE69230525D1
DE69230525D1 DE69230525T DE69230525T DE69230525D1 DE 69230525 D1 DE69230525 D1 DE 69230525D1 DE 69230525 T DE69230525 T DE 69230525T DE 69230525 T DE69230525 T DE 69230525T DE 69230525 D1 DE69230525 D1 DE 69230525D1
Authority
DE
Germany
Prior art keywords
technetium
image formation
labeled polypeptides
mammalian body
imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230525T
Other languages
English (en)
Other versions
DE69230525T2 (de
Inventor
T Dean
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of DE69230525D1 publication Critical patent/DE69230525D1/de
Publication of DE69230525T2 publication Critical patent/DE69230525T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69230525T 1991-02-08 1992-02-07 Technetium-99m markierte Polypeptide zur Bildformung Expired - Fee Related DE69230525T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65301291A 1991-02-08 1991-02-08
PCT/US1992/000757 WO1992013572A1 (en) 1991-02-08 1992-02-07 TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING

Publications (2)

Publication Number Publication Date
DE69230525D1 true DE69230525D1 (de) 2000-02-10
DE69230525T2 DE69230525T2 (de) 2000-06-21

Family

ID=24619134

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230525T Expired - Fee Related DE69230525T2 (de) 1991-02-08 1992-02-07 Technetium-99m markierte Polypeptide zur Bildformung

Country Status (12)

Country Link
US (7) US5654272A (de)
EP (1) EP0570493B1 (de)
JP (1) JP2774378B2 (de)
KR (1) KR930703024A (de)
AT (1) ATE188387T1 (de)
BR (1) BR1100906A (de)
CA (1) CA2101942C (de)
DE (1) DE69230525T2 (de)
DK (1) DK0570493T3 (de)
ES (1) ES2141102T3 (de)
GR (1) GR3032851T3 (de)
WO (1) WO1992013572A1 (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
EP0570493B1 (de) * 1991-02-08 2000-01-05 Diatide, Inc. Technetium-99m markierte Polypeptide zur Bildformung
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5993775A (en) * 1991-11-27 1999-11-30 Diatide, Inc. Radioactively labeled peptides comprising a single thiol moiety
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
ATE197767T1 (de) * 1992-01-03 2000-12-15 Rhomed Inc Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
AU683015B2 (en) * 1992-03-13 1997-10-30 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5989519A (en) * 1992-03-13 1999-11-23 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
JP2941057B2 (ja) * 1992-05-21 1999-08-25 ダイアテク，インコーポレイテッド 血栓造影用のテクネチウム‐９９ｍ標識ペプチド
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
DE69431052T2 (de) * 1993-04-08 2003-03-13 Diatide, Inc. Radiomarkierte verbindungen zur thrombus-bilderzeugung
US5464934A (en) * 1993-05-14 1995-11-07 Mallinckrodt Medical, Inc. Metal chelates as spacer compounds in biologically active peptides
CA2167281C (en) * 1993-07-15 2001-09-04 Richard T. Dean Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
ES2114209T3 (es) * 1993-07-19 1998-05-16 Resolution Pharm Inc Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s.
AU698176B2 (en) * 1993-07-28 1998-10-29 Cis Bio International Radiolabelled glucans
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
JPH07149668A (ja) * 1993-11-30 1995-06-13 Kanegafuchi Chem Ind Co Ltd アミロイド沈着検出用物質
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
DE69529988T2 (de) * 1994-05-02 2003-12-11 Diatide, Inc. Technetium-99m markierte bildformungsmittel
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5827498A (en) * 1994-06-07 1998-10-27 Nihon Medi-Physics Co., Ltd. Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
EP0727225A3 (de) * 1995-02-14 1997-01-15 Sonus Pharma Inc Zusammensetzungen und Verfahren zur Herstellung von gerichteter Ultraschallabbildung
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US6068829A (en) 1995-09-11 2000-05-30 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
AU772778B2 (en) * 1998-07-13 2004-05-06 University Of Southern California Novel inhibitors of angiogenesis and tumor growth
EP1132396A4 (de) * 1998-11-13 2002-05-08 Kyowa Hakko Kogyo Kk Physiologisch aktive peptide
US6436204B1 (en) * 1998-11-20 2002-08-20 Kennametal Pc Inc. Diamond coated cutting tools and method of manufacture
US6314314B1 (en) 1999-01-14 2001-11-06 Seth J. Karp Method for locating an internal bleeding site in a human body
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
TWI290146B (en) * 1999-07-29 2007-11-21 Dyax Corp Binding moieties for fibrin
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
US6984373B2 (en) * 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
EP1390077B1 (de) 2001-05-02 2014-07-16 Purdue Research Foundation Behandlung und diagnose vom makrophagen-vermittelter erkrankung
KR100417218B1 (ko) * 2001-06-13 2004-02-05 한국원자력연구소 ＴＣ-99ｍ 트리카보닐 시스테인 또는 그 유도체를포함하는 신장기능 진단용 방사성의약품
RU2303042C2 (ru) * 2001-07-10 2007-07-20 Джи-И Хелткер АС Соединения на основе пептидов для направленной доставки к рецепторам интегринов
US8043603B2 (en) 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8043602B2 (en) 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
EP2301587B1 (de) 2002-03-01 2014-06-25 Dyax Corp. KDR- und VEGF/KDR-bindende Peptide sowie ihre Verwendung bei der Diagnose und Therapie
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
PT2260875E (pt) 2002-05-06 2014-06-25 Endocyte Inc Agentes de imagiologia direcionados para recetor de folato
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
EP1466629A1 (de) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducte zwischen NMR Vershibungsreagenzen und Substraten mit austauschbaren Protonen für die "CEST" Anwendung
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
GB0317815D0 (en) * 2003-07-30 2003-09-03 Amersham Health As Imaging agents
US20060024229A1 (en) * 2004-07-29 2006-02-02 Seth Karp Method and product for locating an internal bleeding site
PT1737889E (pt) * 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
US7560227B2 (en) * 2005-02-28 2009-07-14 University Of Massachusetts Biomarkers of vulnerable atherosclerotic plaques and methods of use
EP1904183B1 (de) 2005-07-05 2014-10-15 Purdue Research Foundation Pharmazeutische Zusammensetzung zur Behandlung von Arthrose
EP1940473A2 (de) 2005-09-23 2008-07-09 Purdue Research Foundation Verfahren und vorrichtung für die multiphotonen-in-vivo-durchflusszytometrie
US8685752B2 (en) 2006-11-03 2014-04-01 Purdue Research Foundation Ex vivo flow cytometry method and device
US20080167544A1 (en) * 2006-12-01 2008-07-10 Cold Spring Diagnostics, Inc. Compositions And Methods For Locating An Internal Bleeding Site
EP2101826B1 (de) * 2006-12-11 2010-06-23 GE Healthcare AS Radioaktiv markierte verbindungen auf peptidbasis und ihre verwendung
EP2567711A3 (de) 2007-02-07 2013-05-01 Purdue Research Foundation Bildgebungsverfahren für Positronenemissionstomographie
CA2688308A1 (en) 2007-05-25 2008-12-04 Purdue Research Foundation Method of imaging localized infections
JP2010533202A (ja) * 2007-07-11 2010-10-21 エンゾン ファーマシューティカルズ，インコーポレーテッド 多置換芳香族部分を含むポリマー性薬剤送達システム
JP5265762B2 (ja) 2008-05-13 2013-08-14 ユニバーシティ・オブ・カンザス 金属抽出ペプチド（ｍａｐ）タグおよび関連する方法
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
EP2408790A1 (de) 2009-03-19 2012-01-25 Wyeth LLC Verfahren zur herstellung von [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)- en-2-yl)ethyl]phosphonsäure und vorstufen davon
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
US20150344523A1 (en) 2014-05-05 2015-12-03 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2017011769A2 (en) 2015-07-15 2017-01-19 California Institute Of Technology Il-17f-specific capture agents, compositions, and methods of using and making
EP3334466B1 (de) 2015-08-14 2020-05-13 Endocyte, Inc. Verfahren zur bildgebung mit einem chelatbildenden verbindung
US20170319722A1 (en) 2016-04-04 2017-11-09 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
EP3519425B1 (de) 2016-09-29 2024-02-28 Indi Molecular, Inc. Zusammensetzungen zum nachweis, zur hemmung und zur bildgebung von indolamin 2,3-dioxygenase 1 (ido1) und verfahren zur herstellung und verwendung davon
EP3638687A1 (de) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f- und il-17a-spezifische fänger, zusammensetzungen und verfahren zur verwendung und herstellung davon
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
WO2020186091A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
WO2020236969A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4385046A (en) * 1980-12-15 1983-05-24 Minnesota Mining And Manufacturing Company Diagnostic radio-labeled polysaccharide derivatives
US4427646A (en) * 1981-04-02 1984-01-24 Research Corporation Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
CA1183008A (en) * 1981-04-10 1985-02-26 Terence H. Colford Flexible couplings
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4571430A (en) * 1982-11-08 1986-02-18 Medi-Physics, Inc. Homocysteine and homocysteinamide derivatives
US4575556A (en) * 1982-11-08 1986-03-11 Medi-Physics, Inc. Bifunctional chelating agents
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
DE3680924D1 (de) * 1985-01-14 1991-09-26 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US4844895A (en) * 1985-11-01 1989-07-04 New York University Composition containing a peptide fragment of platelet factor four and method for restoring suppressed immune responses
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
FR2604371B1 (fr) * 1986-09-30 1990-07-06 Toulouse Inst Nal Sciences App Procede et dispositif d'echange entre un gaz et un liquide
US4729525A (en) * 1986-12-12 1988-03-08 Trw Vehicle Safety Systems Inc. Seat belt retractor with electrically actuatable locking mechanism
DE3889956T2 (de) * 1987-03-26 1994-12-22 Neorx Corp Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie.
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
WO1989000051A1 (en) * 1987-07-07 1989-01-12 Cytrx Biopool Ltd. Fibrin-binding compound and method
US4843647A (en) * 1987-08-31 1989-07-04 Burlington Industries, Inc. Cold weather system
US4889524A (en) * 1987-09-04 1989-12-26 Haemonetics Corporation Portable centrifuge apparatus
DE3731266A1 (de) * 1987-09-17 1989-04-06 Kernforschungsz Karlsruhe Huellmaterial fuer supraleitende draehte
WO1989002752A1 (en) * 1987-09-25 1989-04-06 Genentech, Inc. Method of diagnosing blood clots using fibrin-binding proteins
US5217705A (en) * 1987-09-25 1993-06-08 Neorx Corporation Method of diagnosing blood clots using fibrin-binding proteins
GB8723547D0 (en) * 1987-10-07 1987-11-11 Automotive Prod Plc Clutch control
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
EP0394326B1 (de) * 1987-12-10 1996-07-31 La Jolla Cancer Research Foundation Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden
WO1989010135A1 (en) * 1988-04-29 1989-11-02 New England Deaconess Hospital Corporation Hybrid peptides and methods of their use
AU3778989A (en) * 1988-04-29 1989-11-29 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
US4896388A (en) * 1988-05-10 1990-01-30 Bard Maurice R Water pillow
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
AU3876789A (en) * 1988-06-20 1990-01-12 Washington University Use of modified tpa to detect blood clots
FR2634400B1 (fr) * 1988-07-19 1991-12-06 Becker Arnaud Broyeur a marteaux pour le dechiquetage d'objets metalliques muni d'un dispositif de protection du tambour d'entrainement des marteaux
ATE172796T1 (de) * 1988-08-03 1998-11-15 Univ California Sonde für hohe auflösung nmr mit wiederorientierung der muster
US5180816A (en) * 1988-08-24 1993-01-19 Centocor One vial method for labeling protein/linker conjugates with technetium-99M
US5372933A (en) * 1988-10-03 1994-12-13 The Scripps Research Institute Polypeptides that mimic receptor-induced binding sites, and methods of using same
JP2859343B2 (ja) * 1988-10-14 1999-02-17 ビーエーエスエフ、コーポレーション 油を含んで成る自由流動性噴霧乾燥食用粉末の製造法
FR2639232A1 (fr) * 1988-10-21 1990-05-25 Sanofi Sa Medicaments contenant une interleukine-2 glycosylee
WO1990006323A2 (en) * 1988-11-29 1990-06-14 Centocor, Inc. Chimeric proteins incorporating a metal binding protein
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
US5095111A (en) * 1989-03-17 1992-03-10 The John Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
JPH02268197A (ja) * 1989-04-07 1990-11-01 Ichikawa Gosei Kagaku Kk 新規ペプチド及びその製造用中間体
NZ314680A (en) * 1989-05-09 2000-08-25 Ortho Pharma Corp Treating localised infection or inflammation with a therapeutically conjugated chemotactic peptide
US5395609A (en) * 1989-06-19 1995-03-07 Antisoma Limited Synthetic peptides for use in tumor detection
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
EP0410537A1 (de) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogen-Rezeptor-Antagonisten
CA2021950A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
EP0410539A1 (de) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogenrezeptorantagonisten
CA2021951A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
DK0486622T3 (da) * 1989-08-09 1999-07-19 Rhomed Inc Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5328840A (en) * 1989-08-15 1994-07-12 The Research Foundation Of The State University Of New York Method for preparing targeted carrier erythrocytes
FR2651077B1 (fr) * 1989-08-18 1994-06-10 Letourneur Gregoire Dispositif de traitement d'echo notamment acoustique dans une ligne telephonique
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
NZ235563A (en) * 1989-10-13 1993-04-28 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical composition
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
CA2027936C (en) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5067529A (en) * 1989-10-30 1991-11-26 Depressurized Technologies International, Inc. Aerosol can recycling apparatus and methods
US5086069A (en) * 1990-02-05 1992-02-04 Rorer Pharmaceutical Corporation Anti-thrombotic peptide and pseudopeptide derivatives
US5190920A (en) * 1990-09-24 1993-03-02 W. R. Grace & Co.-Conn. Method for using synthetic analogs of thrombospondin for inhibiting metastasis activity
IL97459A0 (en) * 1990-03-09 1992-06-21 Hybritech Inc Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
JPH05509294A (ja) * 1990-04-06 1993-12-22 ラ　ホヤ　キャンサー　リサーチ　ファウンデーション 血栓症治療のための方法および組成物
AU8721591A (en) * 1990-09-14 1992-04-15 Mallinckrodt Medical, Inc. Novel nitrogen-sulfur ligands useful in radiographic imaging agents
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical preparations containing them
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
EP0570493B1 (de) * 1991-02-08 2000-01-05 Diatide, Inc. Technetium-99m markierte Polypeptide zur Bildformung
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
JP3258659B2 (ja) * 1991-03-06 2002-02-18 ジー．デイー．サール アンド カンパニー 血小板凝集阻害剤として有用なフェニルアミジン誘導体類
US5321034A (en) * 1991-05-07 1994-06-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5220050A (en) * 1991-05-17 1993-06-15 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
AU666318B2 (en) * 1991-06-28 1996-02-08 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
JP2941057B2 (ja) * 1992-05-21 1999-08-25 ダイアテク，インコーポレイテッド 血栓造影用のテクネチウム‐９９ｍ標識ペプチド
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5380646A (en) * 1992-10-19 1995-01-10 Temple University Of The Commonwealth System Of Higher Education Thrombus detection using radiolabelled disintegrins
ATE149971T1 (de) * 1992-12-14 1997-03-15 Nalco Chemical Co Änderung der trihydrat-kristalle im bayer- verfahren
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
DE69431052T2 (de) * 1993-04-08 2003-03-13 Diatide, Inc. Radiomarkierte verbindungen zur thrombus-bilderzeugung
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
ATE210644T1 (de) * 1994-03-18 2001-12-15 Diatide Inc Piperidyl-4-substituierte thyrosin-derivate als szintigraphische kontrastmittel zur diagnose von thrombosen
DE69529988T2 (de) * 1994-05-02 2003-12-11 Diatide, Inc. Technetium-99m markierte bildformungsmittel

Also Published As

Publication number Publication date
US5654272A (en) 1997-08-05
US5788960A (en) 1998-08-04
CA2101942A1 (en) 1992-08-09
US5681541A (en) 1997-10-28
US5811394A (en) 1998-09-22
ATE188387T1 (de) 2000-01-15
US5888474A (en) 1999-03-30
CA2101942C (en) 2001-01-30
WO1992013572A1 (en) 1992-08-20
DE69230525T2 (de) 2000-06-21
EP0570493B1 (de) 2000-01-05
GR3032851T3 (en) 2000-07-31
EP0570493A1 (de) 1993-11-24
DK0570493T3 (da) 2000-06-26
AU1411792A (en) 1992-09-07
AU658617B2 (en) 1995-04-27
ES2141102T3 (es) 2000-03-16
US5879658A (en) 1999-03-09
JP2774378B2 (ja) 1998-07-09
US5849260A (en) 1998-12-15
BR1100906A (pt) 2002-04-02
KR930703024A (ko) 1993-11-29
JPH06503352A (ja) 1994-04-14

Similar Documents

Publication Publication Date Title
DE69230525D1 (de) Technetium-99m markierte Polypeptide zur Bildformung
CA2124458A1 (en) Technetium-99m Labeled Peptides for Imaging
ATE325625T1 (de) Technetium-99m markierte peptide zur diagnostischen bilderzeugung von entzündungen
DE69534943D1 (de) Technetium-99m markierte peptide zur bildformung
ATE152918T1 (de) Technetium-99m-markierte peptide zur bilderzeugung
DE69326335D1 (de) Technetium-99M-markierte peptide zur Bilderzeugung
ATE237365T1 (de) Technetium-99-markierte peptide zur visualisierung vom entzuendungen
ATE196094T1 (de) Technetium-99m markierte peptide zur bilderzeugung von thrombus
SE8904087L (sv) Peptide derivates
IL94039A0 (en) Antibodies to anti-cytotoxic proteins
MY109957A (en) Improved antibodies to plasmodium falciparum
DE3688333D1 (de) Antikoerper gegen polypeptide, die gegen peptide oder proteine mit mindestens teilweise bekannter aminosaeure oder kodierender nukleotidsequenz komplementaer sind und diesbezuegliches aufbauverfahren.
ES2013328A6 (es) Un metodo para detectar anticuerpos contra antigenos hiv-1.
ATE296312T1 (de) Metalkomplexbildner
IL134011A0 (en) Adipocyte-specific protein homologs
DE69028094D1 (de) Konjugate von antikörpern mit variablen domänen
DE69131289D1 (de) Polypeptide mit einer aktivität des menschlichen dopaminergischen rezeptors, deren kodierende nukleinsäuresequenzen und verwendung dieser polypeptide
GR3026434T3 (en) An antibody to the carboxyl terminus peptide of rat somatotropin binding protein

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: DOERRIES FRANK-MOLNIA POHLMANN, 80538 MUENCHEN

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CIS BIO INTERNATIONAL, GIF-SUR-YVETTE, FR

8328 Change in the person/name/address of the agent

Representative=s name: DF-MP, 80333 MUENCHEN

8339 Ceased/non-payment of the annual fee