JPH06503352A - 映像用テクネチウム−99m標識化ポリペプチド - Google Patents
映像用テクネチウム−99m標識化ポリペプチドInfo
- Publication number
- JPH06503352A JPH06503352A JP4505732A JP50573292A JPH06503352A JP H06503352 A JPH06503352 A JP H06503352A JP 4505732 A JP4505732 A JP 4505732A JP 50573292 A JP50573292 A JP 50573292A JP H06503352 A JPH06503352 A JP H06503352A
- Authority
- JP
- Japan
- Prior art keywords
- array
- technetium
- polypeptide
- specific binding
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
Claims (14)
- 1.(a)映像化されるべき標的部位に特異的に結合する特異的結合ポリペプチ ド領域および (b)式: Cp(aa)Cp [式中、Cpは保護システイン、(aa)はアミノ酸である]で示されるテクネ チウム結合領域からなり、該テクネチウム結合領域が特異的結合ポリペプチド領 域に共有結合される、哺乳動物体内でのテクネチウム−99mによる標識および 標的部位の映像のためのポリペプチド。
- 2.特異的結合ポリペプチド領域およびCp(aa)Cpが1個またはそれ以上 のアミノ酸を介して共有結合される請求項1記載のポリペプチド。
- 3.保護システインが式: −CH2−NH−CO−R [式中、Rは炭素原子1〜6個を有する低級アルキル、フェニルまたは低級アル キル、ヒドロキシ、低級アルコキシ、カルボキシもしくは低級アルコキシカルボ ニルで置換されているフェニル、または2−、3−、4−ピリジルである]で示 される保護基を有する請求項1記載のポリペプチド。
- 4.Cp(aa)Cpが、式: ▲数式、化学式、表等があります▼ を有する請求項1記載のポリペプチド。
- 5.特異的結合ポリペプチド領域が血餅、腫瘍、感染部位、アテローム硬化性プ ラーク、アミロイドプラークまたは骨に特異的に結合する請求項1記載のポリペ プチド。
- 6.特異的結合ポリペプチド領域がアミノ酸配列:【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 【配列があります】 からなるポリペプチドから選択される請求項1記載のポリペプチド。
- 7.テクネチウム−99mに結合した請求項6記載のポリペプチド。
- 8.還元剤の存在下、請求項1記載の化合物とテクネチウム−99mとを反応さ せることによって形成される複合体。
- 9.還元剤が亜ジチオン酸イオン、第一スズイオン、または第一鉄イオンからな る群から選択される請求項8記載の複合体。
- 10.予め還元したテクネチウム−99m複合体のリガンド交換によって請求項 1記載の化合物をテクネチウム−99mで標識化して形成された複合体。
- 11.所定量の請求項1記載の化合物および該化合物をテクネチウム−99mで 標識化するのに充分な量の還元剤を含有する密封バイアルからなる、放射性医薬 調製物の製造用キット。
- 12.テクネチウム−99mで標識化される請求項1記載のポリペプチドの有効 診断量を投与し、ここで、特異的結合ポリペプチド領域が標的部位に結合し、次 いで、局在化したテクネチウム−99mを検出することからなる哺乳動物体内に おける標的部位の映像化方法。
- 13.ペプチドがinvitroで化学的に合成される請求項1記載のペプチド の製造方法。
- 14.ペプチドが固相ペプチド合成法によって合成される請求項13記載のペプ チドの製造方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65301291A | 1991-02-08 | 1991-02-08 | |
US653,012 | 1991-02-08 | ||
PCT/US1992/000757 WO1992013572A1 (en) | 1991-02-08 | 1992-02-07 | TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06503352A true JPH06503352A (ja) | 1994-04-14 |
JP2774378B2 JP2774378B2 (ja) | 1998-07-09 |
Family
ID=24619134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4505732A Expired - Fee Related JP2774378B2 (ja) | 1991-02-08 | 1992-02-07 | 映像用テクネチウム−99m標識化ポリペプチド |
Country Status (12)
Country | Link |
---|---|
US (7) | US5654272A (ja) |
EP (1) | EP0570493B1 (ja) |
JP (1) | JP2774378B2 (ja) |
KR (1) | KR930703024A (ja) |
AT (1) | ATE188387T1 (ja) |
BR (1) | BR1100906A (ja) |
CA (1) | CA2101942C (ja) |
DE (1) | DE69230525T2 (ja) |
DK (1) | DK0570493T3 (ja) |
ES (1) | ES2141102T3 (ja) |
GR (1) | GR3032851T3 (ja) |
WO (1) | WO1992013572A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006501149A (ja) * | 2002-05-06 | 2006-01-12 | エンドサイト,インコーポレイテッド | ビタミンを標的とした造影剤 |
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US5460785A (en) * | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
ES2141102T3 (es) * | 1991-02-08 | 2000-03-16 | Diatide Inc | Polipeptidos marcados con tecnecio-99m para la generacion de imagenes. |
US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5993775A (en) * | 1991-11-27 | 1999-11-30 | Diatide, Inc. | Radioactively labeled peptides comprising a single thiol moiety |
DK0629133T3 (da) * | 1992-01-03 | 2001-04-02 | Rhomed Inc | Farmaceutisk anvendelse af peptidmetalioner |
US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
EP0630265B1 (en) * | 1992-03-13 | 2003-04-16 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION |
US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
EP0641222B1 (en) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
US5750088A (en) | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
DE69431052T2 (de) * | 1993-04-08 | 2003-03-13 | Diatide Inc | Radiomarkierte verbindungen zur thrombus-bilderzeugung |
US5464934A (en) * | 1993-05-14 | 1995-11-07 | Mallinckrodt Medical, Inc. | Metal chelates as spacer compounds in biologically active peptides |
DE69434832D1 (de) * | 1993-06-23 | 2006-10-05 | Diatide Inc | Radioaktiv-markierte Peptidderivate des Somatostatins zur bildformenden und therapeutischen Verwendung |
ES2114209T3 (es) * | 1993-07-19 | 1998-05-16 | Resolution Pharm Inc | Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s. |
ZA945587B (en) * | 1993-07-28 | 1995-05-15 | Diatech Inc | Radiolabeled glucans. |
US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
JPH07149668A (ja) * | 1993-11-30 | 1995-06-13 | Kanegafuchi Chem Ind Co Ltd | アミロイド沈着検出用物質 |
US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
JPH09512555A (ja) * | 1994-05-02 | 1997-12-16 | ダイアテック・インコーポレイテッド | テクネチウム−99m標識イメージング剤 |
US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
US5827498A (en) * | 1994-06-07 | 1998-10-27 | Nihon Medi-Physics Co., Ltd. | Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
CA2165228A1 (en) * | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
EP0727225A3 (en) * | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasonic imaging |
US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
US6068829A (en) | 1995-09-11 | 2000-05-30 | The Burnham Institute | Method of identifying molecules that home to a selected organ in vivo |
US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
CA2337438A1 (en) * | 1998-07-13 | 2000-01-20 | Parkash S. Gill | Novel inhibitors of angiogenesis and tumor growth |
EP1132396A4 (en) * | 1998-11-13 | 2002-05-08 | Kyowa Hakko Kogyo Kk | PHYSIOLOGICALLY ACTIVE PEPTIDES |
US6436204B1 (en) * | 1998-11-20 | 2002-08-20 | Kennametal Pc Inc. | Diamond coated cutting tools and method of manufacture |
US6314314B1 (en) | 1999-01-14 | 2001-11-06 | Seth J. Karp | Method for locating an internal bleeding site in a human body |
US6808698B1 (en) | 1999-03-26 | 2004-10-26 | Bristol-Myers Squibb Pharma Company | Method for localization of blood clots |
US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
AU768859B2 (en) * | 1999-07-29 | 2004-01-08 | Dyax Corp. | Binding moieties for fibrin |
US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
US6984373B2 (en) * | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
CA2445826C (en) | 2001-05-02 | 2014-03-25 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
KR100417218B1 (ko) * | 2001-06-13 | 2004-02-05 | 한국원자력연구소 | TC-99m 트리카보닐 시스테인 또는 그 유도체를포함하는 신장기능 진단용 방사성의약품 |
PL207834B1 (pl) * | 2001-07-10 | 2011-02-28 | Ge Healthcare As | Związki na bazie peptydów, ich zastosowanie oraz zawierająca je kompozycja farmaceutyczna |
US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
CA2477836A1 (en) | 2002-03-01 | 2003-09-12 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
CA2513044A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
CA2517939C (en) | 2003-03-03 | 2015-11-24 | Dyax Corp. | Peptides that specifically bind hgf receptor (cmet) and uses thereof |
EP1466629A1 (en) * | 2003-04-11 | 2004-10-13 | BRACCO IMAGING S.p.A. | Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications |
US7319149B2 (en) * | 2003-06-13 | 2008-01-15 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
US7317104B2 (en) | 2003-06-13 | 2008-01-08 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
GB0317815D0 (en) * | 2003-07-30 | 2003-09-03 | Amersham Health As | Imaging agents |
US20060024229A1 (en) * | 2004-07-29 | 2006-02-02 | Seth Karp | Method and product for locating an internal bleeding site |
EP1737889B1 (en) * | 2004-10-19 | 2010-09-08 | Lonza AG | Method for solid phase peptide synthesis |
US7560227B2 (en) * | 2005-02-28 | 2009-07-14 | University Of Massachusetts | Biomarkers of vulnerable atherosclerotic plaques and methods of use |
US20070009434A1 (en) | 2005-07-05 | 2007-01-11 | Low Philip S | Imaging and therapeutic method using monocytes |
WO2007038346A2 (en) | 2005-09-23 | 2007-04-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
US8685752B2 (en) | 2006-11-03 | 2014-04-01 | Purdue Research Foundation | Ex vivo flow cytometry method and device |
US20080167544A1 (en) * | 2006-12-01 | 2008-07-10 | Cold Spring Diagnostics, Inc. | Compositions And Methods For Locating An Internal Bleeding Site |
RU2009119917A (ru) * | 2006-12-11 | 2011-01-20 | ДжиИ Хелткер АС (NO) | Соединения на основе меченных радиоактивным изотопом пептидов и их применения |
EP2109466B1 (en) | 2007-02-07 | 2014-11-12 | Purdue Research Foundation | Positron emission tomography imaging method |
WO2008148001A2 (en) | 2007-05-25 | 2008-12-04 | Purdue Research Foundation | Method of imaging localized infections |
EP2175878A4 (en) * | 2007-07-11 | 2014-12-03 | Belrose Pharma Inc | POLYMER DRUG DISPENSING SYSTEM WITH A MULTIPLE SUBSTITUTED AROMATIC PART |
KR101430627B1 (ko) | 2008-05-13 | 2014-08-14 | 유니버시티 오브 캔사스 | 금속 추출 펩타이드(map) 태그 및 관련된 방법 |
EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
WO2010121133A2 (en) | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
US20120116074A1 (en) | 2009-03-19 | 2012-05-10 | Thomas Gerard Cullen | Methods for the preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid and precursors thereof |
US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
WO2015171543A1 (en) | 2014-05-05 | 2015-11-12 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
CN115112898A (zh) | 2015-07-15 | 2022-09-27 | 加州理工学院 | Il-17f-特异性捕获剂、组合物以及使用和制造的方法 |
ES2811347T3 (es) | 2015-08-14 | 2021-03-11 | Endocyte Inc | Método de formación de imágenes con un compuesto quelante |
EP3440101B1 (en) | 2016-04-04 | 2021-10-06 | Indi Molecular, Inc. | Cd8-specific capture agents, compositions, and methods of using and making |
US11884707B2 (en) | 2016-09-29 | 2024-01-30 | Regeneron Pharmaceuticals, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same |
WO2018232345A1 (en) | 2017-06-15 | 2018-12-20 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
WO2020097531A1 (en) | 2018-11-08 | 2020-05-14 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
US20200291391A1 (en) | 2019-03-12 | 2020-09-17 | Indi Molecular, Inc. | Cross-linked epitopes and methods of use thereof |
WO2020236969A1 (en) | 2019-05-20 | 2020-11-26 | Indi Molecular, Inc. | Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1) |
US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59104377A (ja) * | 1982-11-08 | 1984-06-16 | アマーシャム インターナショナル ピーエルシー | アミノ酸チオラクトン |
JPS60166625A (ja) * | 1983-10-06 | 1985-08-29 | イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− | 追跡標識コンジユゲ−ト |
JPH02268197A (ja) * | 1989-04-07 | 1990-11-01 | Ichikawa Gosei Kagaku Kk | 新規ペプチド及びその製造用中間体 |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4385046A (en) * | 1980-12-15 | 1983-05-24 | Minnesota Mining And Manufacturing Company | Diagnostic radio-labeled polysaccharide derivatives |
US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
CA1183008A (en) * | 1981-04-10 | 1985-02-26 | Terence H. Colford | Flexible couplings |
US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4792525A (en) * | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4575556A (en) * | 1982-11-08 | 1986-03-11 | Medi-Physics, Inc. | Bifunctional chelating agents |
US4571430A (en) * | 1982-11-08 | 1986-02-18 | Medi-Physics, Inc. | Homocysteine and homocysteinamide derivatives |
US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
US4638051A (en) * | 1984-04-30 | 1987-01-20 | The Johns Hopkins University | Brain imaging radiopharmaceuticals |
EP0188256B1 (en) * | 1985-01-14 | 1991-08-21 | NeoRx | Metal radionuclide labeled proteins for diagnosis and therapy |
US4844895A (en) * | 1985-11-01 | 1989-07-04 | New York University | Composition containing a peptide fragment of platelet factor four and method for restoring suppressed immune responses |
US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
FR2604371B1 (fr) * | 1986-09-30 | 1990-07-06 | Toulouse Inst Nal Sciences App | Procede et dispositif d'echange entre un gaz et un liquide |
US4729525A (en) * | 1986-12-12 | 1988-03-08 | Trw Vehicle Safety Systems Inc. | Seat belt retractor with electrically actuatable locking mechanism |
US4965392A (en) * | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
DE3889956T2 (de) * | 1987-03-26 | 1994-12-22 | Neorx Corp | Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie. |
WO1989000051A1 (en) * | 1987-07-07 | 1989-01-12 | Cytrx Biopool Ltd. | Fibrin-binding compound and method |
US4843647A (en) * | 1987-08-31 | 1989-07-04 | Burlington Industries, Inc. | Cold weather system |
US4889524A (en) * | 1987-09-04 | 1989-12-26 | Haemonetics Corporation | Portable centrifuge apparatus |
DE3731266A1 (de) * | 1987-09-17 | 1989-04-06 | Kernforschungsz Karlsruhe | Huellmaterial fuer supraleitende draehte |
CA1335725C (en) * | 1987-09-25 | 1995-05-30 | Stephen W. Hadley | Method of diagnosing blood clots using fibrin-binding proteins |
US5217705A (en) * | 1987-09-25 | 1993-06-08 | Neorx Corporation | Method of diagnosing blood clots using fibrin-binding proteins |
GB8723547D0 (en) * | 1987-10-07 | 1987-11-11 | Automotive Prod Plc | Clutch control |
US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
EP0731110A1 (en) * | 1987-12-10 | 1996-09-11 | La Jolla Cancer Research Foundation | Methods for the production of conformationally stabilized cell adhesion peptides |
JPH03505087A (ja) * | 1988-04-29 | 1991-11-07 | ニュー イングランド ディーコネス ホスピタル コーポレイション | ハイブリッドペプチド及びその使用方法 |
AU3778989A (en) * | 1988-04-29 | 1989-11-29 | Mallinckrodt, Inc. | Diaminedithiol chelating agents for radiopharmaceuticals |
US4896388A (en) * | 1988-05-10 | 1990-01-30 | Bard Maurice R | Water pillow |
US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
AU3876789A (en) * | 1988-06-20 | 1990-01-12 | Washington University | Use of modified tpa to detect blood clots |
FR2634400B1 (fr) * | 1988-07-19 | 1991-12-06 | Becker Arnaud | Broyeur a marteaux pour le dechiquetage d'objets metalliques muni d'un dispositif de protection du tambour d'entrainement des marteaux |
DE68928842T2 (de) * | 1988-08-03 | 1999-04-29 | Univ California | Sonde für hohe auflösung nmr mit wiederorientierung der muster |
US5180816A (en) * | 1988-08-24 | 1993-01-19 | Centocor | One vial method for labeling protein/linker conjugates with technetium-99M |
US5372933A (en) * | 1988-10-03 | 1994-12-13 | The Scripps Research Institute | Polypeptides that mimic receptor-induced binding sites, and methods of using same |
JP2859343B2 (ja) * | 1988-10-14 | 1999-02-17 | ビーエーエスエフ、コーポレーション | 油を含んで成る自由流動性噴霧乾燥食用粉末の製造法 |
FR2639232A1 (fr) * | 1988-10-21 | 1990-05-25 | Sanofi Sa | Medicaments contenant une interleukine-2 glycosylee |
WO1990006323A2 (en) * | 1988-11-29 | 1990-06-14 | Centocor, Inc. | Chimeric proteins incorporating a metal binding protein |
US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
US5095111A (en) * | 1989-03-17 | 1992-03-10 | The John Hopkins University | Thiolactone bifunctional chelating agents for diagnostic and therapeutic products |
NZ233601A (en) * | 1989-05-09 | 1997-06-24 | Gen Hospital Corp | N-terminal acylated peptides having an initial sequence met (or nle) -leu-phe and having a detectable label bound through dtpa or edta to a c-terminal lys or pu residue |
US5395609A (en) * | 1989-06-19 | 1995-03-07 | Antisoma Limited | Synthetic peptides for use in tumor detection |
GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
CA2021951A1 (en) * | 1989-07-28 | 1991-01-29 | Ruth F. Nutt | Fibrinogen receptor antagonists |
CA2021952A1 (en) * | 1989-07-28 | 1991-01-29 | Ruth F. Nutt | Fibrinogen receptor antagonists |
EP0410541A1 (en) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
US5023233A (en) * | 1989-07-28 | 1991-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0410537A1 (en) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
WO1991001754A1 (en) * | 1989-08-09 | 1991-02-21 | Rhodes Buck A | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
US5328840A (en) * | 1989-08-15 | 1994-07-12 | The Research Foundation Of The State University Of New York | Method for preparing targeted carrier erythrocytes |
US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
FR2651077B1 (fr) * | 1989-08-18 | 1994-06-10 | Letourneur Gregoire | Dispositif de traitement d'echo notamment acoustique dans une ligne telephonique |
NZ235564A (en) * | 1989-10-13 | 1993-10-26 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical compositions |
NZ235563A (en) * | 1989-10-13 | 1993-04-28 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical composition |
AU6470590A (en) * | 1989-10-23 | 1991-04-26 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
US5067529A (en) * | 1989-10-30 | 1991-11-26 | Depressurized Technologies International, Inc. | Aerosol can recycling apparatus and methods |
US5086069A (en) * | 1990-02-05 | 1992-02-04 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptide and pseudopeptide derivatives |
US5190920A (en) * | 1990-09-24 | 1993-03-02 | W. R. Grace & Co.-Conn. | Method for using synthetic analogs of thrombospondin for inhibiting metastasis activity |
IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
DE69126871T2 (de) * | 1990-04-06 | 1998-03-12 | Jolla Cancer Res Found | Verfahren und verbindung zur behandlung von thrombose |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5382654A (en) * | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
WO1992005154A1 (en) * | 1990-09-14 | 1992-04-02 | Mallinckrodt Medical, Inc. | Novel nitrogen-sulfur ligands useful in radiographic imaging agents |
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
ES2141102T3 (es) * | 1991-02-08 | 2000-03-16 | Diatide Inc | Polipeptidos marcados con tecnecio-99m para la generacion de imagenes. |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
CA2099994C (en) * | 1991-03-06 | 2003-05-20 | Robert B. Garland | Phenyl amidines derivatives useful as platelet aggregation inhibitors |
US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5220050A (en) * | 1991-05-17 | 1993-06-15 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
ATE228115T1 (de) * | 1991-06-28 | 2002-12-15 | Smithkline Beecham Corp | Bizyklische fibrinogenantagonisten |
US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
US5371184A (en) * | 1992-02-05 | 1994-12-06 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
EP0641222B1 (en) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
US5380646A (en) * | 1992-10-19 | 1995-01-10 | Temple University Of The Commonwealth System Of Higher Education | Thrombus detection using radiolabelled disintegrins |
EP0602900B1 (en) * | 1992-12-14 | 1997-03-12 | Nalco Chemical Company | Trihydrate crystal modification in the bayer process |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
DE69431052T2 (de) * | 1993-04-08 | 2003-03-13 | Diatide Inc | Radiomarkierte verbindungen zur thrombus-bilderzeugung |
US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
DK0750610T3 (da) * | 1994-03-18 | 2002-03-11 | Diatide Inc | Piperidyl-4-substituerede tyrosinderivater som scintigrafiske billedfrembringende midler til diagnose af thrombose |
JPH09512555A (ja) * | 1994-05-02 | 1997-12-16 | ダイアテック・インコーポレイテッド | テクネチウム−99m標識イメージング剤 |
-
1992
- 1992-02-07 ES ES92906285T patent/ES2141102T3/es not_active Expired - Lifetime
- 1992-02-07 DK DK92906285T patent/DK0570493T3/da active
- 1992-02-07 KR KR1019930702357A patent/KR930703024A/ko not_active Application Discontinuation
- 1992-02-07 JP JP4505732A patent/JP2774378B2/ja not_active Expired - Fee Related
- 1992-02-07 AT AT92906285T patent/ATE188387T1/de not_active IP Right Cessation
- 1992-02-07 WO PCT/US1992/000757 patent/WO1992013572A1/en active IP Right Grant
- 1992-02-07 EP EP92906285A patent/EP0570493B1/en not_active Expired - Lifetime
- 1992-02-07 CA CA002101942A patent/CA2101942C/en not_active Expired - Fee Related
- 1992-02-07 DE DE69230525T patent/DE69230525T2/de not_active Expired - Fee Related
-
1994
- 1994-06-22 US US08/263,758 patent/US5654272A/en not_active Expired - Lifetime
- 1994-07-11 US US08/273,274 patent/US5849260A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/463,052 patent/US5788960A/en not_active Expired - Fee Related
- 1995-06-05 US US08/464,456 patent/US5681541A/en not_active Expired - Lifetime
- 1995-06-07 US US08/480,551 patent/US5811394A/en not_active Expired - Fee Related
- 1995-06-07 US US08/475,041 patent/US5879658A/en not_active Expired - Fee Related
- 1995-06-07 US US08/478,725 patent/US5888474A/en not_active Expired - Fee Related
-
1997
- 1997-05-14 BR BR1100906-3A patent/BR1100906A/pt active IP Right Grant
-
2000
- 2000-03-03 GR GR20000400543T patent/GR3032851T3/el not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59104377A (ja) * | 1982-11-08 | 1984-06-16 | アマーシャム インターナショナル ピーエルシー | アミノ酸チオラクトン |
JPS60166625A (ja) * | 1983-10-06 | 1985-08-29 | イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− | 追跡標識コンジユゲ−ト |
JPH02268197A (ja) * | 1989-04-07 | 1990-11-01 | Ichikawa Gosei Kagaku Kk | 新規ペプチド及びその製造用中間体 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006501149A (ja) * | 2002-05-06 | 2006-01-12 | エンドサイト,インコーポレイテッド | ビタミンを標的とした造影剤 |
JP2011012066A (ja) * | 2002-05-06 | 2011-01-20 | Endocyte Inc | ビタミンを標的とした造影剤 |
Also Published As
Publication number | Publication date |
---|---|
EP0570493B1 (en) | 2000-01-05 |
US5788960A (en) | 1998-08-04 |
US5879658A (en) | 1999-03-09 |
DE69230525D1 (de) | 2000-02-10 |
JP2774378B2 (ja) | 1998-07-09 |
US5849260A (en) | 1998-12-15 |
US5811394A (en) | 1998-09-22 |
DK0570493T3 (da) | 2000-06-26 |
ES2141102T3 (es) | 2000-03-16 |
KR930703024A (ko) | 1993-11-29 |
DE69230525T2 (de) | 2000-06-21 |
AU1411792A (en) | 1992-09-07 |
CA2101942A1 (en) | 1992-08-09 |
US5888474A (en) | 1999-03-30 |
US5681541A (en) | 1997-10-28 |
CA2101942C (en) | 2001-01-30 |
EP0570493A1 (en) | 1993-11-24 |
US5654272A (en) | 1997-08-05 |
AU658617B2 (en) | 1995-04-27 |
GR3032851T3 (en) | 2000-07-31 |
BR1100906A (pt) | 2002-04-02 |
ATE188387T1 (de) | 2000-01-15 |
WO1992013572A1 (en) | 1992-08-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH06503352A (ja) | 映像用テクネチウム−99m標識化ポリペプチド | |
JP3036602B2 (ja) | 撮像用テクネチウム−99m標識ペプチド | |
US5711931A (en) | Technetium-99m labelled peptides for imaging inflammation | |
JP2954354B2 (ja) | 造影用のテクネチウム‐99m標識ペプチド | |
AU700772B2 (en) | Peptide derived radionuclide chelators | |
US5720934A (en) | Technetium-99M labeled peptides for imaging | |
US5382654A (en) | Radiolabelled peptide compounds | |
AU697048B2 (en) | Technetium-99m labeled peptides for imaging | |
JPH08509001A (ja) | 炎症をイメージングするためのテクネチウム−99m標識ペプチド | |
JP2954355B2 (ja) | 血栓イメージング用の放射性同位体標識化合物 | |
US6534038B2 (en) | Ternary ligand complexes useful as radiopharmaceuticals | |
JP2006515612A (ja) | 感染及び炎症の造影用強化シンチグラフィーイメージング剤 | |
AU658617C (en) | Technetium-99m labeled polypeptides for imaging | |
US5993775A (en) | Radioactively labeled peptides comprising a single thiol moiety | |
JP3844138B2 (ja) | 隔離された画像化剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080424 Year of fee payment: 10 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090424 Year of fee payment: 11 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090424 Year of fee payment: 11 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100424 Year of fee payment: 12 |
|
LAPS | Cancellation because of no payment of annual fees |