DE69230163T2 - Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten - Google Patents

Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten

Info

Publication number
DE69230163T2
DE69230163T2 DE69230163T DE69230163T DE69230163T2 DE 69230163 T2 DE69230163 T2 DE 69230163T2 DE 69230163 T DE69230163 T DE 69230163T DE 69230163 T DE69230163 T DE 69230163T DE 69230163 T2 DE69230163 T2 DE 69230163T2
Authority
DE
Germany
Prior art keywords
alkyl
compound
salt
formula
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230163T
Other languages
German (de)
English (en)
Other versions
DE69230163D1 (de
Inventor
Matsuda Hiroshi
Okumura Kazuo
Matsuo Masaaki
Shigenaga Shinji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919117733A external-priority patent/GB9117733D0/en
Priority claimed from GB929201057A external-priority patent/GB9201057D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69230163D1 publication Critical patent/DE69230163D1/de
Application granted granted Critical
Publication of DE69230163T2 publication Critical patent/DE69230163T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69230163T 1991-08-16 1992-08-12 Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten Expired - Fee Related DE69230163T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919117733A GB9117733D0 (en) 1991-08-16 1991-08-16 New thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
GB929201057A GB9201057D0 (en) 1992-01-17 1992-01-17 New thiazolylbenzofuran derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

Publications (2)

Publication Number Publication Date
DE69230163D1 DE69230163D1 (de) 1999-11-25
DE69230163T2 true DE69230163T2 (de) 2000-03-23

Family

ID=26299417

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230163T Expired - Fee Related DE69230163T2 (de) 1991-08-16 1992-08-12 Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten

Country Status (16)

Country Link
US (1) US5296495A (enExample)
EP (1) EP0528337B1 (enExample)
JP (1) JP2600644B2 (enExample)
KR (1) KR930004304A (enExample)
CN (1) CN1033088C (enExample)
AT (1) ATE185807T1 (enExample)
AU (1) AU665007B2 (enExample)
CA (1) CA2076192A1 (enExample)
DE (1) DE69230163T2 (enExample)
DK (1) DK0528337T3 (enExample)
ES (1) ES2137169T3 (enExample)
GR (1) GR3032425T3 (enExample)
HU (2) HUT64336A (enExample)
MX (1) MX9204746A (enExample)
SG (1) SG45259A1 (enExample)
TW (1) TW224464B (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100329887B1 (ko) * 1992-11-02 2002-11-02 시오노기세이야쿠가부시키가이샤 (e)-알콕시이미노-및하이드록시이미노-아세트아미드화합물의제조방법 및 그의 제조용중간체
CA2102078A1 (en) * 1992-11-02 1994-05-03 Akira Takase A process for producing (e)-alkoxyimino or hydroxyiminoacetamide compounds and intermediates therefor
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
EP1170009B1 (en) * 1996-01-22 2004-04-07 Fujisawa Pharmaceutical Co., Ltd. Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists
JPH11193281A (ja) * 1997-10-27 1999-07-21 Takeda Chem Ind Ltd アデノシンａ３受容体拮抗剤およびチアゾール化合物
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
WO2003048140A1 (en) 2001-12-03 2003-06-12 Japan Tobacco Inc. Azole compound and medicinal use thereof
EP1424101A3 (en) * 2002-11-29 2004-08-18 NOZAKI, Masako Use of a leukotriene C4 and D4 receptor antagonist for the preparation of a medicament for treating or preventing brain inflammation and sepsis
US7148248B2 (en) 2002-11-29 2006-12-12 Masako Nozaki Method of treating or inhibiting the development of brain inflammation and sepsis
HK1078086A1 (en) * 2003-04-09 2006-03-03 日本烟草产业株式会社 Heteroaromatic pentacyclic compound and medicinal use thereof
WO2004106317A1 (ja) 2003-05-29 2004-12-09 The New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
CN101022796B (zh) 2004-07-14 2013-02-27 炎症研究中心有限公司 抑制肿瘤转移的方法
WO2006017505A2 (en) * 2004-08-04 2006-02-16 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
MX2007004976A (es) 2004-10-25 2007-06-14 Schering Corp Antagonistas de receptor m1 y/o m3 en combinacion con otros compuestos activos para tratar trastornos respiratorios.
WO2006046683A1 (en) * 2004-10-25 2006-05-04 Astellas Pharma Inc. Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists
US8084492B2 (en) * 2004-11-19 2011-12-27 The New Industry Research Organization Benzofuran compound and pharmaceutical composition containing the same
WO2008008327A2 (en) * 2006-07-11 2008-01-17 Schering Corporation Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound
EP2099757B1 (en) * 2006-11-16 2014-06-25 Allergan, Inc. Sulfoximines as kinase inhibitors
TW201111392A (en) 2009-06-16 2011-04-01 Schering Corp Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
AP2013007331A0 (en) 2011-06-24 2013-12-31 Amgen Inc TRPM8 antagonists and their use in treatments
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
US9012450B2 (en) 2011-12-28 2015-04-21 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
PL2797416T3 (pl) 2011-12-28 2017-12-29 Global Blood Therapeutics, Inc. Podstawione związki benzaldehydowe i sposoby ich zastosowania do zwiększania natlenienia tkanek
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
EP2968299B1 (en) 2013-03-15 2021-01-20 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
BR112015021982B1 (pt) 2013-03-15 2022-12-13 Global Blood Therapeutics, Inc Compostos e seus usos para a modulação de hemoglobina
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AP2016009261A0 (en) 2014-02-07 2016-06-30 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
HRP20211778T1 (hr) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
PL3383392T3 (pl) 2015-12-04 2025-11-17 Global Blood Therapeutics, Inc. Schematy dawkowania dla 2-hydroksy-6-((2-(1-izopropylo-1H-pirazol-5-ilo)pirydyn3-ylo)metoksy)benzaldehydu
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3554494A4 (en) 2016-12-19 2021-02-17 Cellixbio Private Limited INFLAMMATION TREATMENT COMPOSITIONS AND METHODS
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
EP4712967A2 (en) * 2023-05-18 2026-03-25 Enveda Therapeutics, Inc. G-protein coupled receptor antagonist

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62142168A (ja) * 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
US4908357A (en) * 1986-04-30 1990-03-13 Fmc Corporation Photoactive azole pesticides
US5001140A (en) * 1989-04-17 1991-03-19 Hoffmann-La Roche Inc. Cycloalkylthiazoles
JPH02169584A (ja) * 1988-12-22 1990-06-29 Mitsubishi Kasei Corp ビニルチアゾール誘導体およびそれを有効成分とする薬剤
US5032588A (en) * 1989-12-08 1991-07-16 Abbott Laboratories Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
DE3941438A1 (de) * 1989-12-15 1991-06-20 Hoechst Ag Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung

Also Published As

Publication number Publication date
JP2600644B2 (ja) 1997-04-16
DE69230163D1 (de) 1999-11-25
SG45259A1 (en) 1998-01-16
AU2102992A (en) 1993-02-18
TW224464B (enExample) 1994-06-01
DK0528337T3 (da) 2000-03-27
EP0528337B1 (en) 1999-10-20
HU9202656D0 (en) 1992-10-28
US5296495A (en) 1994-03-22
EP0528337A1 (en) 1993-02-24
CA2076192A1 (en) 1993-02-17
ES2137169T3 (es) 1999-12-16
KR930004304A (ko) 1993-03-22
CN1070910A (zh) 1993-04-14
JPH05202040A (ja) 1993-08-10
CN1033088C (zh) 1996-10-23
HU211630A9 (en) 1995-12-28
AU665007B2 (en) 1995-12-14
HUT64336A (en) 1993-12-28
MX9204746A (es) 1994-04-29
ATE185807T1 (de) 1999-11-15
GR3032425T3 (en) 2000-05-31

Similar Documents

Publication Publication Date Title
DE69310501T2 (de) Chinolylbenzofuran derivate als leukotrien-antagonisten
US5296495A (en) Thiazolylbenzofuran derivatives and pharmaceutical composition comprising the same
DE69712042T2 (de) Thiazolylbenzofuranderivate und pharmazeutische zusammensetzungen die sie enthalten
DE69322605T2 (de) Imidazo (1,2-a)pyridine als Bradykinin-Antagonisten
DE69529614T2 (de) Heterobizyklische derivate
DE69426205T2 (de) Gastrin-und cck-rezeptorligande
AU768726B2 (en) Indole derivatives and their use for the treatment of osteoporosis amongst other applications
JP2021011494A (ja) Ｐｄｅ４抑制活性を有する化合物の製造方法
IE904235A1 (en) New isoindolone derivatives, their preparation and the¹pharmaceutical compositions containing them
EP0001113A1 (de) Thienothiazinderivate, deren Herstellung, sowie diese enthaltende Präparate
WO1999000372A1 (fr) Sulfamides et leur utilisation medicale
CA2101521A1 (en) 5-heteroyl indole derivatives
DE69224115T2 (de) Heteroaryl substituierte Hydroxylaminderivate als Lipoxygenase-Inhibitoren
DE69125308T2 (de) Indolderivate
CN110498770B (zh) 一种制备恶拉戈利中间体的方法
CA2356838A1 (en) Imidazole compounds and medicinal use thereof
DE69419917T2 (de) Indazolderivate
DE69624582T2 (de) Ester und amide als pla2-inhibitoren
JPH04211652A (ja) ヘキサヒドロベンズ［ｃｄ］インドール
DE60223227T2 (de) BenzoÄbÄthiophenderivate und Verfahren zu deren Herstellung
JPH0378854B2 (enExample)
JPH0673012A (ja) ４−イミノキノリン、その製法およびその使用
HUT65252A (en) Process for producing of quinolin-2-yl-methoxybenzylhydroxyureas and pharmaceutical compositions comprising them
JPS61176563A (ja) ４，４‐ジアルキル‐２‐アゼチジノン類の製造法
JPH08325265A (ja) チアゾリルベンゾフラン誘導体の製造方法、および該製造方法に用いられる化合物

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee