CA2076192A1 - Thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same - Google Patents

Thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same

Info

Publication number
CA2076192A1
CA2076192A1 CA002076192A CA2076192A CA2076192A1 CA 2076192 A1 CA2076192 A1 CA 2076192A1 CA 002076192 A CA002076192 A CA 002076192A CA 2076192 A CA2076192 A CA 2076192A CA 2076192 A1 CA2076192 A1 CA 2076192A1
Authority
CA
Canada
Prior art keywords
img
compound
alkyl
salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002076192A
Other languages
English (en)
French (fr)
Inventor
Masaaki Matsuo
Kazuo Okumura
Shinji Shigenaga
Hiroshi Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919117733A external-priority patent/GB9117733D0/en
Priority claimed from GB929201057A external-priority patent/GB9201057D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of CA2076192A1 publication Critical patent/CA2076192A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002076192A 1991-08-16 1992-08-14 Thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same Abandoned CA2076192A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9117733.7 1991-08-16
GB919117733A GB9117733D0 (en) 1991-08-16 1991-08-16 New thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
GB9201057.8 1992-01-17
GB929201057A GB9201057D0 (en) 1992-01-17 1992-01-17 New thiazolylbenzofuran derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
CA2076192A1 true CA2076192A1 (en) 1993-02-17

Family

ID=26299417

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002076192A Abandoned CA2076192A1 (en) 1991-08-16 1992-08-14 Thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same

Country Status (16)

Country Link
US (1) US5296495A (enExample)
EP (1) EP0528337B1 (enExample)
JP (1) JP2600644B2 (enExample)
KR (1) KR930004304A (enExample)
CN (1) CN1033088C (enExample)
AT (1) ATE185807T1 (enExample)
AU (1) AU665007B2 (enExample)
CA (1) CA2076192A1 (enExample)
DE (1) DE69230163T2 (enExample)
DK (1) DK0528337T3 (enExample)
ES (1) ES2137169T3 (enExample)
GR (1) GR3032425T3 (enExample)
HU (2) HUT64336A (enExample)
MX (1) MX9204746A (enExample)
SG (1) SG45259A1 (enExample)
TW (1) TW224464B (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2102078A1 (en) * 1992-11-02 1994-05-03 Akira Takase A process for producing (e)-alkoxyimino or hydroxyiminoacetamide compounds and intermediates therefor
KR100329887B1 (ko) * 1992-11-02 2002-11-02 시오노기세이야쿠가부시키가이샤 (e)-알콕시이미노-및하이드록시이미노-아세트아미드화합물의제조방법 및 그의 제조용중간체
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
KR19990076788A (ko) * 1996-01-22 1999-10-15 후지야마 아키라 티아졸릴벤조푸란 유도체 및 그를 함유하는 약제학적 조성물
ATE257703T1 (de) * 1997-10-27 2004-01-15 Takeda Chemical Industries Ltd 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
AU2002349705A1 (en) 2001-12-03 2003-06-17 Japan Tobacco Inc. Azole compound and medicinal use thereof
US7148248B2 (en) 2002-11-29 2006-12-12 Masako Nozaki Method of treating or inhibiting the development of brain inflammation and sepsis
EP1424101A3 (en) * 2002-11-29 2004-08-18 NOZAKI, Masako Use of a leukotriene C4 and D4 receptor antagonist for the preparation of a medicament for treating or preventing brain inflammation and sepsis
WO2004089918A1 (ja) * 2003-04-09 2004-10-21 Japan Tobacco Inc. 複素芳香５員環化合物及びその医薬用途
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
EP1627873A4 (en) 2003-05-29 2007-12-05 New Ind Res Organization BENZOFURAN-BASED COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
CN101022796B (zh) 2004-07-14 2013-02-27 炎症研究中心有限公司 抑制肿瘤转移的方法
MX2007001561A (es) * 2004-08-04 2007-04-16 Schering Corp Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas.
WO2006046683A1 (en) * 2004-10-25 2006-05-04 Astellas Pharma Inc. Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists
US20060110449A1 (en) 2004-10-25 2006-05-25 Lorber Richard R Pharmaceutical composition
JPWO2006054793A1 (ja) * 2004-11-19 2008-06-05 財団法人新産業創造研究機構 ベンゾフラン化合物、およびそれを含有してなる医薬組成物
KR20090026217A (ko) * 2006-07-11 2009-03-11 쉐링 코포레이션 치환된 5-옥사졸-2-일-퀴놀린 화합물의 크시나포에이트 염
CA2669704A1 (en) * 2006-11-16 2008-05-22 Allergan, Inc. Sulfoximines as kinase inhibitors
CA2764830A1 (en) 2009-06-16 2010-12-23 Schering Corporation Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
EP2723717A2 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
AU2012272898A1 (en) 2011-06-24 2013-04-11 Amgen Inc. TRPM8 antagonists and their use in treatments
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
CA3142817A1 (en) * 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
CN112500338A (zh) 2013-03-15 2021-03-16 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP3919056B1 (en) 2013-03-15 2024-08-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP2968299B1 (en) 2013-03-15 2021-01-20 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
SG10201911662YA (en) 2014-02-07 2020-02-27 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
DK3186233T3 (da) 2014-08-29 2021-11-22 Chdi Foundation Inc Prober til billeddannelse af huntingtin-protein
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
HUE072191T2 (hu) 2015-12-04 2025-10-28 Global Blood Therapeutics Inc A 2-hidoxi-6-((2-(1-izopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehid adagolási rendje
TWI825524B (zh) 2016-05-12 2023-12-11 美商全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
WO2018115984A1 (en) 2016-12-19 2018-06-28 Cellix Bio Private Limited Compositions and methods for the treatment of inflammation
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin
TW202500134A (zh) * 2023-05-18 2025-01-01 美商恩維達醫療公司 G-蛋白偶聯受體之拮抗劑

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62142168A (ja) * 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
US4908357A (en) * 1986-04-30 1990-03-13 Fmc Corporation Photoactive azole pesticides
US5001140A (en) * 1989-04-17 1991-03-19 Hoffmann-La Roche Inc. Cycloalkylthiazoles
JPH02169584A (ja) * 1988-12-22 1990-06-29 Mitsubishi Kasei Corp ビニルチアゾール誘導体およびそれを有効成分とする薬剤
US5032588A (en) * 1989-12-08 1991-07-16 Abbott Laboratories Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
DE3941438A1 (de) * 1989-12-15 1991-06-20 Hoechst Ag Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung

Also Published As

Publication number Publication date
EP0528337B1 (en) 1999-10-20
ES2137169T3 (es) 1999-12-16
JP2600644B2 (ja) 1997-04-16
HU211630A9 (en) 1995-12-28
SG45259A1 (en) 1998-01-16
CN1033088C (zh) 1996-10-23
KR930004304A (ko) 1993-03-22
HU9202656D0 (en) 1992-10-28
GR3032425T3 (en) 2000-05-31
MX9204746A (es) 1994-04-29
TW224464B (enExample) 1994-06-01
DE69230163D1 (de) 1999-11-25
AU665007B2 (en) 1995-12-14
JPH05202040A (ja) 1993-08-10
CN1070910A (zh) 1993-04-14
ATE185807T1 (de) 1999-11-15
DE69230163T2 (de) 2000-03-23
AU2102992A (en) 1993-02-18
US5296495A (en) 1994-03-22
DK0528337T3 (da) 2000-03-27
EP0528337A1 (en) 1993-02-24
HUT64336A (en) 1993-12-28

Similar Documents

Publication Publication Date Title
US5296495A (en) Thiazolylbenzofuran derivatives and pharmaceutical composition comprising the same
EP0626956B1 (en) Quinolylbenzofuran derivatives as leukotriene antagonists
US5679678A (en) Thienithiazine derivatives
US5994378A (en) Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them
KR0170458B1 (ko) 신규한 아세틸 콜린에스테라제 저해제로서의 헤테로아릴 아민
AU758325B2 (en) Imidazole compounds and medicinal use thereof
CA2217707A1 (en) Indole derivatives as cgmp-pde inhibitors
CA2102137A1 (en) Heterocyclic compounds
CN101835766B (zh) 作为腺苷a1受体拮抗体的化合物
WO1992012154A1 (en) Imidazotriazine derivatives
CA2031693A1 (en) Antiarrhytmic agents
JPH10130147A (ja) 異項環置換アシルアミノチアゾールを含む医薬組成物
CA2549651A1 (en) Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-hsd-1) for the treatment of diabetes and obesity
WO1998039330A1 (en) Heterocyclic compounds as cox-2 inhibitors
JPH10503770A (ja) 医薬としてのベンゾイルグアニジン誘導体
JPH11508267A (ja) ピラゾール化合物および医薬組成物
CA1247099A (en) 2-oxoindole 3-carboxamide derivative antiinflammatory agents
JPH10114654A (ja) 新規用途
HU203238B (en) Process for producing antiinflammatory tricyclic oxindole derivatives
CA2149429A1 (en) Aryl thiopyrano(2,3,4-c,d)indoles as inhibitors of leukotriene biosynthesis
CA2100682A1 (en) Indoles useful as platelet activating factor antagonists
JP3553127B2 (ja) エーテル誘導体、その製造方法およびロイコトリエンが介在する疾患または症状に使用するためのそれを含有する調剤学的組成物
JPH0378854B2 (enExample)
JPH09509957A (ja) 免疫調節剤としてのキノリン誘導体
AU2351295A (en) Aryl and heteroaryl alkoxynaphthalene derivatives

Legal Events

Date Code Title Description
FZDE Discontinued