DE69228033D1 - 3,6-disubstituierte Pyridazin-Derivate - Google Patents
3,6-disubstituierte Pyridazin-DerivateInfo
- Publication number
- DE69228033D1 DE69228033D1 DE69228033T DE69228033T DE69228033D1 DE 69228033 D1 DE69228033 D1 DE 69228033D1 DE 69228033 T DE69228033 T DE 69228033T DE 69228033 T DE69228033 T DE 69228033T DE 69228033 D1 DE69228033 D1 DE 69228033D1
- Authority
- DE
- Germany
- Prior art keywords
- disubstituted pyridazine
- pyridazine derivatives
- disorder
- disubstituted
- circulation disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24764791 | 1991-09-26 | ||
JP33527791 | 1991-12-18 | ||
JP4239545A JP2730421B2 (ja) | 1991-09-26 | 1992-09-08 | 3,6−ジ置換ピリダジン誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69228033D1 true DE69228033D1 (de) | 1999-02-11 |
DE69228033T2 DE69228033T2 (de) | 1999-07-15 |
Family
ID=27332704
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69228033T Expired - Fee Related DE69228033T2 (de) | 1991-09-26 | 1992-09-24 | 3,6-disubstituierte Pyridazin-Derivate |
Country Status (11)
Country | Link |
---|---|
US (2) | US5324727A (de) |
EP (1) | EP0534443B1 (de) |
JP (1) | JP2730421B2 (de) |
KR (1) | KR100256114B1 (de) |
AT (1) | ATE175200T1 (de) |
CA (1) | CA2078699A1 (de) |
DE (1) | DE69228033T2 (de) |
DK (1) | DK0534443T3 (de) |
ES (1) | ES2128333T3 (de) |
GR (1) | GR3029410T3 (de) |
TW (1) | TW279162B (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69500673T2 (de) | 1994-05-19 | 1998-03-19 | Mitsubishi Chem Corp | Arzneimittel zur therapeutischen und prophylaktischen Behandlung von Krankheiten, die durch Hyperplasie der glatten Muskelzellen bedingt sind |
NZ290952A (en) * | 1994-08-09 | 1998-05-27 | Eisai Co Ltd | Phthalazine derivatives optionally substituted in position-1 by (generally benzyl) amino groups |
EP0825187A1 (de) * | 1996-08-22 | 1998-02-25 | Takeda Chemical Industries, Ltd. | Kondensierte Pyridazinylguanidine, ihre Herstellung und Verwendung |
GB9707693D0 (en) * | 1997-04-16 | 1997-06-04 | Smithkline Beecham Plc | Novel method of treatment |
HUP0100280A3 (en) | 1997-12-05 | 2003-03-28 | Astrazeneca Uk Ltd | Pyrrolo-, thieno-, furano- and pyrazolo- [3,4d]-pyridazinones, process for their preparation and pharmaceutical compositions containing them |
PL339836A1 (en) | 1998-02-19 | 2001-01-02 | Eisai Co Ltd | Phtalazine compounds and therapeutic agents suitable to treat erection disorders |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
US6180629B1 (en) | 1998-08-14 | 2001-01-30 | Cell Pathways, Inc. | [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia |
US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
US6903101B1 (en) | 2000-08-10 | 2005-06-07 | Bayer Pharmaceuticals Corporation | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity |
JPWO2004089412A1 (ja) * | 2003-04-08 | 2006-07-06 | 三菱ウェルファーマ株式会社 | 特異的nad(p)hオキシダーゼ抑制剤 |
WO2005080378A1 (ja) * | 2004-02-24 | 2005-09-01 | Mitsubishi Pharma Corporation | 縮合ピリダジン誘導体 |
AU2005260102A1 (en) * | 2004-05-08 | 2006-01-12 | Novartis International Pharmaceutical Ltd. | 3-aryl-5,6-disubstituted pyridazines |
JP2009120486A (ja) * | 2005-12-05 | 2009-06-04 | Mitsubishi Pharma Corp | 核内オーファン受容体の新規活性化剤及びその用途 |
CN105017187B (zh) | 2009-07-08 | 2017-10-24 | 德米拉(加拿大)公司 | 用于治疗皮肤病症或疾病状态的tofa类似物 |
KR20180030913A (ko) | 2015-07-30 | 2018-03-26 | 브리스톨-마이어스 스큅 컴퍼니 | 아릴 치환된 비시클릭 헤테로아릴 화합물 |
US20190315774A1 (en) | 2016-07-14 | 2019-10-17 | Bristol-Myers Squibb Company | Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as par4 inhibitors |
WO2018013774A1 (en) * | 2016-07-14 | 2018-01-18 | Bristol-Myers Squibb Company | Bicyclic heteroaryl substituted compounds |
KR20220130126A (ko) * | 2019-12-20 | 2022-09-26 | 미라티 테라퓨틱스, 인크. | Sos1 억제제 |
CN115417856A (zh) * | 2021-09-30 | 2022-12-02 | 成都奥睿药业有限公司 | 一类取代杂芳酞嗪衍生物的药学用途及其制备方法 |
WO2023135260A1 (en) * | 2022-01-14 | 2023-07-20 | Jazz Pharmaceuticals Ireland Limited | Novel amine-substituted phthalazines and derivatives as sos1 inhibitors |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
GB1303061A (de) * | 1969-05-03 | 1973-01-17 | ||
JPS565739B2 (de) * | 1972-10-04 | 1981-02-06 | ||
JPS5741469B2 (de) * | 1973-12-05 | 1982-09-03 | ||
JPS5742069B2 (de) * | 1974-01-11 | 1982-09-07 | ||
DE2452491A1 (de) * | 1974-11-05 | 1976-05-06 | Thiemann Chem Pharm Fab | Hydrodipyrano-phthalazinverbindungen und solche verbindungen enthaltende arzneimittel |
JPS5653659A (en) * | 1979-10-09 | 1981-05-13 | Mitsubishi Yuka Yakuhin Kk | Blood platelet coagulation suppressing agent |
JPS5653660A (en) * | 1979-10-09 | 1981-05-13 | Mitsubishi Yuka Yakuhin Kk | 4-phenylphthalazine derivative |
GB2063249A (en) * | 1979-10-09 | 1981-06-03 | Mitsubishi Yuka Pharma | 4-Phenylphthalazine derivatives |
JPS5748972A (en) * | 1980-09-10 | 1982-03-20 | Mitsubishi Yuka Yakuhin Kk | 4-phenylphthalazine derivative |
JPS57167974A (en) * | 1981-04-09 | 1982-10-16 | Mitsubishi Yuka Yakuhin Kk | Preparation of 4-phenylphthalazine derivative |
JPS60218377A (ja) * | 1984-04-16 | 1985-11-01 | Mitsubishi Yuka Yakuhin Kk | 4−フエニルフタラジン誘導体及びそれを有効成分とする循環改善剤 |
JPS60243074A (ja) * | 1985-04-15 | 1985-12-03 | Mitsubishi Yuka Yakuhin Kk | 4−フエニルフタラジン誘導体 |
JPH02129183A (ja) * | 1988-11-04 | 1990-05-17 | Morishita Pharmaceut Co Ltd | 1−アニリノ−4−(1h−イミダゾール−1−イル)フタラジン誘導体及びそれを有効成分とする血小板凝集抑制剤 |
JPH02129182A (ja) * | 1988-11-04 | 1990-05-17 | Morishita Pharmaceut Co Ltd | 1−(1h−イミダゾール−1−イル)−4−置換フェニルフタラジン誘導体及びそれらを含有する血小板凝集抑制剤 |
JPH02129181A (ja) * | 1988-11-04 | 1990-05-17 | Morishita Pharmaceut Co Ltd | 1−アリール−4−(1h−イミダゾール−1−イル)フタラジン誘導体 |
JPH02129180A (ja) * | 1988-11-04 | 1990-05-17 | Morishita Pharmaceut Co Ltd | 1−(1h−イミダゾール−1−イル)フタラジン誘導体 |
JPH03106873A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 1―ピリジルフタラジン誘導体及びそれらを含有する血小板凝集抑制剤 |
JPH03106875A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 1―(3―ピリジルメチル)フタラジン誘導体 |
JPH03106874A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 4―ピリジル―1(2h)フタラジノン |
JPH03106872A (ja) * | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | 1―置換フェニル―4―ピリジルフタラジン誘導体 |
ATE115136T1 (de) * | 1990-03-30 | 1994-12-15 | Mitsubishi Chem Ind | 4-phenylphthalazin-derivate. |
-
1992
- 1992-09-02 TW TW081106956A patent/TW279162B/zh active
- 1992-09-08 JP JP4239545A patent/JP2730421B2/ja not_active Expired - Lifetime
- 1992-09-21 CA CA002078699A patent/CA2078699A1/en not_active Abandoned
- 1992-09-24 ES ES92116413T patent/ES2128333T3/es not_active Expired - Lifetime
- 1992-09-24 EP EP92116413A patent/EP0534443B1/de not_active Expired - Lifetime
- 1992-09-24 AT AT92116413T patent/ATE175200T1/de not_active IP Right Cessation
- 1992-09-24 DE DE69228033T patent/DE69228033T2/de not_active Expired - Fee Related
- 1992-09-24 DK DK92116413T patent/DK0534443T3/da active
- 1992-09-25 US US950947A patent/US5324727A/en not_active Expired - Fee Related
- 1992-09-26 KR KR1019920017593A patent/KR100256114B1/ko not_active IP Right Cessation
-
1994
- 1994-03-21 US US08/215,426 patent/US5462941A/en not_active Expired - Fee Related
-
1999
- 1999-02-16 GR GR990400492T patent/GR3029410T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2128333T3 (es) | 1999-05-16 |
US5324727A (en) | 1994-06-28 |
EP0534443B1 (de) | 1998-12-30 |
KR930005984A (ko) | 1993-04-20 |
DE69228033T2 (de) | 1999-07-15 |
TW279162B (de) | 1996-06-21 |
JP2730421B2 (ja) | 1998-03-25 |
CA2078699A1 (en) | 1993-03-27 |
KR100256114B1 (ko) | 2000-08-01 |
JPH06135938A (ja) | 1994-05-17 |
EP0534443A1 (de) | 1993-03-31 |
GR3029410T3 (en) | 1999-05-28 |
US5462941A (en) | 1995-10-31 |
ATE175200T1 (de) | 1999-01-15 |
DK0534443T3 (da) | 1999-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |