JPS5748972A - 4-phenylphthalazine derivative - Google Patents

4-phenylphthalazine derivative

Info

Publication number
JPS5748972A
JPS5748972A JP12464480A JP12464480A JPS5748972A JP S5748972 A JPS5748972 A JP S5748972A JP 12464480 A JP12464480 A JP 12464480A JP 12464480 A JP12464480 A JP 12464480A JP S5748972 A JPS5748972 A JP S5748972A
Authority
JP
Japan
Prior art keywords
derivative shown
formula
phenylphthalazine
phenylphthalazine derivative
cerebral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12464480A
Other languages
Japanese (ja)
Other versions
JPS6334871B2 (en
Inventor
Yasuhiro Morinaka
Motokuni Mori
Toshimoto Kanayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Yuka Pharmaceutical Co Ltd
Original Assignee
Mitsubishi Yuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Yuka Pharmaceutical Co Ltd filed Critical Mitsubishi Yuka Pharmaceutical Co Ltd
Priority to JP12464480A priority Critical patent/JPS5748972A/en
Priority to GB8030906A priority patent/GB2063249A/en
Priority to NL8005411A priority patent/NL8005411A/en
Priority to FR8021530A priority patent/FR2468593A1/en
Priority to IT25206/80A priority patent/IT1148727B/en
Priority to DE19803038166 priority patent/DE3038166A1/en
Publication of JPS5748972A publication Critical patent/JPS5748972A/en
Publication of JPS6334871B2 publication Critical patent/JPS6334871B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 4-phenylphthalazine derivative shown by the formula I[R1WR3 are alkyl, alkoxy, halogen, alkoxycarbonyl, carboxyl, alkylcarbonyl, hydroxyl, or trifluoromethyl; l, m, and n are 0W3(except that both m and n are 0)] and its pharmaceutically acceptable salt.
EXAMPLE: 1-(3-Chloroanilino)-4-(4-methylphenyl)phthalazine.
USE: A preventive and remedy for cerebral thrombosis, cerebral infarction, myocardial infarction, and arterioscherosis. Stable and has strong inhibiting actions on blood platelet aggregation.
PROCESS: For example, a 1-chloro-4-phenylphthalazine derivative shown by the formula II is reacted with an aniline derivative shown by the formula III preferably in the presence of a catalyst.
COPYRIGHT: (C)1982,JPO&Japio
JP12464480A 1979-10-09 1980-09-10 4-phenylphthalazine derivative Granted JPS5748972A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP12464480A JPS5748972A (en) 1980-09-10 1980-09-10 4-phenylphthalazine derivative
GB8030906A GB2063249A (en) 1979-10-09 1980-09-25 4-Phenylphthalazine derivatives
NL8005411A NL8005411A (en) 1979-10-09 1980-09-30 4-PHENYLFTALAZINE DERIVATIVES.
FR8021530A FR2468593A1 (en) 1979-10-09 1980-10-08 4-PHENYLPHTALAZINE DERIVATIVES AS INHIBITORY DRUGS IN THE AGGREGATION OF BLOOD PLAQUETTES, AND PROCESS FOR THEIR PREPARATION
IT25206/80A IT1148727B (en) 1979-10-09 1980-10-08 THERAPEUTIC ACTION 4-FENYL-PHTALAZINE DERIVATIVES
DE19803038166 DE3038166A1 (en) 1979-10-09 1980-10-09 4-PHENYLPHTHALAZINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12464480A JPS5748972A (en) 1980-09-10 1980-09-10 4-phenylphthalazine derivative

Publications (2)

Publication Number Publication Date
JPS5748972A true JPS5748972A (en) 1982-03-20
JPS6334871B2 JPS6334871B2 (en) 1988-07-12

Family

ID=14890500

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12464480A Granted JPS5748972A (en) 1979-10-09 1980-09-10 4-phenylphthalazine derivative

Country Status (1)

Country Link
JP (1) JPS5748972A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324727A (en) * 1991-09-26 1994-06-28 Mitsubishi Chem Ind 3,6-disubstituted pyridazine derivatives
EP0682947A1 (en) 1994-05-19 1995-11-22 Mitsubishi Chemical Corporation Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia
JP2007536276A (en) * 2004-05-08 2007-12-13 ニューロジェン・コーポレーション 3-Aryl-5,6-disubstituted pyridazines
KR20180046904A (en) * 2016-10-28 2018-05-09 주식회사 대웅제약 Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324727A (en) * 1991-09-26 1994-06-28 Mitsubishi Chem Ind 3,6-disubstituted pyridazine derivatives
US5462941A (en) * 1991-09-26 1995-10-31 Mitsubishi Chemical Corporation 3,6-disubstituted pyradazine derivatives
EP0682947A1 (en) 1994-05-19 1995-11-22 Mitsubishi Chemical Corporation Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia
JP2007536276A (en) * 2004-05-08 2007-12-13 ニューロジェン・コーポレーション 3-Aryl-5,6-disubstituted pyridazines
KR20180046904A (en) * 2016-10-28 2018-05-09 주식회사 대웅제약 Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
JPS6334871B2 (en) 1988-07-12

Similar Documents

Publication Publication Date Title
DE69327536T2 (en) FIBRINOGEN RECEPTOR ANTAGONISTS
JPS5653659A (en) Blood platelet coagulation suppressing agent
JPS5748972A (en) 4-phenylphthalazine derivative
NO911459D0 (en) USE OF METALLION COMPLEXS AS INVESTMENT INHIBITORS.
DE3464603D1 (en) 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acid derivatives, processes for the preparation thereof, and antiallergic agent containing the same
JPS53119866A (en) 5-aryloxy-oxazoleakanoic acid derivatives and their preparation
EP0127124A3 (en) Compounds for treating hypertension
JPS5331669A (en) Novel n-acylpiperidinecaroxyanilide derivatives and their preparation
JPS579771A (en) Tetrazole derivative
JPS52111580A (en) Novel indene derivatives and salts thereof
JPS5295666A (en) 2-imino-1,3-diazacycloalkane derivatives
IE840831L (en) 1,4-dihydropyridine derivatives
JPS535174A (en) Alicyclic derivatives
JPS5239674A (en) Imidazole derivatives and agricultural bactericides therefrom
JPS55102516A (en) Remedy for glaucoma
JPS5328163A (en) Novel 1-benzyl-3-pyrrolidoneoxime derivatives and their preparation
JPS5283652A (en) Benzanthrone derivatives
JPS52139066A (en) 5-(p-diethylaminophenyl)-1,3,4-oxadiazole derivatives and their preparation
JPS5353638A (en) Alpha-acetyl cinnamic acid ester derivatives, their preparation and theirherbicides containing the same
JPS5519224A (en) 4-carboxy-1-phthalazone derivative
DE3164366D1 (en) 4-(2,5-dihydroxyphenyl-1) crotonic acid and its derivatives, and processes for the preparation of these compounds
JPS5283777A (en) Novel 7-methoxycepharosporin
ES8505669A1 (en) Triazolylmethyl-pyridyloxymethyl-carbinol derivatives.
JPS532473A (en) N-3-pyridyl-n#-phenylamidine derivatives, method of preparing same, and fungicides for agriculture and gardening use
JPS5350182A (en) Carbostyril derivatives