JPS5748972A - 4-phenylphthalazine derivative - Google Patents
4-phenylphthalazine derivativeInfo
- Publication number
- JPS5748972A JPS5748972A JP12464480A JP12464480A JPS5748972A JP S5748972 A JPS5748972 A JP S5748972A JP 12464480 A JP12464480 A JP 12464480A JP 12464480 A JP12464480 A JP 12464480A JP S5748972 A JPS5748972 A JP S5748972A
- Authority
- JP
- Japan
- Prior art keywords
- derivative shown
- formula
- phenylphthalazine
- phenylphthalazine derivative
- cerebral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A 4-phenylphthalazine derivative shown by the formula I[R1WR3 are alkyl, alkoxy, halogen, alkoxycarbonyl, carboxyl, alkylcarbonyl, hydroxyl, or trifluoromethyl; l, m, and n are 0W3(except that both m and n are 0)] and its pharmaceutically acceptable salt.
EXAMPLE: 1-(3-Chloroanilino)-4-(4-methylphenyl)phthalazine.
USE: A preventive and remedy for cerebral thrombosis, cerebral infarction, myocardial infarction, and arterioscherosis. Stable and has strong inhibiting actions on blood platelet aggregation.
PROCESS: For example, a 1-chloro-4-phenylphthalazine derivative shown by the formula II is reacted with an aniline derivative shown by the formula III preferably in the presence of a catalyst.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12464480A JPS5748972A (en) | 1980-09-10 | 1980-09-10 | 4-phenylphthalazine derivative |
GB8030906A GB2063249A (en) | 1979-10-09 | 1980-09-25 | 4-Phenylphthalazine derivatives |
NL8005411A NL8005411A (en) | 1979-10-09 | 1980-09-30 | 4-PHENYLFTALAZINE DERIVATIVES. |
FR8021530A FR2468593A1 (en) | 1979-10-09 | 1980-10-08 | 4-PHENYLPHTALAZINE DERIVATIVES AS INHIBITORY DRUGS IN THE AGGREGATION OF BLOOD PLAQUETTES, AND PROCESS FOR THEIR PREPARATION |
IT25206/80A IT1148727B (en) | 1979-10-09 | 1980-10-08 | THERAPEUTIC ACTION 4-FENYL-PHTALAZINE DERIVATIVES |
DE19803038166 DE3038166A1 (en) | 1979-10-09 | 1980-10-09 | 4-PHENYLPHTHALAZINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12464480A JPS5748972A (en) | 1980-09-10 | 1980-09-10 | 4-phenylphthalazine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5748972A true JPS5748972A (en) | 1982-03-20 |
JPS6334871B2 JPS6334871B2 (en) | 1988-07-12 |
Family
ID=14890500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12464480A Granted JPS5748972A (en) | 1979-10-09 | 1980-09-10 | 4-phenylphthalazine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5748972A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324727A (en) * | 1991-09-26 | 1994-06-28 | Mitsubishi Chem Ind | 3,6-disubstituted pyridazine derivatives |
EP0682947A1 (en) | 1994-05-19 | 1995-11-22 | Mitsubishi Chemical Corporation | Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia |
JP2007536276A (en) * | 2004-05-08 | 2007-12-13 | ニューロジェン・コーポレーション | 3-Aryl-5,6-disubstituted pyridazines |
KR20180046904A (en) * | 2016-10-28 | 2018-05-09 | 주식회사 대웅제약 | Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same |
-
1980
- 1980-09-10 JP JP12464480A patent/JPS5748972A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324727A (en) * | 1991-09-26 | 1994-06-28 | Mitsubishi Chem Ind | 3,6-disubstituted pyridazine derivatives |
US5462941A (en) * | 1991-09-26 | 1995-10-31 | Mitsubishi Chemical Corporation | 3,6-disubstituted pyradazine derivatives |
EP0682947A1 (en) | 1994-05-19 | 1995-11-22 | Mitsubishi Chemical Corporation | Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia |
JP2007536276A (en) * | 2004-05-08 | 2007-12-13 | ニューロジェン・コーポレーション | 3-Aryl-5,6-disubstituted pyridazines |
KR20180046904A (en) * | 2016-10-28 | 2018-05-09 | 주식회사 대웅제약 | Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same |
Also Published As
Publication number | Publication date |
---|---|
JPS6334871B2 (en) | 1988-07-12 |
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