DE69133235T2 - Verfahren zur Herstellung von Harzen für die Feststoff-Peptidsynthese - Google Patents

Verfahren zur Herstellung von Harzen für die Feststoff-Peptidsynthese

Info

Publication number
DE69133235T2
DE69133235T2 DE69133235T DE69133235T DE69133235T2 DE 69133235 T2 DE69133235 T2 DE 69133235T2 DE 69133235 T DE69133235 T DE 69133235T DE 69133235 T DE69133235 T DE 69133235T DE 69133235 T2 DE69133235 T2 DE 69133235T2
Authority
DE
Germany
Prior art keywords
resins
preparation
peptide synthesis
solid peptide
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133235T
Other languages
English (en)
Other versions
DE69133235D1 (de
Inventor
George Barany
Jane Chang
Nuria A Sole
Fernando Albericio
Samuel Zalipski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota
Original Assignee
University of Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Minnesota filed Critical University of Minnesota
Application granted granted Critical
Publication of DE69133235D1 publication Critical patent/DE69133235D1/de
Publication of DE69133235T2 publication Critical patent/DE69133235T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69133235T 1990-08-31 1991-08-27 Verfahren zur Herstellung von Harzen für die Feststoff-Peptidsynthese Expired - Lifetime DE69133235T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57631490A 1990-08-31 1990-08-31
US71528991A 1991-06-14 1991-06-14

Publications (2)

Publication Number Publication Date
DE69133235D1 DE69133235D1 (de) 2003-05-15
DE69133235T2 true DE69133235T2 (de) 2003-11-20

Family

ID=27076929

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69120821T Expired - Lifetime DE69120821T2 (de) 1990-08-31 1991-08-27 Polyethylenglykol-Derivate für Festphasenanwendungen
DE69133235T Expired - Lifetime DE69133235T2 (de) 1990-08-31 1991-08-27 Verfahren zur Herstellung von Harzen für die Feststoff-Peptidsynthese
DE69130333T Expired - Lifetime DE69130333T2 (de) 1990-08-31 1991-08-27 Harze für die Feststoff-Peptidsynthese

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69120821T Expired - Lifetime DE69120821T2 (de) 1990-08-31 1991-08-27 Polyethylenglykol-Derivate für Festphasenanwendungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69130333T Expired - Lifetime DE69130333T2 (de) 1990-08-31 1991-08-27 Harze für die Feststoff-Peptidsynthese

Country Status (4)

Country Link
EP (3) EP0687691B1 (de)
JP (3) JP3122460B2 (de)
DE (3) DE69120821T2 (de)
WO (1) WO1992004384A1 (de)

Families Citing this family (35)

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Publication number Priority date Publication date Assignee Title
US5545698A (en) * 1990-08-31 1996-08-13 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
AU7113594A (en) * 1993-06-21 1995-01-17 Enzon, Inc. Site specific synthesis of conjugated peptides
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5629384A (en) * 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
JPH10502102A (ja) * 1994-06-14 1998-02-24 スミスクライン・ビーチャム・コーポレイション 固体合成用樹脂
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5656707A (en) * 1995-06-16 1997-08-12 Regents Of The University Of Minnesota Highly cross-linked polymeric supports
US5858534A (en) * 1995-09-05 1999-01-12 Solid Phase Sciences Corp. Method of making and using derivatized paramagnetic polymer beads
JP2000504368A (ja) * 1996-01-23 2000-04-11 アーゴノート テクノロジーズ，インコーポレイティド 高度に官能化されたポリエチレングリコールグラフト化ポリスチレン支持体
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
US6281245B1 (en) 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
CA2285175A1 (en) * 1997-03-28 1998-10-08 Smithkline Beecham Corporation Rink-chloride linker for solid phase organic synthesis of organic molecules
EP0981554A4 (de) * 1997-05-08 2005-11-09 Smithkline Beecham Corp Chloridverbinder für die organische synthese in der festphase
GB9717173D0 (en) * 1997-08-13 1997-10-22 Akzo Nobel Nv Solid phase supports
GB9718415D0 (en) * 1997-08-29 1997-11-05 Smithkline Beecham Plc Formulation
CA2223114A1 (en) 1997-11-28 1999-05-28 Brent R. Stranix Functional polymers with carbon-linked functional groups
GB9727126D0 (en) * 1997-12-22 1998-02-25 Zeneca Ltd Process
GB9814876D0 (en) * 1998-07-10 1998-09-09 Zeneca Ltd Polymer
DE59914221D1 (de) * 1998-08-28 2007-04-12 Poly An Ges Zur Herstellung Vo Verfahren zur herstellung polymerer festphasenträger
AU2942100A (en) * 1999-03-11 2000-09-28 Kuraray Co., Ltd. Vitamin d derivatives and process for the preparation thereof
US6335438B1 (en) * 1999-03-22 2002-01-01 Geir Fonnum Method for the manufacture of amino group containing support matrices, support matrices prepared by the method, and use of the support matrices
AU2008201460B2 (en) * 1999-03-22 2010-02-04 Ge Healthcare Bio-Sciences Ab Amino group containing support matrices, their use and manufacture
SE9902133D0 (sv) 1999-06-06 1999-06-06 Amersham Pharm Biotech Ab A method for surface modification, a novel support matrix and the use of the matrix
KR100453185B1 (ko) * 2001-11-24 2004-10-15 이은규 고정상 칼럼을 이용한 단백질-폴리머 접합체의 제조방법
SE526038C2 (sv) * 2002-07-08 2005-06-21 Gambro Lundia Ab Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav
KR100936536B1 (ko) 2003-01-18 2010-01-13 주식회사 바이오인프라 목표 부위 이외의 아민이 보호된 펩타이드, 그 제조방법및 이를 이용한 ｐｅｇ가 선택적으로 접합된 펩타이드의제조방법
US7485717B2 (en) 2004-07-02 2009-02-03 Geron Corporation Synthesis of protected 3′-amino nucleoside monomers
KR101088579B1 (ko) * 2004-10-04 2011-12-05 재단법인서울대학교산학협력재단 젤 타입의 코어-쉘 수지
EP2159228A1 (de) * 2008-08-28 2010-03-03 Polymer Laboratories Limited Amphiphiler fester Träger
GB0818074D0 (en) * 2008-10-02 2008-11-05 Lytix Biopharma As Treatment of biofilms
SG11201707893RA (en) 2015-04-23 2017-11-29 Geron Corp Methods of polynucleotide preparation using multivalent cation salt compositions
KR101978446B1 (ko) * 2017-02-28 2019-05-14 주식회사 비드테크 고체상 응용을 위한 에틸렌글리콜 유도체 및 코어-쉘형 그라프트 지지체
CN113248352A (zh) * 2021-05-18 2021-08-13 湖南华腾制药有限公司 一种固相合成七甘醇单甲醚的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602822A5 (en) * 1974-07-16 1978-08-15 Hoffmann La Roche Polyethylene glycol] chloromethyl- or hydroxymethyl-benzoate
GB1559610A (en) * 1975-10-31 1980-01-23 Armour Pharma Synthesis of peptides
DE3500180A1 (de) * 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US4831084A (en) * 1987-05-18 1989-05-16 Bachem Feinchemikalien A.G. Resin-linker combination for the solid-phase synthesis of peptides and intermediates
EP0347145A3 (de) * 1988-06-14 1990-10-24 University Of Utah Research Foundation Heterogene interpenetrierende Polymernetzwerke zur gesteuerten Arzneistofffreisetzung

Also Published As

Publication number Publication date
DE69130333D1 (de) 1998-11-12
DE69120821T2 (de) 1997-01-23
WO1992004384A1 (en) 1992-03-19
EP0801082B1 (de) 2003-04-09
EP0801082A3 (de) 1998-07-22
EP0546055A1 (de) 1993-06-16
DE69120821D1 (de) 1996-08-14
EP0801082A2 (de) 1997-10-15
EP0687691A3 (de) 1995-12-27
JP3122460B2 (ja) 2001-01-09
EP0687691B1 (de) 1998-10-07
JP2001081099A (ja) 2001-03-27
EP0687691A2 (de) 1995-12-20
DE69133235D1 (de) 2003-05-15
JP2002080530A (ja) 2002-03-19
JPH06500331A (ja) 1994-01-13
JP3266600B2 (ja) 2002-03-18
JP3435541B2 (ja) 2003-08-11
DE69130333T2 (de) 1999-03-04
EP0546055B1 (de) 1996-07-10

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