DE69125381T2 - Proteinstruktur des pflanzlichen toxins gelonin - Google Patents
Proteinstruktur des pflanzlichen toxins geloninInfo
- Publication number
- DE69125381T2 DE69125381T2 DE69125381T DE69125381T DE69125381T2 DE 69125381 T2 DE69125381 T2 DE 69125381T2 DE 69125381 T DE69125381 T DE 69125381T DE 69125381 T DE69125381 T DE 69125381T DE 69125381 T2 DE69125381 T2 DE 69125381T2
- Authority
- DE
- Germany
- Prior art keywords
- gelonin
- sequence
- protein
- amino acid
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56722090A | 1990-08-14 | 1990-08-14 | |
| PCT/US1991/005766 WO1992003144A1 (en) | 1990-08-14 | 1991-08-14 | Protein structure of the plant toxin gelonin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69125381D1 DE69125381D1 (de) | 1997-04-30 |
| DE69125381T2 true DE69125381T2 (de) | 1997-07-03 |
Family
ID=24266242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69125381T Expired - Lifetime DE69125381T2 (de) | 1990-08-14 | 1991-08-14 | Proteinstruktur des pflanzlichen toxins gelonin |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5631348A (en:Method) |
| EP (1) | EP0546087B1 (en:Method) |
| JP (1) | JPH06502847A (en:Method) |
| KR (1) | KR100220502B1 (en:Method) |
| CN (1) | CN1055123C (en:Method) |
| AT (1) | ATE150791T1 (en:Method) |
| CA (1) | CA2088068C (en:Method) |
| DE (1) | DE69125381T2 (en:Method) |
| DK (1) | DK0546087T3 (en:Method) |
| ES (1) | ES2100960T3 (en:Method) |
| FI (1) | FI112492B (en:Method) |
| GR (1) | GR3023593T3 (en:Method) |
| HK (1) | HK1006727A1 (en:Method) |
| IE (1) | IE912716A1 (en:Method) |
| IL (1) | IL99079A (en:Method) |
| NO (1) | NO309656B1 (en:Method) |
| NZ (1) | NZ239249A (en:Method) |
| PT (1) | PT98669B (en:Method) |
| RU (1) | RU2104285C1 (en:Method) |
| SA (1) | SA92130322B1 (en:Method) |
| WO (1) | WO1992003144A1 (en:Method) |
| ZA (1) | ZA916171B (en:Method) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA912490B (en) * | 1990-04-19 | 1992-12-30 | Res Dev Foundation | Antibody conjugates for treatment of neoplastic disease |
| IE912716A1 (en) | 1990-08-14 | 1992-02-26 | Res Dev Foundation | Protein Structure of the Plant Toxin Gelonin |
| KR100270195B1 (ko) * | 1991-09-06 | 2001-03-02 | 와일러 제임스 에프. | 겔로닌 폴리펩타이드를 암호화하는 dna 서열 |
| US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
| US6146850A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
| US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| US6599505B1 (en) * | 1992-04-10 | 2003-07-29 | Research Development Foundation | Immunotoxins directed against CD33 related surface antigens |
| WO1994001457A1 (en) * | 1992-07-07 | 1994-01-20 | Fish Eleanor N | Interferon receptor binding peptides |
| ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| NZ530582A (en) * | 2001-07-17 | 2008-06-30 | Res Dev Foundation | Therapeutic agents comprising pro-apoptotic proteins, including granzyme, bax and TNF |
| JP2006506964A (ja) * | 2002-06-12 | 2006-03-02 | リサーチ ディベロップメント ファンデーション | 治療剤としての免疫毒素及びその利用 |
| CN101132813A (zh) * | 2005-02-01 | 2008-02-27 | 研究发展基金会 | 靶向blys受体的blys融合蛋白和用于治疗b细胞增殖性疾病的方法 |
| WO2014127211A1 (en) | 2013-02-15 | 2014-08-21 | Research Development Foundation | Deimmunized gelonin molecules and therapies |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446240A (en) * | 1981-01-30 | 1984-05-01 | Nerenberg Samuel T | Pancreas specific protein systems |
| US4921802A (en) * | 1983-05-05 | 1990-05-01 | Pioneer Hi-Bred International, Inc. | Plant virus cDNA |
| US4888415A (en) * | 1985-03-04 | 1989-12-19 | Dana-Farber Cancer Institute, Inc. | Gelonin immunotoxin |
| US4810648A (en) * | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| EP0341304A4 (en) | 1987-11-24 | 1991-01-30 | Genetics Institute, Inc. | Improved ricin molecules and ricin toxin conjugates |
| GB8801877D0 (en) * | 1988-01-28 | 1988-02-24 | Erba Carlo Spa | Nucleotide sequence encoding plant ribosome inactivating protein |
| IE62463B1 (en) * | 1988-07-07 | 1995-02-08 | Res Dev Foundation | Immunoconjugates for cancer diagnosis and therapy |
| IE912716A1 (en) | 1990-08-14 | 1992-02-26 | Res Dev Foundation | Protein Structure of the Plant Toxin Gelonin |
-
1991
- 1991-07-31 IE IE271691A patent/IE912716A1/en not_active IP Right Cessation
- 1991-08-02 NZ NZ239249A patent/NZ239249A/xx not_active IP Right Cessation
- 1991-08-05 IL IL9907991A patent/IL99079A/en not_active IP Right Cessation
- 1991-08-06 ZA ZA916171A patent/ZA916171B/xx unknown
- 1991-08-13 PT PT98669A patent/PT98669B/pt not_active IP Right Cessation
- 1991-08-14 WO PCT/US1991/005766 patent/WO1992003144A1/en not_active Ceased
- 1991-08-14 ES ES91917004T patent/ES2100960T3/es not_active Expired - Lifetime
- 1991-08-14 DK DK91917004.3T patent/DK0546087T3/da active
- 1991-08-14 CN CN91105802A patent/CN1055123C/zh not_active Expired - Fee Related
- 1991-08-14 EP EP91917004A patent/EP0546087B1/en not_active Expired - Lifetime
- 1991-08-14 KR KR1019930700412A patent/KR100220502B1/ko not_active Expired - Fee Related
- 1991-08-14 RU RU93005126A patent/RU2104285C1/ru not_active IP Right Cessation
- 1991-08-14 CA CA002088068A patent/CA2088068C/en not_active Expired - Lifetime
- 1991-08-14 DE DE69125381T patent/DE69125381T2/de not_active Expired - Lifetime
- 1991-08-14 JP JP3515854A patent/JPH06502847A/ja active Pending
- 1991-08-14 HK HK98106041A patent/HK1006727A1/en not_active IP Right Cessation
- 1991-08-14 AT AT91917004T patent/ATE150791T1/de not_active IP Right Cessation
-
1992
- 1992-12-30 SA SA92130322A patent/SA92130322B1/ar unknown
-
1993
- 1993-02-08 NO NO930428A patent/NO309656B1/no not_active IP Right Cessation
- 1993-02-12 FI FI930626A patent/FI112492B/fi active
-
1994
- 1994-06-06 US US08/254,662 patent/US5631348A/en not_active Ceased
-
1997
- 1997-05-30 GR GR970401236T patent/GR3023593T3/el unknown
-
1999
- 1999-05-20 US US09/316,071 patent/USRE37462E1/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |