DE68922488T2 - Für Ribosomen inaktivierendes Protein aus Pflanzen kodierende Nukleotidsequenz. - Google Patents

Für Ribosomen inaktivierendes Protein aus Pflanzen kodierende Nukleotidsequenz.

Info

Publication number
DE68922488T2
DE68922488T2 DE68922488T DE68922488T DE68922488T2 DE 68922488 T2 DE68922488 T2 DE 68922488T2 DE 68922488 T DE68922488 T DE 68922488T DE 68922488 T DE68922488 T DE 68922488T DE 68922488 T2 DE68922488 T2 DE 68922488T2
Authority
DE
Germany
Prior art keywords
nucleotide sequence
sequence encoding
inactivating protein
encoding plant
plant ribosome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68922488T
Other languages
English (en)
Other versions
DE68922488D1 (de
Inventor
Rolando Lorenzetti
Luca Benatti
Maria Dani
Douglas Lappi
Maria Beatrice Saccardo
Marco Soria
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia SpA filed Critical Pharmacia SpA
Publication of DE68922488D1 publication Critical patent/DE68922488D1/de
Application granted granted Critical
Publication of DE68922488T2 publication Critical patent/DE68922488T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE68922488T 1988-01-28 1989-06-14 Für Ribosomen inaktivierendes Protein aus Pflanzen kodierende Nukleotidsequenz. Expired - Fee Related DE68922488T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB888801877A GB8801877D0 (en) 1988-01-28 1988-01-28 Nucleotide sequence encoding plant ribosome inactivating protein
EP89306016A EP0402544B1 (de) 1988-01-28 1989-06-14 Für Ribosomen inaktivierendes Protein aus Pflanzen kodierende Nukleotidsequenz
AU36540/89A AU613770B2 (en) 1988-01-28 1989-06-19 Nucleotide sequence encoding plant ribosome inactivating protein
CA000603421A CA1340805C (en) 1988-01-28 1989-06-21 Nucleotide sequence incoding plant ribosome inactivating protein

Publications (2)

Publication Number Publication Date
DE68922488D1 DE68922488D1 (de) 1995-06-08
DE68922488T2 true DE68922488T2 (de) 1996-01-25

Family

ID=33568643

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68922488T Expired - Fee Related DE68922488T2 (de) 1988-01-28 1989-06-14 Für Ribosomen inaktivierendes Protein aus Pflanzen kodierende Nukleotidsequenz.

Country Status (6)

Country Link
EP (1) EP0402544B1 (de)
JP (1) JP2771220B2 (de)
AU (1) AU613770B2 (de)
CA (1) CA1340805C (de)
DE (1) DE68922488T2 (de)
GB (2) GB8801877D0 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5529932A (en) * 1988-01-28 1996-06-25 Pharmacia, S.P.A. Isolated DNA encoding a plant ribosome inactivating protein from the leaves of saponaria officinalis
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
US5248606A (en) * 1990-06-11 1993-09-28 Dowelanco Dna encoding inactive precursor and active forms of maize ribosome inactivating protein
US5635384A (en) * 1990-06-11 1997-06-03 Dowelanco Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using
IE912716A1 (en) * 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
DE4040954C2 (de) * 1990-12-20 2001-05-17 Max Planck Gesellschaft Verfahren zur Erzeugung von pathogen-resistenten Pflanzen
JPH06509471A (ja) * 1991-07-31 1994-10-27 イタルファルマコ　エッセ．ピ．ア． リボソーム不活性化タンパク質をコードするヌクレオチド配列
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5376546A (en) * 1991-11-04 1994-12-27 Xoma Corporation Analogs of ribosome-inactivating proteins
GB9304905D0 (en) * 1992-03-16 1993-04-28 Zeneca Ltd Processes
AU685058B2 (en) * 1992-06-16 1998-01-15 Selective Genetics, Inc. Recombinant production of saporin-containing proteins
AU7475694A (en) * 1993-08-02 1995-02-28 Prizm Pharmaceuticals, Inc. Monogenous preparations of cytotoxic conjugates
KR970001565B1 (ko) * 1993-08-28 1997-02-11 장기하 섬자리공 항바이러스성 단백질(pip) 유전자 및 이를 발현하는 미생물
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3724323C2 (de) * 1986-07-29 1995-07-20 Erba Farmitalia Ein neuer Inhibitor für die Proteinsynthese
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein

Also Published As

Publication number Publication date
GB8801877D0 (en) 1988-02-24
GB8901892D0 (en) 1989-03-15
EP0402544B1 (de) 1995-05-03
CA1340805C (en) 1999-10-26
JP2771220B2 (ja) 1998-07-02
GB2216891B (en) 1992-06-03
AU613770B2 (en) 1991-08-08
DE68922488D1 (de) 1995-06-08
EP0402544A1 (de) 1990-12-19
AU3654089A (en) 1990-12-20
JPH02222684A (ja) 1990-09-05
GB2216891A (en) 1989-10-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee