DE69108200T2 - 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indol-5-methansulfonamid Sulfat (2:1). - Google Patents

3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indol-5-methansulfonamid Sulfat (2:1).

Info

Publication number
DE69108200T2
DE69108200T2 DE69108200T DE69108200T DE69108200T2 DE 69108200 T2 DE69108200 T2 DE 69108200T2 DE 69108200 T DE69108200 T DE 69108200T DE 69108200 T DE69108200 T DE 69108200T DE 69108200 T2 DE69108200 T2 DE 69108200T2
Authority
DE
Germany
Prior art keywords
indole
dimethylamino
methyl
ethyl
methanesulfonamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69108200T
Other languages
German (de)
English (en)
Other versions
DE69108200D1 (de
Inventor
Joanne Ware Hertfordshire Sg12 0Dg Craig
Derek Leslie Ware Hertfordshire Sg12 0Dg Crookes
Stephen John Ware Hertfordshire Sg12 0Dg Skittrall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE69108200D1 publication Critical patent/DE69108200D1/de
Application granted granted Critical
Publication of DE69108200T2 publication Critical patent/DE69108200T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
DE69108200T 1990-12-12 1991-12-12 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indol-5-methansulfonamid Sulfat (2:1). Expired - Lifetime DE69108200T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026998A GB9026998D0 (en) 1990-12-12 1990-12-12 Medicaments

Publications (2)

Publication Number Publication Date
DE69108200D1 DE69108200D1 (de) 1995-04-20
DE69108200T2 true DE69108200T2 (de) 1995-07-20

Family

ID=10686904

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108200T Expired - Lifetime DE69108200T2 (de) 1990-12-12 1991-12-12 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indol-5-methansulfonamid Sulfat (2:1).

Country Status (36)

Country Link
US (2) US5554639A (enExample)
EP (1) EP0490689B1 (enExample)
JP (1) JP2994037B2 (enExample)
KR (1) KR100211479B1 (enExample)
CN (2) CN1030890C (enExample)
AP (1) AP230A (enExample)
AT (1) ATE119881T1 (enExample)
AU (1) AU650706B2 (enExample)
BE (1) BE1005085A3 (enExample)
CA (1) CA2098302C (enExample)
CH (1) CH684192A5 (enExample)
CY (1) CY2005A (enExample)
CZ (1) CZ281931B6 (enExample)
DE (1) DE69108200T2 (enExample)
DK (1) DK0490689T3 (enExample)
EG (1) EG20219A (enExample)
ES (1) ES2069836T3 (enExample)
FR (1) FR2670487B1 (enExample)
GB (2) GB9026998D0 (enExample)
GR (1) GR3015430T3 (enExample)
HK (1) HK82697A (enExample)
HU (1) HU211937A9 (enExample)
IE (1) IE62894B1 (enExample)
IL (1) IL100330A (enExample)
IS (1) IS1706B (enExample)
IT (1) IT1252868B (enExample)
MX (1) MX9102501A (enExample)
MY (1) MY109265A (enExample)
NL (1) NL9102071A (enExample)
NZ (1) NZ240942A (enExample)
PT (1) PT99757B (enExample)
RU (1) RU2108328C1 (enExample)
TW (2) TW205035B (enExample)
WO (1) WO1992010477A1 (enExample)
YU (1) YU48926B (enExample)
ZA (1) ZA919750B (enExample)

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US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
US6426084B1 (en) 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132757A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
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US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6562838B2 (en) * 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
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US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
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US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
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US20070065463A1 (en) 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
US20050269402A1 (en) * 2004-06-03 2005-12-08 Tyfone, Inc. System and method for securing financial transactions
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
KR20080012360A (ko) 2005-05-20 2008-02-11 얀센 파마슈티카 엔.브이. 설파미드 유도체의 제조 방법
WO2007070504A2 (en) * 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Stable and palatable oral liquid sumatriptan compositions
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
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US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
GB2448183A (en) * 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
EP3090743A1 (en) 2008-01-09 2016-11-09 Charleston Laboratories, Inc. Pharmaceutical compositions for treating headache and eliminating nausea
US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
CN102046621B (zh) 2008-05-27 2014-11-12 生物区科学管理控股有限公司 抗病毒盐
US8618157B2 (en) * 2008-06-20 2013-12-31 Alphapharm Pty. Ltd. Pharmaceutical formulation
EA018567B1 (ru) 2008-06-23 2013-08-30 Янссен Фармацевтика Нв Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида
JP2011526889A (ja) * 2008-06-30 2011-10-20 アフギン ファーマ，エルエルシー 局所局部的神経作用療法
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
DK2480197T3 (en) 2009-09-25 2016-01-25 Reddys Lab Ltd Dr Compositions containing triptanforbindelser
HK1244715A1 (zh) 2015-03-02 2018-08-17 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US10494405B2 (en) 2015-05-15 2019-12-03 The Regents Of The University Of Michigan Methods and compositions for the treatment of arthritis
CA3055170A1 (en) 2016-03-04 2017-09-08 Charleston Laboratories, Inc. Pharmaceutical compositions
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
CA3079848A1 (en) 2017-11-07 2019-05-16 The Regents Of The University Of Michigan Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use
US20220096438A1 (en) 2018-09-07 2022-03-31 Upsher-Smith Laboratories, Llc Methods of treating migraine
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GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
BE1005085A3 (fr) 1993-04-13
EG20219A (en) 1997-11-30
CZ114093A3 (en) 1994-02-16
ZA919750B (en) 1992-10-28
MX9102501A (es) 1992-09-01
GR3015430T3 (en) 1995-06-30
DK0490689T3 (da) 1995-05-22
DE69108200D1 (de) 1995-04-20
JP2994037B2 (ja) 1999-12-27
IE914317A1 (en) 1992-06-17
WO1992010477A1 (en) 1992-06-25
IL100330A (en) 1996-06-18
IL100330A0 (en) 1992-09-06
US5554639A (en) 1996-09-10
EP0490689B1 (en) 1995-03-15
CY2005A (en) 1997-12-05
ATE119881T1 (de) 1995-04-15
TW205035B (enExample) 1993-05-01
AU650706B2 (en) 1994-06-30
ES2069836T3 (es) 1995-05-16
MY109265A (en) 1996-12-31
US5705520A (en) 1998-01-06
CN1050831C (zh) 2000-03-29
PT99757A (pt) 1992-12-31
CA2098302C (en) 2001-10-16
AP9100339A0 (en) 1992-01-31
HK82697A (en) 1997-06-27
GB2251614A (en) 1992-07-15
CH684192A5 (fr) 1994-07-29
ITRM910922A0 (it) 1991-12-11
CN1128259A (zh) 1996-08-07
TW300886B (enExample) 1997-03-21
ITRM910922A1 (it) 1993-06-11
CZ281931B6 (cs) 1997-04-16
NZ240942A (en) 1994-03-25
AP230A (en) 1993-01-27
FR2670487B1 (fr) 1993-08-20
CN1030890C (zh) 1996-02-07
IT1252868B (it) 1995-06-28
PT99757B (pt) 1999-05-31
GB2251614B (en) 1994-12-14
AU9072091A (en) 1992-07-08
CN1063099A (zh) 1992-07-29
IE62894B1 (en) 1995-03-08
NL9102071A (nl) 1992-07-01
GB9126297D0 (en) 1992-02-12
GB9026998D0 (en) 1991-01-30
KR100211479B1 (ko) 1999-08-02
HU211937A9 (en) 1996-01-29
JPH06503560A (ja) 1994-04-21
FR2670487A1 (fr) 1992-06-19
YU48926B (sh) 2002-12-10
IS3790A7 (is) 1992-06-13
EP0490689A1 (en) 1992-06-17
CA2098302A1 (en) 1992-06-13
RU2108328C1 (ru) 1998-04-10
YU191491A (sh) 1994-04-05
IS1706B (is) 1998-12-10

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