IS1706B - Hliðstæð aðferð til framleiðslu á 3-[-2-(dímeltýlamínó)etýl]-N-metýl-1H-indól-5-metansúlfónamíð súlfat salti - Google Patents

Hliðstæð aðferð til framleiðslu á 3-[-2-(dímeltýlamínó)etýl]-N-metýl-1H-indól-5-metansúlfónamíð súlfat salti

Info

Publication number
IS1706B
IS1706B IS3790A IS3790A IS1706B IS 1706 B IS1706 B IS 1706B IS 3790 A IS3790 A IS 3790A IS 3790 A IS3790 A IS 3790A IS 1706 B IS1706 B IS 1706B
Authority
IS
Iceland
Prior art keywords
indole
dimethylamino
ethyl
methyl
preparation
Prior art date
Application number
IS3790A
Other languages
English (en)
Icelandic (is)
Other versions
IS3790A7 (is
Inventor
Craig Joanne
Leslie Crookes Derek
John Skittrall Stephen
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of IS3790A7 publication Critical patent/IS3790A7/is
Publication of IS1706B publication Critical patent/IS1706B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
IS3790A 1990-12-12 1991-12-11 Hliðstæð aðferð til framleiðslu á 3-[-2-(dímeltýlamínó)etýl]-N-metýl-1H-indól-5-metansúlfónamíð súlfat salti IS1706B (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026998A GB9026998D0 (en) 1990-12-12 1990-12-12 Medicaments

Publications (2)

Publication Number Publication Date
IS3790A7 IS3790A7 (is) 1992-06-13
IS1706B true IS1706B (is) 1998-12-10

Family

ID=10686904

Family Applications (1)

Application Number Title Priority Date Filing Date
IS3790A IS1706B (is) 1990-12-12 1991-12-11 Hliðstæð aðferð til framleiðslu á 3-[-2-(dímeltýlamínó)etýl]-N-metýl-1H-indól-5-metansúlfónamíð súlfat salti

Country Status (36)

Country Link
US (2) US5554639A (enExample)
EP (1) EP0490689B1 (enExample)
JP (1) JP2994037B2 (enExample)
KR (1) KR100211479B1 (enExample)
CN (2) CN1030890C (enExample)
AP (1) AP230A (enExample)
AT (1) ATE119881T1 (enExample)
AU (1) AU650706B2 (enExample)
BE (1) BE1005085A3 (enExample)
CA (1) CA2098302C (enExample)
CH (1) CH684192A5 (enExample)
CY (1) CY2005A (enExample)
CZ (1) CZ281931B6 (enExample)
DE (1) DE69108200T2 (enExample)
DK (1) DK0490689T3 (enExample)
EG (1) EG20219A (enExample)
ES (1) ES2069836T3 (enExample)
FR (1) FR2670487B1 (enExample)
GB (2) GB9026998D0 (enExample)
GR (1) GR3015430T3 (enExample)
HK (1) HK82697A (enExample)
HU (1) HU211937A9 (enExample)
IE (1) IE62894B1 (enExample)
IL (1) IL100330A (enExample)
IS (1) IS1706B (enExample)
IT (1) IT1252868B (enExample)
MX (1) MX9102501A (enExample)
MY (1) MY109265A (enExample)
NL (1) NL9102071A (enExample)
NZ (1) NZ240942A (enExample)
PT (1) PT99757B (enExample)
RU (1) RU2108328C1 (enExample)
TW (2) TW205035B (enExample)
WO (1) WO1992010477A1 (enExample)
YU (1) YU48926B (enExample)
ZA (1) ZA919750B (enExample)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0573221T3 (da) * 1992-06-05 1998-10-07 Merck Sharp & Dohme Sulfatsaltet af en substitueret triazol, farmaceutiske præparater deraf og deres anvendelse i terapi
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6106837A (en) * 1997-05-15 2000-08-22 Hirsch; Alan R. Method of treating headaches, and article of manufacture therefor
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6132757A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
ES2312585T3 (es) * 2001-06-05 2009-03-01 Ronald Aung-Din Terapia contra la migraña por via topica.
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
CA2509023C (en) * 2002-12-26 2011-05-24 Pozen Inc. Multilayer dosage forms containing nsaids and triptans
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
EP1644004A4 (en) * 2003-06-20 2010-10-06 Ronald Aung-Din LOCAL THERAPY FOR THE TREATMENT OF MIGRAINS, MUSCLE CLARIFICATIONS, MUSCLE SPASMS, SPASTICITY AND RELATED CONDITIONS
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
WO2005119607A2 (en) * 2004-06-03 2005-12-15 Tyfone, Inc. System and method for securing financial transactions
WO2005123043A2 (en) * 2004-06-10 2005-12-29 Duramed Pharmaceuticals, Inc. Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
EA200702558A1 (ru) 2005-05-20 2008-06-30 Янссен Фармацевтика Н. В. Способ получения производных сульфамида
US20070166336A1 (en) * 2005-12-13 2007-07-19 David Delmarre Stable and palatable oral liquid sumatriptan compositions
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
EP2026790A2 (en) 2006-05-19 2009-02-25 Janssen Pharmaceutica, N.V. Co-therapy for the treatment of epilepsy and related disorders
CA2665841C (en) 2006-10-09 2016-04-05 Charleston Laboratories, Inc. Pharmaceutical compositions
BRPI0715579A2 (pt) * 2006-10-19 2015-05-26 Auspex Pharmaceuticals Inc "composto, composição farmacêutica e uso de um composto"
US20080275030A1 (en) * 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
GB2448183A (en) * 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
CA3066426A1 (en) 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
CN102046621B (zh) 2008-05-27 2014-11-12 生物区科学管理控股有限公司 抗病毒盐
EP2306998A4 (en) * 2008-06-20 2011-06-15 Alphapharm Pty Ltd PHARMACEUTICAL FORMULATION
NZ590682A (en) 2008-06-23 2012-09-28 Janssen Pharmaceutica Nv Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
CA2729346A1 (en) * 2008-06-30 2010-01-14 Afgin Pharma, Llc Topical regional neuro-affective therapy
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
EP3311667A1 (en) 2009-07-08 2018-04-25 Charleston Laboratories, Inc. Pharmaceutical compositions
AU2010299607B2 (en) * 2009-09-25 2016-07-28 Tonix Medicines, Inc. Formulations comprising triptan compounds
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
EP3265081A4 (en) 2015-03-02 2018-11-21 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
WO2016187013A1 (en) 2015-05-15 2016-11-24 The Regents Of The University Of Michigan Methods and compositions for the treatment of arthritis
EP3423041A4 (en) 2016-03-04 2019-09-11 Charleston Laboratories, Inc. PHARMACEUTICAL COMPOSITIONS
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
EP3706744B1 (en) 2017-11-07 2022-08-17 The Regents of The University of Michigan Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use
US20220096438A1 (en) 2018-09-07 2022-03-31 Upsher-Smith Laboratories, Llc Methods of treating migraine
US11364225B2 (en) * 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same
BR112022016790A2 (pt) * 2020-02-27 2022-11-08 Biohaven Pharm Holding Co Ltd Forma de dosagem oral de dispersão rápida de rimegepant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
GB2251614A (en) 1992-07-15
ITRM910922A1 (it) 1993-06-11
CN1030890C (zh) 1996-02-07
FR2670487A1 (fr) 1992-06-19
EP0490689B1 (en) 1995-03-15
CA2098302C (en) 2001-10-16
PT99757A (pt) 1992-12-31
EP0490689A1 (en) 1992-06-17
CZ281931B6 (cs) 1997-04-16
JPH06503560A (ja) 1994-04-21
AP9100339A0 (en) 1992-01-31
MY109265A (en) 1996-12-31
CN1050831C (zh) 2000-03-29
NZ240942A (en) 1994-03-25
PT99757B (pt) 1999-05-31
IT1252868B (it) 1995-06-28
US5554639A (en) 1996-09-10
ZA919750B (en) 1992-10-28
CY2005A (en) 1997-12-05
IE62894B1 (en) 1995-03-08
FR2670487B1 (fr) 1993-08-20
TW300886B (enExample) 1997-03-21
ATE119881T1 (de) 1995-04-15
CZ114093A3 (en) 1994-02-16
IL100330A0 (en) 1992-09-06
IL100330A (en) 1996-06-18
ES2069836T3 (es) 1995-05-16
GB9126297D0 (en) 1992-02-12
AU9072091A (en) 1992-07-08
AP230A (en) 1993-01-27
EG20219A (en) 1997-11-30
JP2994037B2 (ja) 1999-12-27
NL9102071A (nl) 1992-07-01
GB9026998D0 (en) 1991-01-30
WO1992010477A1 (en) 1992-06-25
IE914317A1 (en) 1992-06-17
CA2098302A1 (en) 1992-06-13
AU650706B2 (en) 1994-06-30
HK82697A (en) 1997-06-27
DE69108200T2 (de) 1995-07-20
GB2251614B (en) 1994-12-14
DE69108200D1 (de) 1995-04-20
US5705520A (en) 1998-01-06
CN1128259A (zh) 1996-08-07
CN1063099A (zh) 1992-07-29
KR100211479B1 (ko) 1999-08-02
TW205035B (enExample) 1993-05-01
CH684192A5 (fr) 1994-07-29
HU211937A9 (en) 1996-01-29
YU48926B (sh) 2002-12-10
ITRM910922A0 (it) 1991-12-11
BE1005085A3 (fr) 1993-04-13
RU2108328C1 (ru) 1998-04-10
YU191491A (sh) 1994-04-05
DK0490689T3 (da) 1995-05-22
MX9102501A (es) 1992-09-01
GR3015430T3 (en) 1995-06-30
IS3790A7 (is) 1992-06-13

Similar Documents

Publication Publication Date Title
IS1706B (is) Hliðstæð aðferð til framleiðslu á 3-[-2-(dímeltýlamínó)etýl]-N-metýl-1H-indól-5-metansúlfónamíð súlfat salti
FI914174A7 (fi) Menetelmä piperidyylialkyyliamiinien valmistamiseksi
DK36491A (da) Praeparat til behandling af erektiv dysfunktion
NO910421D0 (no) Fremgangsmaate for fremstilling av en spiselig emulsjon.
FI905124A0 (fi) Menetelmä pyrimidiinien valmistamiseksi
FI945441A7 (fi) Uusi menetelmä 7beta-substituoitu-4-atsa-5alfa-androstan-3-onien valmi stamiseksi
IS3529A7 (is) Hliðstæð aðferð við framleiðslu á meðferðarvirkum bis-aza-bísýklískum efnasamböndum
NO891109L (no) Badesaltblanding.
FI95036B (fi) Tieno-triatsolo-diatsepiinijohdosten valmistusmenetelmä
FI911713L (fi) Menetelmä stereokemiallisesti puhtaiden ergoliini-8-karboksiamidien valmistamiseksi
DK0721453T3 (da) Fremgangsmåde til fremstilling af N-methyl-3-(1-methyl-4-piperidinyl)-14-indol-5-ethansulfonamid
FI890186A7 (fi) Menetelmä 1-hydroksialkyyli-5-nitroimidatsolien valmistamiseksi
TR26125A (tr) Modifiye edilmis kaucuktan stiren recineler hazirlanmasi icin yöntem
FI961054A7 (fi) Menetelmä 9-(2-hydroksi)etoksimetyyliguaniinin valmistamiseksi
FI890185A7 (fi) Menetelmä 1-alkyyli-5-nitroimidatsolien valmistamiseksi
EE03027B1 (et) Meetod 8-klorokinolooni derivaatide valmistamiseks
FI933755A7 (fi) Menetelmä trans-piperidiini-2,5-dikarboksylaattien valmistamiseksi
FI910847A0 (fi) Menetelmä kolestipolihydrokloridin valmistamiseksi
FI913464A7 (fi) Menetelmä 1-hydroksimetyylipyratsolien valmistamiseksi
FI890188A7 (fi) Menetelmä 1-hydroksialkyyli-2-metyyli-5-nitroimidatsolien valmistamiseksi
FI904570A7 (fi) Menetelmä uusien alkanofenonien valmistamiseksi I
FI923866A7 (fi) Menetelmä 1-hydroksialkyyli-5-nitroimidatsolien valmistamiseksi
FI940338L (fi) Menetelmä 13alfa-sinnamoyylibakkatiini III:n tai -10-desasetyylibakkatiini III:n valmistamiseksi
FI940551A0 (fi) Menetelmä fenyylibentsamidijohdannaisten valmistamiseksi
FI953617L (fi) Menetelmä substituoitujen 4-hydroksikumariinien valmistamiseksi