ES2069836T3 - Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1). - Google Patents

Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1).

Info

Publication number
ES2069836T3
ES2069836T3 ES91311583T ES91311583T ES2069836T3 ES 2069836 T3 ES2069836 T3 ES 2069836T3 ES 91311583 T ES91311583 T ES 91311583T ES 91311583 T ES91311583 T ES 91311583T ES 2069836 T3 ES2069836 T3 ES 2069836T3
Authority
ES
Spain
Prior art keywords
indol
dimethylamine
ethyl
methyl
methanosulfonamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91311583T
Other languages
English (en)
Inventor
Joanne Craig
Derek Leslie Crookes
Stephen John Skittrall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2069836T3 publication Critical patent/ES2069836T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

SE REVELA UNA SAL DE SULFATO 3-(2-DIMETILAMINO)ETIL)-N-METIL-1H-INDOL-5 -METANOSULFONAMIDA (2:1) Y SOLVATADOS FARMACEUTICAMENTE ACEPTABLE DE LO MISMO. EL COMPUESTO ES DE UTILIDAD EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS, PARTICULARMENTE PARA FORMULACIONES INTRANASALES, PARA UTILIZAR EN EL TRATAMIENTO DE CONDICIONES ASOCIADAS CON DOLOR DE CABEZA, EN PARTICULAR MIGRAÑA.
ES91311583T 1990-12-12 1991-12-12 Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1). Expired - Lifetime ES2069836T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026998A GB9026998D0 (en) 1990-12-12 1990-12-12 Medicaments

Publications (1)

Publication Number Publication Date
ES2069836T3 true ES2069836T3 (es) 1995-05-16

Family

ID=10686904

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91311583T Expired - Lifetime ES2069836T3 (es) 1990-12-12 1991-12-12 Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1).

Country Status (36)

Country Link
US (2) US5554639A (es)
EP (1) EP0490689B1 (es)
JP (1) JP2994037B2 (es)
KR (1) KR100211479B1 (es)
CN (2) CN1030890C (es)
AP (1) AP230A (es)
AT (1) ATE119881T1 (es)
AU (1) AU650706B2 (es)
BE (1) BE1005085A3 (es)
CA (1) CA2098302C (es)
CH (1) CH684192A5 (es)
CY (1) CY2005A (es)
CZ (1) CZ281931B6 (es)
DE (1) DE69108200T2 (es)
DK (1) DK0490689T3 (es)
EG (1) EG20219A (es)
ES (1) ES2069836T3 (es)
FR (1) FR2670487B1 (es)
GB (2) GB9026998D0 (es)
GR (1) GR3015430T3 (es)
HK (1) HK82697A (es)
HU (1) HU211937A9 (es)
IE (1) IE62894B1 (es)
IL (1) IL100330A (es)
IS (1) IS1706B (es)
IT (1) IT1252868B (es)
MX (1) MX9102501A (es)
MY (1) MY109265A (es)
NL (1) NL9102071A (es)
NZ (1) NZ240942A (es)
PT (1) PT99757B (es)
RU (1) RU2108328C1 (es)
TW (2) TW300886B (es)
WO (1) WO1992010477A1 (es)
YU (1) YU48926B (es)
ZA (1) ZA919750B (es)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69318212T2 (de) * 1992-06-05 1998-11-19 Merck Sharp & Dohme Sulfatsalz von einem substituierten Triazol, seine pharmazeutischen Zusammensetzungen und ihre Verwendung in Therapie
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6106837A (en) * 1997-05-15 2000-08-22 Hirsch; Alan R. Method of treating headaches, and article of manufacture therefor
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
US6132757A (en) 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
WO2003032983A1 (en) * 2001-06-05 2003-04-24 Ronald Aung-Din Transdermal migraine therapy
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
EP1575566B1 (en) * 2002-12-26 2012-02-22 Pozen, Inc. Multilayer dosage forms containing naproxen and triptans
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
WO2004112723A2 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
US20050269402A1 (en) * 2004-06-03 2005-12-08 Tyfone, Inc. System and method for securing financial transactions
EP1765300A2 (en) * 2004-06-10 2007-03-28 Duramed Pharmaceuticals, Inc. Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
MX2007014613A (es) 2005-05-20 2008-04-02 Johnson & Johnson Procedimiento para la preparacion de derivados de sulfamida.
WO2007070504A2 (en) * 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Stable and palatable oral liquid sumatriptan compositions
AR058389A1 (es) 2005-12-19 2008-01-30 Janssen Pharmaceutica Nv Uso de derivados heterociclicos benzo-fusionados de sulfamida para el tratamiento de la obesidad
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
WO2007137167A2 (en) 2006-05-19 2007-11-29 Janssen Pharmaceutica N.V. Co-therapy for the treatment of epilepsy
EP2813144A1 (en) 2006-10-09 2014-12-17 Charleston Laboratories, Inc. Analgesic compositions comprising an antihistamine
CA2666149A1 (en) * 2006-10-19 2008-04-24 Auspex Pharmaceuticals, Inc. Substituted indoles
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
GB2448183A (en) * 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
EP3090743A1 (en) 2008-01-09 2016-11-09 Charleston Laboratories, Inc. Pharmaceutical compositions for treating headache and eliminating nausea
US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
US8580791B2 (en) 2008-05-27 2013-11-12 Biota Scientific Management Pty Ltd Antiviral 6-{2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy}-3-ethoxy-1,2-benzisoxazole bis-dihydrogen-phosphate salts
US8618157B2 (en) * 2008-06-20 2013-12-31 Alphapharm Pty. Ltd. Pharmaceutical formulation
AU2009271362B2 (en) 2008-06-23 2014-03-13 Janssen Pharmaceutica Nv Crystalline form of (2s)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
EP2296652B1 (en) * 2008-06-30 2017-11-08 Afgin Pharma, Llc Topical regional neuro-affective therapy
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
KR101646079B1 (ko) 2009-09-25 2016-08-12 닥터 레디스 레보러터리즈 리미티드 트립탄 화합물을 포함하는 제제
AU2016226267A1 (en) 2015-03-02 2017-09-28 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
EP3294339B1 (en) 2015-05-15 2020-12-02 The Regents Of The University Of Michigan Methods and compositions for the treatment of arthritis
EP3423041A4 (en) 2016-03-04 2019-09-11 Charleston Laboratories, Inc. PHARMACEUTICAL COMPOSITIONS
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
KR102925234B1 (ko) 2017-11-07 2026-02-09 더 리젠츠 오브 더 유니버시티 오브 미시건 공유 에피토프-칼레티쿨린 상호 작용의 소분자 억제제 및 사용 방법
US20220096438A1 (en) 2018-09-07 2022-03-31 Upsher-Smith Laboratories, Llc Methods of treating migraine
US11364225B2 (en) * 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same
MX2022010407A (es) * 2020-02-27 2022-11-07 Biohaven Pharm Holding Co Ltd Forma de dosis oral de rápida dispersión de rimegepant.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
EG20219A (en) 1997-11-30
BE1005085A3 (fr) 1993-04-13
DE69108200T2 (de) 1995-07-20
IS1706B (is) 1998-12-10
DE69108200D1 (de) 1995-04-20
EP0490689B1 (en) 1995-03-15
AU9072091A (en) 1992-07-08
FR2670487A1 (fr) 1992-06-19
PT99757A (pt) 1992-12-31
GB2251614B (en) 1994-12-14
CN1063099A (zh) 1992-07-29
AP230A (en) 1993-01-27
ATE119881T1 (de) 1995-04-15
HK82697A (en) 1997-06-27
GB2251614A (en) 1992-07-15
KR100211479B1 (ko) 1999-08-02
CN1030890C (zh) 1996-02-07
CN1050831C (zh) 2000-03-29
CZ114093A3 (en) 1994-02-16
JP2994037B2 (ja) 1999-12-27
IE62894B1 (en) 1995-03-08
IL100330A (en) 1996-06-18
RU2108328C1 (ru) 1998-04-10
IL100330A0 (en) 1992-09-06
GB9026998D0 (en) 1991-01-30
ITRM910922A1 (it) 1993-06-11
IT1252868B (it) 1995-06-28
US5705520A (en) 1998-01-06
ITRM910922A0 (it) 1991-12-11
HU211937A9 (en) 1996-01-29
MX9102501A (es) 1992-09-01
WO1992010477A1 (en) 1992-06-25
CA2098302C (en) 2001-10-16
ZA919750B (en) 1992-10-28
CN1128259A (zh) 1996-08-07
CZ281931B6 (cs) 1997-04-16
YU48926B (sh) 2002-12-10
AP9100339A0 (en) 1992-01-31
YU191491A (sh) 1994-04-05
MY109265A (en) 1996-12-31
CY2005A (en) 1997-12-05
PT99757B (pt) 1999-05-31
IE914317A1 (en) 1992-06-17
GR3015430T3 (en) 1995-06-30
DK0490689T3 (da) 1995-05-22
FR2670487B1 (fr) 1993-08-20
NL9102071A (nl) 1992-07-01
TW205035B (es) 1993-05-01
CA2098302A1 (en) 1992-06-13
US5554639A (en) 1996-09-10
AU650706B2 (en) 1994-06-30
NZ240942A (en) 1994-03-25
IS3790A7 (is) 1992-06-13
GB9126297D0 (en) 1992-02-12
JPH06503560A (ja) 1994-04-21
CH684192A5 (fr) 1994-07-29
EP0490689A1 (en) 1992-06-17
TW300886B (es) 1997-03-21

Similar Documents

Publication Publication Date Title
ES2069836T3 (es) Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1).
AU549927B2 (en) 2-oxindole-1-carboxamide derivatives
RU93053493A (ru) Сульфатная соль (2:1)-3-[2-(диметиламино)этил]-n-метил-1н-индол-5-метансульфонамида и ее фармацевтически приемлемые сольваты, способ их получения, фармацевтические композиции на их основе, их применение в терапии, способ лечения головной боли
ES2145922T3 (es) Compuestos espiro-azabiciclicos utiles en terapia.
ES2117015T3 (es) Composiciones que contienen sumatriptan.
NO963053L (no) Kosmetiske eller farmasöytiske preparater inneholdende mangiferin eller derivater derav
NO932670L (no) Blandinger
LU91555I2 (fr) "Brinzolamide et timolol optionnellement sous de sels pharmaceutiquement acceptables te que la combination du produit brinzolamide/timolol maléate (AZARGA)"
NO164093C (no) Pyridinoksyd-mellomprodukter og fremgangsmaate for deres fremstilling.
RU94035686A (ru) 4-ариламино-бензопиран и родственные соединения, фармацевтическая композиция, способ лечения
PT91126A (pt) Processo para a preparacao de derivados de (1-hidroxi-2-piperidinil-alquil)-2- indolonas, 2-quinoleinonas, benzo {b}-2-azepinonas, 2-benzimidazolonas e 2- -quinazolinonas e de composicoes farmaceuticas que os contem
TW336939B (en) Lipopeptide derivatives, a process for their preparation and their use
MX9204637A (es) Nuevos derivados de pirazina y procedimiento para su preparacion.
ATE228364T1 (de) Indolalkaloide als antientzündliche wirkstoffe
ATE155687T1 (de) Pharmakologisch verbesserte formulierungen
YU31592A (sh) 6-HETEROCIKLIČNI-4-AMINO-1,2,2a,3,4,5- HEKSAHIDROBENZ (cd) INDOLI
AR011697A1 (es) Composiciones farmaceuticas, uso de lamivudina en la manufactura de tales composiciones farmaceuticas.
MX9301721A (es) Derivados, composiciones de carbinol de bis-arilo sin puente, y metodos de uso.
ES2082515T3 (es) Composiciones de aseo.
NZ246598A (en) Trazodone derivatives; compounds and preparation, pharmaceutical compositions; intermediate compounds
IT1274483B (it) Composizioni farmaceutiche contenenti gemfibrozil
ECSP941088A (es) Composiciones
DE3465594D1 (en) Tropone derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
HUT49886A (en) Process for producing new beta-lactam antibiotics and pharmaceutical compositions comprising same
IT1265043B1 (it) Derivati di idroisochinolina

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 490689

Country of ref document: ES