DE69108200T2 - 3- [2- (dimethylamino) ethyl] -N-methyl-1H-indole-5-methanesulfonamide sulfate (2: 1). - Google Patents

3- [2- (dimethylamino) ethyl] -N-methyl-1H-indole-5-methanesulfonamide sulfate (2: 1).

Info

Publication number
DE69108200T2
DE69108200T2 DE69108200T DE69108200T DE69108200T2 DE 69108200 T2 DE69108200 T2 DE 69108200T2 DE 69108200 T DE69108200 T DE 69108200T DE 69108200 T DE69108200 T DE 69108200T DE 69108200 T2 DE69108200 T2 DE 69108200T2
Authority
DE
Germany
Prior art keywords
indole
dimethylamino
ethyl
methyl
methanesulfonamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69108200T
Other languages
German (de)
Other versions
DE69108200D1 (en
Inventor
Joanne Craig
Derek Leslie Crookes
Stephen John Skittrall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE69108200D1 publication Critical patent/DE69108200D1/en
Application granted granted Critical
Publication of DE69108200T2 publication Critical patent/DE69108200T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
DE69108200T 1990-12-12 1991-12-12 3- [2- (dimethylamino) ethyl] -N-methyl-1H-indole-5-methanesulfonamide sulfate (2: 1). Expired - Lifetime DE69108200T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026998A GB9026998D0 (en) 1990-12-12 1990-12-12 Medicaments

Publications (2)

Publication Number Publication Date
DE69108200D1 DE69108200D1 (en) 1995-04-20
DE69108200T2 true DE69108200T2 (en) 1995-07-20

Family

ID=10686904

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108200T Expired - Lifetime DE69108200T2 (en) 1990-12-12 1991-12-12 3- [2- (dimethylamino) ethyl] -N-methyl-1H-indole-5-methanesulfonamide sulfate (2: 1).

Country Status (36)

Country Link
US (2) US5554639A (en)
EP (1) EP0490689B1 (en)
JP (1) JP2994037B2 (en)
KR (1) KR100211479B1 (en)
CN (2) CN1030890C (en)
AP (1) AP230A (en)
AT (1) ATE119881T1 (en)
AU (1) AU650706B2 (en)
BE (1) BE1005085A3 (en)
CA (1) CA2098302C (en)
CH (1) CH684192A5 (en)
CY (1) CY2005A (en)
CZ (1) CZ281931B6 (en)
DE (1) DE69108200T2 (en)
DK (1) DK0490689T3 (en)
EG (1) EG20219A (en)
ES (1) ES2069836T3 (en)
FR (1) FR2670487B1 (en)
GB (2) GB9026998D0 (en)
GR (1) GR3015430T3 (en)
HK (1) HK82697A (en)
HU (1) HU211937A9 (en)
IE (1) IE62894B1 (en)
IL (1) IL100330A (en)
IS (1) IS1706B (en)
IT (1) IT1252868B (en)
MX (1) MX9102501A (en)
MY (1) MY109265A (en)
NL (1) NL9102071A (en)
NZ (1) NZ240942A (en)
PT (1) PT99757B (en)
RU (1) RU2108328C1 (en)
TW (2) TW205035B (en)
WO (1) WO1992010477A1 (en)
YU (1) YU48926B (en)
ZA (1) ZA919750B (en)

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US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
US6132757A (en) 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
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US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en) * 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
ATE404193T1 (en) * 2001-06-05 2008-08-15 Ronald Aung-Din TOPICAL MIGRAINE THERAPY
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
AU2003303631B2 (en) * 2002-12-26 2008-05-29 Nuvo Pharmaceuticals (Ireland) Designated Activity Company Multilayer Dosage Forms Containing NSAIDs and Triptans
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
US20070065463A1 (en) * 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
WO2005119607A2 (en) * 2004-06-03 2005-12-15 Tyfone, Inc. System and method for securing financial transactions
WO2005123043A2 (en) * 2004-06-10 2005-12-29 Duramed Pharmaceuticals, Inc. Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
US8283478B2 (en) 2005-05-20 2012-10-09 Janssen Pharmaceutica Nv Process for preparation of sulfamide derivatives
US20070166336A1 (en) * 2005-12-13 2007-07-19 David Delmarre Stable and palatable oral liquid sumatriptan compositions
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
AR058389A1 (en) 2005-12-19 2008-01-30 Janssen Pharmaceutica Nv USE OF SULFAMIDE BENZO-FUSED HETEROCICLIC DERIVATIVES FOR THE TREATMENT OF OBESITY
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
EA200870556A1 (en) 2006-05-19 2009-06-30 Янссен Фармацевтика Н.В. COMBINED THERAPY IN THE TREATMENT OF EPILEPSY AND RELATED DISORDERS
US8653066B2 (en) 2006-10-09 2014-02-18 Charleston Laboratories, Inc. Pharmaceutical compositions
AU2007310949A1 (en) * 2006-10-19 2008-04-24 Auspex Pharmaceuticals, Inc. Substituted indoles
US20080275030A1 (en) * 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
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US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
MX2010013019A (en) 2008-05-27 2011-03-21 Biota Scient Management Pty Ltd Antiviral salts.
EP2306998A4 (en) * 2008-06-20 2011-06-15 Alphapharm Pty Ltd Pharmaceutical formulation
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US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
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US9211282B2 (en) 2009-09-25 2015-12-15 Dr. Reddy's Laboratories Ltd. Formulations comprising triptan compounds
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
US10716766B2 (en) 2015-03-02 2020-07-21 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US10494405B2 (en) 2015-05-15 2019-12-03 The Regents Of The University Of Michigan Methods and compositions for the treatment of arthritis
JP2019507181A (en) 2016-03-04 2019-03-14 チャールストン ラボラトリーズ，インコーポレイテッド Pharmaceutical composition
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
US10723718B2 (en) 2017-11-07 2020-07-28 The Regents Of The University Of Michigan Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use
WO2020049523A1 (en) 2018-09-07 2020-03-12 Upsher-Smith Laboratories, Llc Methods of treating migraine
US11364225B2 (en) * 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same
IL295926A (en) * 2020-02-27 2022-10-01 Biohaven Pharmaceutical Holding Company Ltd Virgin Island Brited Company ׂLtdׁD Brr Oral fast-dispersing dosage form of rimegepant

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GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
EG20219A (en) 1997-11-30
MX9102501A (en) 1992-09-01
CZ114093A3 (en) 1994-02-16
NL9102071A (en) 1992-07-01
GB9026998D0 (en) 1991-01-30
AP9100339A0 (en) 1992-01-31
ITRM910922A1 (en) 1993-06-11
IE62894B1 (en) 1995-03-08
US5554639A (en) 1996-09-10
IL100330A0 (en) 1992-09-06
TW205035B (en) 1993-05-01
AU9072091A (en) 1992-07-08
NZ240942A (en) 1994-03-25
CY2005A (en) 1997-12-05
TW300886B (en) 1997-03-21
DE69108200D1 (en) 1995-04-20
IL100330A (en) 1996-06-18
ZA919750B (en) 1992-10-28
RU2108328C1 (en) 1998-04-10
GB2251614A (en) 1992-07-15
CA2098302C (en) 2001-10-16
DK0490689T3 (en) 1995-05-22
CZ281931B6 (en) 1997-04-16
HU211937A9 (en) 1996-01-29
HK82697A (en) 1997-06-27
CN1128259A (en) 1996-08-07
FR2670487B1 (en) 1993-08-20
BE1005085A3 (en) 1993-04-13
CA2098302A1 (en) 1992-06-13
GB2251614B (en) 1994-12-14
GR3015430T3 (en) 1995-06-30
JPH06503560A (en) 1994-04-21
YU191491A (en) 1994-04-05
ATE119881T1 (en) 1995-04-15
ITRM910922A0 (en) 1991-12-11
ES2069836T3 (en) 1995-05-16
AU650706B2 (en) 1994-06-30
IE914317A1 (en) 1992-06-17
US5705520A (en) 1998-01-06
JP2994037B2 (en) 1999-12-27
EP0490689B1 (en) 1995-03-15
IS1706B (en) 1998-12-10
CH684192A5 (en) 1994-07-29
FR2670487A1 (en) 1992-06-19
KR100211479B1 (en) 1999-08-02
EP0490689A1 (en) 1992-06-17
IT1252868B (en) 1995-06-28
CN1050831C (en) 2000-03-29
GB9126297D0 (en) 1992-02-12
WO1992010477A1 (en) 1992-06-25
IS3790A7 (en) 1992-06-13
CN1030890C (en) 1996-02-07
YU48926B (en) 2002-12-10
MY109265A (en) 1996-12-31
CN1063099A (en) 1992-07-29
AP230A (en) 1993-01-27
PT99757A (en) 1992-12-31
PT99757B (en) 1999-05-31

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